Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells by Rossella Benedetti, Michele Di Crosta, Maria Saveria Gilardini Montani, Gabriella D’Orazi, Mara Cirone

“…Our findings indicate that mutp53 mitigates ER stress-induced DNA damage by sustaining high levels of Ku70, a critical protein in DNA repair via the non-homologous end joining (NHEJ) pathway, which functions alongside Ku80. HDAC6 upregulation emerged as a crucial driver of this response. …”
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A comparative typology of verbal affixes in Riau-Malay and Sundanese by Azhary Tambusai, Khairina Nasution

“…By comparing and contrasting the verbal affixation systems in these languages, this study aims to reveal striking differences in terms of affix types, attachment patterns, and grammatical functions. The analysis explored the morphology of verbal affixes used in Riau-Malay and its comparison in Sundanese. …”
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Human Resource Management in Public Administration: The Ongoing Tension Between Reform Requirements and Resistance to Change by Branka Zolak Poljašević, Ana Marija Gričnik, Simona Šarotar Žižek

“…This study also highlights that while legal and procedural adjustments have been made, many public administrations struggle with the practical application of reform policies due to entrenched bureaucratic cultures and limited professionalization of HRM functions. By providing a structured synthesis of existing research, this study contributes to a deeper understanding of HRM transformation in post-socialist public administrations. …”
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Influence of Large Vehicles on the Speed of Expressway Traffic Flow by Chao Gao, Jinliang Xu, Xingli Jia, Yaping Dong, Han Ru

“…A laser roadside traffic survey instrument with automatic vehicle type identification functionality was used to collect cross section traffic flow data. …”
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Multi-Aspect Probability Model of Expected Profit Subject to Uncertainty for Managerial Decision-Making in Local Transport Problems by Martin Holubčík, Lukáš Falát, Jakub Soviar, Juraj Dubovec

“…These models incorporate probabilistic functions to calculate expected costs and profits, considering various factors such as reparation costs, financial compensations, social costs, and time-related costs, as well as long-term benefits like increased investment and lives saved. …”
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PROSPECTS OF THE USE OF BUCCAL FAT PAD FOR CLOSING DEFECTS OF THE ALVEOLAR PROCESS OF THE JAWS by O. V. Ruzhytska

“…In recent years numerous studies are aimed at developing such surgical techniques, which and promote the would provide sanation of the inflammatory focus, support physiological processes on sites of soft tissue defects or promote their recovery and normal functioning. The easy access to buccal fat pad continues to attract interest regarding its application for the closure of defects. …”
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Reconstruction of the core and extended regulons of global transcription factors. by Yann S Dufour, Patricia J Kiley, Timothy J Donohue

“…Our results show that this approach correctly predicted many regulon members, provided new insights into the biological functions of the respective regulons for these regulators, and suggested models for the evolution of the corresponding transcriptional networks. …”
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A clinical survey of laryngectomy patients to detect presence of the false perception of an intact larynx or the "phantom larynx" phenomenon by Pankaj Chaturvedi, Prashant V Pawar, Suhail Syed, Deepa Nair, Sourav Dutta, Devendra Chaukar, Anil K D′Cruz

“…A questionnaire containing 11 questions was served to these laryngectomees pertaining to false perception of persistent laryngeal functions and adaptation to the post-laryngectomy status. …”
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Biography or Hagiography: The Story of Sengya 僧崖 in the <i>Continuing Biographies of Eminent Monks</i> by Limei Chi

“…By examining the rhetorical and ideological dimensions of this genre, this study contributes to a more nuanced understanding of how religious hagiography functioned as a tool for shaping sainthood, authorizing extreme religious practices, and negotiating the spiritual and social landscapes of medieval China.…”
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Evolution and co-evolution of the suck behaviour, a postcopulatory female resistance trait that manipulates received ejaculate by Pragya Singh, Jeremias N. Brand, Lukas Schärer

“…Conclusions Together, our study demonstrates sexually antagonistic coevolution leading to the evolution of a postcopulatory behavioural trait that functions as a female counter-adaptation allowing individuals to gain control over received ejaculate in a hermaphroditic sexual system.…”
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Ecological evolution of salmonids by V. N. Dolganov

“…The salmonids developed marine and oceanic feeding that led to their stocks increasing and a subsequent imbalance with freshwater prey. Adapting to this imbalance, the species of gen. Oncorhynchus came to irreversible reduction of organs and functions in the fresh water and absolute mortality of producers. …”
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Double difference earthquake location with graph neural networks by Ian W. McBrearty, Gregory C. Beroza

“…We obtain high resolution relocations in these tests, and our model shows adaptability to variable types of loss functions and location objectives, including learning station corrections and mapping into the reference frame of a different catalog. …”
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The Modularized Development of a Wheel-Side Electric Drive System Using the Process of Hobbing and Form Grinding by Xiaoyu Ding, Wei Wang, Xinbo Chen

“…The gears are manufactured by a hobbing and form grinding process, which is described functionally along with the relationship between the tooling parameters and tooth profile curves. …”
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Institutional provision of the coordinated realization of tax policy at the modern stage of the Ukrainian society's development by O.V. Zhelai

“…The article identifies the main priorities of the Ministry of Finance of Ukraine in ensuring the formation and implementation of the state tax policy, which are: improving the efficiency, stability and predictability of the tax system; improving the quality and efficiency of tax administration; effective accumulation of resources necessary for the state to fulfill its functions; ensuring the fairness and equality of the tax system, adapting it to the rules and regulations of the European Union; the absence of negative impact on doing business and promoting economic development; expanding the tax base. …”
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Triple Down on Robustness: Understanding the Impact of Adversarial Triplet Compositions on Adversarial Robustness by Sander Joos, Tim Van hamme, Willem Verheyen, Davy Preuveneers, Wouter Joosen

“…Adversarial training, a widely used technique for fortifying the robustness of machine learning models, has seen its effectiveness further bolstered by modifying loss functions or incorporating additional terms into the training objective. …”
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Topical issues of drug addiction criminological characteristics in Ukraine by S. V. Lukianenko, N. O. Pribytkova

“…In the course of drug addiction, a pathological dependence on any narcotic substance develops, which is accompanied by physical and mental addiction to the drug, which in turn negatively affects the psychophysiological functioning of the body. It has been argued that the key problems of drug addiction in Ukraine are the following: socio-economic problems in the country; insufficient preventive work among the population; perception of drugs as a means of social interaction; lack of alternatives in solving personal problems; unproductive justice system; high level of corruption; low level of self-awareness; open borders. …”
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Comparison of Eddy Current Loss Calculation Techniques for Axial Flux Motors with Printed Circuit Board Windings by Andreas Bauer, Daniel Dieterich, Sven Urschel

“…Finite element simulations can achieve very precise results, but unlike semi-analytical approximation functions, they are very time-consuming and therefore not the method of choice for design space exploration. …”
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Temporary Facility Location Problem in Humanitarian Logistics: A Systematic Literature Review by María Fernanda Carnero Quispe, Lucciana Débora Chambilla Mamani, Hugo Tsugunobu Yoshida Yoshizaki, Irineu de Brito Junior

“…Further studies are also needed on facilities functioning as collection and processing centers, given their critical role in the humanitarian supply chain.…”
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ANALYSIS OF GENERAL PLOW BODY TRACTIVE RESISTANCE by A. Yu. Izmaylov, A. A. Artyushin, N. E. Evtyushenkov, G. S. Bisenov, V. F. Rozhin, D. N. Kynev

“…The problem of optimum construction and functioning of harvest and transport complexes of the agricultural enterprises with use of replaceable adapters and navigation satellite systems of GLONASS/GPS is actual. …”
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Assessing stress, anxiety, and depression in children and adolescents: Validation of the DASS-Y in Poland. by Andrzej Śliwerski, Karolina Koszałkowska, Izabela Socha

“…While the instrument functions similarly across genders in terms of structure, caution is advised when comparing mean scores between boys and girls due to partial scalar invariance. …”
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