Effect of superficial cervical plexus nerve block with Ropivacaine or a combination of different adjuvants on perioperative analgesia and quality of postoperative recovery in patie... by Xiaoyu Kang, Caifen Li, Liuyu Lu, Xiaotong Qin, Yonghao Wang, Yang Lu, Li Ma, Shaoliang Zhu, Zheng Gong

“…The primary observation index were postoperative resting and active Visual Analogue Score. The secondary observation index were hemodynamics, intraoperative sedative and analgesic medication use, postoperative analgesic requirements, postoperative recovery indicators, Richards-Campbell Sleep Questionnaire scores, Quality of Postoperative Recovery-15 scores, and adverse reactions. …”
Get full text

Differential effects of sound interventions tuned to 432 Hz or 443 Hz on cardiovascular parameters in cancer patients: a randomized cross-over trial by Anna Hohneck, Ánxelo Maia Rodríguez, Simone Weingärtner, Kirsten Merx, Felicitas Sarodnick, Fritjof von Gagern, Athanasios Mavratzas, Iris Burkholder, Gerhard Schumacher, Wolf-Karsten Hofmann, Ralf-Dieter Hofheinz

“…Abstract Background This study investigated whether a sound intervention tuned to 432 Hz (Hz) yields differential effects on cardiovascular parameters and psychological outcomes compared to 443 Hz, which is the concert pitch in German professional orchestras. Methods Using a randomized cross-over design, patients with cancer were recruited to receive both a 15-minute sound intervention with a body monochord tuned to 432–443 Hz. …”
Get full text

Metformin treatment for patients with hand osteoarthritis: protocol for the multicentre, randomised, placebo-controlled METRO trial by David J Hunter, Robin Christensen, Marius Henriksen, Henning Bliddal, Karen Ellegaard, Mikael Boesen, Tue Kragstrup, Filip K Knop, Anna Dossing, Kasper Staberg Madsen, Asbjørn S Poulsen, Rasmus Oscar

“…The primary endpoint is the between-group difference in least squares means for the change in the Visual Analogue Scale (VAS) finger joint pain scores between the metformin and placebo groups at 16 weeks. …”
Get full text

Neurophysiological findings in Attention Deficit Hyperactivity Disorder, a Pandora’s box with therapeutic implications by Montserrat Gerez-Malo, Armando Tello, Maria Jimena Martin-Salas, Lauro Castanedo, Arturo Mendizábal, Oscar Meneses Luna, Leslie Quintanar, Carlos Acosta

“…This study aimed to identify dysfunctional mechanisms behind ADHD symptoms and test if targeting these dysfunctions can improve clinical outcomes. Methods: 230 children with ADHD diagnosis studied with hypothesis-related variables from electroencephalogram (EEG) visual inspection and quantitative z-scored power, coherence and ratios, and from event-related brain potentials (ERPs) z-sored P50, N100, N200, P300 latencies amplitudes and ratios. …”
Get full text

Efficacy of repetitive transcranial magnetic stimulation for smoking cessation: a systematic review and meta-analysis by Youssef A. Ismail, Omar K. Habib, Yahya El-Banan, Raneem Ramadan, Mohamed O. Henidak, Mohamed E. El-Badry, Ahmed R. Rabea, Amira A. Fouad, Salsapeel I. El-Tahlawy, Rahma M. El-Shawa, Mohamed Atef, Rahma A. Abd El-Kader, Abdullah El-Lawendy, Mariam El-Morsy, Mariam S. El-Rayes, Hanem El-Hasanen, Moaz Abouelmagd

“…Objective To evaluate the efficacy of rTMS in smoking cessation, its impact on abstinence rates, nicotine dependence, and craving. Methods We conducted a comprehensive search across multiple databases (PubMed, Scopus, Web of Science, Cochrane, PsycINFO, and Clinicaltrials.gov) from inception to August 2024. …”
Get full text

Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes by Charlie R. Faulks, Dean T. Biddau, Michael D. Selby, Ralph J. Mobbs, Gregory M. Malham

“…Patient reported outcome measures included visual analog scale (VAS) back pain, Oswestry disability index (ODI) and 12-Item Short Form Survey (SF-12) measured at preoperative, 6-week, 6-month, 12-month, and 24-month time points. …”
Get full text

Anterior cervical discectomy and fusion in treating acute myelopathy caused by Brucella cervical spondylitis: a case series by Long Chen, Tao Zhang, Xing-yu Chen, Yi-zhe Wang, Xing-guo Tan, Da-shuai Huang, Yan-peng Lu, Song-kai Li

“…This study aims to begin to investigate the clinical characteristics of acute cervical myelitis caused by Brucella infection and to evaluate the profile of clinical benefit of anterior cervical discectomy and fusion (ACDF) for this condition.Methods This retrospective case series included 6 patients who underwent surgical treatment for acute cervical spinal cord impairment due to Brucella infection at our institution between January 1, 2013, and January 1, 2023. …”
Get full text

Multimodal Analgesia Approach in Acute Low Back Pain Management: A Phase III Study of a Novel Analgesic Combination of Etoricoxib/Tramadol by Miguel A. Zuqui-Ramírez, Victor M. Belalcazar-López, Adelfia Urenda-Quezada, Alejandro González-Rebatu y González, José G. Sander-Padilla, Laura A. Lugo-Sánchez, Ileana C. Rodríguez-Vázquez, Kevin F. Rios-Brito, María M. Arguedas-Núñez, Emmanuel Canales-Vázquez, Jorge González-Canudas

“…The proportion of patients with a 30% reduction in Visual Analogue Scale (VAS) score was statistically significant when comparing the treatment groups on the third day of follow-up [p = 0.008, CI 95% 0.241 (0.061–0.421)]. …”
Get full text

Efficacy and safety of first-line or second-line selective laser trabeculoplasty for normal-tension glaucoma: a multicentre cohort study by Tomoko Naito, Kazuyuki Hirooka, Toru Nakazawa, Masaki Tanito, Shiro Mizoue, Katsuyoshi Suzuki, Keiji Yoshikawa, Itaru Kimura, Yasushi Ikuno, Takako Miki, Kazuhisa Sugiyama, Tairo Kimura, Akiko Narita, Tadashi Nakano, Tomoyuki Watanabe, Koji Nitta, Kae Sugihara, Maki Katai, Takuji Matsuda, Hiroaki Ozaki, Kaori Komatsu, Yoshiaki Saito, Takeshi Sagara, Aika Tsutsui, Akiko Ishida, Satoru Tsuda, Toyoaki Tsumura, Naoki Tojo, Naoto Tokuda, Kenji Nakamoto, Naka Shiratori, Mami Nanno, Naoya Nezu, Yoshitaka Tasaka, Shigeru Mori, Shigeki Yamabayashi, Kimihito Konno, Miyuki Domoto

“…Background/aims This study aimed to investigate and compare the efficacy and safety of first-line and second-line selective laser trabeculoplasty (SLT) in Japanese patients with normal-tension glaucoma (NTG).Methods 100 patients with NTG were enrolled in this study. …”
Get full text

Individual-level characteristics and geospatial factors associated with cervical cancer screening participation in Alberta, Canada: a population-based cross-sectional study by Jessica Law, Geneviève Jessiman-Perreault, Amanda Alberga Machado, Linan Xu, Bonnie Chiang, Huiming Yang, Lisa Allen Scott, Rizwan Shahid, Curtis Mabilangan, Alvin Li, Kamala Adhikari, Gary Teare

“…This study aimed to identify these characteristics related to cervical cancer screening status. Methods The study population included women between the ages of 28 to 69 years in Alberta. …”
Get full text

Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging by Qian-Qian Zeng, Shi-Zhe An, Chao-Nan Chen, Zhen Wang, Jia-Cheng Liu, Ming-Xi Wan, Yu-Jin Zong, Xiao-Hua Jian, Jie Yu, Ping Liang

“…Methods Patients with FLLs between June 2022 and February 2023 were prospectively screened. …”
Get full text

Combinations of polymorphisms in the regulatory regions of cytokine genes are associated with diabetic retinopathy in type 2 diabetic patients by V. I. Konenkov, A. V. Shevchenko, V. F. Prokof`ev, V. V. Klimontov, N. V. Tyan, V. V. Chernykh, D. V. Chernykh, A. V. Eremina, A. N. Trunov

“…Accordingly, we aimed to assess the frequencies of combinations of SNPs from promoters of cytokine genes in type 2 diabetic subjects with and without DR.Materials and methods: We enrolled 201 caucasian subjects with type 2 diabetes, including 90 ones with non-proliferative or preproliferative retinopathy and 111 subjects without DR. …”
Get full text

The Swiss Endometriosis Database: a retrospective multicentre cohort study on pain levels and multimodal treatment needs of endometriosis patients by Sara Imboden, Selina Lang, Antonalla Martino, Peter Martin Fehr, Lea Duempelmann, Cloé Vaineau, Heike Willi, Nicolas Samartzis, Simone Kamm, Dimitri Sarlos, Stephanie Verta, Tina Rohrbach, Christian Polli, Alexandra Kochanowski, Michael Mueller

“… STUDY AIMS: This study aimed to deepen the understanding of endometriosis symptoms, types, and therapy recommendations for Swiss endometriosis patients in Swiss-certified endometriosis centres in 2022. METHODS:In this exploratory retrospective multicentre cohort study, data from 3538 women who had their first consultation at a certified endometriosis centre in Switzerland in 2022 were analysed retrospectively. …”
Get full text

Erector spinae plane block versus transversus abdominis plane block with rectus sheath block for postoperative analgesia in laparoscopic hepatectomy: a randomized clinical trial by Mengke Liu, Xuan Mo, Ruonan Zhan, Han Wang, Yangxi Zhao, Yi Zhang

“…This study aims to compare the efficacy of bilateral ultrasound-guided ESPB versus subcostal TAPB with RSB for postoperative analgesia, addressing the gap in current research and optimizing pain management strategies for this procedure. Methods Sixty patients scheduled for laparoscopic hepatectomy were randomly divided into two groups: E group received ultrasound-guided ESPB, while the TR group received subcostal TAPB with RSB. …”
Get full text

Am I attached? A patient-partnered approach to creating infographics about attachment to primary care in Ontario, Canada by Maggie MacNeil, Aya Tagami, Peter Sheffield, Vivian R. Ramsden, Joan Barker, Jennifer Boyle, Clare Cruickshank, Eliot Frymire, Richard H. Glazier, Anita Gombos Hill, Michael E. Green, Mary Huang, Marijke Jurriaans, Caron Leid, Melissa McCallum, Sarah Precious, Jo-Ann Stans, Julie Vizza, Murray Walz, Sue Wilkins, Rebecca Ganann

“…Our approach to engaging patients prevented both oversimplification and unnecessary complexity in a public-facing visual about attachment to primary care.…”
Get full text

The Effect of Polymorphisms in the CYP2D6 and CYP2C9 Genes on the Clinical Efficacy of Tramadol and Ketorolac When Using the Accelerated Recovery Protocol in Patients With Uncompli... by A. A. Muradyan, D. A. Blagovestnov, D. A. Sychev, P. A. Yartsev, M. L. Rogal, L. N. Kerimova, V. T. Koroshvili, I. A. Yepifanova

“…Analgesic efficacy was assessed using a visual analog scale (VAS) and McGill Pain Questionnaire.Results. …”
Get full text

Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study by Xiaobo Liu, Bin Wan, Xi-Han Zhang, Ruifang Cui, Siyu Long, Ruiyang Ge, Lang Liu, Jinming Xiao, Zhen-Qi Liu, Jiadong Yan, Ke Xie, Meng Yao, Xin Wen, Sanwang Wang, Yujun Gao

“…The mBD showed expanded visual and prefrontal regions but compressed motor and precuneus regions. …”
Get full text

Melanin-concentrating hormone attenuates the hedonic feeding induced by orexin-A in the ventral tegmental area of high-fat diet male mice by Xiaoning Liu, Xiaoning Liu, Helin Yang, Wenguang Xu, Xuezhe Wang, Wenhui Tang, Xiaoxuan Wang, Yang Jiao, Xinchi Luan, Pengmeng Li, Feifei Guo

“…This study aims to investigate the modulatory role of MCH and OX-A in hedonic feeding within the VTA of high-fat diet (HFD) mice.MethodsMale mice were subjected to an 8-week high-fat diet. …”
Get full text

Comparison of clinical effectiveness between stapled transanal rectal resection and procedure for prolapse and hemorrhoids for young male patients with prolapsed hemorrhoids by Pei Yan, Gao Jihua, Qi Wenyue, Tian Maosheng, Wu Qiong, Duan Bingqian, Wang Ran, Liu Ziyi

“…[Objectives] To compare the clinical effectiveness between stapled transanal rectal resection (STARR) and procedure for prolapse and hemorrhoids (PPH) for young male patients with prolapsed hemorrhoids. [Methods] This was a retrospective analysis of 84 young male patients with prolapsed hemorrhoids who were treated at the Department of Colorectal Surgery, The First Affiliated Hospital of Hebei College of Chinese Medicine, between January 2019 and December 2019. …”
Get full text

Psychiatric drugs dispensing trends in the affected population following Brumadinho dam failure by Marcelo Farah Dell'Aringa, Gabriel Elias Correa-Oliveira, Francesco Della Corte, Luca Ragazzoni, Ives Hubloue, Virginia Murray, Thais Piazza, Claudia Garcia Serpa Osorio-de-Castro, Elaine Miranda, Francesco Barone-Adesi

“…This study aims to investigate the impact of this disaster in the dispensing of psychiatric drugs.MethodsWe evaluated monthly aggregated data from 12 months before to 12 months after the event from two data sources, one accounting for psychiatric drugs dispensed by private pharmacies and the other by public health services. …”
Get full text