Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models by Jian Ye, Brian A Belt, Shuyang S Qin, Rachel Jewell, Laura M Calvi, Bradley N Mills, Tara G Vrooman, Carl J Johnston, Scott A Gerber, Angela L Hughson, Gary Hannon, Maggie L Lesch, Jim Eyles, Nadia Luheshi, Noah A Salama, Sidney Lesser, Sarah L Eckl, Lauren Benoodt, Edith Lord, David Linehan

“…Anti-LIF antibody therapy has demonstrated safety and tolerability but limited efficacy in phase 1 clinical trial in advanced solid tumors. This prompted us to explore combination therapies, suggesting that LIF blockade, when combined with standard-of-care chemotherapy, radiotherapy, and/or immunotherapy, could present a promising therapeutic strategy.Methods We evaluated the impact of combining systemic inhibition of LIF/programmed death-ligand 1 (PD-L1) with localized stereotactic body radiotherapy (SBRT) on tumor progression across multiple murine orthotopic pancreatic tumor models and examined systemic antitumor immunity using a hepatic rechallenge model. …”
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Mapping heat-related risks in Swiss cities under different urban tree scenarios by Myke Koopmans, Jonas Schwaab, Ana M. Vicedo-Cabrera, Edouard L. Davin

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Myotonic dystrophy-related CDC42-binding kinase alpha (MRCKα) mediates methionine- and leucine-stimulated β-casein synthesis in bovine mammary epithelial cells via targeting mTOR by Fang Wang, Jürgen van Baal, Lu Ma, Xuejun Gao, Jan Dijkstra, Dengpan Bu

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Modeling and forecast of gas hydrate distribution in the Black Sea: main principles and approaches by Volodymyr Iemelianov, Olena Ivanik, Olena Ivanik, Tamara Kukovska, Natalia Fedoronchuk, Natalia Fedoronchuk, Ihor Shuraiev, Eduard Petrushenko, Kateryna Hadiatska

“…Spatial analysis and modeling techniques, including weighted overlay methods, were applied to assess the influence of geological and environmental factors on gas hydrate formation. …”
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Antioxidant and immunomodulatory activity of Perna canaliculus oil extract in combination with low molecular weight fucoidan extracted from Undaria pinnatifida by Belgheis Ebrahimi, Roberta Cardim Lessa, Saeid Baroutian, Qiang Zhou, Xi Chen, Jun Lu

“…The rising prevalence of chronic non-communicable illnesses is often linked to persistent low-grade systemic inflammation, with inflammation and oxidative stress playing significant roles in their development. …”
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Harnessing Lactiplantibacillus plantarum EP21 and its membrane vesicles to inhibit myopia development by Chi-Fong Lin, Yu-An Hsu, Yung-Lan Chou, Ying-Chi Chen, En-Shyh Lin, Peng-Tai Tien, Jamie jiin-Yi Chen, Ming-Yen Wu, Chia-Hung Lin, Hui-Ju Lin, Lei Wan

“…EP21 administration, besides MV release, altered systemic metabolites, including tryptophan derivatives and short-chain fatty acids. …”
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Mechanistic investigation of Shuanghuanglian against infectious bronchitis in chickens: a network pharmacology and molecular dynamics study by Fuming You, Hanzhao Zhang, Linghao Meng, Chuanhong Li, Yuxia Yang, Yongqiang Wang, Rigetu Zhao, Luomeng Chao, Luomeng Chao, Luomeng Chao

“…Importantly, BCL2 and IL6 were recognized as key targets in the protein–protein interaction (PPI) network analysis, highlighting their roles in apoptosis and inflammation. …”
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Classifying Dry Eye Disease Patients from Healthy Controls Using Machine Learning and Metabolomics Data by Sajad Amouei Sheshkal, Morten Gundersen, Michael Alexander Riegler, Øygunn Aass Utheim, Kjell Gunnar Gundersen, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Hugo Lewi Hammer

“…In this study, we explored the use of machine learning and metabolomics data to identify cataract patients who suffer from dry eye disease, a topic that, to our knowledge, has not been previously explored. …”
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Progress on the Global Research Agenda for Antimicrobial Resistance in Human Health in Pakistan: Findings and Implications by Maryam S, Saleem Z, Haseeb A, Qamar MU, Amir A, Almarzoky Abuhussain SS, Imam MT, Afzal S, Meyer JC, Mudenda S, Godman B

“…The intention is to identify key gaps, achievements, and future areas of focus to help reduce rising AMR rates in Pakistan.Methods: Utilizing a systematic-narrative hybrid literature review methodology approach, recent research publication and policy initiatives related to AMR, including those published on the internet, were examined and documented.Findings: The findings from 349 published studies were divided into the 40 research priority areas. …”
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Sepsis beyond bundles: contextualising paediatric care in resource-limited settings through situational analysis by John Adabie Appiah, Leah Ratner, Sheila Agyeiwaa Owusu, Ahmet Uluer, Gustav Nettey, Allysa Warling, Charles Martyn-Dickens, Emma Otchere, R. Elaine Cagnina, Maame Fremah Kotoh- Mortty, Eugene Martey

“…Future qualitative research will explore pre- and peri-hospital barriers to care and inform more effective, contextually appropriate interventions.…”
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Khejri seed extract (KSE) enhances the growth, digestive, metabolic, and immunological responses of Labeo rohita fingerlings by Rohitash Yadav, Manish Jayant, Narinder Kumar Chadha, Ved Prakash Saini, Paramita Banerjee Sawant, Manohar Lal Ojha, Bhanu Kumar Sharma, Dharmendra Kumar Meena

“…The onset of diseases, combined with the reliance on therapeutics such as chemicals and antibiotics, as well as the alarming rise of antibiotic-resistant pathogen strains, postulates the urgent exploration of alternatives to antibiotics in semi-intensive and intensive aquaculture systems. …”
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Multi-omics analysis reveals the efficacy of two probiotic strains in managing feline chronic kidney disease through gut microbiome and host metabolome by Hsiao-Wen Huang, Tzu-Chien Kuo, Tzu-Chien Kuo, Ya-Jane Lee, Ya-Jane Lee, Ming-Ju Chen, Ming-Ju Chen

“…During this period, creatinine and blood urea nitrogen levels were stabilized or reduced in most cats, and gut-derived uremic toxins (GDUTs) showed modest numerical reductions without statistically significant changes. …”
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Enhanced photothermal therapy for oral cancer using benzothiadiazole-based nanoparticle-loaded hydrogels by Zi Fu, Ling Huang, Xinyu Zhang, Zhichao Zheng, Lihong Wu, Huade Zheng

“…However, challenges such as poor stability and limited retention at the tumour site persist, necessitating the development of advanced delivery systems to optimize the effectiveness of these NPs in clinical applications. …”
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IARA: An Underwater Acoustic Database by Fabio Oliveira Baptista Da Silva, Julio De Castro Vargas Fernandes, William Soares Filho, Joao Baptista De Oliveira E Souza Filho, Angela Spengler, Natanael Nunes De Moura

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MΦ macrophage – N0 neutrophil dialogue in the presence of TNF-α affects the endothelium by Sergiu-Marian VATAMANU, Monica ȚUCUREANU, Andreea MIHĂILĂ, Elena BUTOI, Anca FARKAS

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Agricultural legacy shapes plant diversity patterns in mountain grasslands of Maramureș and Bukovina: A cross‐border perspective (Ukraine, Romania) by Monika Janišová, Martin Magnes, Igor Bojko, Liubov M. Borsukevych, Vasyl V. Budzhak, Illya Chorney, Anamaria Iuga, Cosmin Marius Ivașcu, Roman Kish, Anna Kuzemko, Salza Palpurina, Katarína Skokanová, Pavel Širka, Alla Tokaryuk, Polina Dayneko

“…Modifications to farming systems, observed in all studied villages, were mainly due to declining population and livestock numbers. …”
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Strengthening neonatal care through ward assistants: a Kenyan case study in enhancing infection prevention and control practices by Michuki Maina, Nancy Odinga, Vincent Kagonya, Gloria Ngaiza, Sebastian Fuller, Onesmus Onyango, Caroline Waithira, Dorothy Oluoch, David Gathara, Peter Mwangi, Loise Mwangi, Penina Musyoka, Lucy Kinyua, Lydia Thuranira, Virginia Njoroge, Ngina Mwangi, Zainab Kioni, Mike English, Edna Mutua

“…However, these benefits alone are insufficient to address systemic barriers to IPC, including resource constraints and variability in adherence among staff. …”
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Complex physicochemical analysis of transformer oil parameters using the inductively coupled plasma mass spectrometry technique by T. K. Nurubeyli, A. M. Hashimov, N. E. Imamverdiyev, G. N. Mammadova

“…Transformers are crucial and expensive components of power systems, experiencing electrical, thermal, and chemical stresses. …”
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Value Propositions for Digital Shared Medication Plans to Boost Patient–Health Care Professional Partnerships: Co-Design Study by Benjamin Bugnon, Francesca Bosisio, Alain Kaufmann, Pascal Bonnabry, Antoine Geissbuhler, Christian von Plessen

“… BackgroundHealth authorities worldwide have invested in digital technologies to establish robust information exchange systems for improving the safety and efficiency of medication management. …”
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Ruminal-buccal microbiota transmission and their diagnostic roles in subacute rumen acidosis in dairy goats by Tao Liu, Jingyi Xu, Xiaodong Chen, Jianrong Ren, Jinhui He, Yue Wang, Yangchun Cao, Le Luo Guan, Junhu Yao, Shengru Wu

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