Results of a 24-week open-label, non-interventional study on the efficacy and safety of olokizumab therapy in patients with rheumatoid arthritis after switching from anti-B-cell th... by A. V. Fedorova, N. E. Banshchikova, A. E. Sizikov, A. A. Mullagaliev, E. A. Letyagina, A. A. Akimova, N. A. Ilyina, Yu. D. Kurochkina, Yu. B. Ubshaeva, V. O. Omelchenko, O. A. Chumasova, N. S. Shkaruba, M. A. Korolev

“…Objective: to evaluate the efficacy and safety of OKZ (Artlegia®; solution for subcutaneous administration, 160 mg/ml – 0.4 ml) for the treatment of patients with RA in real-life clinical practice after switching from RTM during the COVID-19 pandemic.   Material and methods. The study included 19 patients with a confirmed diagnosis of RA who had received RTM at a dose of 500–1000 mg twice every 14 days at least 6 months ago. …”
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Recapitulation of physiologic and pathophysiologic pulsatile CSF flow in purpose-built high-throughput hydrocephalus bioreactors by Ahmad Faryami, Adam Menkara, Shaheer Ajaz, Christopher Roberts, Ryan Jaroudi, Blake Gura, Tala Hussini, Carolyn A. Harris

“…The impact of the internal geometry of the chamber types on flow vectors during pulsatile physiologic and pathophysiologic flow was visualized using Computational Fluid Dynamics (CFD). …”
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Comparative Analysis of Short-Term and Long-Term Clinical Efficacy of Mesenchymal Stem Cells from Different Sources in Knee Osteoarthritis: A Network Meta-Analysis by Qi Xin Ding, Xu Wang, Tian Shu Li, Yue Fang Li, Wan Yue Li, Jia Huan Gao, Yu Rong Liu, WeiSheng Zhuang

“…Therefore, this study aimed to explore the differences between the effectiveness and safety of different sources of MSCs. Materials and Methods. For inclusion consideration, we searched trial registries and published databases, including PubMed, Cochrane Library, Embase, and Web of Science databases. …”
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Comparative efficacy of tofacitinib and adalimumab in patients with psoriatic arthritis in real clinical practice. Data from the Russian nationwide register of patients with psoria... by E. Yu. Loginova, T. V. Korotaeva, E. E. Gubar, Yu. L. Korsakova, S. I. Glukhova, E. A. Vasilenko, A. A. Vasilenko, N. A. Kuznetsova, I. M. Patrikeyeva, E. L. Nasonov

“…Objective: to compare the clinical efficacy in real clinical practice of the targeted synthetic disease-modifying antirheumatic drug (sDMARD) tofacitinib (TOFA) and the biologic DMARD (bDMARD), an inhibitor of tumor necrosis factor alpha (TNFα), adalimumab (ADA) in patients with psoriatic arthritis (PsA), included in the Russian nationwide register of patients with PsA.Patients and methods. The study included 77 patients with PsA (43 men and 34 women) who met the CASPAR criteria and were observed in the Russian nationwide register. …”
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Risk factors associated with post-tuberculosis sequelae: a systematic review and meta-analysisResearch in context by Temesgen Yihunie Akalu, Archie C.A. Clements, Alemneh Mekuriaw Liyew, Beth Gilmour, Megan B. Murray, Kefyalew Addis Alene

“…This systematic review and meta-analysis aims to identify risk factors associated with long-term physical sequelae among TB survivors. Methods: We systematically searched Medline, Embase, PROQUEST, and Scopus for studies on long-term physical sequelae among TB survivors up to December 12, 2023. …”
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Motor-Based Interventions in Children with Developmental Coordination Disorder: A Systematic Review and Meta-analysis of Randomised Controlled Trials by Jiaxin Gao, Yihan Yang, Xiaqing Xu, Dunbing Huang, Yangxin Wu, Hongfei Ren, Anren Zhang, Xiaohua Ke, Wei Song

“…Therefore, the aim of this study was to assess the effectiveness of MBI on standardized motor tests, body functions, activity and participation performance, and psychosocial factors in children with DCD, and to explore the differential effects of different types of interventions (including process-oriented, task-oriented, or combined task- and process-oriented) on the above outcome parameters. Methods We conducted a systematic literature search of all studies published in PubMed, Web of Science, Embase, and the Cochrane Library up to January 31, 2024 to compile all RCTs on MBI for children with DCD. …”
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Comparative characteristics of early psoriatic arthritis with and without axial skeleton injury (a subanalysis of the all-Russian registry of patients with psoriatic arthritis) by E. E. Gubar, E. Yu. Loginova, T. V. Korotaeva, S. I. Glukhova, E. L. Nasonov

“…Objective: to compare the clinical features of two groups of patients with early psoriatic arthritis (PsA): with the involvement of the axial skeleton and without axial lesion.Subjects and methods. Examinations were made in 95 patients (47 men and 48 women) with early PsA from the Russian registry, the diagnosis met the CASPAR criteria; their mean age was 36.5+10.7 years; the duration of arthritis was 12.1 + 10.3 months. …”
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Small Target Detection Algorithm for UAV Aerial Images Based on Improved YOLOv7-tiny by ZHANG Guanghua, LI Congfa, LI Gangying, LU Weidang

“…This study proposes a small target detection algorithm for UAV aerial images using a ConvMixer detection head based on the improved YOLOv7-tiny to address the problems of missed detection and false detection caused by significant variations in target scale, densely distributed small-sized targets and complex backgrounds in UAV aerial images.MethodsFirst, the activation function LeakyReLU is replaced with SiLU to compensate for the limited nonlinear expression of LeakyReLU and to enhance convergence speed and model generalization during training. …”
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Fish Diversity Patterns in Rivers Receiving Ecological Water Supplement Driven by Riparian Land Use by LIU Han, LI Lu-dan, GUO Wei-jie, QIAO Qiang-long, GONG Dan-dan, DU Qi, LI Hang, ZHAO Wei-hua

“…The research focused on two major water-supplemented systems—the Ziya River Basin and Baiyangdian Lake Basin—during the ecological water supplement period from 2020 to 2022. [Methods] Field surveys were conducted annually during the water supplement period. …”
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Architecture and the Time of Space by Deborah Hauptman

“…My interest also developed from a general disposition towards others and world founded in principles of human equality and rights with respect to both freedom and responsibility. …”
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Association of Birthweight Discordance with Adverse Birth Outcomes Among Live-Born Twins: A Multi-Center Study in China by Shi B, Tan X, Chen Q, Lu D, Ren S, Huang K, Shen W, Chen Z, Liu J, You C, Li G, Jiang H, Rao H, Qiu J, Wei X, Zhang Y, Lin X, Jiang H, Han S, Wang F, Yang X, Wang Y, Lin N, Lin L, Lin X, Cui Q

“…Birthweight discordance (BWD), a critical complication, remains understudied in its epidemiological context, particularly regarding its population-level associations with adverse neonatal outcomes.Methods: This multi-center, retrospective cohort study leveraged data from 21 hospitals across 18 Chinese cities (2018– 2020) to assess BWD and its epidemiological implications. …”
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Effect of the Foliar Application of Copper Nanoparticles on the Growth and Yield of Persian Leek (Allium ampeloprasum subsp. Persicum) under Salinity Stress by F. Shakarami, S. Mousavi-Fard, A. Rezaei Nejad, F. Beiranvand

“…The soil mixture comprised an equal ratio of agricultural soil, cow manure, and sand, maintaining a clay-sand loam texture. …”
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Developing a Randomised Efficacy PREcision medicine Platform trial design for Cavernomas: the CARE PREP study by Rustam Al-Shahi Salman, Kasia Adamczuk, Richard A Parker, Christopher J Weir, Roberto Latini, Helen Kim, David White, Helen Evans, Jana Bergholtz, Cornelia Lee, Carlos Casaus

“…A trial manager supported the Chief Investigator in growing and leading a multidisciplinary international collaboration, including a patient and public involvement advisory group, in a series of meetings to optimise study design, equality, diversity and inclusion. Edinburgh Innovations established connections with commercial partners with candidate drugs. …”
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Standardized aqueous extract of Abutilon theophrasti Medic. ameliorates oxidative stress and inflammatory responses against hydrochloric acid/ethanol-induced gastric ulcer in rats by Hui Guo, Hui Guo, Zihan Xu, Zihan Xu, Lili Zhu, Meng Zhu, Meng Zhu, Weijin Zhang, Weijin Zhang, Man Gong, Mengyun Liu, Mengyun Liu, Mengmeng Wang, Mengmeng Wang, Erping Xu, Liping Dai, Liping Dai

“…A protein–protein–substance network construction and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to explore and visualize the biological targets, effective substances, and signaling pathways involved in the anti-GU effects of ATAE. …”
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A nomogram for predicting unfavorable outcomes of antituberculosis treatment among individuals with AIDS combined with pulmonary tuberculosis in China by Xiaoxu Han, Xiaoxu Han, Jin Sun, Jin Sun, Yuan Gao, Yuan Gao, Hongxia Yan, Hongxia Yan, Xiangchuan He, Yuanyuan Ma, Peng Xu, Peng Xu, Ning Ding, Ning Ding, Xin Zhang, Xin Zhang, Meixin Ren, Meixin Ren, Taiyi Jiang, Taiyi Jiang, Tong Zhang, Tong Zhang, Bin Su, Bin Su, Bin Su, Bin Su

“…Therefore, exploring the risk factors affecting the outcome of anti-TB treatment in patients with AIDS combined with TB and developing relevant predictive models will help clinicians rapidly identify patients at greater risk of treatment failure, which is highly valuable for clinical management.MethodsWe conducted a retrospective cohort study including inpatients with AIDS combined with pulmonary tuberculosis (PTB) who were treated at Beijing Youan Hospital between January 2020 and January 2024. …”
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Investigating the relationship between thalamic iron concentration and disease severity in secondary progressive multiple sclerosis using quantitative susceptibility mapping: Cross... by Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David MacManus, Francesco Grussu, Anita Karsa, Becky Samson, Marco Battiston, Claudia A.M. Gandini Wheeler-Kingshott, Karin Shmueli, Olga Ciccarelli, Frederik Barkhof, Jeremy Chataway, Jeremy Chataway, Thomas Williams, Nevin John, Floriana De Angelis, Alberto Calvi, Alessia Bianchi, Sarah Wright, Madiha Shatila, Anisha Doshi, Wallace Brownlee, Claudia AM. Gandini Wheeler-Kingshott, Frederik Barkhof, Olga Ciccarelli, Jonathan Stutters, Ferran Prados Carrasco, Antonio Ricciardi, Marios Yiannakas, David MacManus, Megan Wynne, Marie Braisher, James Blackstone, Leanne Hockey, Josephine Parker, Jennifer Flight, Chris Frost, Jennifer Nicholas, Stuart Nixon, Judy Beveridge

“…The observed relationships between lower thalamic susceptibility and more severe physical, cognitive and visual disability suggests that reductions in thalamic iron may correlate with important mechanisms of clinical disease progression. …”
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Efficacy and safety of rapid dose escalation of methotrexate in rheumatoid arthritis. Results of the multicenter “METEOR” study by V. N. Amirjanova, E. Yu. Polishchuk, O. N. Anoshenkova, I. B. Vinogradova, E. V. Zonova, L. V. Ivanova, R. R. Samigullina, T. S. Salnikova, E. L. Shakhramanova, E. I. Shmidt, S. P. Yakupova, A. M. Lila, E. L. Nasonov

“…Rompharm Company S.R.L) in patients with rheumatoid arthritis (RA) with high disease activity and rapid dose escalation, to assess their quality of life (QoL) in real clinical practice.Material and methods. The study included 105 patients, mostly women, with a reliable diagnosis of RA with high disease activity (DAS-28 (Disease Activity Score 28) ≥5.1) aged 18 years and older and ineffectiveness of previous oral MTX therapy for at least 6 months or who had not received MTX. …”
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Evaluating the Elements of Vitality in Jahānshahr Walkway, Karaj City, Iran by Mina Heydari Tamrabadi, Habibollah Fasihi, Tajaddin Karami

“…This research aimed to evaluate the vitality components of Jahānshahr Walkway, a major thoroughfare that played a significant social, economic, and cultural role in the bustling and lively part of Karaj City, Iran. Materials & Methods:The study focused on Jahānshahr Walkway located in the northeastern region of Karaj, Iran. …”
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Application of acupuncture therapy in relieving the anxiety among patients undergoing glaucoma surgery (针灸疗法缓解青光眼手术患者焦虑的效果观察) by LI Gonghui (李贡辉), (毛珍), MA Di (马迪), HUANG Chukai (黄楚开), TAN Ronghui (谭容慧)

“…Objective To investigate the effect of acupuncture therapy in relieving the anxiety of patients undergoing glaucoma surgery. Methods Totally 95 glaucoma patients undergoing trabeculectomy were randomly divided into two groups: control group with 47 cases and observation group with 48 cases. …”
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Study of Planting Pattern and Herbicide Effects on Weed Population and Chickpea (Cicer arietinum L.) Grain Yield by Hossein Najafi, Soheyla Pourheydar Ghafarbi, Gholamreza Gahramanian, Ajang Jahedi

“…Optimizing chickpea row-spacing and the application possibility of non-selective herbicides in chickpea was our objective in this experiment. Materials and Methods In order to study planting pattern and chemical control effects on weed population and yield of rain-fed chickpea farming, two experiments conducted. …”
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