The feasibility and efficacy of the Position Acute Tone External system score in evaluating hemorrhoid severity and guiding clinical treatment by Sun Songpeng, Wan Weiping, Li Tianyu, Wu Yao, Wang Jianguo, Xu Fangfang, Zhang Zhiyun, Tian Ying, Lin Mei, Cao Qiaorong, Wang Zhanjun, Li Xinjian, Yang Tianqing, Liao Riyu, Xieyida Kuerban, Ni Hong, Huo Xingxiao, Jia Shan, Long Junhong, Zhang Shuxin

“…[Objectives] To analyze the feasibility and efficacy of the Position Acute Tone External (PATE) system score in evaluating hemorrhoid severity and guiding clinical treatment. [Methods] This cross-sectional study conducted a questionnaire survey among patients with hemorrhoids in outpatient/ward settings at six anorectal centers from November 2021 to November 2022. …”
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Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients by Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Vicente Zanón-Moreno, Vicente Zanón-Moreno, Carolina García–Villanueva, Alessio Martucci, Cristina Peris-Martínez, Cristina Peris-Martínez, Jorge Vila-Arteaga, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Irene Andrés–Blasco, Irene Andrés–Blasco, Irene Andrés–Blasco, Alex Gallego–Martínez, Alex Gallego–Martínez, Carlo Nucci, Julian García–Feijoo

“…As a response to high intraocular pressure, the clinical and molecular glaucoma biomarkers indicate the biological state of the visual system. Classical and uncovering novel biomarkers of glaucoma development and progression, follow-up, and monitoring the response to treatment are key objectives to improve vision outcomes. …”
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Application of platelet-rich plasma therapy combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis (富血小板血浆联合5E康复护理模式在膝骨性关节炎患者中的应用)... by AN Linjing (安林静), ZHAO Chen (赵晨), CHANG Yueyuan (常月圆), PAN Yaying (潘亚英), CHEN Yanqi (程艳琪), ZHANG Bing (张兵), CHEN Weinan (陈炜楠), GAO Bei (高蓓), NIU Jing (牛静), ZHANG Ting (张婷)

“…Objective To explore the clinical effect of platelet-rich plasma therapy (PRP) combined with 5E rehabilitation nursing mode for patients with knee osteoarthritis. Methods Totally 80 patients with knee osteoarthritis admitted to the orthopedics department of the hospital from March 2021 to March 2023 were selected as subjects. …”
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Evaluation of the effectiveness of Tofacitinib in rheumatoid arthritis in real clinical practice: The relationship between pain relief in the first 4 weeks and disease activity aft... by A. E. Karateev, E. Yu. Pogozheva, V. N. Amirjanova, E. S. Filatova, A. M. Lila, V. I. Mazurov, R. R. Samigullina, A. M. Dadalova, A. Yu. Dyo, D. S. Chakieva, A. A. Baranov, N. A. Lapkina, E. N. Koltsova, N. A. Kiryukhina, I. N. Shchendrigin, T. G. Rasevich, A. F. Davydova, I. V. Semizarova, I. A. Shafieva, I. B. Bashkova, D. A. Bobrikova, D. A. Murtazalieva, I. N. Kushnir, E. V. Kalinina, T. S. Salnikova, I. M. Marusenko, O. V. Semagina, I. B. Vinogradova, D. G. Krechikova, M. Yu. Semchenkova, E. L. Nasonov

“…However, it is not clear how pain reduction is associated with achieving low activity in rheumatoid arthritis (RA).The aim of the study was to assess the relationship between the early clinical response to tofacitinib and a decrease in rheumatoid arthritis activity after 3 and 6 months.Material and methods. The study group consisted of 88 RA patients (age – 53±11.5 years; 79.3% of women) who received basic anti-inflammatory drugs (59.5% – methotrexate, 19.8% – leflunomide) and who were prescribed TOFA in a dose 10 mg/day. …”
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Cultural influences on fidelity components in recovery colleges: a study across 28 countries and territories by Charlotte Hanlon, Lisa Brophy, Peter Bates, Samson Tse, Claire Henderson, Ioannis Bakolis, Mike Slade, Michio Murakami, Julie Cooper, Vicky Stergiopoulos, Michael Ryan, Susana Ochoa, Daniel Hayes, Amy Ronaldson, Bernd Puschner, Ashleigh Charles, Ramona Hiltensperger, Yasuhiro Kotera, Wouter Vanderplasschen, Julie Repper, Simran Takhi, Simon Felix, Mariam Namasaba, Simon Lawrence, Vanessa Kellermann, Agnieszka Kapka, Danielle Dunnett, Tesnime Jebara, Sara Meddings, Clara De Ruysscher, Lene Eplov, Charlotte Toernes, Dagmar Narusson, Yuki Miyamoto, Stynke Castelein, Trude Gøril Klevan, Hannah Morland-Jones, Edith Moore, Gianfranco Zuaboni, Laura Asher, Jonna Tolonen, Mário Andrade, Daniel Elton, Jason Grant

“…The 12-item Recovery Colleges Characterisation and Testing (RECOLLECT) Fidelity Measure (RFM) evaluates the operational fidelity of RCs based on 12 components, but cultural influences on these components remain underexplored.Aims To assess associations between Hofstede’s cultural dimensions and RFM items to identify cultural influences on fidelity components.Methods A cross-sectional survey of RC managers was conducted across all 221 RCs. …”
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Artificial intelligence contouring in radiotherapy for organs-at-risk and lymph node areas by Céline Meyer, Sandrine Huger, Marie Bruand, Thomas Leroy, Jérémy Palisson, Paul Rétif, Thomas Sarrade, Anais Barateau, Sophie Renard, Maria Jolnerovski, Nicolas Demogeot, Johann Marcel, Nicolas Martz, Anaïs Stefani, Selima Sellami, Juliette Jacques, Emma Agnoux, William Gehin, Ida Trampetti, Agathe Margulies, Constance Golfier, Yassir Khattabi, Olivier Cravéreau, Alizée Renan, Jean-François Py, Jean-Christophe Faivre

“…The objective of this study is to compare eight available AI software programs in terms of technical aspects and accuracy for contouring organs-at-risk and lymph node areas with current international contouring recommendations. Material and methods From January–July 2023, we performed a blinded study of the contour scoring of the organs-at-risk and lymph node areas by eight self-contouring AI programs by 20 radiation oncologists. …”
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The TESS Ten Thousand Catalog: 10,001 Uniformly Vetted and Validated Eclipsing Binary Stars Detected in Full-frame Image Data by Machine Learning and Analyzed by Citizen Scientists by Veselin B. Kostov, Brian P. Powell, Aline U. Fornear, Marco Z. Di Fraia, Robert Gagliano, Thomas L. Jacobs, Julien S. de Lambilly, Hugo A. Durantini Luca, Steven R. Majewski, Mark Omohundro, Jerome Orosz, Saul A. Rappaport, Ryan Salik, Donald Short, William Welsh, Svetoslav Alexandrov, Cledison Marcos da Silva, Erika Dunning, Gerd Gühne, Marc Huten, Michiharu Hyogo, Davide Iannone, Sam Lee, Christian Magliano, Manya Sharma, Allan Tarr, John Yablonsky, Sovan Acharya, Fred Adams, Thomas Barclay, Benjamin T. Montet, Susan Mullally, Greg Olmschenk, Andrej Prša, Elisa Quintana, Robert Wilson, Hasret Balcioglu, Ethan Kruse, The Eclipsing Binary Patrol Collaboration

“…Of these, we have performed an in-depth analysis on ∼60,000 targets using automated methods and manual inspection by citizen scientists. …”
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Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled cl... by Yange Wei, Yange Wei, Shanyuan He, Peng Luo, Hanshuo Su, Yuanle Chen, Shisen Qin, Zhongguo Zhang, Rongxun Liu, Dongshuai Wei, Juan Wang, Fei Wang, Fei Wang, Chuansheng Wang

“…This study aims to examine the synergistic efficacy of tDCS and MT on cognitive impairments in individuals with schizophrenia and to elucidate the potential mechanisms involved in this process.MethodsThe study is designed as a randomized, double-blind, sham-controlled trial. …”
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Standardized aqueous extract of Abutilon theophrasti Medic. ameliorates oxidative stress and inflammatory responses against hydrochloric acid/ethanol-induced gastric ulcer in rats by Hui Guo, Hui Guo, Zihan Xu, Zihan Xu, Lili Zhu, Meng Zhu, Meng Zhu, Weijin Zhang, Weijin Zhang, Man Gong, Mengyun Liu, Mengyun Liu, Mengmeng Wang, Mengmeng Wang, Erping Xu, Liping Dai, Liping Dai

“…However, the pharmacological basis of this herb for treating peptic ulcer, also an inflammatory condition in the GI tract, remains insufficiently understood.PurposeThe aim of this study is to investigate the ameliorating effects of a standardized aqueous extract of AT (ATAE) on experimental gastric ulcer (GU) in rats and explore whether the human GU-associated molecules/signaling pathways obtained using bioinformatics have a role to play in the drug’s efficacy for molecular mechanism elucidation.MethodsUltra-performance liquid chromatography (UPLC) and UPLC coupled to tandem mass spectrometry (UPLC-MS) were used for standardization of ATAE. …”
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Comparison of Deep Learning and Clinician Performance for Detecting Referable Glaucoma from Fundus Photographs in a Safety Net Population by Van Nguyen, MD, Sreenidhi Iyengar, Haroon Rasheed, MD, Galo Apolo, Zhiwei Li, Aniket Kumar, Hong Nguyen, Austin Bohner, MD, Kyle Bolo, MD, Rahul Dhodapkar, MD, Jiun Do, MD, PhD, Andrew T. Duong, MD, Jeffrey Gluckstein, MD, Kendra Hong, MD, Lucas L. Humayun, Alanna James, MD, Junhui Lee, MD, Kent Nguyen, OD, Brandon J. Wong, MD, Jose-Luis Ambite, PhD, Carl Kesselman, PhD, Lauren P. Daskivich, MD, Michael Pazzani, PhD, Benjamin Y. Xu, MD, PhD

“…Participants: A total of 6116 patients from the Los Angeles County (LAC) Department of Health Services (DHS) were included. Methods: Fundus photographs and patient-level labels of referable glaucoma (cup-to-disc ratio ≥0.6) provided by 21 certified optometrists. …”
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Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias—the cross-sectional diagnostic test accuracy study... by Stefanie Hahner, Philipp Hartrampf, Felix Beuschlein, Matthias Miederer, Konstanze Miehle, Wiebke Schlötelburg, Carmina Teresa Fuß, Thomas Pfluger, Christian Fottner, Anke Tönjes, Ken Herrmann, Holger Amthauer, Martin Reincke, Mathias Schreckenberger, Osama Sabri, Johanna Werner, Miriam Reuter, Stefan Kircher, Wiebke Arlt, Martin Fassnacht, Andreas Konrad Buck, Hans-Helge Müller, Andreas Schirbel, Christian Furth, Knut Mai, Marcus Quinkler, Frank Weber, Henning Dralle, Benjamin Sandner, Thomas Lincke, Regine Kluge, Nada Rayes, Matthias Weber, Martina Gräsl, Wolfgang Saeger, Joachim Reibetanz

“…We proposed that combined molecular imaging with [18F]Fluorodeoxyglucose-positron emission tomography (FDG PET) and [123I]Iodometomidate-single photon emission tomography (IMTO SPECT) improves non-invasive classification of ACA. Methods: This cross-sectional, multicentre diagnostic study included patients (≥30 years) with non-functioning indeterminate adrenal masses (>3 cm or increase >1 cm, Hounsfield units [HU] ≥10 on unenhanced computed tomography [CT]) scheduled for surgery. …”
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An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape by Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen

“…BackgroundAlthough immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.MethodsWe retrieved the germline sequences for the IGHV from the IMGT database to illustrate the amino acid polymorphism present within germline sequences of IGHV genes. …”
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Cost-effectiveness of angiographic quantitative flow ratio-guided coronary intervention: A multicenter, randomized, sham-controlled trial by Yanyan Zhao, Changdong Guan, Yang Wang, Zening Jin, Bo Yu, Guosheng Fu, Yundai Chen, Lijun Guo, Xinkai Qu, Yaojun Zhang, Kefei Dou, Yongjian Wu, Weixian Yang, Shengxian Tu, Javier Escaned, William F. Fearon, Shubin Qiao, David J. Cohen, Harlan M. Krumholz, Bo Xu, Lei Song, On behalf of FAVOR III China Study Group, Ting Gao

“…This study aimed to assess the cost-effectiveness of QFR-guided PCI from the perspective of the current Chinese healthcare system. Methods:. This study is a pre-specified analysis of the FAVOR III China trial, which included 3825 patients randomized between December 25, 2018, and January 19, 2020, from 26 centers in China. …”
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Efficacy and safety of rapid dose escalation of methotrexate in rheumatoid arthritis. Results of the multicenter “METEOR” study by V. N. Amirjanova, E. Yu. Polishchuk, O. N. Anoshenkova, I. B. Vinogradova, E. V. Zonova, L. V. Ivanova, R. R. Samigullina, T. S. Salnikova, E. L. Shakhramanova, E. I. Shmidt, S. P. Yakupova, A. M. Lila, E. L. Nasonov

“…Rompharm Company S.R.L) in patients with rheumatoid arthritis (RA) with high disease activity and rapid dose escalation, to assess their quality of life (QoL) in real clinical practice.Material and methods. The study included 105 patients, mostly women, with a reliable diagnosis of RA with high disease activity (DAS-28 (Disease Activity Score 28) ≥5.1) aged 18 years and older and ineffectiveness of previous oral MTX therapy for at least 6 months or who had not received MTX. …”
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Evaluating the Elements of Vitality in Jahānshahr Walkway, Karaj City, Iran by Mina Heydari Tamrabadi, Habibollah Fasihi, Tajaddin Karami

“…This research aimed to evaluate the vitality components of Jahānshahr Walkway, a major thoroughfare that played a significant social, economic, and cultural role in the bustling and lively part of Karaj City, Iran. Materials & Methods:The study focused on Jahānshahr Walkway located in the northeastern region of Karaj, Iran. …”
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Application of acupuncture therapy in relieving the anxiety among patients undergoing glaucoma surgery (针灸疗法缓解青光眼手术患者焦虑的效果观察) by LI Gonghui (李贡辉), (毛珍), MA Di (马迪), HUANG Chukai (黄楚开), TAN Ronghui (谭容慧)

“…Objective To investigate the effect of acupuncture therapy in relieving the anxiety of patients undergoing glaucoma surgery. Methods Totally 95 glaucoma patients undergoing trabeculectomy were randomly divided into two groups: control group with 47 cases and observation group with 48 cases. …”
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Study of Planting Pattern and Herbicide Effects on Weed Population and Chickpea (Cicer arietinum L.) Grain Yield by Hossein Najafi, Soheyla Pourheydar Ghafarbi, Gholamreza Gahramanian, Ajang Jahedi

“…Optimizing chickpea row-spacing and the application possibility of non-selective herbicides in chickpea was our objective in this experiment. Materials and Methods In order to study planting pattern and chemical control effects on weed population and yield of rain-fed chickpea farming, two experiments conducted. …”
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Specific features of axial involvement in psoriatic arthritis: data from real clinical practice by E. E. Gubar, E. Yu. Loginova, Yu. L. Kоrsakova, T. V. Korotayeva, S. I. Glukhova, M. V. Sedunova, I. N. Pristavsky, I. N. Bondareva, I. F. Umnova, E. L. Nasonov

“…To compare clinical features in psoriatic arthritis (PsA) patients with and without axial involvement. Subjects and methods. 385 PsA patients (172 males and 213 females) from National PsA Register were examined, their diagnosis verified according to CASPAR criteria. …”
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Risk Prediction Model for High Myopia in Primary and Secondary School Students: Based on Nested Case-control Study by CHEN Shenglan, ZHENG Yongtao, HU Wangcheng, NI Zuowei, XIA Bing, YE Chunmei, DU Chixin, CHEN Xiaodan

“…Objective To investigate the prevalence and risk factors of high myopia in primary and secondary school students, and conduct a risk prediction model to provide a scientific basis for myopia prevention. Methods A nested case-control study was conducted in 2023, involving students with moderate myopia from 12 schools in Hangzhou to establish a cohort. …”
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Switching from interleukin-6 receptor inhibitors to the direct interleukin-6 inhibitor olokizumab in patients with rheumatoid arthritis: efficacy and safety during one year of ther... by P. A. Shesternya, A. A. Baranov, I. B. Vinogradova, O. N. Anoshenkova, O. V. Antipova, E. A. Bogdanova, Yu. Yu. Grabovetskaya, E. P. Ilivanova, A. N. Kalyagin, A. A. Blinova, N. A. Lapkina, M. V. Mokrousova, O. B. Nesmeyanova, N. M. Nikitina, N. V. Yudina, E. N. Alekseev, E. L. Nasonov, A. M. Lila

“…Objective: to investigate the efficacy and safety of olokizumab (OKZ) in patients with rheumatoid arthritis (RA) over a 12-month period after switching from interleukin (IL)-6 receptor inhibitors (iIL6R) for non-medical reasons.Material and methods. A retrospective cohort study conducted in 11 centers in the Russian Federation included 110 patients with confirmed diagnosis of RA according to 2010 ACR/EULAR criteria. …”
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