Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

“…Background: We aimed to examine the therapeutic efficacy of exosome-enriched conditioned media (CM), known for its high concentration of extracellular vesicles (EVs), in comparision with mesenchymal stromal/stem cells (MSCs) in treating non-obstructive azoospermia.Materials and Methods: In this experimental study, we used adipose tissue-derived MSCs (AT-MSCs), bone marrow-derived MSCs (BM-MSCs), and BMCM containing EVs to treat busulfan-induced azoospermia in animal models. …”
Get full text

Comparison of short-term clinical outcomes and muscle injury in patients with lumbar spinal stenosis undergoing arthroscopic-assisted uni-portal spinal surgery, unilateral biportal... by Shihao Zhou, Xiaowan Xu, Tianluo Guo, Junhao Sun, jiancuo A

“…Additionally, muscle injury associated with these procedures is evaluated by analyzing changes in creatine kinase (CK) and C-reactive protein (CRP) levels. Methods A total of 288 patients diagnosed with single-segment unilateral LSS and treated between January 2021 and June 2024 were included in this study. …”
Get full text

Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape by Salma Kabbashi, Yvonne Prince, Ndonwi Elvis Ngwa, Haly Holmes, Glenda Mary Davison, Saarah F. G. Davids, Manogari Chetty

“…Therefore, this study was conducted to characterize the subgingival bacterial biodiversity in the periodontal pockets of patients with periodontitis in a Western Cape population.Materials & methodsPooled subgingival plaque samples were collected from the deepest pocket/crevices of five periodontitis cases and five controls using sterile paper points. …”
Get full text

Short-term digital ocular massage may weaken corneal biomechanics by Andrew K. C. Lam, Andrew K. C. Lam, Andrew K. C. Lam, Sandy N. S. Lee, Mason W. S. Mui, Venus H. Y. Ng

“…In this study, a device employing Corneal Visualization Scheimpflug Technology (Corvis ST) was used to monitor changes in IOP and corneal biomechanics following short-term digital ocular massage in low and high myopes.MethodsIn total, 29 low myopes and 29 high myopes participated in this study. …”
Get full text

Single-round performance of colorectal cancer screening programs: a network meta-analysis of randomized clinical trials by Teruhiko Terasawa, Toshihiro Tadano, Koichiro Abe, Seiju Sasaki, Satoyo Hosono, Takafumi Katayama, Keika Hoshi, Tomio Nakayama, Chisato Hamashima

“…We systematically reviewed single-round program performance outcomes using a stepwise approach proposed by the World Endoscopy Organization CRC Screening Committee framework. Methods The MEDLINE, EMBASE, Central, and Ichushi Web databases were searched until October 28, 2024, to find RCTs comparing guaiac-based and immunochemical fecal occult blood testing (gFOBT and FIT), flexible sigmoidoscopy (FS), computed tomographic colonography (CTC), and total colonoscopy (TCS). …”
Get full text

Circulating Tumor DNA Combining with Imaging Analysis for Lesion Detection of Langerhans Cell Histiocytosis in Children by Siying Liu, Yongbing Zhu, Yu Chen, Yaqin Wang, Dedong Zhang, Jiasi Zhang, Yao Wang, Ai Zhang, Qun Hu, Aiguo Liu

“…In this retrospective study, the significance of ctDNA and imaging in Langerhans cell histiocytosis (LCH) monitoring was first examined, and the broader role of ctDNA in monitoring LCH was additionally explored. Methods: First, data visualization and survival analysis models were used to generalize the concordance between cfBRAF^V600E molecular response and radiographic response on clinical outcomes. …”
Get full text

ADME gene-driven prognostic model for bladder cancer: a breakthrough in predicting survival and personalized treatment by Haojie Dai, Xi Zhang, You Zhao, Jun Nie, Zhenyu Hang, Xin Huang, Hongxiang Ma, Li Wang, Zihao Li, Ming Wu, Jun Fan, Ke Jiang, Weiping Luo, Chao Qin

“…Meanwhile, variability in clinical outcomes and responses to treatment is notable in bladder cancer (BLCA). Methods Our study utilized expansive datasets from TCGA and the GEO to explore prognostic factors in bladder cancer. …”
Get full text

Co-Designing a Consumer-Focused Digital Reporting Health Platform to Improve Adverse Medicine Event Reporting: Protocol for a Multimethod Research Project (the ReMedi Project) by Eyob Alemayehu Gebreyohannes, Christopher Thornton, Myra Thiessen, Sieta T de Vries, Andre Q Andrade, Lisa Kalisch Ellett, Oliver Frank, Phaik Yeong Cheah, Kim-Kwang Raymond Choo, Tracey Lea Laba, Elizabeth E Roughead, Indae Hwang, Geraldine Moses, Renly Lim

“…ObjectiveWe describe a project that aims to co-design a digital reporting platform to improve detection and management of AMEs by consumers and health care professionals and improve reporting to regulators. MethodsThe project will be conducted in 3 phases and uses a co-design methodology that prioritizes equity in designing with stakeholders. …”
Get full text

Changes in the cardiovascular profile in patients 3 and 12 months after COVID-19 pneumonia: parameters of arterial stiffness, global longitudinal strain, and diastolic function of... by E. I. Yaroslavskaya, N. E. Shirokov, D. V. Krinochkin, A. V. Migacheva, I. O. Korovina, N. A. Osokina, A. D. Sapozhnikova, T. I. Petelina

“…To study changes in the brachial – ankle pulse wave velocity (baPWV), ankle – brachial index (ABI), diastolic function, and global longitudinal strain of the left ventricle (LV) 3 and 12 months after COVID-19 pneumonia.Materials and methods. The dynamics of vascular age and LV global longitudinal strain was studied in 154 patients 3 and 12 months after COVID-19 pneumonia (51 ± 12 years, 48% were women). …”
Get full text

Genomic analysis of virulence, antimicrobial resistance, and capsular polysaccharide locus of group B Streptococcus isolated from Indonesia by Yustinus Maladan, Ratna Fathma Sari, Rosantia Sarassari, Sarah Azhari Balqis, Ghina Athyah Wahid, Waode Fifin Ervina, Nina Dwi Putri, Dodi Safari

“…This study aims to analyze the genomic characteristics of GBS, including antibiotic resistance genes, virulence genes, and the capsular polysaccharide (CPS) locus, in isolates from Indonesia. Methods: Genomic DNA was extracted from 18 archived GBS isolated from colonized pregnant women in Jakarta, Indonesia in 2015–2020, and library preparation was performed using the TruSeq DNA Nano® kit. …”
Get full text

ON THE QUESTION OF THE PRINCIPLES OF FAMILY LAW by NESMEIANOVA I.A.

“…The article considers the issue of mixing in the Family Code of the Russian Federation the principles of family law, which can really be called the basic principles of family legislation and principles-ideas that are exclusively declarative, respectively, non-compliance with them cannot entail the responsibility of the violator. The methods used. In addition to general scientific methods, special research methods such as the comparative legal method and the formal legal method were used in the preparation of the article. …”
Get full text

Ground-Based Remote Sensing Cloud Image Segmentation Using Convolution-MLP Network by Shuang Liu, Jiafeng Zhang, Zhong Zhang, Shuzhen Hu, Baihua Xiao

“…However, MLPs-based methods usually treat all the tokens equally, which is difficult to segment challenging cloud regions. …”
Get full text

Qualitative and quantitative wear rate analysis of direct restorative materials by Sandra Moura, Andréa Tavares, Janaína Lima, Antônio Muench, Paulo Eduardo Cardoso

“…The aim of this in vitro study was to analyze the wear rate of three direct restorative materials (Dispersalloy,Z250 and Surefil) using two methods of evaluation: visual M-L scale and profilometry. …”
Get full text

“The Solar System and Beyond” How Teachers Teaching This Unit? by Esra Yılmaz, Canan Laçin Şimşek

“…The data is obtained by interviewing 49 teachers working in Sakarya province with the easily accessible sample method. The data obtained is examined with the concept analysis and presented in an analytic method. …”
Get full text

Higher Dimensional Kadomtsev–Petviashvili Equation: New Collision Phenomena by Hajar F. Ismael, Usman Younas, Tukur Abdulkadir Sulaiman, Muhammad Amin S. Murad, Nehad Ali Shah, Shams Forruque Ahmed

“…In this study, we successfully apply the Hirota bilinear method with the adoption of several test strategies. …”
Get full text

Evaluation of Concept Maps Strategy in Learning al-Qowa’id al-Nahwiyyah l Taqwim Istiratijiyyah Kharaith al-Mafahim fi Ta’lim al-Qawa’id al-Nahwiyyah by Nur Qomari, Khairul Mizan, Fatimatuz Zahro, Bakri Mohammed Bakheet Ahmed, Khusnul Khotimah

“…Therefore, teaching al-Qowa’id al-Nahwiyyah  using the concept maps strategy was not more effective compared to the lecture method as both could equally enhance students' abilities optimally. …”
Get full text

High-Performance Liquid Chromatography with DAD Detection for the Determination of Cannabinoids in Commercial Veterinary CBD Oil by Zehra Hajrulai-Musliu, Elizabeta Dimitreska Stojkovikj, Dimitar Gusheski, Dea Musliu, Daniel Velkovski

“…The LOD and LOQ values calculated from the calibration curve ranged from 0.05 to 0.13 and 0.50 to 0.61 µg/mL, respectively. The method also exhibited acceptable precision, with relative standard deviation values lower than or equal to 2%. …”
Get full text

SAR-DeCR: Latent Diffusion for SAR-Fused Thick Cloud Removal by Meilin Wang, Shihao Hu, Yexing Song, Yukai Shi

“…To overcome these challenges, we introduce SAR-DeCR, a novel method for thick cloud removal in satellite remote-sensing images. …”
Get full text

Schizophrenia detection from electroencephalogram signals using image encoding and wrapper-based deep feature selection approach by Utathya Aich, Arghyasree Saha, Marcin Woźniak, Muhammad Fazal Ijaz, Pawan Kumar Singh

“…Many methods have been proposed to identify schizophrenia for diagnosis. …”
Get full text

The Problem with Time: Application of Partial Least Squares Analysis on Time-Frequency Plots to Account for Varying Time Intervals with Applied EEG Data by Jessie M. H. Szostakiwskyj, Filomeno Cortese, Raneen Abdul-Rhaman, Sarah J. Anderson, Amy L. Warren, Rebecca Archer, Emma Read, Kent G. Hecker

“…<b>Methods:</b> Epochs are converted to time-frequency space where they are resampled to contain an equal number of timepoints representing the proportion of trial complete rather than true time. …”
Get full text