The effectiveness of psychosocial interventions for reducing problematic substance use, mental ill health, and housing instability in people experiencing homelessness in high incom... by Chris O'Leary, Esther Coren, Sandor Gellen, Anton Roberts, Harry Armitage

“…Objectives To summarise the existing evidence of whether psychosocial interventions work in reducing problematic substance use, mental ill health, and housing instability for adults experiencing homelessness in high income countries. Search Methods We used searches undertaken for the Homelessness Effectiveness Evidence and Gap Map (EGM) 5th edition. …”
Get full text

Comparison of Clinical Outcomes between the Fourth Day and the Fifth Day Embryo Transfer in IVF/ICSI Cycles: A Retrospective Cohort Study before and after PSM by Yasong Geng, Fangfang Dai, Meiyang Du, Linlin Tao, Haoyang Dai, Bo Zheng, Shusong Wang

“…It is important to explore whether the fourth day morulae could be a widely used alternative transplantation option to replace the fifth day blastocysts. Methods: This study involved 1167 patients undergoing their first in in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. …”
Get full text

Serum LCAT as a Gender-Neutral Biomarker for Early Osteoporosis: A Multicenter Cohort Validation Study by Wen Y, Cheng S, Gou L, Zhou W, Li Y, Wang R, Wu J, Dai X, Gao M, Wang L, Xue B, Wang Y

“…Yali Wen,1,* Shoujun Cheng,2,* Liming Gou,3,* Weihong Zhou,4,* Yishan Li,5 Ruoxuan Wang,6 Ji Wu,7 Xuening Dai,8 Ming Gao,9 Lei Wang,10 Bin Xue,3,11,12 Yinhe Wang1,13 1Department of Orthopedics, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Department of Clinical Laboratory, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 3Department of Translational Medicine Research Center, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 4Department of Health Management Centre, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 5Department of Translation Studies, Army Engineering University of PLA, Nanjing, People’s Republic of China; 6Department of Clinical Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 7Department of Orthopedics, Sir Run Run Hospital, Nanjing, Jiangsu, People’s Republic of China; 8Department of Geriatrics, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 9Department of Endocrinology, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 10Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 11Department of Jiangsu Key Laboratory of Early Development and Chronic Diseases Prevention in Children, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 12Department of General Surgery, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China; 13Department of Orthopedics, Clinical College, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yinhe Wang, Department of Orthopedics, Nanjing Drum Tower Hospital, Nanjing University of Chinese Medicine, Nanjing, 210000, People’s Republic of China, Email milkyway199@hotmail.com Bin Xue, Translational Medicine Research Center, Children’s Hospital of Nanjing Medical University, Nanjing, 210008, People’s Republic of China, Email xuebin@njmu.edu.cnPurpose: This study aims to identify a novel biomarker for the early detection and prevention of osteoporosis.Methods: A cross-sectional study (n=138, from 497 screened) was conducted at Nanjing Drum Tower Hospital (Sep 2023-Jun 2024). …”
Get full text

Efficacy and safety of doravirine/lamivudine/tenofovir disoproxil fumarate in HIV treatment: a real-world single-center study in China by Aixin Li, Letian Liu, Hongwei Zhang, Xi Wang, Zaicun Li, An Liu, Lili Dai, Jingji Zhang, Yue Gao, Jiangzhu Ye, Jianwei Li, Lijun Sun, Lijun Sun

“…This study presents real-world results of a retrospective analysis of patients who initiated DOR/3TC/TDF at a Chinese HIV center.MethodsThis retrospective analysis was carried out on patients who received DOR/3TC/TDF (initial or switch) at the outpatient clinic of the Infection Center in Beijing Youan Hospital in China. …”
Get full text

Immune Microenvironment Characterization and Machine Learning-Guided Identification of Diagnostic Biomarkers for Ulcerative Colitis by Zheng Q, Wang L, Zhang Y, Peng J, Hou J, Wang H, Ma Y, Tang P, Li Y, Li H, Chen Y, Li J, Chen Y

“…Current treatments often show limited efficacy, highlighting the need for novel diagnostic and therapeutic approaches.Methods: RNA-Seq data from 495 UC patients and 320 controls (training dataset) and 389 UC patients and 209 controls (testing dataset) were analyzed. …”
Get full text

Optimizing Treatment for Hospitalized Patients with COPD: A Study on the Impact of a LINE App-Based Multidisciplinary Team Approach Targeting Pharmacological Treatment, Lifestyle C... by Huang HY, Chen CL, Lin YL, Chen SC, Lee LC, Dai HM, Chiang CY, Chang YF, Lu H, Lee MR, Yang CC, Su CH, Chiang YZ, Yang MC, Shyu RY, Lan CC

“…This study explored the effectiveness of LINE-based MDT interventions in hospitalized patients with COPD.Methods: This retrospective analysis included patients with COPD admitted for exacerbations and compared their outcomes before and after the implementation of LINE-based MDT care. …”
Get full text

Adverse childhood experiences and subsequent experiences of intimate partner violence in adulthood: a gender perspective by Zheng Tian, Nan Zhang, Yimiao Li, Yibo Wu, Lan Wang

“…Abstract Aims Investigate the prevalence of adverse childhood experience (ACE) and intimate partner violence (IPV) using a large representative Chinese sample, explore the association mechanism between ACE and adult exposure to IPV and to examine gender differences. Methods A total of 21,154 participants were included in this study. …”
Get full text

Analysis of the Rights and Obligations of Stakeholders in China’s National Park Concession System by Le ZHONG, Zhicong ZHAO

“…Following the principle of equality of stakeholders’ rights and obligations, this research aims to provide a comprehensive theoretical and practical framework to guide ongoing research and the systematic construction of China’s national park concession system.MethodsThis research is designed to investigate the overarching and universal challenges associated with the establishment of the national park concession system in China. …”
Get full text

Comprehensive Analysis of Differences in N6-Methyladenosine RNA Methylation Groups in CVB3-Induced Viral Myocarditis and Identification of the Anti-Apoptotic Role of RBM15B by Hu Y, Lin J, Yi L, Cheng S, You G, Chang H, Liu H, Yang Z, Chen S

“…In this study, we investigated alterations in global RNA m6A methylation levels during CVB3 infection using both in vitro and in vivo models, and further examined the regulatory role of the m6A methyltransferase RBM15B in vitro.Methods: First, the total quantity of m6A was quantified in Balb/c mice and HL-1 cells with CVB3 infection via m6A dot blot analysis. …”
Get full text

Overtime Histological Changes in the Lungs after Intoxication with Baclofen Alone or in Combination with Ethanol (Experimental Study) by O. L. Romanova, M. L. Blagonravov, P. G. Dzhuvalyakov, V. I. Torshin, A. V. Ershov, E. Kh. Barinov

“…The aim of the study was to evaluate the overtime histological changes in the lungs after intoxication with baclofen alone or in combination with ethanol.Materials and methods. The experiment was carried out on 35 male Wistar rats weighing 290-350 g and aged 20 weeks. …”
Get full text

ASSESSMENT OF ADHERENCE TO TREATMENT AND FACTORS AFFECTING IT IN PATIENTS WITH STABLE ISCHEMIC HEART DISEASE DURING THERAPY WITH NICORANDIL by S. Yu. Martsevich, Yu. V. Lukina, N. P. Kutishenko, A. V. Akimova, V. P. Voronina, O. V. Lerman, O. V. Gaisenok, T. A. Gomova, A. V. Ezhov, A. D. Kuimov, R. A. Libis, G. V. Matyushin, T. N. Mitroshina, G. I. Nechaeva, I. I. Reznik, V. V. Skibitsky, L. A. Sokolova, A. I. Chesnikova, N. V. Dobrynina, S. S. Yakushin

“…To study the adherence to treatment and the factors that affect it in patients with stable coronary heart disease during the treatment with nicorandil. Material and methods. The use of nicorandil in addition to standard antianginal therapy was recommended to patients (n=590) in a prospective, observational, multicenter NIKEA study. …”
Get full text

Prognostic Significance of Elevated Platelet Count (>200 x 10^9 per L) in BCLC Stages B and C of Hepatocellular Carcinoma: A Retrospective Multicenter Analysis by Munker S, Rodriguez I, Bernhart K, Ben Khaled N, Findik M, Siegmund LK, Ye L, Reiter FP, Roessler D, Nasseh D, Balcar L, Pomej K, Scheiner B, Weiss C, Pinter M, Seidensticker M, Mayerle J, Philipp AB, De Toni EN

“…However, recent evidence suggests that elevated platelet count may also predict worse outcomes in advanced stages, suggesting a stage-dependent prognostic impact.Aim: This study evaluated the prognostic role of platelet counts across BCLC stages, adjusted for portal hypertension, to improve individualized patient management.Methods: In this retrospective, multicenter study, platelet count of 1112 patients with HCC in different tumor stages was analyzed. …”
Get full text

Validating the SONG-PKD Pain Instrument, a Core Outcome Measure for Pain in ADPKD by Rosanna Cazzolli, Angela Ju, Patrizia Natale, Armando Teixeira-Pinto, Martin Howell, Allison Jaure, Ronald D. Perrone, Eva Burnette, Niek F. Casteleijn, Arlene Chapman, Jonathan C. Craig, Sarah Eastty, Ron T. Gansevoort, Tess Harris, Marie C. Hogan, Shigeo Horie, Bertrand Knebelmann, Richard Lee, Karine Manera, Reem A. Mustafa, Richard Sandford, Gopala K. Rangan, Bénédicte Sautenet, Andrea K. Viecelli, Yeoungjee Cho

“…This study aimed to validate the Standardized Outcomes in Nephrology-Polycystic Kidney Disease (SONG-PKD) Pain measure, which includes 3 items related to pain (frequency, severity, and impact on life participation) measured on a 5-point Likert scale, in adults with ADPKD. Methods: A total of 316 adults with ADPKD from 21 countries participated online. …”
Get full text

Metabolic response to burn injury: a comprehensive bibliometric study by Yixu Li, Yixu Li, Yifan Liu, Sujie Xie, Sujie Xie, Yushu Zhu, Yushu Zhu, Xinran Ding, Xinran Ding, Wei Zhang, Wei Zhang, Shuyuan Xian, Shuyuan Xian, Guosheng Wu, Guosheng Wu, Hanlin Sun, Hanlin Sun, Jiale Yan, Bingnan Lu, Yuntao Yao, Weijin Qian, Yuwei Lu, Yiting Yang, Dayuan Xu, Dayuan Xu, Runzhi Huang, Runzhi Huang, Shizhao Ji, Shizhao Ji

“…Ultimately, we conducted an extensive review of the literature, synthesizing the findings to clarify the present understanding within our field of study.MethodsWe obtained 8,823 scientific publications on burn injury and metabolism from the core Web of Science (WOS) database collection. …”
Get full text

Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress by Zhuhui Huang, William Adiwignya Winata, Kui Zhang, Yang Zhao, Yang Li, Ning Zhou, Shaoyou Zhou, Wei Fu, Bokang Qiao, Guoqi Li, Yihui Shao, Jubing Zheng, Ran Dong

“…However, the lncRNA-miRNA-mRNA ceRNA network in endothelial cells under cyclic stretch is seldom studied. Methods. The miRNA, mRNA, and lncRNA expression profiles of 6 human umbilical vein endothelial cells (HUVECs) under circumferential stress were obtained by next-generation sequencing (NGS). …”
Get full text

Cost‐effectiveness of a multicomponent intervention against cognitive decline by Christian Brettschneider, Elżbieta Buczak‐Stec, Melanie Luppa, Andrea Zülke, Bernhard Michalowsky, Anika Rädke, Alexander Bauer, Christine Brütting, Robert P. Kosilek, Isabel Zöllinger, Juliane Döhring, Martin Williamson, Birgitt Wiese, Wolfgang Hoffmann, Thomas Frese, Jochen Gensichen, Hanna Kaduszkiewicz, Jochen René Thyrian, Steffi G. Riedel‐Heller, Hans‐Helmut König, the AGEWELL.DE study group

“…The aim of this multicenter cluster‐randomized controlled trial was to assess the cost‐effectiveness of a multi‐domain intervention to prevent cognitive decline in older people who are at risk for dementia. METHODS We used data from a multi‐centric, two‐armed, cluster‐randomized controlled trial (AgeWell.de trial, ID: DRKS00013555). …”
Get full text

First-phase ejection fraction is associated with myocardial fibrosis in the pressure overloaded heart by Shukun He, Shukun He, Jingrong Jiang, Jingrong Jiang, Yanting Zhang, Yanting Zhang, Tianshu Liu, Tianshu Liu, Wenhui Deng, Wenhui Deng, Yuji Xie, Yuji Xie, Wenqu Li, Wenqu Li, Yuting Tan, Yuting Tan, Lingyun Fang, Lingyun Fang, Jing Zhang, Jing Zhang, Lin He, Lin He, Qiaofeng Jin, Qiaofeng Jin, Yuman Li, Yuman Li, Li Zhang, Li Zhang, Phil Chowienczyk, Mingxing Xie, Mingxing Xie, Haotian Gu, Jing Wang, Jing Wang

“…This study aimed to explore the relationship between EF1 and MF in the pressure overloaded heart.MethodsThe pressure overloaded heart was induced by minimally invasive transverse aortic constriction (MTAC) in rats. …”
Get full text

The Activity of Influenza Viruses during 2017-2018 Season in Russia and Countries of the Northern Hemisphere: Conflict by the B-virus Vaccine Component by D. K. Lvov, E. I. Burtseva, E. A. Mukasheva, L. V. Kolobukhina, S. V. Trushakova, N. V. Breslav, E. L. Feodoritova, L. N. Merkulova, K. G. Krasnoslobotsev, E. O. Morozova, I. T. Fedyakina, A. V. Aristova, R. V. Vartanian, L. B. Kisteneva, A. G. Prilipov, S. V. Alkhovsky, A. G. Rosatkevich, I. S. Kruzhkova, A. L. Belyaev, E. V. Axselrod, M. V. Bazarova, S. V. Smetanina

“…The purpose Aims of the work is to analyze the features of the epidemic season of2017-2018.Materials and methods. The collection of data on the incidence and laboratory diagnosis of influenza and ARVI was carried out in the framework of the epidemiological surveillance of the circulation of influenza viruses in the Russian Federation. …”
Get full text

Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within... by Deborah D Stocken, Charles H Knowles, Jared Torkington, David Jayne, Julie Hepburn, Laura Knight, Neil Corrigan, Julie Cornish, Katie Gordon, Ashley Douglas, Kate Wilson, Megan Dale, Julie Croft, Christina Lloydwin, Alexandra Harriet Coxon-Meggy, Judith White, Alun Meggy, Aaron Quyn, Emily Farrow, Kheng-Seong Ng, Hannah Mather, Huey Yi Chong, Betty Tan, Ralph Powell, Andrea Warwick

“…Despite this, little is known about the natural history and there is poor evidence to support current treatment options.Methods and analysis The objectives of POLARiS are to explore the natural history of LARS and to evaluate the clinical and cost-effectiveness of transanal irrigation (TAI) or sacral neuromodulation (SNM) compared with optimised conservative management (OCM) for people with major LARS.POLARiS is a prospective, international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort design, with internal pilot phase, qualitative sub-study, process evaluation and economic evaluation. …”
Get full text

Nano-based perivascular intervention sustains a nine-month long-term suppression of intimal hyperplasia in vein grafts by Takuro Shirasu, Go Urabe, Nisakorn Yodsanit, Yitao Huang, Ruosen Xie, Matthew S. Stratton, Matthew Joseph, Zhanpeng Zhang, Yuyuan Wang, Jing Li, Runze Tang, Lynn M. Marcho, Li Yin, Eric W. Kent, Kaijie Zhang, Ki Ho Park, Bowen Wang, K. Craig Kent, Shaoqin Gong, Lian-Wang Guo

Get full text