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YAP/Nrf2 suppresses ferroptosis to alleviate acute lung injury induced by intestinal ischemia/reperfusion
Published 2025-10-01“…However, whether YAP is involved in regulating II/R-induced ALI remains to be further explored. This study aimed to investigate the regulatory role of YAP in ALI and ferroptosis caused by II/R, and to explore whether YAP exerts anti-ferroptosis and anti-inflammatory effects by promoting nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear entry and upregulating Nrf2 expression. …”
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13203
Significance of the gut tract in the therapeutic mechanisms of polydopamine for acute cerebral infarction: neuro-immune interaction through the gut-brain axis
Published 2025-03-01“…Additionally, the activation of astrocytes in the hippocampal region and neuronal apoptosis were observed in ACI mice. Importantly, our study is the first to provide evidence demonstrating that PDA effectively suppresses the neuroimmune interactions of the gut-brain axis and significantly improves intestinal epithelial barrier integrity.ConclusionWe hope that our discoveries will serve as a foundation for further explorations of the therapeutic mechanisms of PDA in ACI, particularly in elucidating the protective roles of gut microbiota and intestinal barrier function, as well as in the development of more targeted clinical interventions for ACI.…”
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13204
Mixtures of entomopathogenic nematodes provided successful suppression of Bactrocera tau by stimulated dispersal, aggregation, and invasion
Published 2025-09-01“…Laboratory bioassays identified Steinernema carpocapsae (Sc) and Heterorhabditis indica (Hi), that were highly virulent to B. tau larvae, achieving up to 100 % mortality at 25 infective juveniles (IJs) /larva. …”
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13205
Machine Learning for the Photonic Evaluation of Cranial and Extracranial Sites in Healthy Individuals and in Patients with Multiple Sclerosis
Published 2025-07-01“…This approach allowed us to explore novel biomarkers of neural and systemic impairment in MS, paving the way for potential clinical applications of SWIR spectroscopy in disease monitoring and management. …”
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13206
Factors explaining failure to suppress viral load in pregnant women living with HIV in Mbandaka, Equateur Province (Democratic Republic of Congo)
Published 2025-04-01“…Strengthening adherence counselling, promoting early ART initiation, and enhancing social support systems—particularly through marital or community frameworks—are crucial for reducing MTCT. …”
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13207
Cultural keystone species as a tool for biocultural stewardship. A global review
Published 2025-05-01“…This work examines the current use of the term CKS to reconcile a definition and explore its practical applications for biocultural stewardship. …”
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13208
The Capabilities of Optical and C-Band Radar Satellite Data to Detect and Understand Faba Bean Phenology over a 6-Year Period
Published 2025-06-01“…Future applications could extend this methodology to other crops and explore alternative radar systems for improved monitoring (such as TerraSAR-X, Cosmos-SkyMed, ALOS-2/PALSAR, NISAR, ROSE-L…).…”
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13209
Acute changes in functional connectivity associated with first osteopathic manual treatment in chronic low back pain spatially overlap with opioid receptor expression
Published 2025-06-01“…Methods: We combined a data-driven approach with a seed-based connectivity analysis to examine the pattern of whole-brain rs-FC in a cohort of thirty cLBP patients before and after a first acute session of OMT (N = 16) or a sham treatment (N = 14). Correlation analyses were performed to explore the relationship between the resulting rs-FC maps and receptor density/gene expression maps derived from in vivo brain atlases, focusing on the opioid and cannabinoid systems. …”
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RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats’ intervertebral dis...
Published 2025-06-01“…These findings support further clinical exploration of RTA 408 as a novel Nrf2-targeted therapy for IDD.…”
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13211
Effects of physical activity and resilience on emotional and behavioral problems in Chinese adolescent: a chained mediation model
Published 2025-07-01“…While parenting styles and physical activity (PA) independently influence adolescent psychological outcomes, their synergistic effects through psychological resilience remain inadequately explored, particularly regarding cultural nuances in Chinese parenting practices (e.g., dual interpretations of overprotection) and chained mediation pathways (parenting → PA → resilience → EBPs).ObjectiveThis study examined the chained mediating roles of physical activity and psychological resilience in the relationship between multidimensional parenting styles (emotional warmth, rejection, overprotection) and EBPs among Chinese adolescents, testing pathways informed by family systems theory and bioecological frameworks.Participants and settingA sample of 503 adolescents (51.09% male; SD = 1.41) was recruited through three-stage cluster sampling across Zhuhai, Guangdong, China. …”
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13212
DEVELOPING YOUTH RESILIENCE IN CONDITIONS OF SOCIAL INSTABILITY AND WAR
Published 2025-06-01“…Particularly effective were the modules focused on emo- tional literacy, adaptive coping mechanisms, and community-based support. …”
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Estrogen protects against postpartum Concanavalin A-induced hepatitis by promoting intrahepatic CD4⁺CD25⁺ Treg expansion through activation of the PI3K/Akt signaling pathway in HBV...
Published 2025-07-01“…Objectives Our objective was to explore estrogen’s role in postpartum hepatitis flares in HBV transgenic mice. …”
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Indigenous rights-based approaches to decolonising research methodologies in settler colonial contexts
Published 2025-07-01“…After working collaboratively, it became possible to analyse the similarities and differences in the use of IBRA across various fields of study.ResultsOur analysis reveals five key aspects that were revealed during the implementation of the Indigenous rights-based approach: (1) Indigenous People as Data, (2) Protocols of engagement, (3) Privileging Indigenous Knowledge Systems, (4) Community Benefit, and (5) Tackling Doctoral Research Training.DiscussionWe found that an Indigenous rights-based approach is crucial for decolonising research in settler colonial states such as Australia. …”
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13217
Symptom Trajectories and Clinical Subtypes in Post–COVID-19 Condition: Systematic Review and Clustering Analysis
Published 2025-07-01“…MethodsThe PubMed, Web of Science, and Embase databases were searched from December 1, 2019, to March 1, 2024. …”
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Advanced Numerical Analysis of Heat Transfer in Medium and Large-Scale Heat Sinks Using Cascaded Lattice Boltzmann Method
Published 2025-06-01“…Medium- and large-scale heat sinks are critical for thermal load management in high-performance systems. However, their high heat flux densities and limited space complicate cooling, leading to risks of overheating, performance degradation, or failure. …”
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Adversarial denoising of EEG signals: a comparative analysis of standard GAN and WGAN-GP approaches
Published 2025-05-01Get full text
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Impact of Iron Deficiency on the Growth and Bioelectrical Profile of Different Gut Bacteria
Published 2025-06-01Get full text
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