Glucagon and Glucose Availability Influence Metabolic Heterogeneity and Malignancy in Pancreatic Neuroendocrine Tumour (pNET) Cells: Novel Routes for Therapeutic Targeting by Bárbara Ferreira, Isabel Lemos, Cindy Mendes, Beatriz Chumbinho, Fernanda Silva, Daniela Pereira, Emanuel Vigia, Luís G. Gonçalves, António Figueiredo, Daniela Cavaco, Jacinta Serpa

“…This suggests that gluconeogenesis may be beneficial for some pNET subsets, pointing out novel metabolism-based strategies to manage pNETs, as well as a step forward in endocrinology and systemic metabolism. The association between GCGR expression and malignancy and a negative correlation between glucagon receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R) expression was observed, indicating a biological role of glucagon in pNETs that deserves to be explored.…”
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Application status and development prospect of fermented ingredients in aquaculture by Bin Li, Abir Boukhennou, Jianchun Shao, Liang Miao, Yang Du, Jiong Chen

“…Factors affecting the quality of fermented ingredients, such as the type of microorganisms used, fermentation conditions, and substrate composition, were also explored. This review proposes strategies to promote and implement the use of microbial fermented ingredients in aquaculture practices, with the aim of developing a sustainable and cost-effective solution for aquafeed. …”
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Seeing beyond words: nanotechnology in hepatocellular carcinoma - a bibliometric study by Talaiti Tuergan, Talaiti Tuergan, Aimitaji Abulaiti, Alimu Tulahong, Alimu Tulahong, Ruiqing Zhang, Ruiqing Zhang, Zhongdian Yuan, Zhongdian Yuan, Yanze Lin, Yanze Lin, Yingmei Shao, Yingmei Shao, Yingmei Shao, Tuerganaili Aji, Tuerganaili Aji

“…Notable contributions were made by the Chinese Academy of Sciences and authors Gao Jie and Li Yan. …”
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Advancing life expectancy in Saudi Arabia: insights from global best practices by Hala Alosaimi, Haitham Alnouri, Ibrahim Alasiri, Saad Almushawah, Mansour Mohammed, Ameera Abdulrahman, Rana A. Alotaibi, Rasha Alfawaz, Abdulaziz Abdulbaqi, Weam Banjar, Tareef Alaama, Mariam M. AlEissa

“…The primary data sources used include peer-reviewed literature databases such as PubMed, the Lancet and Springer. The data were also derived from reports of global health organizations, such as the WHO, World Bank and OECD publications. …”
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Sclareolide as Antifungal Strategy Against <i>Cryptococcus neoformans</i>: Unveiling Its Mechanisms of Action by Arumugam Ganeshkumar, Patricia Michelle Nagai de Lima, Jebiti Haribabu, Bruno Montanari Borges, Nycolas Willian Preite, Flavio Vieira Loures, Arunachalam Arulraj, Juliana Campos Junqueira

“…Cryptococcal infection commonly begins as an opportunistic infection in humans, however, this can escalate to a systemic or life-threatening form in immunocompromised individuals. …”
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Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury by Zhang C, Chen F, Jiang Y, Deng J, Yan X, Yin X, Su B, Liu W

“…The pharmacological mechanisms of CHQF were explored using network pharmacology, transcriptomics, and metabolomics, which enabled the identification of potential therapeutic targets and pathways, as further validated by in vivo and in vitro experiments.Results: CHQF administration significantly improved the survival rates, reduced systemic inflammation, and restored liver function in CLP-induced sepsis mice, while also mitigating liver tissue injury. …”
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Ethyl acetate extract of Ruta graveolens: a specific and potent inhibitor against the drug-resistant EGFR_T790M mutant in NSCLC by Vikas Kumar, Leena Chauhan, Deepa Singh, Akash Kumar, Rajkumar Kulandaisamy, Tushar Kushwaha, Kamal Baswal, Rajan Singh, Saroj Kumar, Shivajirao L. Gholap, P. Hariprasad, S. Babu Dadinaboyina, Jagadeshwar R. Thota, Deepak Sehgal, Mohan B. Appaiahgari, Krishna K. Inampudi

“…With this objective, the present work explored the therapeutic potential of R. graveolens leaf extracts against EGFR_T790M-mediated drug resistance in NSCLC. …”
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Use of Rapid Qualitative Analysis to Support Collaborative Synergy Within a Community Coalition for Health Equity in Detroit by Hayley S. Thompson, Ten-Niah Kinney, Carrie Leach, Alexandra Sass, Ariel Washington, Rhonda Dailey, Elizabeth Towner, Alyssa Beavers, Rodlescia Sneed, Karen Solomon Edwards, Ijeoma Nnodim Opara, Arthur Hampton, Zachary Cichon, Afsana Rinky, Joneigh Khaldun

“…Results: Participants were majority female, Black/African American, and over 60 years old. …”
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Which explanations do clinicians prefer? A comparative evaluation of XAI understandability and actionability in predicting the need for hospitalization by Laura Bergomi, Giovanna Nicora, Marta Anna Orlowska, Chiara Podrecca, Riccardo Bellazzi, Caterina Fregosi, Francesco Salinaro, Marco Bonzano, Giuseppe Crescenzi, Francesco Speciale, Santi Di Pietro, Valentina Zuccaro, Erika Asperges, Paolo Sacchi, Pietro Valsecchi, Elisabetta Pagani, Michele Catalano, Chandra Bortolotto, Lorenzo Preda, Enea Parimbelli

“…Two cognitive statements for each method were rated on a Likert scale, as well as the agreement with the prediction. …”
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Prebiotics in animal nutrition: Harnessing agro-industrial waste for improved gut health and performance by M. Cristina Ravanal, Carolina A. Contador, Wing-Tak Wong, Qile Zhang, Analese Roman-Benn, Kong Shun Ah-Hen, Pilar E. Ulloa, Hon-Ming Lam

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Ethnic disparities in the association between maternal socioeconomic status and childhood anemia in Peru: a nationwide multiyear cross-sectional studyResearch in context by Ali Al-kassab-Córdova, Claudio Intimayta-Escalante, Pamela Robles-Valcarcel, Diego Urrunaga-Pastor, Baltica Cabieses

“…However, the marginalization-related diminished returns theory suggests that increases in SES yield smaller health gains for marginalized populations—such as Afro-Peruvian and Indigenous groups—compared to majority groups like Mestizos, largely due to systemic barriers and social disadvantage. Therefore, the current study aimed to explore ethnic disparities in the association between maternal SES on childhood anemia in Peru. …”
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Analysis of MHD hybrid nanofluid flow over cone and wedge with exponential and thermal heat source and activation energy by Alshehry Azzh Saad, Noor Saima, Abas Syed Arshad, Fiza Mehreen, Ullah Hakeem

“…In many industrial processes, magnetohydrodynamic (MHD) hybrid nanofluid flow plays a vital role in controlling mass and heat transfer in systems involving precipitation and chemical processing. …”
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Noninvasive Methods Unveil the Trophic Transmission of the Tapeworm Ligula intestinalis in Gull‐Billed Terns by Sofía Capasso, Manuel Parejo, José Manuel Reyes‐González, Juan G. Navedo, Ricardo Morán‐López, José A. Masero, Jorge S. Gutiérrez

“…This integrative coprodiagnostic protocol can be applied to other host–parasite systems, allowing researchers to study helminth infections in wild populations using a noninvasive approach.…”
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What is known about the health of location-based and online web-based digital labour platform workers? A scoping review of the literature by Nuria Matilla-Santander, Filippa Lundh, Signild Kvart, Sherry L. Baron, Theo Bodin, Jessie Gevaert, Carin Håkansta, Julio C. Hernando, Carles Muntaner, Bertina Kreshpaj

“…Limited evidence suggests a correlation between business practices—algorithmic management and rating systems—and poor mental health. Knowledge gaps include the health impact of web-based platforms, especially medical consultation ones and location-based domestic and care services platforms, and less-explored outcomes like musculoskeletal pain and occupational injuries. …”
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Efficacy and safety of tildrakizumab in elderly patients: real-world multicenter study (ESTER – study) by Diego Orsini, Giacomo Caldarola, Annunziata Dattola, Elena Campione, Nicoletta Bernardini, Pasquale Frascione, Clara De Simone, Antonio G. Richetta, Marco Galluzzo, Nevena Skroza, Chiara Assorgi, Emanuele Amore, Gennaro M. Falco, Ruslana Gaeta Shumak, Fabio Artosi, Giulia Maretti, Concetta Potenza, Luca Bianchi, Giovanni Pellacani, Ketty Peris, Claudio Bonifati, Dario Graceffa

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Extreme Warming Coordinately Shifts Root and Leaf Traits of Alpine Plants toward Conservatism by Jingya Zhang, Jianghui Chen, Yixuan Huang, Luhang Jiang, Ziyi Zheng, Huimin Zhou, Hao Wang, Huiying Liu

“…More importantly, we found that the changes in leaf and root traits in response to extreme warming were coupled, resulting in both systems adopting more conservative strategies. …”
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A Novel Therapeutic Calcium Peroxide Loaded Injectable Bio-adhesive Hydrogel Against Periodontitis by Shaojie Dong, Yukun Mei, Yuwei Zhang, Wenqing Bu, Yifei Zhang, Changjie Sun, Rui Zou, Lin Niu

“…Objectives: Periodontitis is a prevalent oral disease that can significantly impact patients' life quality and systemic health. However, non-surgical subgingival scaling is largely compromised due to poor patient compliance, leading to a high recurrence rate of periodontitis. …”
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The role of cytokine licensing in shaping the therapeutic potential of wharton’s jelly MSCs: metabolic shift towards immunomodulation at the expense of differentiation by Olena Rogulska, Eliska Vavrinova, Irena Vackova, Jarmila Havelkova, Klara Gotvaldova, Pavel Abaffy, Sarka Kubinova, Michal Sima, Pavel Rossner, Lucie Bacakova, Pavla Jendelova, Katarina Smolkova, Yuriy Petrenko

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Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis by Liyun Zhou, Zhiying Li, Shengli Zhou, Bin Wang, Zhen Liang, Sen Hu, Hang Zhang, Lin Duan, Dongxu Zhao, Luyao Cheng, Hang Ren, Hiroaki Wakimoto, Ming Li

“…Systemic treatment with NAMPT inhibitors demonstrated intracranial activity in an NSCLC BM model. …”
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Structuring and enriching the rearing environment in conventional broiler chicken production: effects on behavioral indicators, emotional states, and cecal microbiota composition by M. Guinebretière, M. Guyard-Nicodème, F. Mocz, L. Calandreau, A. Scheubel, J.P. Moysan, M. Chemaly, A. Keita, L. Warin

“…Providing a variety of elements in the rearing environment may offer a promising way to transition conventional broiler production towards more animal-friendly production systems. This study aimed to investigate the effect of a complex and structured rearing environment on broiler welfare by comparing three complex enriched rooms (E) with visual cues and multiple elements for resting or exploration, to three control rooms (C) with minimal enrichments. …”
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