Effect of Traditional Chinese Formula Dingkun Pill on Primary Dysmenorrhea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial by Xuesong Ding, Shiyang Zhu, Yan Deng, Xiao Ma, Jingwen Gan, Yanfang Wang, Aijun Sun

“…Therefore, this trial aimed to assess the efficacy and safety of DKP in patients with PD. Methods: Our study was a multicenter, prospective, randomized, double-blind, placebo-controlled study. …”
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Sub‐Acromioclavicular Decompression Increases the Risk of Postoperative Shoulder Stiffness after Arthroscopic Rotator Cuff Repair by Cheng Li, Zhiling Wang, Maslah Idiris Ali, Yi Long, Ymuhanmode Alike, Min Zhou, Dedong Cui, Zhenze Zheng, Ke Meng, Jingyi Hou, Rui Yang

“…This study is aim to evaluate the impact of additional sub‐acromioclavicular (SAC) decompression during arthroscopic rotator cuff repair on the postoperative shoulder stiffness (POSS) in patients. Methods This retrospective study examined digital data from patients with full‐thickness rotator cuff tears who underwent arthroscopic rotator cuff repair at a local institution. …”
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The Potential Benefits of a Novel Food Supplement Based on Cannabis Sativa, Boswellia, and Fish Oil for Pain and Inflammation in Physical Activity: Unraveling the Role of Orexin-A... by Antonietta Messina, Antonietta Monda, Valentina Vassallo, Girolamo Di Maio, Rita Polito, Marco La Marra, Salvatore Allocca, Maria Casillo, Fiorenzo Moscatelli, Cristina Scavone, Francesco Taturi, Vincenzo Monda, Giovanni Messina, Chiara Schiraldi, Marcellino Monda

“…Pain was assessed using the Visual Analog Scale (VAS). Metabolic parameters, inflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, and IL-10), and serum orexin-A levels were measured before and after the intervention. …”
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Gadoxetic acid-enhanced MRI for identifying cholangiocyte phenotype hepatocellular carcinoma by interpretable machine learning: individual application of SHAP by Wei Liu, Zhiping Cai, Yifan Chen, Xingqun Guan, Jieying Feng, Haixiong Chen, Baoliang Guo, Fusheng OuYang, Chun Luo, Rong Zhang, Xinjie Chen, Xiaohong Li, Cuiru Zhou, Shaomin Yang, Ziwei Liu, Qiugen Hu

“…This study aims to develop and validate an optimal machine learning model to predict cholangiocyte phenotype HCC based on T1 mapping gadoxetic acid-enhanced MRI and to implement individual applications via the Shapley Additive explanation (SHAP). Methods We included 180 patients with histologically confirmed HCC from two institutions. …”
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Post-exertional malaise in Long COVID: subjective reporting versus objective assessment by Barbara Stussman, Nathan Camarillo, Gayle McCrossin, Marybeth Stockman, Gina Norato, C. Stephenie Vetter, Alenka Ferrufino, Ashade Adedamola, Nicholas Grayson, Avindra Nath, Leighton Chan, Brian Walitt, Lisa M. K. Chin

“…EC also performed a standardized exercise test (cardiopulmonary exercise test, CPET), and the PEM response to CPET was assessed using visual analog scales and qualitative interviews (QIs) administered serially over 72 h. …”
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Impact of postoperative depression and immune-inflammatory biomarkers on the prognosis of patients with esophageal cancer receiving minimally invasive esophagectomy: a retrospectiv... by Pei-xin Tan, Lin-xin Wu, Shuang Ma, Shi-jing Wei, Tai-hang Wang, Bing-chen Wang, Bing-bing Fu, Jia-shuo Yang, Qing Zhao, Qing Zhao, Li Sun, Yi Liu, Tao Yan

“…This study aimed to investigate the interrelationship between depression and prognosis in patients with EC, with a focus on immune-inflammatory biomarkers.MethodsThis single-center retrospective trial was conducted at the National Cancer Center/Cancer Hospital of the Chinese Academy of Medical Sciences. …”
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EFFICIENCY OF DYNAMIC ELECTRONEUROSTIMULATION IN KNEE OSTEOARTHRITIS: RESULTS OF A MULTICENTER RANDOMIZED STUDY by O. M. Lesnyak, E. Yu. Kadochnikova, L. I. Alekseeva, I. G. Dydykina, O. B. Ershova, E. M. Zaitseva, T. A. Korotkova, T. A. Popova, M. L. Sukhareva, E. A. Taskina, V. N. Khodyrev, E. P. Sharapova, A. G. Solodovnikov, A. A. Vlasov

“…Dynamic electroneurostimulation (DENS) is a type of percutaneous electroneurostimulation with a differentiation approach to choosing exposure areas and to optimizing electrocutaneous therapeutic action on the reflexogenic areas and acupuncture points for analgesia and for the treatment of functional disorders.Objective: to study the clinical efficiency and safety of therapy using a DiaDENS-PC apparatus in the treatment of knee osteoarthritis (OA).Subjects and methods. A multicenter randomized double-blind placebo-controlled study was conducted in 132 knee OA patients with pain value above 40 mm on visual analogue scale (VAS) and Lequesne’s index of 4–12. …”
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The effect of taurine supplementation on markers of muscle damage and muscle pain in an athletic population: A systematic review and meta-analysis of randomized controlled trials a... by Elaheh Dehghani, Fatemeh Naeini, Sakineh Shab Bidar, Mohammad Beba, Erfan Mortezapour, Ruhollah Nourian, Khashayar Danandeh, Zahra Gohari Dezfuli, Kurosh Djafarian

“…This systematic review and meta-analysis examines the effects of TS on EIMD and muscle pain in athletes. Methods: PubMed, Scopus, and Web of Science were systematically searched for randomized controlled trials (RCTs) on TS in athletic populations until March 2025. …”
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Factors influencing the prevalence and death rate of COPD: a pan-database ecological study covering 201 countries and regions from 1990 to 2021Research in context by Zihui Wang, Wenhan Cao, Zhixuan You, Shaoqiang Li, Mingshan Xue, Haiyang Li, Junfeng Lin, Guannan Cai, Yuqi Chen, Zhiman Liang, Chengtao Zhou, Xiaofang Wu, Guanghui Dong, Nanshan Zhong, Baoqing Sun, Zhangkai J. Cheng

“…This study aims to investigate the wide range of potential factors influencing COPD based on a pan-database ecological analysis. Methods: We integrated data from 17 global databases (e.g., the Global Burden of Disease Study) which encompass social, environmental, and health data across various regions. …”
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Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain regist... by Tatiana Cobo-Ibáñez, Ivan Castellví, Ana Pros, Marta Domínguez-Álvaro, Laura Nuño-Nuño, Julia Martínez-Barrio, Vega Jovaní, Fredeswinda Romero-Bueno, Esther Ruiz-Lucea, Eva Tomero, Ernesto Trallero-Araguás, Javier Narváez, Jordi Camins-Fàbregas, Alberto Ruiz-Román, Jesús Loarce-Martos, Susana Holgado-Pérez, V Miguel Flores-Rodríguez, Francisca Sivera, Carolina Merino-Argumanez, Antonio Juan-Mas, Irene Altabás-González, María Martín-López, Joaquín María Belzunegui-Otano, Carmen Carrasco-Cubero, Mercedes Freire-González, Iñigo Rúa-Figueroa, Nuria Lozano-Rivas, Julio David Suarez-Cuba, Olga Martínez, Rafaela Ortega-Castro, Patricia Alcocer, Alejandro Gómez-Gómez, Olga Sánchez-Pernaute, José Luis Tandaipan, Irene Carrión-Barberà, Chamaida Plasencia-Rodríguez, Oihane Ibarguengoitia-Barrena, Paola Vidal-Montal, Vera Ortiz-Santamaria, Noemi Garrido-Puñal, Anne Riveros, Esmeralda Delgado-Frías, Juan Miguel López-Gómez, Carmen Barbadillo, José María Pego-Reigosa, Beatriz E. Joven-Ibáñez, Jesús Alejandro Valero-Jaimes, Elena Naveda, Ana Isabel Turrión-Nieves, Daniel Seoane-Mato, Francisco Javier Prado-Galbarro, M Ángeles Puche-Larrubia

“…Abstract Objective To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Methods Cross-sectional multicenter study within the Spanish Myo-Spain registry. …”
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Circulating DNA methylation level of CXCR5 correlates with inflammation in patients with rheumatoid arthritis by Yiming Shi, Cen Chang, Lingxia Xu, Ping Jiang, Kai Wei, Jianan Zhao, Linshuai Xu, Yehua Jin, Runrun Zhang, Huijuan Wang, Yi Qian, Yingying Qin, Qin Ding, Ting Jiang, Shicheng Guo, Rongsheng Wang, Dongyi He

“…Abstract Objectives To assess the differences in circulating DNA methylation levels of CXCR5 between rheumatoid arthritis (RA) and osteoarthritis (OA) and healthy controls (HC), and the correlation of methylation changes with clinical characteristics of RA patients. Methods Peripheral blood samples were collected from 239 RA patients, 30 patients with OA, and 29 HC. …”
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Implementing a Common Data Model in Ophthalmology: Mapping Structured Electronic Health Record Ophthalmic Examination Data to Standard Vocabularies by Justin C. Quon, MD, Christopher P. Long, MD, William Halfpenny, MBBS, MEng, Amy Chuang, MS, Cindy X. Cai, MD, MS, Sally L. Baxter, MD, MSc, Vamsi Daketi, MS, Amanda Schmitz, BS, Neil Bahroos, MS, Benjamin Y. Xu, MD, PhD, Brian C. Toy, MD

“…Subjects: Not applicable. Methods: Source eye examination data elements from the default Cerner Model Experience EHR and a local implementation of the Cerner Millennium EHR were extracted, classified into one of 8 subject categories, and mapped to the semantically closest standard concept in the OMOP CDM. …”
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Evidence of functional connectivity disruptions between auditory and non-auditory regions in adolescents living with HIV by Joanah Madzime, Joanah Madzime, Marcin Jankiewicz, Marcin Jankiewicz, Marcin Jankiewicz, Ernesta M. Meintjes, Ernesta M. Meintjes, Ernesta M. Meintjes, Peter Torre, Barbara Laughton, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes

“…Investigating the functional connectivity (FC) within the CAS and between the CAS and non-auditory regions may reveal the influence of HIV on regions involved in auditory function.MethodsWithin a Bayesian statistical framework, we used resting-state functional magnetic resonance imaging to map FC in the CAS as well as between CAS regions and non-auditory regions of 11-year-old CPHIV. …”
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16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomiz... by Stephanie M. Van Riper, Jacob V. Ninneman, Jacob V. Ninneman, Aaron J. Stegner, Aaron J. Stegner, Brady A. Riedner, Brady A. Riedner, Laura D. Ellingson, Ryan J. Dougherty, Patrick J. O’Connor, Gunnar A. Roberge, Gunnar A. Roberge, Andrew L. Alexander, Andrew L. Alexander, Andrew L. Alexander, Doug C. Dean, Doug C. Dean, Doug C. Dean, Jill N. Barnes, Dane B. Cook, Dane B. Cook

“…This study tested the effects of 16 weeks of resistance exercise training (RET) on gray matter (GM) volume and white matter (WM) microstructure in Gulf War Veterans (GWVs) with CMP compared to GWV waitlist controls (WLC).MethodsFifty-four GWVs were randomly assigned to 16 weeks of RET (n = 28) or WLC (n = 26). …”
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Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…As group therapy has proven to be a valuable and effective treatment option for managing anxiety and depression, the aim of this study was to determine its effects on patients with CHD and anxious–depressive symptoms. <i>Methods</i>: We used non-pharmacological psychological group intervention, of six weekly sessions of 90 min each, administered by trained personnel, in adult patients with CHD. …”
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Assessment of the diagnostic utility of the electroencephalogram in pediatric emergencies by M.J. Abenza Abildúa, T. Olmedo Menchen, A. Pérez Villena, S. Ruhland Paulete, F.J. Navacerrada Barrero, J. de Ojeda Ruíz de Luna, C. Algarra Lucas, G. Cordero Martín, S. Martínez Ubierna, C. Jimeno Montero, I.J. Navarro López, E. Suárez Gisbert, Á. Gómez de la Riva, C. Pérez López, M.L. Herreros Fernández

“…Introduction: We analyze the diagnostic utility of urgent EEG (electroencephalogram) performed in children under 16 years of age in our center. Material and methods: Descriptive, retrospective, observational study of consecutive patients from 0 to 16 years of age, who underwent an urgent EEG for any reason, from January to December 2022. …”
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Impact of Low Hand Grip Strength on Quality of Life, Utilization of Healthcare, and Mental Health in Individuals with Airflow Limitation by Kim SH, Zo S, Kong SA, Cho JH, Do JG, Shin SH, Park HY

“…However, data on the impact of sarcopenia on quality of life, utilization of healthcare, and mental health in individuals with AFL are limited.Patients and methods: We used data from the 2014– 2019 Korea National Health and Nutrition Examination Survey (KNHANES), and participants with AFL were included. …”
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An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningo... by Xiuwen Sui, Zhujun Shao, Yuanyuan Ji, Hairui Wang, Qingfu Xu, Bochao Wei, Zhuojun Duan, Chang Wang, Ying Yang, Jiayu Zhao, Tao Zhu

“…Acute and long-term toxicity studies were conducted in Sprague-Dawley (SD) rats with equal numbers of male and female animals. Immunogenicity was assessed in female NIH mice and SD rats using a three-dose regimen at 14-day intervals. …”
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Prognostic Significance of Circulating Immune Subset Counts in Nasopharyngeal Carcinoma by Xie H, Zhang L, Chen L, Zhou W, Zhang L, Su Y, Li B, Ding P, Xiao Y, Lu T, Gong X, Li J

“…Honghui Xie,1– 3,&amp;ast; Lin Zhang,1,3,4,&amp;ast; Lizhi Chen,5,&amp;ast; Wenchao Zhou,1,6 Lijuan Zhang,1,3 Yong Su,1– 3 Bocheng Li,1,6 Peng Ding,1,6 Yun Xiao,1– 3 Tianzhu Lu,1,2,4,7 Xiaochang Gong,1,2,4,7 Jingao Li1,2,4,7 1NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 2Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 3Jiangxi Clinical Research Center for Cancer, Jiangxi Cancer Hospital &amp; Institute, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330029, People’s Republic of China; 4JXHC Key Laboratory of Tumour Metastasis, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 5Department of Oncology, Shangrao People’s Hospital, Shangrao, Jiangxi, 334000, People’s Republic of China; 6Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330064, People’s Republic of China; 7JXHC Key Laboratory of Tumor Microenvironment and Immunoregulation, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xiaochang Gong, NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, No. 519, Beijing East Road, Nanchang, Jiangxi, 330029, People’s Republic of China, Email gxcanddw@163.com Jingao Li, NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, No. 519, Beijing East Road, Nanchang, Jiangxi, 330029, People’s Republic of China, Email lijingao@hotmail.comPurpose: This study aimed to assess the prognostic value of circulating immune cells in newly diagnosed, non-metastatic nasopharyngeal carcinoma (NPC) and to develop a nomogram combining immune cell counts with clinical characteristics.Methods: In this retrospective study, patients with non-metastatic NPC treated between January 2015 and December 2018 were included. …”
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PEG-Coated Ceria-Zirconia Nanoparticle Prevent Weight Gain and Obesity-Related Organ Damage Through Autophagy Flux Activation and ROS Scavenging by Kim EK, Hong SE, Choi YS, Yu SL, Kang J, Park CG, Lee HY, Lee SK, Lee DC, Hwang WM, Yun SR, Park Y, Park MH, Lee J, Yoon KR, Lerman LO, Yoon SH

“…In this study, we examined the therapeutic efficacy of PEG-CZNPs against obesity-induced organ complications and investigated the associated intracellular mechanisms.Methods: Palmitate was used to establish a cellular model of obesity in HK-2 cells. …”
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