Serum matrix metalloproteinase‐7, Syndecan‐1, and CA 19‐9 as a biomarker panel for diagnosis of pancreatic ductal adenocarcinoma by Doron Yablecovitch, Moshe Nadler, Shomron Ben‐Horin, Orit Picard, Miri Yavzori, Ella Fudim, Moran Tardio Duchan, Emad Sakhnini, Alon Lang, Maor Lahav, Talia Saker, Sandra Neuman, Limor Selinger, Biana Freitz, Revital Dvir, Maria Raitses‐Gurevich, Talia Golan, Idan Levy, Ido Laish

“…Abstract Aims and Background Matrix metalloproteinase‐7 (MMP‐7) and Syndecan‐1 (SDC1) are involved in multiple functions during tumorigenesis. We aimed to evaluate the diagnostic and prognostic performance of these serum proteins, as potential biomarkers, in patients with pancreatic ductal adenocarcinoma (PDAC) and benign pancreatic cysts. …”
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The maize gene ZmSBP17 encoding an SBP transcription factor confers osmotic resistance in transgenic Arabidopsis by Lifang Sun, Lifang Sun, Lijiao Wang, Jinping Niu, Wei Yang, Zhifang Li, Libin Liu, Libin Liu, Shuren Gao, Shuren Gao

“…These results indicate that the overexpression of ZmSBP17 in Arabidopsis thaliana significantly increased tolerance to osmotic stress during the germination and seedling stages, which may enhance our understanding of the biological functions of SBPs in maize under abiotic stresses.…”
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Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth into Retinal Photoreceptor-Like Cells and Their Sustainability In Vivo by Xiaoxia Li, Jing Xie, Yue Zhai, Tengjiaozi Fang, Nanquan Rao, Shuang Hu, Liping Yang, Yuming Zhao, Yixiang Wang, Lihong Ge

“…Many studies have reported that mesenchymal stem cell transplantation can sustain retinal structure and prolong retinal functions based on two mechanisms. One is cell replacement, and the other is the paracrine action of stem cells. …”
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Evolution history dominantly regulates fine root lifespan in tree species across the world by Xingzhao Huang, Zhouying Lu, Fangbing Li, Yang Deng, Fangfang Wan, Quancheng Wang, Fousseni Folega, Jinsong Wang, Zijian Guo

“…We compiled a dataset of 421 fine root lifespan observations from 76 tree species globally to assess phylogenetic signals among species, explored relationships between fine root lifespan and biotic and abiotic factors, and quantified the relative importance of phylogeny, root system structure and functions, climatic and edaphic factors in driving global fine root lifespan variations. …”
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The potential habitat of Phlomoides rotata in Tibet was based on an optimized MaxEnt model by Jun-Wei Wang, Jun-Wei Wang, Min Xu, Norbu Ngawang, Yonghao Chen, Ngawang Bonjor, Xiaoyan Jia, Zhefei Zeng, Zhefei Zeng, La Qiong, La Qiong

“…IntroductionPhlomoides rotata, an important Tibetan medicinal plant, has garnered significant attention due to its remarkable medicinal value and ecological functions. However, overharvesting and climate change have progressively reduced its distribution range, threatening its survival.MethodsThis study employed an optimized MaxEnt model, integrating field survey data and multiple environmental variables, to predict and analyze the potential suitable distribution of P. rotata in Tibet.ResultsThe model achieved high predictive accuracy, with Ture skill statistic (TSS) = 0.87 and Cohen’s Kappa Coefficient (Kappa) = 0.81. …”
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HIV-1 Vpu interacts with RBM10 to promote HIV-1 infection by Boye Li, Yanzhe Hao, Xianbin Meng, Xiaoming Wang, Qingyan Li, Runqing Jia, Yishu Yang, Jinning Yang, Boyang Yu, Tian Chen, Wenmei Zhang, Xiaoguang Zhang, Xiayan Wang, Qin Hu

“…ABSTRACT Viral protein U (Vpu), an accessory protein of HIV-1, functions by antagonizing or hijacking various host factors to allow the virus to evade host immune surveillance and facilitate viral release. …”
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Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model by Alexander A. Oliver, Alexander A. Oliver, Alexander A. Oliver, Cem Bilgin, Jonathan Cortese, Jonathan Cortese, Esref A. Bayraktar, Daying Dai, Yong Hong Ding, Kent D. Carlson, Adam J. Griebel, Jeremy E. Schaffer, Mitchell L. Connon, Dan Dragomir-Daescu, Dan Dragomir-Daescu, Ramanathan Kadirvel, Roger J. Guillory, David F. Kallmes, David F. Kallmes

“…We previously prototyped BRFDs using an iron-manganese-nitrogen (FeMnN) alloy and demonstrated their flow diversion functionality, radial strength, bioresorbability, and MRI compatibility in benchtop tests. …”
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Modulatory effect of various essential oils on different GABAA receptor subtypes present in the central nervous system by Christian Böhm, Anna-Lena Wiessler, Dieter Janzen, Julian Nausester, Benedikt Slavik, Helene M. Loos, Carmen Villmann, Andrea Buettner

“…Methods: The chemical composition of the EOs was investigated by gas chromatography coupled with mass spectrometry. EOs were functionally investigated on transfected HEK293 cells with GABAARs by patch-clamp whole-cell recordings. …”
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Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro‐Angiogenic Macrophage Polarization via Activation of the PI3K‐Akt Signaling Pathway by Qun Cui, Xiaona Zheng, Yunyang Bai, Yaru Guo, Shuo Liu, Yanhui Lu, Lulu Liu, Jia Song, Yang Liu, Boon Chin Heng, Fuping You, Mingming Xu, Xuliang Deng, Xuehui Zhang

“…This study elucidates the cascade of biological processes by which heterogeneous electrical signals at the micro‐ and nanoscale modulate macrophage functions to promote vascularization and bone regeneration. …”
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TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection by Liang Wang, Liang Wang, Yumei Liu, Yuyu Ma, Xuan Zhou, Xuan Zhou, Maidinaimu Aibibula, Xue Zhang, Hui Zhao, Jinping Zhou, Fengming Tian, Fengming Tian, Xiumin Ma

“…The liver immune microenvironment at the middle and late stages of mice infected with E. multilocularis was established in vitro to assess cytokine dynamics and liver fibrosis biomarkers.ResultsClinical analysis revealed the upregulation of Tim-4 within the hepatic lesions of patients with AE, with its expression spatially localized to macrophage-enriched regions and functionally linked to extracellular inflammatory modulation. …”
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A Study of Real-time Detection Methods for Solar Radio Burst Identification by YongLin Yu, ChengLong Qiao, Shuo Xu, QinZheng Li, YanRui Su, HongQiang Song, FaBao Yan

“…The method also includes functionalities for email alerts, burst information recording, and control parameter adjustment, confirming its effectiveness and practicality. …”
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Genotypic richness of Phragmites australis negatively impacts ecosystem multifunctionality in the coastal wetland of Yellow River Delta, China by Liwen Zhang, Lianjun Zhao, Siqun Lan, Lin Chen, Guangxuan Han

“…The study of the relationship between genetic diversity and ecosystem functions (EFs) primarily focuses on the relationship between species diversity and EFs, with less emphasis on investigating the connection between genetic diversity and EFs, particularly in relation to ecosystem multifunctionality. …”
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The Molecular Mechanism of Interaction Between SEPALLATA3 and APETALA1 in Arabidopsis thaliana by Xiao‐Min Tan, Ya‐Ru Li, Man‐Ru Song, Ling‐Na Yuan, Zi‐Xin Zhao, Ye Liu, Qi Meng, Xuan Huang, Ye‐Ye Ma, Zi‐Qin Xu

“…In Arabidopsis, SEP3 functions as a central integrator, combining MADS proteins into a tetrameric complex, with its interaction with AP1 playing a key role in sepal and petal formation. …”
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Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies by Nikola Dordevic, Clemens Dierks, Essi Hantikainen, Vadim Farztdinov, Fatma Amari, Vinicius Verri Hernandes, Alessandro De Grandi, Francisco S. Domingues, Orr Shomroni, Kathrin Textoris-Taube, Vivien Bahr, Hannah Schmid, Ilja Demuth, Florian Kurth, Michael Mülleder, Peter Paul Pramstaller, Johannes Rainer, Markus Ralser

“…Methods Utilizing high-throughput mass spectrometry, we quantified 148 highly abundant proteins, functioning in the innate and adaptive immune system, coagulation and nutrient transport in 3632 blood plasma, and 500 serum samples from the CHRIS and BASE-II cross-sectional population studies, respectively. …”
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Bifidobacterium animalis suppresses non-small cell lung cancer progression and modulates tumor immunity through indole-3-acetic acid by Qian Song, Xinpei Li, Qing Li, Shijie Shang, Shuling Ma, Zijun Zhai, Fengxin Sun, You Mo, Ling Wei, Meng Wu, Yuequn Ma, Jinming Yu, Dawei Chen

“…Moreover, B. animalis and IAA diminish polarization of M2 macrophage and enhance CD8+ T cell functions by suppressing interleukin-6 (IL-6). B. animalis and its derived IAA protect against NSCLC by modulating AHR/METTL3/STAT3 and bolstering antitumor immunity through gut-lung axis. …”
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lncRNA <i>EGOT</i> Is the Marker of HPV Infection and a Prognostic Factor for HNSCC Patients by Tomasz Kolenda, Piotr Białas, Kacper Guglas, Maciej Stasiak, Joanna Kozłowska-Masłoń, Karina Tylkowska, Anna Zapłata, Paulina Poter, Marlena Janiczek-Polewska, Patrycja Mantaj, Paulina Gieremek, Urszula Kazimierczak, Anna Przybyła, Katarzyna Regulska, Beata Stanisz, Ewa Leporowska, Andrzej Mackiewicz, Jacek Mackiewicz, Joanna Kazmierska, Zefiryn Cybulski, Anna Teresiak

“…<b>Background:</b> High-risk human papillomavirus (HPV) contributes to oropharyngeal cancers through mechanisms involving the deregulation of host cell functions by oncoproteins E6 and E7. Changes in the epigenome, particularly involving long non-coding RNAs (lncRNAs), are crucial for understanding HPV-related carcinogenesis. …”
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A splice donor variant in SLAMF1 is associated with canine atopic dermatitis by Oliver P. Forman, Jamie Freyer, Abigail Kerr, Julia D. Labadie, Michael Denyer, Debbie J. Gow, Janet Alexander, Michelle Daya, Yaindrys Rodriguez Olivera, Cecilia Lozoya, Christian Leutenegger, Christian Savard, Jason T. Huff, Rebecca Chodroff Foran

“…Whole-genome resequencing revealed a compelling splice donor variant in the signaling lymphocytic activation molecule 1 (SLAMF1), a transmembrane receptor with important functions in immune cells. Further analysis of additional genome sequences and RNA samples from the MARS PETCARE BIOBANK confirmed that the SLAMF1 splice variant is a strong potential contributor to an increased risk of atopic dermatitis.DiscussionThe discovery represents the first compelling genetic variant associated with CAD to be validated in more than one breed of dog. …”
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Unveiling the Full Protein Effectorome of the Black Sigatoka Pathogen <i>Pseudocercospora fijiensis</i>—An In Silico Approach by Karla Gisel Carreón-Anguiano, Jewel Nicole Anna Todd, César De los Santos-Briones, Santy Peraza-Echeverría, Ignacio Islas-Flores, Blondy Canto-Canché

“…Protein families related to key functions of the hemibiotrophic lifestyle, such as Salicylate hydroxylase and Isochorismatase, are widely represented families of effectors in the <i>P. fijiensis</i> genome. …”
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Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…Primary outcomes will include adolescent internalising problems and social support, family functioning and attendance during the programme. Secondary outcomes will assess broader aspects of mental health among caregivers and adolescents, as well as implementation and cost outcomes. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…Furthermore, we functionally demonstrate the inhibitory effect of the selected nanobodies in cell-based transmigration assays of the human colorectal cancer cell line HT-29.DiscussionIn summary, our study has identified and characterized four novel inhibitory high-affinity gp130 nanobodies with potential for use in cytokine-dependent autoimmunity or cancer therapy.…”
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