Population structure, genetic diversity, and GWAS analyses with GBS-derived SNPs and silicodart markers unveil genetic potential for breeding and candidate genes for agronomic and... by Noor Maiwan Bahjat, Mehtap Yıldız, Muhammad Azhar Nadeem, Andres Morales, Josefina Wohlfeiler, Faheem Shahzad Baloch, Murat Tunçtürk, Metin Koçak, Yong Suk Chung, Dariusz Grzebelus, Gökhan Sadik, Cansu Kuzğun, Pablo Federico Cavagnaro

“…GWAS on 13 root and leaf phenotypic traits allowed the identification of 35 significant marker-trait associations for nine traits and, based on predicted functions of the genes in the genomic regions surrounding the significant markers, 25 candidate genes were identified for four root (fresh weight, width, length, and color) and three leaf traits (shape, blade color, and veins color). …”
Get full text

Protocol of the pilot study to test and evaluate the iCARE tool: a machine learning-based e-platform tool to make health prognoses and support decision-making for the care of older... by John P Hirdes, Hao Luo, Davide L Vetrano, Graziano Onder, Jonathan Chen, Violetta Kijowska, Katarzyna Szczerbińska, Johanna Edgren, Amaia Calderón-Larrañaga, George Heckman, Ron MC Herings, Johanna de Almeida Mello, Anja Declercq, Mark Hoogendoorn, Caitlin McArthur, Mari Aaltonen, Yi Chai, Karlijn J Joling, Micaela Jantzi, Rosa Liperoti, Melissa Northwood, Ilona Barańska, Agata Stodolska, Hein P J van Hout, Margaret Saari, Luca Mariotti, Emiel O Hoogendijk, Luke Turcotte, Louk Smalbil, Elizabeth P Howard, John N Morris, Daniela Fialová, Eline CM Kooijmans, Riikka-Leena Leskelä, Jokke Häsä, Georg Ruppe, Carmen Angioletti, Olena Antonenko, Shireen Aziz, Gustavo Betini, Jovana Brkič, Roberto Da Cas, Daniel Da Cunha Leme, Lu Dai, Cecilia Damiano, Natalia Drapała, Bonaventure Egbujie, Collin JC Exmann, Harriet Finne-Soveri, Charlene France, Tiziana Grisetti, Ira Haavisto, Sophie Hogeveen, Paweł Jagielski, Laurian Jongejan, Jet E Klunder, Ingrid Kummer, Anna Lukačišinová, Matti Mäkelä, Krista Mathias, Amanda Mofina, Reem Mulla, Mikko Nuutinen, Sandra Ochwat, Paula Pennanen, Jitka Pokladníková, Bregtje Proost, Ahmer Raza, Emanuele Rocco Villani, Jindra Reissigová, Erez Schachter, Katarzyna Sekulak, Chi-Ling Joanna Sinn, Andrea Vokálová, Adrianna Ziuziakowska, Mari Lahelma, Anna-Maria Hiltunen, Anna Salminen, Mor Alon, Collin Exmann, Wiebe Boorsma, Johanna de Almeida Mello, Hein PJ van Hout

“…All notes and text field data will be translated into English, and a thematic analysis will be performed. The pilot testing started in September 2024, and data collection ended in January 2025. …”
Get full text

Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo by Essha Chatterjee, Essha Chatterjee, Ram Sharma, Biswajit Dey, Biswajit Dey, Hoshiyar Singh, Aliva Naik, Anjesh Khan, Santanu Basak, Ankush Bansode, Ritika Sachdeva, Anamika Sharma, Rahul Kumar, Pradeep Naik, Pankaj Kumar Singh, Kunal Nepali, Santosh Kumar Guru

“…Protein and gene expression related to the RM-3-22 induced pathway were evaluated via immunofluorescence (IF), Western blotting, and RT-PCR. Functional gene analysis was performed using siRNA-mediated knockdown. …”
Get full text

Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity by Shiyang Chen, Shaohua Chen, Qingyang Kang, Fangzheng Lin, Fangzheng Lin, Fangzheng Lin, Shuting Zheng, Xixi Liu, Chunhong Guo, Chunhong Guo, Yongjin Li, Yongjin Li, Dingkun Lin, Dingkun Lin, Xiaolong Zeng

“…However, further research is needed to explore the clinical functional effects of knee laxity.…”
Get full text

Persistence of activated anti‐mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal carcinomas by Sameer Mir, Abhilash Venugopalan, Jingli Zhang, Nishanth Ulhas Nair, Manjistha Sengupta, Manakamana Khanal, Chaido Stathopoulou, Qun Jiang, Raffit Hassan

“…In NSG mouse‐models, hYP218 CAR T cells demonstrated anti‐tumour efficacy and persisted in the tumour microenvironment in a functional state at day 40 posttreatment with expression of activation markers CD39 and CD69, increased production of IFN‐γ and TNF‐α and ability to kill tumour cells in vitro when isolated from tumours. …”
Get full text

Deciphering the tumor ecosystem dynamics undergoing immunochemotherapy therapy across multiple cancer types unveils the immunosuppressive role of S100A4 in fibroblasts by promoting... by Bo Yang, Bo Yang, Ruiji Chen, Ruiji Chen, Mali Zu, Jie Yao, Hong Ren, Hong Ren, Yingxue Lin, Yingxue Lin, Bo Zhang, Tianjiao Ji, Yang Liu

“…Cell-cell communication analysis, Meta-Programs (MPs) via non-negative matrix factorization, and functional enrichment were performed. Immunohistochemistry (IHC) and Western blot validated S100A4 expression and PD-L1 induction in vitro.ResultsWe constructed a single-cell map across cancer types and systematically characterized dynamic changes in tumor cells and diverse microenvironmental cell populations following neoadjuvant therapy, along with thier gene expression and pathway alterations. …”
Get full text

Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation by Ying Zhuge, Gonghao Li, Mingyue Sun, Jiajia Zhang, Jiafeng Zou, Feng Gao, Fang Wang

Get full text

Revealing the potential therapeutic mechanism of Lonicerae Japonicae Flos in Alzheimer’s disease: a computational biology approach by Qin Xiang, Qin Xiang, Qin Xiang, Qin Xiang, Yu Xiang, Yao Liu, Yongjun Chen, Qi He, Taolin Chen, Liang Tang, Liang Tang, Binsheng He, Jianming Li

Get full text

Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment – A post-hoc analysis from the phase 2B FORWARD study by Felix Eckstein, Susanne Maschek, Wolfgang Wirth, Christoph Ladel, Asger Reinstrup Bihlet, Chris Knight, Kenneth Somberg, Luping Zhao

Get full text

Novel oxidative stress- and ferroptosis-related gene prognostic signature for erectile dysfunction by Meijun Liu, Maobin Yu, ZiYang Ma, Zilong Xu, Tao Zhang, Hongsen Zeng, Ze Li, XiYu Dang, Peihai Zhang

“…Additionally, a gene set enrichment analysis (GSEA) was performed to investigate the functions of the key target genes, and the mRNA-miRNA and TF-mRNA regulatory networks were developed to explore the potential regulation of these key genes. …”
Get full text

SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: Time-to-Event Analysis of a Hospital-Based Cohort Study of Pregnant Women in Rio de Janeiro, Brazil by Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhaes de Oliveira, Larissa Rangel Mageste, Karin Nielsen-Saines, Patricia Brasil

“…Cesarean section deliveries were performed in 57% (135/237) SARS CoV-2+ participants vs. 43% (391/914) of uninfected participants, <i>p</i> < 0.001. …”
Get full text

A novel stemness-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity of clear cell renal cell carcinoma by Jia Liu, Lin Yao, Yong Yang, Jinchao Ma, Ruijian You, Ziyi Yu, Peng Du

“…Enrichment analysis was performed to explore the potential functions of SRmRNAs. …”
Get full text

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy by Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li

“…Further analysis revealed high heterogeneity in tissue preference, gene expression, functional enrichment, immunodynamics, transcriptional regulatory factors, metabolic changes, and communication patterns in fibroblasts and myeloid cells. …”
Get full text

Spectrum of mutations and their phenotypic manifestations in children and adults with long QT syndrome by N. N. Chakova, S. M. Komissarova, E. A. Zasim, T. V. Dolmatovich, E. S. Rebeko, S. S. Niyazova, E. V. Zaklyazminskaya, L. I. Plashchinskaya, M. V. Dudko

“…The genetic study was performed by nextgeneration sequencing (NGS) using the MiSeq system (Illumina). …”
Get full text

SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study by Linqin Du, Yangyang Cui, Yang Zhou, Ofe Eugene Kwaku, Xuefeng Ding, Lang Zeng, Shikang Li, Lijuan Xiong, Yonghong Zhang, Peng Zhou, Kun Wang, Rongchuan Yue

“…Additionally, the study explored the involvement of social factors through a two-step MR analysis. The research team performed a thorough screening of differentially expressed genes in MS based on GEO database, identifying potential target genes that may be associated with genetic risk of CHD. …”
Get full text

Gratitude and sleep disturbance in primary care patients: the mediating roles of health self-efficacy, health behaviors, and psychological distress by Heather R. Altier, Jameson K. Hirsch, Annemarie Weber, Niko Kohls, Jörg Schelling, Loren L. Toussaint, Fuschia M. Sirois, Martin Offenbächer, Martin Offenbächer

“…., recognition and appreciation of experiences, relationships, and surroundings), a positive psychological cognitive-emotional characteristic, may serve as a catalyst of these beneficial downstream effects, given its association with improved health functioning and sleep.MethodsIn a sample of primary care patients (N = 869, M age = 53; 60.7% female) from 50 urban and 30 rural practices in Germany, health self-efficacy (i.e., belief in ability to perform necessary actions to manage health) and constructive health behaviors (i.e., actions taken to modify health positively), separately and together as parallel first-order mediators, and stress, anxiety, and depression, as parallel second-order mediators, were investigated as potential serial mediators of the association between gratitude and sleep disturbances. …”
Get full text

THE ROLE OF MAGNETIC RESONANCE RESEARCH IN THE TREATMENT OF DYSFUNCTION OF THE TEMPOROMANDIBULAR JOINT by V.M. Novikov, M.A. Korostashova, V.I. Dodatko, O.S. Svyryda, Ya.O. Yushchenko

“…Therefore, the next stage of treatment depended on the anatomical and functional changes of TMJ and consolidation of therapeutic effect was been necessary. …”
Get full text

Hilbert–Huang transform and spectrum-weighted reconstruction integration for millimeter wave radar-based heart rate detection by Hao CUI, Luyao LIU, Hao CHEN, Wendong XIAO

“…By extracting the intrinsic mode functions corresponding to the HR range and designing a spectral weighting reconstruction method, we segment and enhance the HR range, because of which respiratory harmonics and noise interference in the heartbeat signal are further suppressed, thereby improving the resolution of HR detection. …”
Get full text

hNIS-based imaging to monitor treatment with the novel oncolytic virus CF33-hNIS-antiPDL1 in humans with advanced triple negative breast cancer by Jamie Rand, Dave Yamauchi, Shyambabu Chaurasiya, Jianying Zhang, Supriya Deshpande, Leslie Chong, Amanda Seiz, Hans Meisen, Yuman Fong, Yuan Yuan

“…CF33-hNIS-antiPDL1-infected tumor cells express functional human sodium iodide symporter (hNIS) and are visible by single-photon emission computed tomography (SPECT) or positron emission tomography (PET). …”
Get full text

Expression characteristics of miR-502-5p/p53/NF-κB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodolo... by Xiaozhe Zhang, Kesong Shi, Anmin Ruan, Pu Chen, Tao Zhang, Qingpu Wang

“…Histopathological analysis was performed using hematoxylin and eosin (HE) staining with Mankin's scoring system. …”
Get full text