Metabolomic Profiling of the Blood of Patients with Chronic Consciousness Disorders by A. A. Orlova, E. A. Kondrat'eva, Ya. A. Dubrovskii, N. V. Dryagina, E. V. Verbitskaya, S. A. Kondratev, A. A. Kostareva, A. N. Kondratev

“…The aim of the study was to investigate the main differences in metabolomic abnormalities in patients with VS / UWS and MCS, as well as to identify changes in metabolomics depending on sleep or wakefulness phase.   Materials and Methods. Untargeted metabolome analysis of blood plasma of 10 patients in VS / UWS (group 1) and 6 patients in MCS (group 2) was performed using reversed-phase and hydrophilic chromatography methods. …”
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Photon counting detector CT-derived virtual non-contrast images of the liver: comparison of conventional and liver-specific algorithms across arterial and portal venous phase scans by Anna-Katharina Gerstner, Franka Risch, Luca Canalini, Gerlig Widmann, Elke R. Gizewski, Stefanie Bette, Simon Hellbrueck, Thomas Kroencke, Josua A. Decker

“…Bland-Altman plots were utilised to visually assess the agreement between results and Passing-Bablok regression, thereby quantifying the observed agreement. …”
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Research Progress on the Impact of Nighttime Outdoor Environments on Residents’ Health by Chongxian CHEN, Xinrui XIONG, Guangsi LIN, Jingyi LIU

“…The ultimate goal is to provide a scientific foundation for health-oriented nighttime urban planning and policymaking.MethodsThis research conducts a comprehensive review of Chinese and English literature on nighttime outdoor environments and public health, using publications retrieved from the Web of Science (WoS) and China National Knowledge Infrastructure (CNKI) databases that span the period from 1999 to 2025. …”
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From background diabetic retinopathy to its proliferative stage. What is the role of gut microbiota in the trajectory of DR? a Mendelian randomization study with mediation analysis by Yifan Zhou, Jialong Dong, Zhenyu Wang, Chen Huang, Xiaotong Yu, Xinjun Wang, Bo Yang, Yuechen Wu, Qing Peng

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Pragmatic Randomized Controlled Trial of Pharmacopuncture Therapy for Cervical Disc Herniation: A Pilot Study by Lee SW, Ahn YJ, Kim S, Lee Y, Cho HW, Hong Y, Nam D, Park YC, Kim EJ, Lee YJ, Ha IH

“…Although pharmacopuncture therapy is one of the most widely used treatment methods for CDH in Korean medicine clinical practice, there are few high-quality studies conducted in Korea. …”
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Influence of dendritic cells on corneal nerve morphological analysis and clinical relevance in chronic dry eye disease after femtosecond laser-assisted laser in situ keratomileusis by Yilin Liu, Yilin Liu, Baikai Ma, Baikai Ma, Lu Zhao, Hongshuo Li, Wenlong Li, Wenlong Li, Zhengze Sun, Zhengze Sun, Hongyu Duan, Hongyu Duan, Yitian Zhao, Hong Qi, Hong Qi

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Clinical characteristics and risk factors of bacillary layer detachment in central serous chorioretinopathy: a comparative multicenter study by Antonio M. Casella, Raphaela M. Fuganti, Ahmad M. Mansour, José Ignácio Fernández-Vigo, Suthasinee Sinawat, Ali Osman Saatci, Jay Chhablani, Arman Zarnegar, Juliana Prazeres, Igor Kozak, Lorenzo López Guajardo, Michel E. Farah, Claudio Zett, Francisco Rodriguez, William E. Smiddy, Janet L. Davis, Philip J. Rosenfeld, Stephen G. Schwartz, Luiz H. Lima, Maurício Maia

“…Inclusion criteria included a CSC diagnosis with RPE leakage, BALAD confirmed by three authors, age over 18, and a detailed medical history from the 30 days before symptom onset. The study assessed visual acuity, choroidal thickness, psychiatric disorders, corticosteroid use, prior CSC treatments, and hyperreflective material on OCT. …”
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Comparative Efficacy of Bone Graft Materials in Transforaminal Lumbar Interbody Fusion: A Systematic Review and Meta-Analysis by Sami Al Eissa, Fahad Al Helal, Majed Abaalkhail, Abdullah Al Shehri, Raed Al Mousa, Abdullah Bin Shabib, Hussam Al Angari, Abdulrahman M. AlJahani, Dana W. AlDughiman

“…Aim This study aims to compare the efficacy and safety of different bone graft materials used in TLIF surgeries by analyzing fusion rates, clinical outcomes, and complication rates across various studies. Methods A systematic search was conducted on PubMed and Google Scholar for studies related to TLIF and bone graft materials up to December 2023. …”
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Association between out-of-pocket expenditure and health-related quality of life among patients receiving cancer treatment: a cross-sectional study from Nepal by Pratik Khanal, Suman Sapkota, Nirmal Poudel, Achyut Raj Pandey, Bidwata Bhattarai, Etna Khatiwada, Ravi Kant Mishra, Biraj Man Karmacharya, Shiva Raj Adhikari, Kjell Arne Johansson, Krishna Kumar Aryal

“…We used the European Quality of Life 5 dimensions (EQ-5D-5L) and the European Quality of Life Visual Analogue Scale (EQ-VAS) to obtain their HRQoL. …”
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Effects of exercise and exercise timing on energy intake and appetite control in Danish individuals with overweight or obesity with and without type 2 diabetes: a protocol for a ra... by Louise Groth Grunnet, Martin Bæk Blond, Jonas Salling Quist, Kristine Beaulieu, Graham Finlayson, Kristine Færch, Lea Jalking, Natja Poder Launbo, Marie Møller Jensen, Hanne Enghoff Pedersen, Marina Kjærgaard Gerstenberg

“…Introduction The aim of this study is to investigate the effects of acute exercise on appetite control and whether this differs between morning and late afternoon in individuals with overweight/obesity with or without type 2 diabetes (T2D).Methods and analysis The hedonic and homeostatic appetite control in obesity and type 2 diabetes in the context of meal and exercise timing (TIMEX) study is a randomised, controlled, cross-over trial. …”
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Efficiency and safety of leflunomide in rheumatoid arthritis: Results of a Russian observational multicenter of trial by R. M. Balabanova, T. V. Dubinina, D. V. Goryachev, O. N. Anoshenkova, E. A. Antonova, I. Yu. Ilyevsky, O. V. Semagina, N. V. Yasyukevih

“…In 2011, the Russian Federation registered and since it has been successfully using leflunomide**.Objective: to evaluate the efficacy and tolerability of leflunomide** used to treat RA in routine clinical practice.Subjects and methods.The investigation enrolled patients with varying duration of RA that met the 1987 classification criteria. …”
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Dynamical network-based evaluation for neuromuscular dysfunction in stroke-induced hemiplegia during standing by Jinping Li, Na Zhang, Ying Xu, Juan Wang, Xianglian Kang, Runing Ji, Ke Li, Ying Hou

“…This study aimed to investigate the hemiplegia-linked neuromuscular dysfunction during standing from the perspective of multi-muscle dynamical coordination by utilizing a novel network approach – weighted recurrence network (WRN). Methods Ten male hemiplegic patients with first-ever stroke and 10 age-matched healthy male adults were instructed to stand on a platform quietly for 30 s with eyes opened and eyes closed, respectively. …”
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Effect of holistic nursing interventions for patients undergoing Laser-assisted tympanostomy under otoendoscopy for secretory otitis media (分泌性中耳炎耳内镜下鼓膜激光打孔治疗中整体护理干预的应用效果)... by ZHOU Xiaojing (周晓静), ZHANG Yi (张燚), CHEN Xiaoping (陈晓平), GUAN Li (管丽)

“…Objective To investigate the effect of holistic nursing intervention for patients undergoing Laser-assisted tympanostomy under otoendoscopy for secretory otitis media. Methods Totally 126 (155 ears) patients with secretory otitis media were randomly divided into the observation group and the control group, with 63 cases in each group. …”
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Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults by Tjard Sattler, Sophie Gottschalk, Hans-Helmut König, Tobias Braun, Gisela Büchele, Michael Denkinger, Tim Fleiner, Corinna Nerz, Kilian Rapp, Martina Schäufele, Christian Werner, Judith Dams

“…Unlike previous studies that examined only few mediating variables, this study aimed to develop a more comprehensive path model explaining the association between FoF and HrQoL. Methods A theoretical path model was developed based on existing evidence and expert feedback and fitted to cross-sectional baseline data on 385 community-dwelling (pre-)frail older adults from the PromeTheus randomized controlled trial using robust weighted least squares estimation. …”
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Percutaneous unilateral biportal endoscopic discectomy for symptomatic lumbar disc herniation in geriatric patients by Rongqing Qin, Rongqing Qin, Anhong Guan, Anhong Guan, Min Zhu, Pin Zhou, Bing Zhou, Bing Zhou, Ruihua Zhou, Ruihua Zhou, Zaiyong Guan, Zaiyong Guan

“…PurposeThe purpose of this study is to investigate the surgical efficacy and safety of percutaneous unilateral biportal endoscopic discectomy (UBED) for symptomatic lumbar disc herniation (LDH) in geriatric patients.MethodsSeventy-two geriatric patients, aged 65–86 years (mean age: 73.2 years), with single or two-level LDH who underwent UBED from January 2020 to September 2022 were retrospectively analyzed. …”
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Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma by Junjue Chen, Huimin Zhong, Bingqiao Shen, Huan Yu, Yang Zhang, Ruiqi Han, Ping Huang, Shouyue Huang, Yisheng Zhong

“…In addition, we found that ablation of TXNIP promoted retinal ganglion cells (RGCs) survival and alleviated visual function impairment in experimental glaucoma. …”
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AI-Based Noise-Reduction Filter for Whole-Body Planar Bone Scintigraphy Reliably Improves Low-Count Images by Csaba Csikos, Sándor Barna, Ákos Kovács, Péter Czina, Ádám Budai, Melinda Szoliková, Iván Gábor Nagy, Borbála Husztik, Gábor Kiszler, Ildikó Garai

“…<b>Results</b>: Based on visual assessment, observers agreed that image contrast and quality were better in the BS-AI-filtered images, increasing their diagnostic confidence. …”
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A Closer Look at Periocular Necrotizing Fasciitis: A Systematic Review of Literature by David Oliver-Gutierrez, Elena Ros-Sanchez, Gloria Segura-Duch, Tirso Alonso, Miguel Ángel Arcediano, Alejandra Herranz-Cabarcos, Jessica Matas, Roberto Castro Seco, R. L. P. van der Veen, Anna Boixadera, José García-Arumí, Joan Oliveres

“…To address this critical issue, we conducted the largest and most comprehensive systematic review to date, providing valuable insights into the diagnosis and treatment of PNF to improve clinical practice and patient prognosis. <b>Methods</b>: A search on Pubmed, Scopus, Embase, and WOS from January 2013 to August 2024 was performed. …”
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Multidisciplinary, Clinical Assessment of Accelerated Deep-Learning MRI Protocols at 1.5 T and 3 T After Intracranial Tumor Surgery and Their Influence on Residual Tumor Perception by Christer Ruff, Till-Karsten Hauser, Constantin Roder, Daniel Feucht, Paula Bombach, Leonie Zerweck, Deborah Staber, Frank Paulsen, Ulrike Ernemann, Georg Gohla

“…The image quality metrics NQM, SNR, and PSNR showed better results for DLR. Visual assessment of residual tumor was similar at 3 T but differed at 1.5 T, with more residual tumor detected with DLR, especially by the neurosurgeon (<i>n</i> = 4). …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Subjects and participants: Fourteen healthy individuals (28 eyes, age range: 22-54 years) underwent TRT measurements using both Old and New OCT models, with each eye receiving three consecutive scans per visit. Methods and testing: TRT measurements were performed using the Posterior Pole Algorithm (PPA) and Early Treatment Diabetic Retinopathy Study (ETDRS) grid protocols. …”
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