Insights into De Quervain’s Tenosynovitis as an Unintended Consequence of Problematic Smartphone Usage: A Cross-sectional Observational Study by Aswin Sugumaran, Dilip Kumar Naidu, Madhan Raju, Sabari Vaasan Lakshmikanthan, S Karthikeyan, Kevin Dhas, Vamsi Krishna, Praveen Raja

“…Materials and Methods: A cross-sectional observational study was conducted at the Department of Orthopaedics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, India, from July 2024 to September 2024, with 300 participants aged 20-50 years. …”
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The Incorporation of CBD into Biodegradable DL-Lactide/Glycolide Copolymers Creates a Persistent Antibacterial Environment: An In Vitro Study on <i>Streptococcus mutans</i> and <i>... by Ronit Vogt Sionov, Ahmad Siag, Emma Theresa Mersini, Natalya M. Kogan, Tatiana Alkhazov, Igor Koman, Praveen Rowlo, Vitaly Gutkin, Menachem Gross, Doron Steinberg

“…Biofilm formation on the polymer scaffolds was visualized by HR-SEM. Its anti-inflammatory effect was determined by measuring the IL-6 release from LPS-stimulated RAW 264.7 macrophages by ELISA. …”
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Pseudomonas oryzihabitans D1-104/3 and P. gessardii C31-106/3 differentially modulate the antioxidative response of duckweed (Lemna minor L.) to salt stress by Tatjana Popržen, Dragana Antonić Reljin, Branka Uzelac, Marija Milovančević, Danijela Paunović, Milana Trifunović-Momčilov, Marija Marković, Martin Raspor, Ivan Nikolić, Slaviša Stanković, Olga Radulović

“…Fluorescence microscopy was used to visualize bacterial presence on duckweeds.ResultsFluorescence microscope revealed that Pseudomonas bacteria colonized all duckweed surfaces. …”
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The value of home-centered dressing change model in wound healing after low simple anal fistulectomy—a cross-sectional study by Zhang Linhan, Jia Shize, Wei Kaikai, Wan Xingyang, Ren Donglin, Lin Hongcheng, Liu Zhimin

“…[Objectives] To investigate the value of home-centered dressing change model in wound healing after low simple anal fistulectomy. [Methods] Total of the sixty-four patients with low simple anal fistula who underwent fistulectomy at the Department of Anorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University from June 2022 to December 2022 were included as the study subjects. …”
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HORNBILL: A First-in-Human Phase I/IIa Study of the Safety, Tolerability, and Early Pharmacodynamics of BI 764524 for Diabetic Macular Ischemia by Quan Dong Nguyen, MD, MSc, Chirag Jhaveri, MD, Maged Habib, MD, Yasir J. Sepah, MBBS, Khaled Nassar, MD, PhD, Bartlomiej Krawczyk, PhD, Gudrun Simons, PhD, Andrea Giani, MD, Elizabeth Pearce, PhD, Martin Gliem, MD, Mohamed Ahmed, MBBCh, MD, Sobha Sivaprasad, DM

“…Participants: Adults with DMI and stable diabetic retinopathy (DR) treated with pan-retinal photocoagulation and without center-involving diabetic macular edema. Methods: Twelve participants received single IVT doses of BI 764524 0.5 mg (n = 3), 1.0 mg (n = 3), or 2.5 mg (n = 6) in the SRD part. …”
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Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Valid... by Yaoyao Xu, Qiaoyan Cai, Chunyu Zhao, Weixiang Zhang, Xinting Xu, Haowei Lin, Yuxing Lin, Daxin Chen, Shan Lin, Peizhi Jia, Meiling Wang, Ling Zhang, Wei Lin

“…But the precise mechanisms underlying its anti-inflammatory and anti-tumor effects are not fully elucidated. <b>Methods</b>: Use network pharmacology to identify targets and pathways of GQD. …”
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Good Arts, Good Mental Health®: the effectiveness of an Australian health promotion media campaign in promoting community mental wellbeing via the arts by Christina R. Davies, Melanie T. Pescud, Rhonda Clifford, Richard McGrath, Annie Thomson, Mia Jeffrey, Melissa Stoneham, Terri Pikora, Peter Wright, Sonya Girdler, Sonya Girdler, Loretta Baldassar, Stephen Clift

“…The objectives of the campaign (Wave 1) were to increase brand awareness, comprehension, and agreement with the tagline Good Arts, Good Mental Health® and empower the general population to form an intention to engage in the Arts for their mental wellbeing.MethodsThe campaign ran from August to September 2024 (4 weeks), cost AUD$198,965 (23% creative and 77% media/advertising distribution), and targeted the Western Australian (WA) general population aged 18–65 years, all genders, in both metropolitan and regional areas. …”
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A novel nomogram for predicting osteoporosis with low back pain among the patients in Wenshan Zhuang and Miao Autonomous Prefecture of China by Man Jia, Man Jia, Qinzuo Dong, Zeqin Ren, Liwei Xing, Jinjie Li, Xiaomei Wang, Shun Yu, Xiaoyan Wang, Rong Zhao, Rong Zhao

“…However, there are currently no convenient tools available to identify patients with low back pain caused by osteoporosis.MethodsWe consecutively enrolled 769 patients diagnosed with low back pain in our hospital from January 2019 to March 2024. …”
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The clinical course and outcomes following arthroscopic frozen shoulder 360° release by Brandon Ziegenfuss, BSc(Hons), MPH, Kristine Italia, MD, FPOA, Kathir Azhagan Stalin, MBBS, Sarah Whitehouse, PhD, Ashish Gupta, MBBS, MSc, FRACS, FAOrthA, Kenneth Cutbush, MBBS, FRACS, FAOrthA

“…The aim of this study is to evaluate the clinical outcomes following the FS 360° arthroscopic release. Methods: An observational prospective cohort study was conducted assessing patient-reported outcome measures (PROMs) in patients who underwent the 360° arthroscopic release between July 2013 and January 2019. …”
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L-shaped association between oxidative balance score and vision-related functional burden in adults in the United States, NHANES 2005–2008 by Juntong Li, Juntong Li, Sheng Ye, Xiang Li, Xiang Li, Hui Liu, Yue Yang, Xuelei Lu, Heyue Jin, Li Liu, Li Liu

“…ObjectiveThis study aims to investigate the relationship between oxidative balance score (OBS) and vision-related functional burden (VRFB) in US adults.MethodsThe study utilized data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008. …”
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PSMA response evaluation in follow-up PSMA-PET/CT after stereotactic ablative body radiotherapy (SABR) for oligometastases in prostate cancer by Anna-Lena Zang, Timo Maier, Sandra Freitag-Wolf, Alexander Fabian, Severin Rodler, Jürgen Dunst, David Krug, Ulf Lützen, Olaf Wittenstein

“…PSMA response was evaluated by visual and quantitative assessment of local PSMA uptake pre- and post-SABR. …”
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Analysis of the Impact of Effectiveness of Media (Seda-va-Sima) Advertisement on the Extent of Consumers’ Urge to Consume National Commodities by Abolfazl Danaei

“…Other secondary hypotheses were also confirmed, with path coefficients for various roles including: information features (0.594), advertising selection activities (0.506), advertising ranking (0.591), advertising engagement (0.623), advertising tools and visual methods (0.523), emotional features (0.498), motivational dimensions (0.522), overall advertisement viewing (0.618), internal vs. external product evaluation (0.642), consumer nationalism (0.705), and preference for domestic vs. foreign products (0.603). …”
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Distinct immunity dynamics of natural killer cells in mild and moderate COVID-19 cases during the Omicron variant phase by Yukari Nishikawa, Kosuke Yamaguchi, Ma’arif Athok Shofiudin, Momone Mimura, Miyako Takata, Shu Mihara, Takeru Kawakami, Ayumu Doi, Risa Matsuda, Hiroyuki Kato, Ryo Okamoto, Kengo Mukuda, Naoki Kinoshita, Kensaku Okada, Tsuyoshi Kitaura, Masaki Nakamoto, Hisashi Noma, Yusuke Endo, Akira Yamasaki, Hiroki Chikumi

“…This study analyzed alterations in natural killer (NK) cell-associated immunity dynamics in mild and moderate COVID-19 cases during the Omicron phase of the COVID-19 pandemic.MethodsWe conducted a retrospective observational cohort study of patients aged ≥16 with confirmed SARS-CoV-2 infection who were hospitalized at Tottori University Hospital between January 2022 and May 2022. …”
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Patient-reported outcome tools of acupuncture clinical trials in mainland China: a cross-sectional study by Feng Cao, Feng Cao, Yue Dong, Zhi-Qiang Li, Zhi-Qiang Li, Xue-Feng Wang, Xue-Feng Wang, Cheng-Yuan Su, Cheng-Yuan Su, Jia-Xuan Lv, Zhong-Yu Shi, Ming-Hong Du, Xin-Yue Zhang, Hong-Guo Rong, Hong-Guo Rong, Hong-Guo Rong, Yu-Tong Fei, Yu-Tong Fei, Yu-Tong Fei

“…This study aims to evaluate the characteristics and application of PRO measurements in acupuncture clinical trials in mainland China, further exploring and developing patient-reported outcomes (PROs) that are in line with the characteristics of acupuncture treatment.MethodsThis cross-sectional study analyzed acupuncture clinical trials in mainland China (2010–2022). …”
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Elevated septal native T1 time in cardiac magnetic resonance imaging suggesting myocardial fibrosis in young kidney transplant recipients by Tim Alexander Ubenauf, Jeannine von der Born, Rizky I. Sugianto, Carl Grabitz, Elena Lehmann, Nima Memaran, Nele Kanzelmeyer, Jan Falk, Nigar Babazade, Samir Sarikouch, Diane Miriam Renz, Bernhard Magnus Wilhelm Schmidt, Anette Melk

“…This study aimed to explore cardiac function and structure with focus on myocardial fibrosis and associated risk factors in KTx recipients. Methods: Forty-six KTx recipients (mean age 16.0 ± 3.5 years) and 46 age- and sex-matched healthy controls were examined with non-contrast CMR imaging. …”
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Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium by Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou

“…This study aimed to improve the protective immunity of a previously developed growth-deficient strain—a double auxotroph for D-glutamate and D-alanine—by engineering the inducible expression of type 1 fimbriae. <b>Methods</b>: P<i>_tetA</i>-driven expression of the <i>fim</i> operon was achieved by λ-Red mutagenesis. …”
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Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled cl... by Yange Wei, Yange Wei, Shanyuan He, Peng Luo, Hanshuo Su, Yuanle Chen, Shisen Qin, Zhongguo Zhang, Rongxun Liu, Dongshuai Wei, Juan Wang, Fei Wang, Fei Wang, Chuansheng Wang

“…This study aims to examine the synergistic efficacy of tDCS and MT on cognitive impairments in individuals with schizophrenia and to elucidate the potential mechanisms involved in this process.MethodsThe study is designed as a randomized, double-blind, sham-controlled trial. …”
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Fatal risk factors and the efficacy of glucocorticoid therapy in severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study by Fang Zhong, Shiyu Zhang, Chengxi Zheng, Dilihumaer Zhayier, Shuting Liu, Qinyu You, Hongming Huang, Bin Zhu, Jin Tian, Zhiliang Hu, Zhiliang Hu, Zhiliang Hu, Xin Zheng, Baoju Wang, Zhihang Peng, Zhihang Peng, Zhihang Peng

“…Glucocorticoids (GCs) can be used as anti-inflammatory agents for SFTS, but no standardized protocols have been proposed.MethodsA total of 901 patients with SFTS diagnosed at two hospitals between July 2017 and October 2023 were included in this retrospective cohort study. …”
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Meta-analysis of the synergistic effect of traditional Chinese medicine compounds combined with conventional Western medicine in the treatment of osteoporosis by Huan Jin, Huan Jin, Cai Huang, Yan Zhang, Ying Dong, Qi Xiong, Di Wang, Di Wang, Ziyi He, Ziyi He, Lin Shen, Chen Ma, Zixian Wang, Lingfeng Zeng, Bo Shuai

“…This study systematically evaluated the synergistic effect of traditional Chinese medicine (TCM) compounds combined with conventional Western medicine (such as bisphosphonates and calcium) compared to Western medicine alone in the treatment of OP through a meta-analysis.MethodsBased on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Measurement Tool for Systematic Review Assessment guidelines, databases such as PubMed and Embase were systematically searched (as of March 2025), and 13 randomized controlled trials (RCTs), involving a total of 2,403 patients, were included.ResultsThe integrated Chinese and Western medicine group showed significantly higher lumbar and femoral neck Bone mineral density (BMD) growth rates than the control group, alongside reduced pain visual analogue scale (VAS) scores. …”
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Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate by Chenquan Lin, Chenquan Lin, Chenquan Lin, Rui Ma, Rui Ma, Rui Ma, Xiao Zeng, Xiao Zeng, Xiao Zeng, Bikui Zhang, Bikui Zhang, Bikui Zhang, Ting Cao, Ting Cao, Ting Cao, Shimeng Jiao, Shimeng Jiao, Shimeng Jiao, Hui Chen, Hui Chen, Hui Chen, Yifang He, Yifang He, Yifang He, Mouze Liu, Mouze Liu, Mouze Liu, Hualin Cai, Hualin Cai, Hualin Cai

“…Additionally, individual variations including genetic underpinnings attributable to disparities in therapeutic effects and clinical toxicity remain to be elucidated.MethodsA total of 374 patients receiving initial HD-MTX treatment were selected for this study, which aimed to establish a predictive model using binary logistic regression and a visual nomogram for DILI risk assessment. …”
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