Developing a multivariate drought index to assess drought characteristics based on the SWAT-Copula method in the Poyang Lake basin, China by Liping Guo, Fusheng Chen, Bin Wang, De Li Liu, Xiulong Chen, Hongsheng Huang, Hua Bai, Kaitao Liao, Zhiming Xia, Keyu Xiang, Linchao Li, Taihui Zheng, Qiang Yu

“…Additionally, our wavelet period analysis showed an increase in drought frequency after the year 2000, with less distinct periodicity. …”
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Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry by Tamara W. van Hal, Juul M. P. A. van den Reek, Mark H. Wenink, Marisol E. Otero, Paul M. Ossenkoppele, Marcellus D. Njoo, Annet Oostveen, Bas Peters, Milan Tjioe, Else N. Kop, John E. M. Körver, Sharon R. P. Dodemont, Marloes M. Kleinpenning, Maartje A. M. Berends, Wendelien R. Veldkamp, Martijn B. A. van Doorn, Johannes M. Mommers, Robert-Jan Lindhout, Astrid L. A. Kuijpers, Paula P. van Lümig, C. (Els) J. de Jonge, Ron A. Tupker, Judith Hendricksen, Romy R. Keijsers, Frank H. J. van den Hoogen, Johanna E. Vriezekolk, Elke M. G. J. de Jong

“…Associations between impairments and contextual factors varied, but all impairments were associated with worse mental/physical general functioning.Conclusion: Patients with psoriasis using biologicals are less likely to have work-for-pay. …”
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Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin by Irene García-Jiménez, Irene García-Jiménez, Lídia Sans-de San Nicolàs, Sandra Díez-Ribas, Laia Curto-Barredo, Marta Bertolín-Colilla, Ana Vivancos-Melenchón, Ignasi Figueras-Nart, Montserrat Bonfill-Ortí, Anna Ryzhkova, Marta Ferran, Tali Czarnowicki, Ramon M. Pujol, Luis F. Santamaria-Babí

“…IL22P showed an increased degree of epidermal thickness, overexpression of IL22 in lesional skin areas, elevated specific IgE levels against HDM and SEB in plasma, and a higher proinflammatory profile compared to IL22NP.ConclusionsThis is the first report showing that allergen-specific CLA+ T-cell-mediated IL-22 in vitro response functionally distinguish moderate-to-severe adult AD patients with specific clinical features and activated IL-22 pathway in their lesional skin, paving the way for the selection of patients that may benefit from IL-22-directed therapies.…”
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Single-cell RNA sequencing reveals a fibroblast gene signature that promotes T-cell infiltration in muscle-invasive bladder cancer by Zige Liu, Xingning Mao, Yuli Xie, Yunkun Yan, Xiang Wang, Junhao Mi, Hao Yuan, Jiange Zhang, Caisheng Huang, Jianxin Chen, Mujia Jili, Shengzhu Huang, Qingyun Zhang, Fubo Wang, Zengnan Mo, Rirong Yang

“…Here, single-cell RNA sequencing of 19 tissue samples from 12 patients—7 MIBC, 3 non-muscle-invasive bladder cancer (NMIBC), and 9 normal tissue samples—identified 13 transcriptionally distinct fibroblast clusters and 10 functionally heterogeneous T-cell subsets. Two interferon (IFN)-responsive fibroblast populations, F-ISG15 (inflammatory CAFs) and F-POSTN (myofibroblastic CAFs), were shown to predominate in the MIBC TME. …”
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RsWRKY40 coordinates the cold stress response by integrating RsSPS1-mediated sucrose accumulation and the CBF-dependent pathway in radish (Raphanus sativus L.) by Sen Chen, Liang Xu, Yan Wang, Baozhen Mao, Xiaoli Zhang, Qiyu Song, Feng Cui, Yingbo Ma, Junhui Dong, Kai Wang, Hongyu Bi, Liwang Liu

“…Moreover, RsWRKY40 was identified as the upstream transcription activator of RsSPS1 by binding to its promoter. RsWRKY40 functioned in cambium activity and cold tolerance by modulating RsSPS1-mediated sucrose accumulation. …”
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Effects of Micro-Topography on Soil Nutrients and Plant Diversity of Artificial Shrub Forest in the Mu Us Sandy Land by Kai Zhao, Long Hai, Fucang Qin, Lei Liu, Guangyu Hong, Zihao Li, Long Li, Yongjie Yue, Xiaoyu Dong, Rong He, Dongming Shi

“…Additionally, redundancy analysis (RDA) was conducted to explore the direct and indirect relationships between micro-topography, shrub species, soil nutrients, and plant diversity. …”
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Development and validation of a fluency rating scale for Swiss German Sign Language by Tobias Haug, Nivja H. de Jong, Franz Holzknecht, Katja Tissi, Sandra Sidler-Miserez, Alessia Battisti, Regula Perrollaz, Sarah Ebling, Sabine Reinhard, Sarah Caminada

“…Overall, the rating scale functioned well, with each score category being modal at some point on the continuum. …”
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Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota by Lingyu Ruan, Zhennan Wang, Mengyun Zheng, Qi Zheng, Qing Qing, Hongyan Lin, Yuheng Tao, Liqun Wang, Junsong Wang, Wenhao Ge, Wenhao Ge

“…Further, 1H NMR based metabolomics and 16S rRNA gene sequencing examined gut microbiota metabolites and profiles, respectively, in order to elucidate the underlying mechanisms from the perspective of the gut-brain axis.ResultsPMP significantly improved the neurologic functions and reduced the cerebral infarction volume in MCAO/R rats. …”
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Individual Pharmacotherapy Management (IPM-II) for Patient and Drug Safety in Polypharmacy via Clinical Electronic Health Record Is Associated with Significant Fall Prevention by Ursula Wolf, Luise Drewas, Hassan Ghadir, Christian Bauer, Lars Becherer, Karl-Stefan Delank, Rüdiger Neef

“…A retrospective pre-post intervention study in geriatric traumatology on ≥70 years old patients compared 200 patients before IPM implementation (CG) with 204 patients from the IPM intervention period (IG) for the entire medication list, organ, cardiovascular and vital functions and fall risk parameters. Results: Statistically similar baseline data allowed a comparison of the average 80-year-old patient with a mean of 11.1 ± 4.9 (CG) versus 10.4 ± 3.6 (IG) medications. …”
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Cyperotundone promotes chemosensitivity of breast cancer via SRSF1 by Chao Li, Chao Li, Lin Wang, Zhaoyun Liu, Xinzhao Wang, Luhao Sun, Xiang Song, Zhiyong Yu, Zhiyong Yu

“…Cyperotundone (CYT) is the major bioactive component of sedge and reported to exhibit multiple biological functions, including its potent cytotoxic effect on breast cancer cells. …”
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Ultrasound Assessment in Polycystic Ovary Syndrome Diagnosis: From Origins to Future Perspectives—A Comprehensive Review by Stefano Di Michele, Anna Maria Fulghesu, Elena Pittui, Martina Cordella, Gilda Sicilia, Giuseppina Mandurino, Maurizio Nicola D’Alterio, Salvatore Giovanni Vitale, Stefano Angioni

“…<b>Results</b>: Conventional 2D ultrasound remains essential in clinical practice, with follicle number per ovary (FNPO) and ovarian volume (OV) functioning as primary diagnostic criteria. However, sensitivity and specificity values vary significantly depending on probe frequency, cut-off thresholds (≥12, ≥20, or ≥25 follicles), and patient characteristics (e.g., adolescence, obesity). …”
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NLRP3: a key regulator of skin wound healing and macrophage-fibroblast interactions in mice by Jiamin Zhao, Shuangyi Zhang, Zhiguo Gong, Wei Mao, Wenhui Bao, Qianru Li, Yunjie Bai, Feifei Gao, Shuang Feng

“…Supplementing NLRP3−/− conditioned media with PGE2 partially restored the impaired functions, suggesting that PGE2 acts as a downstream mediator of NLRP3-regulated macrophage-myofibroblast interactions. …”
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Association between TSH Values and GFR Levels in Euthyroid Cases with Metabolic Syndrome by H. Keskin, K. Cadirci, K. Gungor, T. Karaaslan, T. Usta, A. Ozkeskin, A. Musayeva, F. Yesildal, F. Isman, H. Y. Zengin

“…Independent of age and BMI, elevated TSH even in the euthyroid range showed an association with the eGFR in female MetS cases who had normal kidney functions. This correlation was stronger than the correlations between the eGFR and the MetS diagnostic parameters. …”
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How trait mindfulness protects late adolescents from stress-induced sleep problems: the unique role of mindfulness facets and gender differences by Huiting Cao, Jing Qian, Fenghua Tang, Yunyan Dong, Haining Ren, Xiaoran Xue, Ningning Mao, Xiaoyu Liu

“…While previous research has demonstrated the potential protective effect of trait mindfulness, facets of mindfulness were found to have unique functions against the negative impact of stress, and the unique impact of each facet of mindfulness on the sleep problems caused by the negative impact of stress remains unclear. …”
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CONFRONTATION AND MUTUAL REFLECTION OF TWO WORLDS IN “THE GRASS DANCER” BY SUSAN POWER by Oksana G. Shostak

“…The main purpose of this article is to outline a coherent theoretical and empirical model of multi-level functioning of Dakota national identity concept in the novel “The Grass Dancer” by Susan Power. …”
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Community-based exercise for health promotion and secondary cancer prevention in Canada: protocol for a hybrid effectiveness-implementation study by Margaret L McNeely, Christopher Sellar, Tanya Williamson, Melissa Shea-Budgell, Anil Abraham Joy, Harold Y Lau, Jacob C Easaw, Albert D Murtha, Jeffrey Vallance, Kerry Courneya, John R Mackey, Matthew Parliament, Nicole Culos-Reed

“…Research evidence supports the benefit of exercise during and following cancer treatments for cancer-related symptoms, physical functioning and fitness, and health-related quality of life. …”
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Optimizing the Construction Supply Chain Network Considering the Flow of Materials, Equipment, Manpower, Drawings and Technical Documents by Seyed Saeid Helli, Hadi Mokhtari, Saeed Dehnavi

“…All indices, parameters, decision variables, objective functions and constraints have been introduced and presented in the proposed model. …”
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A Smart Glass Telemedicine Application for Prehospital Communication: User-Centered Design Study by Zhan Zhang, Enze Bai, Yincao Xu, Aram Stepanian, Jared M. Kutzin, Kathleen Adelgais, Mustafa Ozkaynak

“…The iterative design process led to the identification of 5 key features that could potentially address the identified challenges: video call functionality with OLMC physicians, call priority indication for expedited OLMC contact, direct communication with receiving hospitals, multimedia patient information sharing, and touchless interaction methods for operating the smart glasses. …”
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Predicting Index Trend Using Hybrid Neural Networks with a Focus on Multi-Scale Temporal Feature Extraction in the Tehran Stock Exchange by Mohammad Osoolian, Ali Nikmaram, Mahdi Karimi

“…The primary focus of this research endeavor revolves around the predictive analysis of the Tehran Stock Exchange (TSE) Composite Index, wherein a novel hybrid neural network framework is employed. …”
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CTF development, verification, and validation for VVER core thermal-hydraulics and multi-physics modeling and simulation by Yesim Kutlu, Ivan Spasov, Svetlomir Mitkov, Pascal Rouxelin, Agustin Abarca, Nikola Kolev, Maria Avramova, Kostadin Ivanov, Kostadin Ivanov

“…In recent years, there has been considerable progress in code development, including new functionalities, application-specific correlations, various multi-physics applications, built-in pre- and post-processors, improved solvers, parallelization, and extensive testing. …”
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