AI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study by Jirong Yi, PhD, Anna M Marcinkiewicz, MD, Aakash Shanbhag, MSc, Robert J H Miller, MD, Jolien Geers, MD, Wenhao Zhang, PhD, Aditya Killekar, MSc, Nipun Manral, MSc, Mark Lemley, BSc, Mikolaj Buchwald, PhD, Jacek Kwiecinski, MD, Jianhang Zhou, MSc, Paul B Kavanagh, MSc, Joanna X Liang, MPH, Valerie Builoff, BSc, ProfMD Terrence D Ruddy, BSc, ProfMD Andrew J Einstein, BSc, Attila Feher, MD, Edward J Miller, Prof, ProfMD Albert J Sinusas, Prof, ProfMD Daniel S Berman, Prof, ProfPhD Damini Dey, Prof, Piotr J Slomka, PhD

“…Methods: We applied AI-based segmentation and image-processing techniques on CTAC scans from a large international image-based registry at four sites (Yale University, University of Calgary, Columbia University, and University of Ottawa), to define the chest rib cage and multiple tissues. …”
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The feasibility and efficacy of the Position Acute Tone External system score in evaluating hemorrhoid severity and guiding clinical treatment by Sun Songpeng, Wan Weiping, Li Tianyu, Wu Yao, Wang Jianguo, Xu Fangfang, Zhang Zhiyun, Tian Ying, Lin Mei, Cao Qiaorong, Wang Zhanjun, Li Xinjian, Yang Tianqing, Liao Riyu, Xieyida Kuerban, Ni Hong, Huo Xingxiao, Jia Shan, Long Junhong, Zhang Shuxin

“…[Objectives] To analyze the feasibility and efficacy of the Position Acute Tone External (PATE) system score in evaluating hemorrhoid severity and guiding clinical treatment. [Methods] This cross-sectional study conducted a questionnaire survey among patients with hemorrhoids in outpatient/ward settings at six anorectal centers from November 2021 to November 2022. …”
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Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system by Xueqian Yang, Meiqi Wu, Menglin Liang, Haiqiong Zhang, Bo Li, Chenhui Mao, Liling Dong, Yuan Wang, Haiqun Xing, Chao Ren, Zhenghai Huang, Qingxiang Wen, Qi Ge, Zhengqing Yu, Feng Feng, Jing Gao, Li Huo

“…The study aims to establish a faster acquisition protocol for [18F]florbetapir PET imaging using digital PET/CT scanner uMI Panorama, while ensuring adequate image quality and amyloid-β (Aβ) detectability comparable to the standard 10-minute scan. Methods Thirty-eight participants (29 Aβ positive and 9 Aβ negative) from a prospective dementia cohort at Peking Union Medical University Hospital underwent routine [18F]florbetapir PET scans using the uMI Panorama PET/CT scanner and a T1-weighted brain MRI scan. …”
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Convergent construct validity and test-retest reliability of both German versions of the original and the revised Niigata PPPD Questionnaire: NPQ and NPQ-R by Sarah Chételat, Sarah Chételat, Eve-Yaël Gerber, Eve-Yaël Gerber, Sarah El Khadlaoui, Frank Behrendt, Frank Behrendt, Michaela Stark, Michaela Stark, Stefan Schädler, Stefan Schädler, Maximilian Maywald, Lena Fabritius, Johannes Gerb, Johannes Gerb, Denis Grabova, Wiebke Trost, Andreas Zwergal, Andreas Zwergal, Ralf Strobl, Ralf Strobl, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Sandra Becker-Bense, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…Characteristic provocation factors are moving or complex visual stimuli and exclusion of organic diseases. …”
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Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients by Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Vicente Zanón-Moreno, Vicente Zanón-Moreno, Carolina García–Villanueva, Alessio Martucci, Cristina Peris-Martínez, Cristina Peris-Martínez, Jorge Vila-Arteaga, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Irene Andrés–Blasco, Irene Andrés–Blasco, Irene Andrés–Blasco, Alex Gallego–Martínez, Alex Gallego–Martínez, Carlo Nucci, Julian García–Feijoo

“…As a response to high intraocular pressure, the clinical and molecular glaucoma biomarkers indicate the biological state of the visual system. Classical and uncovering novel biomarkers of glaucoma development and progression, follow-up, and monitoring the response to treatment are key objectives to improve vision outcomes. …”
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Application of platelet-rich plasma therapy combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis (富血小板血浆联合5E康复护理模式在膝骨性关节炎患者中的应用)... by AN Linjing (安林静), ZHAO Chen (赵晨), CHANG Yueyuan (常月圆), PAN Yaying (潘亚英), CHEN Yanqi (程艳琪), ZHANG Bing (张兵), CHEN Weinan (陈炜楠), GAO Bei (高蓓), NIU Jing (牛静), ZHANG Ting (张婷)

“…Objective To explore the clinical effect of platelet-rich plasma therapy (PRP) combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis. Methods Totally 80 patients with knee osteoarthritis admitted to the orthopedics department of the hospital from March 2021 to March 2023 were selected as subjects. …”
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Evaluation of the effectiveness of Tofacitinib in rheumatoid arthritis in real clinical practice: The relationship between pain relief in the first 4 weeks and disease activity aft... by A. E. Karateev, E. Yu. Pogozheva, V. N. Amirjanova, E. S. Filatova, A. M. Lila, V. I. Mazurov, R. R. Samigullina, A. M. Dadalova, A. Yu. Dyo, D. S. Chakieva, A. A. Baranov, N. A. Lapkina, E. N. Koltsova, N. A. Kiryukhina, I. N. Shchendrigin, T. G. Rasevich, A. F. Davydova, I. V. Semizarova, I. A. Shafieva, I. B. Bashkova, D. A. Bobrikova, D. A. Murtazalieva, I. N. Kushnir, E. V. Kalinina, T. S. Salnikova, I. M. Marusenko, O. V. Semagina, I. B. Vinogradova, D. G. Krechikova, M. Yu. Semchenkova, E. L. Nasonov

“…However, it is not clear how pain reduction is associated with achieving low activity in rheumatoid arthritis (RA).The aim of the study was to assess the relationship between the early clinical response to tofacitinib and a decrease in rheumatoid arthritis activity after 3 and 6 months.Material and methods. The study group consisted of 88 RA patients (age – 53±11.5 years; 79.3% of women) who received basic anti-inflammatory drugs (59.5% – methotrexate, 19.8% – leflunomide) and who were prescribed TOFA in a dose 10 mg/day. …”
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Inhibition of Ferroptosis by Adipose Stem Cell-Derived Apoptotic Vesicles Enhances Angiogenesis and Accelerates Diabetic Wound Healing by Zhang J, Kuang J, Gong S, Wang H, Ding F, Zhao L, Shi L, Liu S, Zhao Y, Liu J, Dou G

“…This study aims to investigate whether adipose stem cell-derived apoptotic vesicles (ASCs-apoVs) promote angiogenesis and accelerate diabetic wound healing by inhibiting endothelial cell ferroptosis.Methods: Diabetic mice model was established by feeding with high-fat diet (HFD) for 3 months followed by full-thickness skin wound preparation. …”
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Análise de lesões musculoesqueléticas em praticantes de musculação e corrida (Analisis de lesión musculoesquelética em practicantes de musculación y de las carreras) (Analysis of... by Flavio Boechat de Oliveira, Wallin do Couto Conceição, Rafael Barreto, Igor Carvalho, Giovanne Moraes de L. Ribeiro, Rodrigo Gomes de Souza Vale

“…Of this total 40 injuries were due to running and 39 Bodybuilding. This shows an equality between the two activities and the risk of injury. …”
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Patient buy-in to social prescribing through link workers as part of person-centred care: a realist evaluation by Stephanie Tierney, Geoffrey Wong, Debra Westlake, Amadea Turk, Steven Markham, Jordan Gorenberg, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Tony Meacock, Catherine Pope, Beccy Baird, Kamal R Mahtani

“…Setting Patients engaging with link workers in seven different parts of England were involved. Methods As part of data collection, we observed link workers interacting with 35 patients. …”
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Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. by Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh

“…Yet it is inconclusive whether these associations are causal.<h4>Methods and findings</h4>We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). …”
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Role and mechanism of action of nuclear receptor coactivator 4 in the development of acquired resis-tance to targeted inhibitors in pancreatic cancer with KRAS G12C mutation by CHANG Hao, WANG Ya'nan, LIU Shihai, WANG Jing

“…Objective To investigate the role and mechanism of action of nuclear receptor coactivator 4 (NCOA4) in acquired resistance to targeted inhibitors in pancreatic cancer with KRAS G12C mutation. Methods Human pancreatic cancer cell lines CFPAC-1, PANC-1, and MIA-PaCa-2 were cultured in vitro. …”
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THE EFFICACY AND SAFETY OF CARMOLIS GEL IN THE COMBINATION THERAPY OF KNEE OSTEOARTHRITIS: RESULTS OF A MULTICENTER CLINICAL TRIAL by I. N. Denisov, I. A. Zborovskaya, B. V. Zavodovsky, B. A. Alikhanov, I. V. Karapetyan, V. A. Shalygina, V. E. Budushkina, O. Yu. Vakulenko, A. D. Nasrullaeva, V. N. Sorotskaya, E. A. Leonova, A. I. Mironcheva, D. V. Goryachev

“…The same holds true for not only the symptomatic and disease-modifying effects of chondroprotectors, but also topical therapy options.Objective: to evaluate the clinical efficacy and safety of Carmolis gel in patients with knee OA.Subjects and methods.The trial included 280 patients with knee OA (a study group consisted of 190 patents; a control group comprised 90 patients). …”
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Plasma biomarkers for early detection of alzheimer’s disease: a cross-sectional study in a Japanese cohort by Masahito Kubota, Shogyoku Bun, Keisuke Takahata, Shin Kurose, Yuki Momota, Yu Iwabuchi, Toshiki Tezuka, Hajime Tabuchi, Morinobu Seki, Yasuharu Yamamoto, Ryo Shikimoto, Yu Mimura, Takayuki Hoshino, Sho Shimohama, Natsumi Suzuki, Ayaka Morimoto, Azusa Oosumi, Yuka Hoshino, Kenji Tai, Hirofumi Aoyagi, Yoshiaki Sato, Junro Kuromitsu, Jin Nakahara, Masaru Mimura, Daisuke Ito

“…HISCL-based plasma Aβ42/40 detects Aβ accumulation earlier than Aβ PET visual reading threshold, underscoring its utility as an early diagnostic marker.…”
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Peripheral Iridotomy-Less Approach in Descemet&rsquo;s Membrane Endothelial Keratoplasty Using Pupil-Dilating Eye Drops, a Retrospective Case&ndash;Control Study by Bayyoud T, Bartz-Schmidt KU, Rohrbach M, Gelisken F, Goldblum D, Martus P, Thaler S

“…Postoperatively, mydriatic eye drops were administered for three days 4x/d (phenylephrine 25 mg/mL, tropicamide 5 mg/mL). The best-corrected visual acuity (BCVA), endothelial cell density (ECD), and IOP were assessed. …”
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Metabolome Profiling and Predictive Modeling of Dark Green Leaf Trait in Bunching Onion Varieties by Tetsuya Nakajima, Mari Kobayashi, Masato Fuji, Kouei Fujii, Mostafa Abdelrahman, Yasumasa Matsuoka, Jun’ichi Mano, Muneo Sato, Masami Yokota Hirai, Naoki Yamauchi, Masayoshi Shigyo

“…<b>Background:</b> The dark green coloration of bunching onion leaf blades is a key determinant of market value, nutritional quality, and visual appeal. This trait is regulated by a complex network of pigment interactions, which not only determine coloration but also serve as critical indicators of plant growth dynamics and stress responses. …”
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Impact of tofacitinib on patient-reported outcomes in patients with psoriatic arthritis. Data from the real clinical practice by L. D. Vorobyeva, T. V. Korotaeva, E. Yu. Loginova, Yu. L. Korsakova, E. E. Gubar, E. L. Nasonov

“…Objective – to study the effect of tofacitinib (TOFA) on Patient-Reported Outcomes (PROs) in psoriatic arthritis (PsA) patients (pts) activity in real clinical practice.Material and methods. Included 41 patients, predominantly men (58.9%), with a reliable diagnosis of psoriatic arthritis (PsA) according to the CASPAR criteria (2006), and signed informed consent to participate in the study. …”
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Construction of a random survival forest model based on a machine learning algorithm to predict early recurrence after hepatectomy for adult hepatocellular carcinoma by Ji Zhang, Qing Chen, Yu Zhang, Jie Zhou

“…This analysis seeks to elucidate the potential advantages of the RSF model over the CPH model in addressing this clinical challenge. Methods The present retrospective cohort study was conducted at a single center. …”
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The effect of perioperative application of enhance recovery after surgery for elderly patients with hip fracture: A Meta-analysis (加速康复外科理念在老年髋部骨折患者围手术期中应用效果的Meta分析)... by GE Ruolan (葛若兰), XIA Xiaomei (夏晓妹), YANG Shipeng (杨士鹏), CUI Limin (崔立敏)

“…Objective To systematically evaluate the effect of enhance recovery after surgery(ERAS) during the perioperative period for elderly patients with hip fracture. Methods The China National knowledge Infrastructure, China Biomedical Database, Wanfang database, VIP citation database and PubMed, Web of Science, EMBASE, Cochrane Library database were retrieved. …”
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Impacts of Chelated Iron Supplement with Organic Acid and Amino Acid on Growth Performance, Nutrient Digestibility, Feeding Behaviors, and Blood Parameters in Suckling Calves by Mahdi Ghavidel, Abdolhakim Toghdory, Taghi Ghoorchi, Mohammad Asadi

“…During days 61 to 63 of the experimental period, nutritional behaviors, including eating, resting, chewing, standing, and ruminating activities, were measured visually for all animals every 5 min for 48 hours. …”
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