Factors influencing the prevalence and death rate of COPD: a pan-database ecological study covering 201 countries and regions from 1990 to 2021Research in context by Zihui Wang, Wenhan Cao, Zhixuan You, Shaoqiang Li, Mingshan Xue, Haiyang Li, Junfeng Lin, Guannan Cai, Yuqi Chen, Zhiman Liang, Chengtao Zhou, Xiaofang Wu, Guanghui Dong, Nanshan Zhong, Baoqing Sun, Zhangkai J. Cheng

“…This study aims to investigate the wide range of potential factors influencing COPD based on a pan-database ecological analysis. Methods: We integrated data from 17 global databases (e.g., the Global Burden of Disease Study) which encompass social, environmental, and health data across various regions. …”
Get full text

Neoadjuvant sintilimab and chemotherapy followed by transoral surgery for HPV-positive resectable oropharyngeal cancer: a single-arm, two-centre, phase 2 trialResearch in context by Shida Yan, Xing Zhang, Fengjiao Li, Ankui Yang, Hui Li, Wanming Hu, Qiaohong Lin, Xiyuan Li, Mingyuan Du, Jingtao Chen, Guodong Man, Jianwei Zhang, Xuemei Fang, Li Ning, Shiting Zhang, Lili Han, Yanmei Ma, Jun Wang, Shuwei Chen, Ming Song

“…We aimed to explore the efficacy and safety of neoadjuvant immunochemotherapy and the feasibility of sequential transoral surgery in patients with resectable HPV+OPSCC. Methods: In this single-arm, two-centre, phase 2 trial, patients with resectable HPV+OPSCC (clinical stage T2-4N0-3M0) were recruited and received two cycles of neoadjuvant sintilimab, cisplatin, and nab-paclitaxel every three weeks, followed by transoral surgery, including transoral robotic surgery (TORS). …”
Get full text

Convergent construct validity and test-retest reliability of both German versions of the original and the revised Niigata PPPD Questionnaire: NPQ and NPQ-R by Sarah Chételat, Sarah Chételat, Eve-Yaël Gerber, Eve-Yaël Gerber, Sarah El Khadlaoui, Frank Behrendt, Frank Behrendt, Michaela Stark, Michaela Stark, Stefan Schädler, Stefan Schädler, Maximilian Maywald, Lena Fabritius, Johannes Gerb, Johannes Gerb, Denis Grabova, Wiebke Trost, Andreas Zwergal, Andreas Zwergal, Ralf Strobl, Ralf Strobl, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Sandra Becker-Bense, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…Characteristic provocation factors are moving or complex visual stimuli and exclusion of organic diseases. …”
Get full text

Daily digital biomarkers in the follow-up and clustering of patients with asthma by Bernardo Sousa-Pinto, Florence Schleich, Gilles Louis, Bilun Gemicioglu, Violeta Kvedarienė, Frederico S. Regateiro, Claudia Chaves Loureiro, Luis Taborda-Barata, Rita Amaral, Josep M. Antó, Anna Bedbrook, Wienczyslawa Czarlewski, Ignacio J. Ansotegui, Karl-C Bergmann, Matteo Bonini, Apostolos Bossios, Louis-Philippe Boulet, Fulvio Braido, Christopher Brightling, Guy Brusselle, Luisa Brussino, G. Walter Canonica, Alvaro A. Cruz, Tari Haahtela, Liam G. Heaney, Michael Hyland, Juan Carlos Ivancevich, Ludger Klimek, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Desiree E. Larenas-Linnemann, Michael Makris, Manuel Marques-Cruz, Sara Gil-Mata, Mário Morais-Almeida, Marek Niedoszytko, Markus Ollert, Nikolaos G. Papadopoulos, Vincenzo Patella, Oliver Pfaar, Celeste Porsbjerg, Francesca Puggioni, Santiago Quirce, Carlos Robalo Cordeiro, Nicolas Roche, Boleslaw Samolinski, Joaquin Sastre, Nicola Scichilone, Sabina Skrgat, Sanna Toppila-Salmi, Omar S. Usmani, Arunas Valiulis, Brigita Gradauskiene, Ilgim Vardaloğlu Koyuncu, Maria Teresa Ventura, Rafael José Vieira, Arzu Yorgancioglu, João A. Fonseca, Torsten Zuberbier, Benoit Pétré, Renaud Louis, Jean Bousquet

“…Background and Research question We aimed to assess whether levels of digital biomarkers can reflect monthly patterns of asthma controlStudy design and methods We performed a longitudinal study on patients with asthma and comorbid rhinitis who filled ≥26 days of data in a month in the MASK-air® app and who reported at least 1 day of treatment with an inhaled corticosteroid with or without a long-acting β2-agonist (ICS ± LABA). …”
Get full text

Sex differences in psychosocial functioning and neurocognition in bipolar disorder: a systematic review and meta-analysis by Maria Serra-Navarro, Derek Clougher, Vincenzo Oliva, Clàudia Valenzuela-Pascual, Michele De Prisco, María Florencia Forte, Marina Garriga, Brisa Solé, Jose Sánchez-Moreno, Norma Verdolini, Giulia Menculini, Alfonso Tortorella, Miquel Bernardo, J. Antoni Ramos-Quiroga, Anabel Martinez-Aran, Eduard Vieta, Silvia Amoretti, Carla Torrent

“…The present systematic review and meta-analysis examined whether males and females with BD demonstrate differences in psychosocial functioning and NC performance. Methods The Cochrane Library, EMBASE, PsycINFO, PubMed, Scopus, and Web of Science databases were systematically searched from inception until November 20, 2023. …”
Get full text

Modular and efficient assembly of CRISPR vectors and construction of an apple gene editing efficiency evaluation system by HOU Feifan, HUANG Chuanmi, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo, JIAO Jian

“…We aim to develop a modular and efficient CRISPR vector system, optimize the Agrobacterium-mediated transient delivery system in apple plantlets, and establish a corresponding evaluation system for assessing the efficiency of gene editing in apple. [Methods] The conventional vectors pUC19 (DNA cloning plasmid) and pHK2 (Dicotyledonous gene editing plasmid based on pCAMBIA1300 modification) were firstly modified by inserting a pair of type Ⅱ S restriction enzyme sites (such as Esp3 Ⅰ or Bsa Ⅰ etc.) into selected positions, to construct the intermediate vector pUC19-Esp3 Ⅰ-Bb and the plant expression vector backbone pHK2-Bsa Ⅰ-Bb. …”
Get full text

Inhibition of Ferroptosis by Adipose Stem Cell-Derived Apoptotic Vesicles Enhances Angiogenesis and Accelerates Diabetic Wound Healing by Zhang J, Kuang J, Gong S, Wang H, Ding F, Zhao L, Shi L, Liu S, Zhao Y, Liu J, Dou G

“…This study aims to investigate whether adipose stem cell-derived apoptotic vesicles (ASCs-apoVs) promote angiogenesis and accelerate diabetic wound healing by inhibiting endothelial cell ferroptosis.Methods: Diabetic mice model was established by feeding with high-fat diet (HFD) for 3 months followed by full-thickness skin wound preparation. …”
Get full text

Análise de lesões musculoesqueléticas em praticantes de musculação e corrida (Analisis de lesión musculoesquelética em practicantes de musculación y de las carreras) (Analysis of... by Flavio Boechat de Oliveira, Wallin do Couto Conceição, Rafael Barreto, Igor Carvalho, Giovanne Moraes de L. Ribeiro, Rodrigo Gomes de Souza Vale

“…Objective: To characterize and analyze the prevalence of musculoskeletal injuries in bodybuilders and runners. Methods: The sample consisted of 30 bodybuilders and runners with more than 12 months of practice. …”
Get full text

Patient buy-in to social prescribing through link workers as part of person-centred care: a realist evaluation by Stephanie Tierney, Geoffrey Wong, Debra Westlake, Amadea Turk, Steven Markham, Jordan Gorenberg, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Tony Meacock, Catherine Pope, Beccy Baird, Kamal R Mahtani

“…Setting Patients engaging with link workers in seven different parts of England were involved. Methods As part of data collection, we observed link workers interacting with 35 patients. …”
Get full text

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. by Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh

“…Yet it is inconclusive whether these associations are causal.<h4>Methods and findings</h4>We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). …”
Get full text

Role and mechanism of action of nuclear receptor coactivator 4 in the development of acquired resis-tance to targeted inhibitors in pancreatic cancer with KRAS G12C mutation by CHANG Hao, WANG Ya'nan, LIU Shihai, WANG Jing

“…Objective To investigate the role and mechanism of action of nuclear receptor coactivator 4 (NCOA4) in acquired resistance to targeted inhibitors in pancreatic cancer with KRAS G12C mutation. Methods Human pancreatic cancer cell lines CFPAC-1, PANC-1, and MIA-PaCa-2 were cultured in vitro. …”
Get full text

Screening cognitive impairment in patients with atrial fibrillation: A deep learning model based on retinal fundus photographs by Zhen Wang, MD, Mingxiao Li, MD, Peng Xia, BS, Chao Jiang, MD, Ting Shen, MD, Jiaming Ma, MD, Yu Bai, MD, Suhui Zhang, MD, Yiwei Lai, MD, Sitong Li, MS, Hui Xu, MD, Yang Xu, MD, Tong Ma, MS, Lie Ju, PhD, Liu He, PhD, Li Dong, MD, Caihua Sang, MD, Deyong Long, MD, Yuzhong Chen, PhD, Xin Du, MD, Zongyuan Ge, PhD, Jianzeng Dong, MD, Wen-Bin Wei, MD, Changsheng Ma, MD

Get full text

Genomic analysis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) causing infections in children—a Spanish multicenter study by Silvia García-Cobos, Silvia García-Cobos, Natalia Seco Alberca, Blanca Bravo-Queipo-de-Llano, Verónica Casquero-García, Eva Ramírez de Arellano, Eva Ramírez de Arellano, Cristina Calvo, Cristina Calvo, Guillermo Ruíz-Carrascoso, Guillermo Ruíz-Carrascoso, Iker Falces-Romero, Iker Falces-Romero, Nieves Larrosa Escartín, Nieves Larrosa Escartín, Nieves Larrosa Escartín, Belén Viñado-Perez, Belén Viñado-Perez, Miguel Ángel Martínez-López, Susana Melendo Pérez, Enrique Ruíz de Gopegui, Enrique Ruíz de Gopegui, Santiago Pérez Vázquez, Jaime Carrasco-Colom, Belén Aracil García, Belén Aracil García, María Pérez-Vázquez, María Pérez-Vázquez, Ana Méndez-Echevarría, Ana Méndez-Echevarría, Jesús Oteo Iglesias, Jesús Oteo Iglesias

“…This study investigated the molecular traits of community-associated methicillin-resistant S. aureus (CA-MRSA) isolates causing infections in children in Spain.MethodsAntibiotic susceptibility testing and whole-genome sequencing were performed in 98 CA-MRSA isolates (4.2 median age, 52% males). …”
Get full text

Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts by Kristen D. Brantley, Michael E. Jones, Rulla M. Tamimi, Bernard A. Rosner, Peter Kraft, Hazel B. Nichols, Katie M. O’Brien, Hans-Olov Adami, Amaia Aizpurua, Amy Berrington de González, William J. Blot, Tonje Braaten, Yu Chen, Jessica Clague DeHart, Laure Dossus, Sjoerd Elias, Renée T. Fortner, Montserrat Garcia-Closas, Inger T. Gram, Niclas Håkansson, Susan E. Hankinson, Cari M. Kitahara, Woon-Puay Koh, Martha S. Linet, Robert J. MacInnis, Giovanna Masala, Lene Mellemkjær, Roger L. Milne, David C. Muller, Hannah Lui Park, Kathryn J. Ruddy, Sven Sandin, Xiao-Ou Shu, Sandar Tin Tin, Thérèse Truong, Celine M. Vachon, Lars J. Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter Willett, Alicja Wolk, Jian-Min Yuan, Wei Zheng, Dale P. Sandler, Minouk J. Schoemaker, Anthony J. Swerdlow, A. Heather Eliassen

“…Abstract Background Incidence of premenopausal breast cancer (BC) has risen in recent years, though most existing BC prediction models are not generalizable to young women due to underrepresentation of this age group in model development. Methods Using questionnaire-based data from 19 prospective studies harmonized within the Premenopausal Breast Cancer Collaborative Group (PBCCG), representing 783,830 women, we developed a premenopausal BC risk prediction model. …”
Get full text

Gender Influence on Bimekizumab Response in Patients with Psoriasis: Results of a Real-World Multicenter Retrospective Study—IL PSO (Italian Landscape PSOriasis) by Helena Gioacchini, Agnese Rossi, Maria Esposito, Emanuele Vagnozzi, Maria Concetta Fargnoli, Paolo Gisondi, Francesco Bellinato, Chiara Assorgi, Pina Brianti, Santo Raffaele Mercuri, Martina Burlando, Emanuele Cozzani, Giovanna Brunasso, Stefano Caccavale, Anna Balato, Giacomo Caldarola, Clara De Simone, Elena Campione, Alessandro Giunta, Francesco Tonon, Marina Venturini, Carlo Giovanni Carrera, Angelo Valerio Marzano, Andrea Carugno, Paolo Sena, Antonio Costanzo, Alessandra Narcisi, Francesco Cusano, Paolo Dapavo, Pietro Quaglino, Annunziata Dattola, Antonio Giovanni Richetta, Francesca Gaiani, Piergiorgio Malagoli, Matteo Megna, Luca Potestio, Edoardo Mortato, Francesco Loconsole, Francesca Romano, Andrea Faragalli, Rosaria Gesuita, Tommaso Bianchelli, Federico Diotallevi, Diego Orsini, Anna Campanati

“…Notably, no studies have specifically investigated bimekizumab, a humanized, full-length IgG1 monoclonal antibody that acts as a dual inhibitor of interleukin (IL)-17A and IL-17F. Methods This was a cross-sectional, observational, retrospective, multicenter analysis. …”
Get full text

Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Magnetic resonance imaging neuronavigation personalised repetitive transcranial magnetic stimulation or intermittent theta burst stimulation are acceptable methods to reduce depression symptoms over 26 weeks in treatment-resistant depression alongside other reasons for improvement. …”
Get full text

Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain regist... by Tatiana Cobo-Ibáñez, Ivan Castellví, Ana Pros, Marta Domínguez-Álvaro, Laura Nuño-Nuño, Julia Martínez-Barrio, Vega Jovaní, Fredeswinda Romero-Bueno, Esther Ruiz-Lucea, Eva Tomero, Ernesto Trallero-Araguás, Javier Narváez, Jordi Camins-Fàbregas, Alberto Ruiz-Román, Jesús Loarce-Martos, Susana Holgado-Pérez, V Miguel Flores-Rodríguez, Francisca Sivera, Carolina Merino-Argumanez, Antonio Juan-Mas, Irene Altabás-González, María Martín-López, Joaquín María Belzunegui-Otano, Carmen Carrasco-Cubero, Mercedes Freire-González, Iñigo Rúa-Figueroa, Nuria Lozano-Rivas, Julio David Suarez-Cuba, Olga Martínez, Rafaela Ortega-Castro, Patricia Alcocer, Alejandro Gómez-Gómez, Olga Sánchez-Pernaute, José Luis Tandaipan, Irene Carrión-Barberà, Chamaida Plasencia-Rodríguez, Oihane Ibarguengoitia-Barrena, Paola Vidal-Montal, Vera Ortiz-Santamaria, Noemi Garrido-Puñal, Anne Riveros, Esmeralda Delgado-Frías, Juan Miguel López-Gómez, Carmen Barbadillo, José María Pego-Reigosa, Beatriz E. Joven-Ibáñez, Jesús Alejandro Valero-Jaimes, Elena Naveda, Ana Isabel Turrión-Nieves, Daniel Seoane-Mato, Francisco Javier Prado-Galbarro, M Ángeles Puche-Larrubia

“…Abstract Objective To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Methods Cross-sectional multicenter study within the Spanish Myo-Spain registry. …”
Get full text

Assessment of the diagnostic utility of the electroencephalogram in pediatric emergencies by M.J. Abenza Abildúa, T. Olmedo Menchen, A. Pérez Villena, S. Ruhland Paulete, F.J. Navacerrada Barrero, J. de Ojeda Ruíz de Luna, C. Algarra Lucas, G. Cordero Martín, S. Martínez Ubierna, C. Jimeno Montero, I.J. Navarro López, E. Suárez Gisbert, Á. Gómez de la Riva, C. Pérez López, M.L. Herreros Fernández

“…Introduction: We analyze the diagnostic utility of urgent EEG (electroencephalogram) performed in children under 16 years of age in our center. Material and methods: Descriptive, retrospective, observational study of consecutive patients from 0 to 16 years of age, who underwent an urgent EEG for any reason, from January to December 2022. …”
Get full text

Analysis of the Impact of Effectiveness of Media (Seda-va-Sima) Advertisement on the Extent of Consumers’ Urge to Consume National Commodities by Abolfazl Danaei

“…Other secondary hypotheses were also confirmed, with path coefficients for various roles including: information features (0.594), advertising selection activities (0.506), advertising ranking (0.591), advertising engagement (0.623), advertising tools and visual methods (0.523), emotional features (0.498), motivational dimensions (0.522), overall advertisement viewing (0.618), internal vs. external product evaluation (0.642), consumer nationalism (0.705), and preference for domestic vs. foreign products (0.603). …”
Get full text

A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC by Jun-Chieh J. Tsay, MD, MS, Antonio Velez, MD, Destiny Collazo, BS, Isaac Laniado, MD, Jamie Bessich, MD, Vivek Murthy, MD, Andrew DeMaio, MD, Samaan Rafeq, MD, Benjamin Kwok, MD, Fares Darawshy, MD, Ray Pillai, MD, Kendrew Wong, MD, Yonghua Li, MD, PhD, Rosemary Schluger, RN, Alena Lukovnikova, BS, Sofia Roldan, BS, Matt Blaisdell, BS, Fernanda Paz, Kelsey Krolikowski, BS, Katherine Gershner, MD, Yong Liu, PhD, Judy Gong, BA, Sara Borghi, PhD, Fang Zhou, MD, Aristotelis Tsirigos, PhD, Harvey Pass, MD, Leopoldo N. Segal, MD, MS, Daniel H. Sterman, MD

“…In this first-in-human phase I clinical trial, we investigated the safety and feasibility of bronchoscopic cryoimmunotherapy (BCI) delivered during standard-of-care bronchoscopy and explored associated systemic immune responses. Methods: Subjects with known or suspected advanced-stage NSCLC were recruited. …”
Get full text