Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma by Cheng-Hui Lu, Xue-Lai Yin, Zhuo-Deng Huang, Si-Ang Lv, Jun Wu, Jie Wei

“…The four most significantly differentially expressed genes were selected for further functional analysis, and small interfering RNA (siRNA) vectors targeting these genes were transfected into OSCC CAL27 cells. …”
Get full text

Catalase Activity in the Brain Is Associated with Recovery from Brain Injury in a Piglet Model of Traumatic Brain Injury by Stephanie T. Dubrof, Sarah L. Schantz, Taylor H. LePage, Sydney E. Sneed, Savannah R. Cheek, Holly A. Kinder, Kylee J. Duberstein, David A. DeWahl, Jerry O. Stern, Alexander B. Baguisi, Erin E. Kaiser, Franklin D. West, Hea Jin Park

“…Treatments began 1 h after TBI induction and continued for 5 days. MRI was performed throughout the study period to evaluate brain recovery. …”
Get full text

Anchoring of 2D layered materials of Ge5Si5O20 for (Li/Na/K)-(Rb/Cs) batteries towards Eco-friendly energy storage by Fatemeh Mollaamin

“…In this research, hydrogen energy sources on functionalized 2D materials by metals have been shown as promising alternatives for clean energy systems. …”
Get full text

The study of promising secure information systems based on signal modeling by V. A. Sizov, D. M. Malinichev, Kh. K. Kuchmezov

“…Instead, you have to think about such things as data manipulation attacks, which, for example, can be used to command the mechanisms to perform certain actions (for example, open the door or take control of an unmanned vehicle). …”
Get full text

Factores de riesgo para complicaciones en artroplastia total de cadera by L.A. Hoyos-Velasco, J.C. Palacio, W.P. Stangl, C.L. Chacón-Castillo, V. Palacio-Aragón, J.P. Pulgarín

“…Comparison of variables between two groups was performed; 38 participants in the group with complications and 266 participants in the group without complications. …”
Get full text

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…Therefore, this study aimed to identify the optimal scFv and investigate its biological functions to further optimize the therapeutic potential of CAR-T cells targeting CEA-positive carcinoma.MethodsWe screened four reported humanized or fully human anti-CEA antibodies (M5A, hMN-14, BW431/26, and C2-45), and inserted them into a 3rd-generation CAR structure. …”
Get full text

ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling by Yujia Li, Chenjun Huang, Weiguo Fan, Seddik Hammad, Cyrill Géraud, Lea Berger, Shanshan Wang, Ye Yao, Chenhao Tong, Claudia Rubie, Laura Kim Feiner, Zeribe C. Nwosu, Frederik Link, Pia Erdösi, Weronika Piorońska, Kerry Gould, Christoph Meyer, Rilu Feng, Hui Liu, Chen Shao, Bing Sun, Huiguo Ding, Roman Liebe, Matthias P.A. Ebert, Honglei Weng, Matthias Glanemann, Chunfang Gao, Peter ten Dijke, Steven Dooley, Sai Wang

“…Methods: We used promoter analysis to predict Ecm1 transcriptional regulators and assessed the expression of Ecm1-related genes by single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq. Functional assays were performed with AML12 cells, mouse and human primary hepatocytes, and liver tissue from mice and patients. …”
Get full text

Abstract 200: ICA Lesion Etiology does not affect the Outcomes after Endovascular Treatment of Acute Tandem LVO by Milagros R. Galecio Castillo, Mudassir Farooqui, Ameer Hassan, Mouhammad Jumaa, Afshin Divani, Marc Ribo, Michael Abraham, Nils Petersen, Johanna Fifi, Waldo Guerrero, Amer Malik, James Siegler, Thanh Nguyen, Sunil Sheth, Albert Yoo, Guillermo Linares, Nazli Janjua, Darko Quispe‐Orozco, Wondewossen Tekle, Syed Zahid Ali, Asad Ikram, Cynthia Zevallos, Marta Olivé‐Gadea, Abid Qureshi, Alex Devarajan, Nicholas Vigilante, Mohamad Abdalkader, Sergio Salazar‐Marioni, Jazba Soomro, Weston Gordon, Charoskhon Turabova, Juan Vivanco‐Suarez, Aaron Rodriguez‐Calienes, Maxim Mokin, Dileep Yavagal, Santiago Ortega‐Gutierrez

“…Clinical outcomes, including recanalization success, functional independence and hemorrhagic events were assessed with multivariable analyses. …”
Get full text

Hybrid Integration of a Beam-Steering Leaky-Wave Antenna and Power Amplifier MMIC Using UPD Printing in 220 to 325 GHz Range by Georg Gramlich, Elizabeth Bekker, Luca Valenziano, Joel Dittmer, Martin Roemhild, Holger Baur, Fabian Thome, Axel Tessmann, Michael Kuri, Tom Neerfeld, Andreas Stohr, Sebastian Randel, Christian Koos, Norbert Fruehauf, Thomas Zwick, Akanksha Bhutani

“…The hybrid assembly achieves a reflection coefficient of less than -10 dB and a peak gain of up to 26 dBi across the sub- THz range. The beamsteering functionality of the hybrid assembly is successfully validated only in the forward quadrant due to measurement restrictions in the backward quadrant. …”
Get full text

miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthmaResearch in context by Rinku Sharma, Kevin Mendez, Sofina Begum, Su Chu, Nicole Prince, Julian Hecker, Rachel S. Kelly, Qingwen Chen, Craig E. Wheelock, Juan C. Celedón, Clary Clish, Robert Gertszen, Kelan G. Tantisira, Scott T. Weiss, Jessica Lasky-Su, Michael McGeachie

“…These findings imply that the indirect regulation of metabolism and cellular functions by miRNA influences Th2 inflammation, AHR, and airflow obstruction in childhood asthma. …”
Get full text

Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement by Xinyu Wang, Qianye Chen, Jiping Sun, Zihan Huang, Zijian Zhang, Tingwei Lu, Xiangru Huang, Siyuan Sun, Yuanqi Liu, Houwen Pan, Li Mei, Paul R. Cooper, Qinggang Dai, Lei Shen, Lingyong Jiang

“…Although most investigations have centered on mesenchymal stem cells (MSCs) from long bones, the distinct properties and immunoregulatory functions of craniofacial bone marrow derived MSCs remain largely unexplored. …”
Get full text

In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China by Weilun Zuo, Weilun Zuo, Chen Wei, Meiyan He, Mengyao Zhang, Jiangli Liang, Xiao Ma, Na Gao, Qin Gu, Yan Ma, Jingyan Li, Shuyuan Liu, Yan Huang, Mingbo Sun, Li Shi

“…In vivo RNA-seq results revealed that BP-L2 significantly upregulated relA (log2FC = 2.1, FDR P-value = 0.019) and sodA (log2FC =2.4, FDR P-value = 8.61E-06) compared to BP-L1, functionally linked to enhanced stringent response and oxidative stress defense. …”
Get full text

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways by Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie

“…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted to elucidate the functions of pivotal targets within the protein–protein interaction network. …”
Get full text

Study the effect of Lactobacillus plantarum ATCC 14917 for caries prevention and anti-obesity by Wei Yang, Wei Yang, Mingxin Jiang, Bairu Chen, Bairu Chen, Kongzhao Jiang, Nan Ma, Nan Ma, Yimin Li, Yimin Li, Meng Wang, Meng Wang, Meihua Bao, Meihua Bao, Chengyue Wang, Chengyue Wang, Xiaopeng Yang, Xiaopeng Yang

“…Support the management of dental caries and obesity, and establish a foundation for future functional food research and development.…”
Get full text

Activity and mechanism of naringin in the treatment of post-infectious cough by Yinghan Chen, Dong Wang, Meng Song, Weiqi Pan, Wenda Guan, Zifeng Yang, Shan Zhong

“…GO (Gene Ontology) functional annotation and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analyses were performed with Metascape. …”
Get full text

Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Metabolic profiling was performed in global Gpr45 knockout animals including body weight, food intake, body mass, energy expenditure, and body temperature measurements. …”
Get full text

Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer by Lin-Ting Zhang, Yuejia Zhou, Tiantian Wang, Boran Chen, Zhigao Cai, Shubin Wang, Gangling Tong

“…This research aims to investigate the expression levels of a novel circRNA, hsa_circ_0002238, in CRC and to explore its association with alterations in CRC functional phenotypes.MethodsHigh-throughput RNA sequencing identified abnormal circRNA expressions, and qRT-PCR validated hsa_circ_0002238 expression. …”
Get full text

RETRACTED: In-depth systems biological evaluation of bovine alveolar macrophages suggests novel insights into molecular mechanisms underlying Mycobacterium bovis infection by Aliakbar Hasankhani, Abolfazl Bahrami, Abolfazl Bahrami, Shayan Mackie, Sairan Maghsoodi, Heba Saed Kariem Alawamleh, Negin Sheybani, Farhad Safarpoor Dehkordi, Farhad Safarpoor Dehkordi, Fatemeh Rajabi, Ghazaleh Javanmard, Hosein Khadem, Herman W. Barkema, Marcos De Donato

“…Next, weighted gene co-expression network analysis (WGCNA) was performed to identify the co-expression modules in non-infected control bAMs as reference set. …”
Get full text

Water Diplomacy by Implementing Energy Consumption Reduction Scenarios in the Sistan Region by Fazel Ghobeyshavi, Ali Sardar Shahraki, Mahdi Safdari, Neda Aliahmadi

“…Based on the method of dynamic systems, the following steps are performed. 1- Understanding the system 2- Identification and definition of the problem 3- Conceptualization of the system (cause-effect relationships - informational feedbacks) 4- Formulation of the model (decision variables - physical flows of information) In order to build the flow model, the trends of the variables over time are taken into consideration, and based on these trends and based on mathematical laws and regression functions, the relationship between the variables was formulated.Discussion and Results The results, modeling the water, food, energy nexus (NEXUS) with several water diplomacy in the Trans Boundary River show that the current scenarios with water are After applying each of the policies separately on the model as well as applying the combined policy, the scenario of reducing energy consumption by 50%, reducing water loss (evaporation) by 50%, from the solution to improve the security of water, food and energy resources for ten. …”
Get full text

TGF-β Decreases NK Cell Mobility and Cytotoxic Efficacy in Complex in vitro Models of the Leukemia Microenvironment by Švubová V, Janstová L, Jedlička M, Mašínová E, Szabová J, Feglarová T, Kuglerová K, Bosáková V, Brodská B, Boráková K, Kundrát D, Trsová I, Böhmová M, Kuželová K, Hrdý J, Gašová Z, Vydra J, Dostálová Merkerová M, Hortová-Kohoutková M, Frič J

“…Bulk RNA sequencing (RNA-seq) was performed to analyze global gene expression changes in TGF-β-treated primary human NK cells. …”
Get full text