Garlic Extracts Nanoliposome as an Enhancer of Bioavailability of ABA and Thiamine Content and as an Antifungal Agent Against <i>Fusarium oxysporum</i> f. sp. <i>pisi</i> Infecting... by Barbara Kutasy, Géza Hegedűs, Márta Kiniczky, József Péter Pallos, Ágnes Nagy, István Pócsi, Klaudia Pákozdi, Máté Kállai, Csaba Weingart, Katalin Andor, Bettina Kovács, Eszter Virág

“…Furthermore, the absence of <i>Fusarium</i> infection in the treated small-plot field cultures suggests that the tested garlic extracts formulation functions as a promising preventive biostimulant against plant fungal diseases.…”
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Effects of Three Different Bee Pollen on Digestion, Immunity, Antioxidant Capacity, and Gut Microbes in <i>Apis mellifera</i> by Xin-Meng Li, Ying Wang, Li Lei, Ge Zhang, Bao-Hua Xu

“…In summary, honeybees had the worst digestibility of Sunflower bee-collected pollen; sunflower bee pollen had a greater effect on antioxidant and immune functions, and intestinal flora of honeybees. These findings underscore the influence of different types of pollen on honeybee nutrition, immunity, and gut microbiota, offering a foundation for optimizing pollen diets to support honeybee health.…”
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Chlorophyllase (PsCLH1) and light-harvesting chlorophyll a/b binding protein 1 (PsLhcb1) and PsLhcb5 maintain petal greenness in Paeonia suffruticosa ‘Lv Mu Yin Yu’ by Qing Hao, Tongtong Li, Gaojie Lu, Shuo Wang, Zhen Li, Cancan Gu, Fan Kong, Qingyan Shu, Yang Li

“…Based on comparative transcriptomes, differentially expressed genes (DEGs) were identified, among which three were functionally characterized through overexpression in tobacco plants or silencing in ‘LMYY’ petals. …”
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The Effect of Disulfiram and N-Acetylcysteine, Potential Compensators for Sulfur Disorders, on Lipopolysaccharide-Induced Neuroinflammation Leading to Memory Impairment and the Met... by Małgorzata Iciek, Anna Bilska-Wilkosz, Magdalena Górny, Marek Bednarski, Małgorzata Zygmunt, Anthea Miller, Noemi Nicosia, Giorgia Pia Lombardo, Paula Zammit, Magdalena Kotańska

“…Behavior was evaluated by the novel object recognition (NOR) test and object location (OL) test, and the level of brain-derived neurotrophic factor (BDNF) was assayed to evaluate neuronal functioning. Cerebral cortex homogenates were tested for hydrogen sulfide (H₂S), sulfane sulfur, sulfates, non-protein sulfhydryl groups (NPSH), nitric oxide (NO), and reactive oxygen species (ROS) by biochemical analysis. …”
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Genetic diversity of TLR2, TLR4, and VDR loci and pulmonary tuberculosis in Moroccan patients by Naima Arji, Marc Busson, Ghali Iraqi, Jamal Eddine Bourkadi, Abdelaziz Benjouad, Abdellatif Bouayad, Christina Mariaselvam, Sofiane Salah, Catherine Fortier, Kahina Amokrane, François Marzais, Wahid Boukouaci, Rajagopal Krishnamoorthy, Dominique Charron, Rajae El Aouad, Ryad Tamouza

“…The VDR [f,b,a,T] haplotype was found to confer protection (pc < 0.00001; OR = 0.18; CI = 0.09 - 0.35), while the TLR2 [-16934T,+597C,+1349T] haplotype seemed to be at risk (p = 0.03; OR = 1.52; CI = 1.01 - 2.30), but  statistical significance was not reached. Finally, cross-analysis between polymorphisms of the three studied genes revealed significant interaction between TLR2 +597 and TLR4 +4434 SNPs towards protection against PTB (pc = 0.036), suggesting that the functionally relevant TLR4 +4434 SNP may act synergistically with TLR2 SNPs. …”
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Temporal dynamics of medium and micronutrient requirements in Epimedium pubescens: key elements regulating growth and Icariin-Flavonoids biosynthesis by Xiaojing An, Yanting Wang, Shangnian Liu, Ying Wang, Xianen Li, Baolin Guo, Haiying Wang, Caixia Chen

“…Nutrient deficiency experiments confirmed Mg, Fe, and Zn functioned as core elements governing growth, with deficiency causing chlorophyll loss and biomass reduction. …”
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Effect of monovalent/divalent ions and SiO2-based nanocomposite dosage on thermochemical stability of HPAM polymeric solutions by Jhon F. Gallego, Lady J. Giraldo, Henderson I. Quintero, Hugo A. García, Karol Zapata, Samira Heidari, Masoud Riazi, Camilo A. Franco, Farid B. Cortés

“…This study evaluated the effect of monovalent and divalent ions and the dosage of a SiO2-based nanocomposite on the thermochemical stability of HPAM polymeric solution. Chelating amine–functionalized NPs (AFNPs) were used to enhance the thermochemical stability of HPAM based on capturing monovalent/divalent ions after seven days at 70°C. …”
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Acetylation suppresses breast cancer progression by sustaining CLYBL stability by Xinyue Deng, Chenglong Ma, Xingyu Chen, Ming Yi, Qianhua Cao, Ruocen Liao, Xingyu Lei, Longchang Bai, Bin Zhao, Yingnan Wang, Zhuoyang Shen, Liujing Wu, Chenfang Dong, Zhijun Dai

“…The acetylation patterns of CLYBL and the related regulatory functions were detected by high resolution mass spectrometry, immunoprecipitation assays, and western blot analysis. …”
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Three Decades of Land Cover Dynamics in a Boreal Coastal Basin: A Multisensor Spectral Index and Machine Learning Approach Using Landsat Data and GB-SAR Data by Jinsong Zhang, Bochi Zou, Yifei Yuan, Asad Khan, Muhammad Bilawal Junaid, Qaiser Abbas, Rana Muhammad Zulqarnain, Nazih Y. Rebouh, Olga D. Kucher, Hassan Alzahrani

“…Boreal coastal habitats, with their complex hydrological, ecological, and geological functions, play a pivotal role in regulating regional climate, supporting biodiversity, and sustaining local communities. …”
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Bindarit attenuates neuroinflammation after subarachnoid hemorrhage by regulating the CCL2/CCR2/NF-κB pathway by Yanting Yao, Qiaowei Wu, Kaikun Yuan, Pei Wu, Chao Xu, Zhiyong Ji, Weishi Xu, Hongli Yu, Anyu Xu, Yanchen Liu, Huaizhang Shi

“…Bindarit improved neurological functions and reduced neuroinflammation by regulating the CCL2/CCR2/NF-κB pathway in early brain injury after SAH.…”
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Evaluation of the efficacy and safety of a precise thymalfasin-regulated PRaG regimen for advanced refractory solid tumours: protocol for the open-label, prospective, multicentre s... by Yong Peng, Hong Zhang, Junjun Zhang, Liyuan Zhang, Pengfei Xing, Yuehong Kong, Rongzheng Chen, Meiling Xu, Guangqiang Chen, Zhihui Hong, Xiaoxiao Dai, Yifu Ma, Xiangrong Zhao, Chenyang Zhang

“…Coupling the PRaG regimen with immunomodulatory agents that augment the number and functionality of lymphocytes may yield further survival benefits in this cohort of patients.Objective The aim of this study is to investigate the effectiveness and safety of a meticulously thymalfasin-controlled PRaG regimen in patients with advanced and chemotherapy-resistant solid tumours.Methods and analysis The study has a prospective, single-arm, open-label, multicentre design and aims to recruit up to 60 patients with histologically confirmed advanced solid tumours that have relapsed or metastasised. …”
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Insights into the Biological Activity and Bio‐Interaction Properties of Nanoscale Imine‐Based 2D and 3D Covalent Organic Frameworks by Hao Ye, Carlos Franco, Mostafa A. Aboouf, Markus Thiersch, Semih Sevim, Joaquin Llacer‐Wintle, Andrea Veciana, Gemma Llauradó‐Capdevila, Kaiyuan Wang, Xiang‐Zhong Chen, Qiao Tang, Roc Matheu, Pedro D. Wendel‐Garcia, Pedro A. Sánchez‐Murcia, Bradley J. Nelson, Cong Luo, Josep Puigmartí‐Luis, Salvador Pané

“…Their customizable functionalities and tunable pore structures make them valuable for various biomedical applications such as biosensing, bioimaging, antimicrobial activity, and targeted drug delivery. …”
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Label-Free Optical Transmission Tomography for Direct Mycological Examination and Monitoring of Intracellular Dynamics by Eliott Teston, Marc Sautour, Léa Boulnois, Nicolas Augey, Abdellah Dighab, Christophe Guillet, Dea Garcia-Hermoso, Fanny Lanternier, Marie-Elisabeth Bougnoux, Frédéric Dalle, Louise Basmaciyan, Mathieu Blot, Pierre-Emmanuel Charles, Jean-Pierre Quenot, Bianca Podac, Catherine Neuwirth, Claude Boccara, Martine Boccara, Olivier Thouvenin, Thomas Maldiney

“…Live-cell imaging generally requires pretreatment with fluorophores to either monitor cellular functions or the dynamics of intracellular processes and structures. …”
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Composition of Triterpene Glycosides of the Far Eastern Sea Cucumber <i>Cucumaria conicospermium</i> Levin et Stepanov; Structure Elucidation of Five Minor Conicospermiumosides A<s... by Alexandra S. Silchenko, Ekaterina A. Chingizova, Ekaterina S. Menchinskaya, Elena A. Zelepuga, Anatoly I. Kalinovsky, Sergey A. Avilov, Kseniya M. Tabakmakher, Roman S. Popov, Pavel. S. Dmitrenok, Salim Sh. Dautov, Vladimir I. Kalinin

“…The structures of new compounds were established on the basis of extensive analysis of the 1D and 2D NMR spectra, as well as by the HR-ESI-MS data. …”
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Bioactive Coatings on 3D Printed Polycaprolactone Scaffolds for Bone Regeneration: A Novel Murine Femur Defect Model for Examination of the Biomaterial Capacity for Repair by Karen M. Marshall, Jonathan P. Wojciechowski, Vineetha Jayawarna, Abshar Hasan, Cécile Echalier, Sebastien J. P. Callens, Tao Yang, Janos M. Kanczler, Jonathan I. Dawson, Alvaro Mata, Manuel Salmeron‐Sanchez, Molly M. Stevens, Richard O. C. Oreffo

“…The current study examines bone augmentation in critical‐sized bone defects, using functionalized scaffolds, with the hypothesized potential to induce skeletal cell differentiation. 3D printed, porous poly(caprolactone) trimethacrylate (PCL‐TMA900) scaffolds are applied within a murine femur defect, stabilized by a polyimide intramedullary (IM) pin. …”
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<i>MECP2</i> mRNA Profile in Brain Tissues from a Rett Syndrome Patient and Three Human Controls: Mutated Allele Preferential Transcription and In Situ RNA Mapping by Martina Mietto, Silvia Montanari, Maria Sofia Falzarano, Elisa Manzati, Paola Rimessi, Marina Fabris, Rita Selvatici, Francesca Gualandi, Marcella Neri, Fernanda Fortunato, Miryam Rosa Stella Foti, Stefania Bigoni, Marco Gessi, Marcella Vacca, Silvia Torelli, Joussef Hayek, Alessandra Ferlini

“…In the RTT brain specimen, RT-PCR analysis detected preferential transcription of the mutated mRNA. …”
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On the determination of the interaction time of GeV neutrinos in large argon gas TPCs by A. Saá-Hernández, D. González-Díaz, J. Martín-Albo, M. Tuzi, P. Amedo, J. Baldonedo, C. Benítez, S. Bounasser, E. Casarejos, J. Collazo, A. Fernández-Prieto, D. J. Fernández-Posada, R. Hafeji, S. Leardini, D. Rodas-Rodríguez, A. L. Saborido, A. Segade, A. Slater

“…We propose to accomplish this through an optically-read time projection chamber (TPC) filled with high-pressure argon and equipped with both tracking and timing functions. In this work, we present a detailed study of the time-tagging capabilities of such a device, based on end-to-end optical simulations that include the effect of photon propagation, photosensor response, dark count rate and pulse reconstruction. …”
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Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis by Ningning Yue, Hailan Zhao, Peng Hu, Yuan Zhang, Chengmei Tian, Chen Kong, Zhiliang Mai, Longbin Huang, Qianjun Luo, Daoru Wei, Ruiyue Shi, Shaohui Tang, Yuqiang Nie, Yujie Liang, Jun Yao, Lisheng Wang, Defeng Li

“…Second, L. reuteri-CMVs were taken up by intestinal epithelial cells (IECs), elevated the expression of ZO-1, E-cadherin (Cdh1), and Occludin (Ocln), decreased intestinal permeability, and exerted protective effects on epithelial tight junction functionality. RNA sequencing analysis demonstrated that L. reuteri-CMVs repaired intestinal barrier by activating the HIF-1 signaling pathway and upregulating HMOX1 expression. …”
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Evidence of Interaction between Ion-scale Waves and Ion Velocity Distributions in the Solar Wind by Yogesh, Leon Ofman, Scott A. Boardsen, Kristopher Klein, Mihailo Martinović, Viacheslav M. Sadykov, Jaye L. Verniero, Niranjana Shankarappa, Lan K. Jian, Parisa Mostafavi, Jia Huang, K. W. Paulson

“…During PSP Encounter 17 (at 11.4 R _s ) on 2023 September 26, the PSP/FIELDS instrument detected enhanced ion-scale wave activity associated with deviations from local thermodynamic equilibrium in ion velocity distribution functions (VDFs) observed by the PSP/Solar Probe Analyzers-Ion. …”
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ROS-activated CD147-type I interferon signaling axis drives vascular smooth muscle cell fate transition and abdominal aortic aneurysm progression by Fangyuan Zhong, Hengyuan Zhang, Xinning Guo, Yichao Zhao, Yufei Wang, Wenli Li, Yuyan Lyu, Heng Ge, Xiyuan Lu, Jun Pu

“…Functionally, CD147 deletion in VSMCs significantly mitigated Angiotensin II- and CaPO4-induced AAA formation, accompanied by improved VSMC phenotype, reduced vascular inflammation and extracellular matrix degradation in vivo. …”
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