Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure by Dan Liu, Li Liu, Nan Li, Yiling Zhou, Hongmei Huang, Jidong He, Heling Yao, Xiangyang Chen, Xiaochi Tang, Miye Wang, Ying Qi, Si Wang, Ye Zhu, Haoming Tian, Zhenmei An, Sheyu Li

“…Baseline AST/ALT ratio was calculated. The primary outcomes were all-cause death within 30 days after discharge, composite cardiac events, major acute kidney injury, and major systemic infection. …”
Get full text

Accepting the Legitimacy of Difference: Tools to Support the Decolonisation of Human Research Ethics in Western Health Research by Erin J. Rooney, Melsina Makaza, Rhonda L. Wilson

“…Cultural insensitivity, systemic biases, and a lack of representation of First Nations peoples may also worsen these issues. …”
Get full text

Bioconversion of Meat and Fish-Based Former Foodstuffs by Black Soldier Fly Larvae: A Sustainable Pathway for Reducing Food Waste, Enhancing Nutrient Recovery, with a Circular Econ... by Antonio Franco, Valentina Pucciarelli, Seyed Ali Hosseini, Eric Schmitt, Fulvia Bovera, Carmen Scieuzo, Patrizia Falabella

“…In this study, five different former foodstuffs containing meat and/or fish were tested to evaluate their suitability for BSFL rearing. …”
Get full text

Effects of Vegetation Restoration Type on Abundant and Scarce Soil Microbial Taxa in a Loess Plateau Mining Area by Yanping Miao, Daren Zhou, Hongchao Zhao, Pengfei Li, Shiqi Sun, Hangxian Lai, Qiao Guo, Jianxuan Shang

“…Shrubland vegetation enhanced soil nutrient retention and carbon stabilization, whereas the mixed grass–shrub systems promoted niche partitioning among rare taxa. …”
Get full text

Metastasis of Squamous Cell Carcinoma of the Larynx to the Right Adrenal Gland—A Case Report by Eliza Działach, Michał Simlot, Karolina Osowiecka, Elżbieta Nowara, Jarosław Markowski, Mateusz Grajek

“…Diagnostic imaging and histopathological examination were complemented by biochemical evaluations to assess hormonal activity. …”
Get full text

A validation study of three early warning scores in early identification of gastric cancer patients with deteriorating condition after gastrectomy by Xinli Shi, Huijuan Jie, Naifa Li, Qiongshan Liu, Yue Wang, Changquan Wu, Wenwen Jiang, Bolin Zhang, Shurong Lai, Honglu Xu

“…The discriminating ability (receiver operating characteristic curves), calibration (goodness-of-fit test) and net benefit (clinical decision curves) of the three EWS (NEWS, SEWS, MEWS) were explored to compare their early warning performance for patients at risk of post-operative deterioration. …”
Get full text

Prediction of heart failure risk factors from retinal optical imaging via explainable machine learning by Sona M. Al Younis, Samit Kumar Ghosh, Hina Raja, Feryal A. Alskafi, Siamak Yousefi, Siamak Yousefi, Ahsan H. Khandoker

“…Our analysis revealed that retinal thickness metrics, particularly ISOS-RPE and macular thickness in various regions, were significantly reduced in heart failure patients. …”
Get full text

英國、臺灣、馬來西亞戶外冒險教育發展之 比較分析 A Comparative Analysis on Outdoor Adventure Education Development in England, Taiwan, and Malaysia by 李晟瑋 Cheng-Wei Li, 葉優寧 Evelyn Yeap Ewe Lin

“…This cross-cultural study explored the development and interpretation of OAE in academic systems of three countries, namely England, Taiwan, and Malaysia. …”
Get full text

Psychological and cultural correlates of illness conception and menopausal symptoms: a cross-sectional and longitudinal comparative study of Mosuo, Yi, and Han women by Limin Gao, Limin Gao, Jinyi Wang, Ying Zhang, Xudong Zhao, Xudong Zhao, Haojie Fu, Haojie Fu

Get full text

CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models by Magdalena Surdyka, Żaneta Kalinowska-Pośka, Anna Niewiadomska-Cimicka, Ewelina Jesion, Agnieszka Fiszer, Elisabeth Singer-Mikosch, Lorraine Fievet, Lukasz Przybyl, Nicholas S. Caron, Michael R. Hayden, Huu Phuc Nguyen, Yvon Trottier, Maciej Figiel

“…In polyglutamine (polyQ) diseases, including Huntington disease (HD) and spinocerebellar ataxia type 3 (SCA3), targeting the mutant CAG tract in mRNA could be a therapeutic strategy for lowering pathogenic protein. We explored the viability of this therapeutic strategy in vivo at the level of the reagent design, toxicity, systemic delivery, brain regions transduction, silencing efficiency, and allele preference. …”
Get full text

A patient self-report disability identifier within health service electronic medical records: evaluation of patient, carer and clinician acceptability by Joanne Rowe, Alexandra Devine, Nicole Merrick, Marie Huska, Kristen Morris, Kath Feely, Ahuva Segal, Louise Mogg, Jenni Medland, Rebecca Jamwal, Alison Smith, Maricar Gleich, Jeremiah Munakabayo, Christine Imms

“…Methods The Disability Identifier questions were integrated into Electronic Medical Record systems across the five health services in March 2023, with the evaluation period spanning the first nine months of implementation (1st March–30th November 2023). …”
Get full text

The potential therapeutic approaches targeting gut health in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a narrative review by Chou-Yi Hsu, Irfan Ahmad, Rana Warid Maya, Mayada Ahmed Abass, Jitendra Gupta, Abhayveer Singh, Kamal Kant Joshi, J. Premkumar, Samir Sahoo, Mohsen Khosravi

“…Results The study found notable changes in the gut microbiota diversity and composition in ME/CFS patients, contributing to systemic inflammation and worsening cognitive and physical impairments. …”
Get full text

REGIONAL ADAPTATION TO CLIMATE CHANGE: PLANNING CHALLENGES AND THE APPROACH OF THE SAKHA REPUBLIC (YAKUTIA) by Nikita I. Tananaev, Tuyara N. Gavrilyeva, Nadezhda A. Krasilnikova, Zhanna F. Poselskaya, Irina V. Samsonova, Evgeny S. Kolganov

“…Priority is given to initiatives that yield rapid results at minimal cost—such as establishing monitoring and response systems, involving municipalities and industries through subsidies in climate action efforts, and implementing scientific and educational policies. …”

Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges by Ayesha Siddiqa, Rahmatullah Qureshi, Ghazala Yasmin, Shaista Rafique, Noor-Ul-Ain Zafar, Chudary Sadam Hussain, Sana ur Rehman, Neelum Naheed

“…These nanodrugs have been observed to significantly influence regulatory mechanisms through their effects on pancreatic α-amylase, intestinal α-glucosidase, insulin action, and glucose uptake across various in vivo and in vitro systems. Moreover, integrating nanotechnological methodologies with the exploration of herbal compounds further enhances the understanding of their chemical potential. …”
Get full text

Mycophenolate Mofetil in the Management of Oral Mucocutaneous Diseases: Current Evidence and Future Perspectives by Khalid Aljohani, Ghada H. Naguib, Abdulghani I. Mira, Abeer Alnowaiser, Mohamed T. Hamed, Ahmed O. Abougazia, Ghaida A. Alzarani, Raghad M. Noorsaeed, Rayyan A. Kayal

“…<b>Background/Objectives:</b> Mycophenolate mofetil (MMF) has emerged as a valuable immunosuppressive agent used in the management of oral mucocutaneous diseases, particularly in autoimmune and inflammatory conditions, such as pemphigus vulgaris (PV), oral lichen planus (OLP), mucous membrane pemphigoid (MMP), systemic lupus erythematosus (SLE), erythema multiforme (EM) and recurrent aphthous stomatitis (RAS). …”
Get full text

Comparing the Fate of eDNA by Particle Sizes and Molecule Lengths in Recirculating Streams by Pedro F. P. Brandão‐Dias, Elise Snyder, Jennifer L. Tank, Ursula H. Mahl, Brett Peters, Arial J. Shogren, Diogo Bolster, Gary A. Lamberti, Kyle Bibby, Scott P. Egan

“…A crucial aspect of the complexity of eDNA ecology is that eDNA is a heterogeneous mix of components that vary in size and other properties, thereby influencing interactions with the environment in diverse ways. In this study, we explore the interplay between three eDNA particle sizes (the physical dimension of eDNA‐containing particles) and two molecule lengths (DNA size in base pairs) in flowing water systems. …”
Get full text

Yiqi Huayu Jiedu Decoction reduces colorectal cancer liver metastasis by promoting N1 neutrophil chemotaxis by Hua-Jian Zhou, Bai-Xiang Mu, Meng-Chao Wen, Qi Zhao, Yuanxiang Li, Wen-Xuan Zhao, Hong-Ye Yin, Shuai Ren, Jin-Yong Zhou, Jin-Yong Zhou, Min Chen

Get full text

Direct engulfment of synapses by overactivated microglia due to cadmium exposure and the protective role of Nrf2 by Siyao Li, Mingdan You, Chengjie Chen, Jingqi Fu, Yuanyuan Xu, Jingbo Pi, Yi Wang

“…Nrf2 knockout mice and wild-type mice were used to explore prolonged Cd exposure-induced synaptic damages, learning-memory impairments, and microglial activation. …”
Get full text

The relationship between dietary inflammatory index (DII) and early renal injury in population with/without hypertension: analysis of the National health and nutrition examination... by Jingda Huang, Huimin Li, Xu Yang, Chuyue Qian, Yihui Wei, Mindan Sun

“…Participant characteristics were analyzed, and association between DII, hypertension, and early renal injury markers was explored using multiple linear and logistic regression models.Results The average age of participants was 53.9 years. …”
Get full text

Malaria treatment for prevention: a modelling study of the impact of routine case management on malaria prevalence and burden by Flavia Camponovo, Aurélie Jeandron, Laura A Skrip, Monica Golumbeanu, Clara Champagne, Tasmin L Symons, Mark Connell, Peter W Gething, Theodoor Visser, Arnaud Le Menach, Justin M Cohen, Emilie Pothin

“…Measuring the impact of effective treatment on burden and transmission via field studies or routine surveillance systems is difficult and potentially unethical. This project uses mathematical modeling to explore how increasing treatment of symptomatic cases impacts malaria prevalence and incidence. …”
Get full text