Interleukin-35 impairs human NK cell effector functions and induces their ILC1-like conversion with tissue residency features by Valentin Picant, Lara Revol-Bauz, Laurie Tonon, Timothée Casini, Aurélien Voissière, Dominique Poujol, Emilie Picard, Céline Rodriguez, Cyril Degletagne, Emily Sible, Uzma Hasan, Anthony Ferrari, Christophe Caux, Nathalie Bendriss-Vermare

“…Abstract Natural Killer (NK) cells play pivotal immunological roles including direct cytotoxic effector function and secretion of inflammatory and immunomodulating cytokines. …”
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The sucrose synthase gene family in blueberry (Vaccinium darrowii): functional insights into the role of VdSUS4 in salt stress tolerance by Yanwen Wang, Yanwen Wang, Yanwen Wang, Lei Yang, Lei Yang, Lei Yang, Lei Yang, Lei Yang, Wenzhu Geng, Wenzhu Geng, Wenzhu Geng, Hongxia Zhang, Hongxia Zhang, Hongxia Zhang, Hongxia Zhang, Hongxia Zhang, Houjun Zhou, Houjun Zhou, Houjun Zhou, Houjun Zhou, Houjun Zhou

“…Our analysis encompassed the physicochemical properties, gene structures, conserved motifs, promoter cis-acting elements, chromosomal locations, evolutionary relationships and expression profiles of these family members, allowing us to predict their potential functions. ResultsWe identified seven distinct SUS genes, mapped across six chromosomes, showcasing the complexity of this gene family in blueberries. …”
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Influence of the biophosphomag preparation and biologically active substances from milk thistle seeds (Silybum marianum) on the metabolism of lymphocytes and their functional featu... by Petro Fedyshyn, Olga Pavliuk, Ivan Stupak, Taisa Dovbynchuk, Yulia Pysmenna, Volodymyr Liashenko, Natalia Senchylo, Serhii Holopura, Liliia Kalachniuk, Liudmyla Garmanchuk

“…Considering that the immune system is adaptive and functions to protect the body by suppressing pathogenic microorganisms and tumor growth through a series of coordina­ted signals that regulate activation, proliferation, and differentiation of T cell populations, the aim of this study was to assess proliferative activity, cell viability, and SH-group levels in lymphocytes under the influence of the OVA, OVA+, and V3 protective agents. …”
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Effects of Twelve Weeks of Square Stepping Exercises on Physical and Cognitive Function and Plasma Content of SMP30: A Randomised Control Trial by Juan Manuel Franco-García, Jorge Pérez-Gómez, Antonio Castillo-Paredes, Pedro Cosme Redondo, Jorge Rojo-Ramos, Noelia Mayordomo-Pinilla, Santos Villafaina, Mari Carmen Gómez-Álvaro, Maria Melo-Alonso, Jorge Carlos-Vivas

“…Background: Ageing and sedentary lifestyles affect physical and cognitive function and markers of frailty, increasing the risk of falls in older adults and affecting their quality of life. …”
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Brain-wide mapping of acute hypoxia-induced neuronal activation in mice: A c-Fos immunofluorescence study by Xingyao Yu, Pai Pang, Tao Liu, Xiufang Jiang, Jiayi Zhang, Xiangpei Yue, Jianjun Guo, Xiang Cheng, Tong Zhao, Yongqi Zhao, Zhonghua Dai, Lingling Zhu

“…Acute hypobaric hypoxic exposure, defined as rapid ascent to high altitude with brief sojourn, triggers profound physiological adaptations while increasing risks of acute mountain sickness (e.g., gastrointestinal distress, pulmonary/cerebral edema). …”
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QUELLE (S) FONCTION (S) COMMUNICATIVE (S) POUR LA QUESTION DANS LE DISCOURS RADIOPHONIQUE ALGÉRIEN? by Hamza Kernou

“…This study aims to analyze the communicative functions of questions in Algerian radio discourse. …”
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A New Family of Odd Nakagami Exponential (NE-G) Distributions by Mathee Pongkitiwitoon, Obalowa Job, İbrahim Abdullahi

“…Quantile, hazard rate function, moments, incomplete moments, order statistics, and entropies are only a few of the statistical features that are investigated. …”
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Dynamic analysis of a Caputo fractional-order SEIR model with a general incidence rate by Shenghu Xu, Yanhui Hu

“…Based on Lyapunov functions, we rigorously prove that the disease-free equilibrium is globally asymptotically stable when $$R_0<1$$ R 0 < 1 , and the endemic equilibrium is globally stable when $$R_0>1$$ R 0 > 1 . …”
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Research Progress of DNA Methylation in Fish by Hai HUANG, Yan LU, Liu CAO

“…DNA methylation occurs primarily at the CG site and allows fish to precisely regulate gene expression and adapt to different environmental factors. Differential methylation—cytosine-phosphate-guanine sites—is involved in apoptosis, epigenetic regulation, autophagy, collagen metabolism, cell membrane function, and homeobox protein generation through gene expression regulation. …”
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Predictors of Occupational Adaptation in Individuals With Parkinson’s Disease by Jafar Haj Ghani, Ghorban Taghizadeh, Akram Azad, Seyed Amir Hasan Habibi

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Rsp5-mediated ubiquitination of a functional analog of the Rim8 arrestin facilitates Rim pathway activation in Cryptococcus neoformans by Lukas M. du Plooy, Corinna Probst, Matthew E. Capobianco, Charles Giamberardino, Claudia A. Petrucco, J. Andrew Alspaugh

“…ABSTRACT Pathogenic microorganisms use varied cellular processes to adapt to the particular stresses encountered in the infected host. …”
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Effects of individualized resistance training prescription with heart rate variability on muscle strength, muscle size and functional performance in older women by Diego Bittencourt, Ramon Martins de Oliveira, Deivid Gomes da Silva, João Guilherme Almeida Bergamasco, Marcelo de Castro Cesar, Daniela Godoi Jacomassi, Júlio Benvenutti Bueno de Camargo, J. Derek Kingsley, Cleiton Augusto Libardi

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Functional analysis of two SfHsp90 genes in response to high temperature and insecticide stress in Spodoptera frugiperda (Lepidoptera: Noctuidae) by Hong-Yun RUAN, Lv ZHOU, Lei YANG, Jian-Yu MENG, Chang-Yu ZHANG

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Leveraging flexible pipette-based tool changes to transform liquid handling systems into dual-function sample preparation and imaging platforms by Mohammad Nazeri, Jeffrey Watchorn, Sheldon Mei, Alex Zhang, Christine Allen, Frank Gu

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LuCSD3 enhances salt stress tolerance in flax: genome-wide profiling and functional validation of the SOD gene family by Yuan Zhang, Ruinan Wang, Hengping Wang, Huiyan Wang

“…Superoxide dismutase (SOD) serves as a critical regulator of plant stress adaptation to salinity, drought, and heavy metal toxicity. …”
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Comparative genomics of obligate predatory bacteria belonging to phylum Bdellovibrionota highlights distribution and predicted functions of lineage-specific protein families by Sidney C. Davis, Joseph Cerra, Laura E. Williams

“…Our analyses highlight key genome content differences between obligate predatory bacteria and non-predatory relatives and identify gene clusters that may encode enzymes adapted to predatory lifestyles. These lineage-specific proteins are strong candidates for functional characterization to clarify their role in predation.IMPORTANCEEvolution of predation as a bacterial lifestyle involves selective pressure on and adaptation of enzymes that contribute to killing and digestion of prey bacteria, in some cases from within the prey itself. …”
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Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers by Syed K. Hasan, Sundarraj Jayakumar, Eliezer Espina Barroso, Anup Jha, Gianfranco Catalano, Santosh K. Sandur, Nelida I. Noguera

“…This review provides a comprehensive overview of Nrf2 regulation and function, highlighting its unique features in cancer biology, particularly its role in metabolic adaptation and drug resistance. …”
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Functional Investigation of the Receptor to the Major Pheromone Component in the C-Strain and the R-Strain of the Fall Armyworm <i>Spodoptera frugiperda</i> by Arthur Comte, Alizée Delarue, Marie-Christine François, Christelle Monsempes, Camille Meslin, Nicolas Montagné, Emmanuelle Jacquin-Joly

“…To address this gap, we functionally expressed the receptors to the major sex pheromone component of the two strains in <i>Drosophila</i> olfactory sensory neurons and challenged them with a large panel of pheromone compounds using single-sensillum recordings. …”
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Luteolin, a common flavone in vegetables, acts as a hormetin possessing neurotrophic function: signaling mediated by inducing mitochondrial stress by Alex Xiong Gao, Tracy Chenxi Xia, Maggie Suisui Guo, Gary Kawing Yuen, Kevin Qiyun Wu, Tina Tingxia Dong, Karl Wah-Keung Tsim

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Impaired Caveolae Function and Upregulation of Alternative Endocytic Pathways Induced by Experimental Modulation of Intersectin-1s Expression in Mouse Lung Endothelium by Dan N. Predescu, Radu Neamu, Cristina Bardita, Minhua Wang, Sanda A. Predescu

“…Moreover, our results demonstrate that ECs are highly adapted to perform their transport function while maintaining lung homeostasis.…”
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