H2FPEF and HFA‐PEFF scores for heart failure risk stratification in hypertrophic cardiomyopathy patients by Yi‐Peng Gao, Hong‐Yun Liu, Xiao‐Jun Bi, Jie Sun, Ying Zhu, Wei Zhou, Ya‐Ting Fan, Xue‐Qing Cheng, Pei‐Na Huang, Ya‐Ni Liu, You‐Bin Deng

“…This study aimed to explore the value of the H2FPEF and HFA‐PEFF scores for HF risk stratification in patients with hypertrophic cardiomyopathy (HCM). Methods and results In this cohort study, 1068 HCM patients were included. …”
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Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy against Enterococcus faecalis in root canal disinfection by Rizwan Jouhar, FCPS, Mohamad Syahrizal Halim, M.Rest.Dent, Sayed A. Quadri, MD, Muhammad Adeel Ahmed, PhD, Faheem Shah, PhD

“…Abstract: Objective: This study assessed the antimicrobial efficacy of photodynamic therapy (PDT) using functionalized graphene oxide with methylene blue (MB/rGO) to achieve root canal disinfection against Enterococcus faecalis. Methods: In this in vitro study, E. faecalis biofilms were developed on 105 single-rooted teeth after decoronation over 21 days. …”
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Delivery of miR-26a-5p by Subcutaneous Adipose Tissue-Derived Extracellular Vesicles Alleviates Acute Lung Injury in Mice Through CHUK/NF-κB Pathway by Xie Y, Ran L, Yue C, Wang C, Chen F, Su Y, Qin Y, Zhang Q, Liu J, Du N, Zhang L, Jiang Y, Liu G

“…This study aimed to elucidate the immunomodulatory roles and underlying mechanisms of adipose tissue-derived EVs in the pathogenesis of ARDS.Methods: Subcutaneous adipose tissue extracellular vesicles (SAT-EVs) were collected from the mice via ultracentrifugation. …”
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Genetic Variants of UGP2 and FBP2 in the Glycolysis Pathway Independently Predict Survival of Patients with HBV-Related Hepatocellular Carcinoma by Gong R, Qiu M, Liu Y, Cao J, Zhou Z, Lin Q, Jiang Y, Liang X, Wei Y, Wen Q, Chen P, Wei X, Wei J, Zhan S, Zhang R, Ye D, Yu H

“…However, the effect of genetic variants in glycolysis pathway genes in survival of patients with hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) remains unclear.Methods: We employed multivariable Cox proportional hazards regression analyses to estimate associations between genetic variants in 240 glycolysis pathway genes and overall survival (OS) of 866 patients with HBV-HCC, and we also used false positive report probability for multiple testing corrections.Results: We found that UGP2 rs4293553 G allele was significantly associated with a better OS of HBV-HCC patients [hazards ratio (HR) = 0.73, 95% confidence interval (CI) = 0.62– 0.86, P < 0.001], and that FBP2 rs635087 G allele was significantly associated with a worse OS in these patients (HR = 1.38, 95% CI = 1.18– 1.61, P < 0.001). …”
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IL-17A as a Key Mediator of Pulmonary-Intestinal Immune Interactions in a Mouse Model of Asthma and Colitis by Wu C, Hu X, Mo Z, Meng Y, Du Y, Duan Y, Zeng Z, Shan J, Li J, Zhang N, Ma Y, Wang H, Liu C, Zhang G, Foster PS, Xu H, Li F, Yang M

“…While IL-17A has been implicated in both asthma and colitis independently, its role in coordinating systemic immune responses across tissue compartments is not well defined.Methods: In this study, we developed a combined house dust mite-induced asthma model and dextran sulfate sodium-induced colitis model to investigate the role of IL-17A in driving inflammation in both the lungs and the intestines.Results: Our findings demonstrate that IL-17A neutralization markedly reduced airway and intestinal inflammation, attenuated mucus hypersecretion, downregulated pro-inflammatory cytokine expression, and alleviated colitis severity. …”
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Radiation-Based Multi-Modal Therapy Combining with Immunotherapy to Develop a Vaccine-Like Effective Treatment for Triple-Negative Breast Cancer by Dai M, Tian Z, Xu F, Yao B, Liang H, Li D, Wang J, Rong J, Liu T, Tang H, Lu H, Zhang W

“…Current treatments like chemotherapy and immunotherapy face challenges due to chemotherapy side effects, limited immunotherapy applicability, and TNBC’s immunosuppressive microenvironment.Purpose: To achieve a more effective treatment for TNBC, a novel therapeutic strategy has been developed, which uses X-ray excited photodynamic therapy (X-PDT) to activate the tumor immune microenvironment following with the immunotherapy of Anti-CTLA4.Methods: Base on the 4T1 tumor mouse model, this study initially investigated the regulatory effects of X-PDT on the tumor immune microenvironment. …”
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Sodium-glucose co-transporter-2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes: systematic review and meta-analysis by Gordon Guyatt, Arnav Agarwal, Thomas Agoritsas, Haoming Tian, Sheyu Li, Chang Xu, Ping Fu, Qingyang Shi, Xiaoxi Zeng, Per Olav Vandvik, Xinyu Zou, Yunhe Mao, Qinbo Yang, Xianghang Luo, Belen Ponte

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HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages by Zhou J, Ding L, Chen J, Chen C, Jiang P, Mei Z, Jiang Q, Hua X

“…This study aimed to investigate HMGB1’s potential contributions to the pathogenesis of CP/CPPS, offering new perspectives for innovative treatments.Materials and Methods: We have successfully extracted prostate antigens from Sprague–Dawley rat prostate tissue and established an experimental autoimmune prostatitis (EAP) mouse model in non-obese diabetic (NOD) mice. …”
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Identification of Single-Nucleotide Polymorphisms in B3GAT2, CPQ, and HPSE Genes in the Liver Tissue of Arian Broilers with Ascites using RNA-seq Data by Somayeh Hassnvand, Ayoub Farhadi, Elham Yonesi, Ghodrat Rahimimianji, Karim Hasan Pur

“…The present study aimed to identify single-nucleotide polymorphisms (SNPs) in CPQ, B3AGT2, and HPSE genes in the liver tissue of Arain broiler chickens with ascites syndrome using RNA-seq data. Methods: This research was conducted in two phases, including the first phase (ascites induction) and the second phase (normal rearing conditions). …”
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Alcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America. by Sabine Naudin, Molin Wang, Niki Dimou, Elmira Ebrahimi, Jeanine Genkinger, Hans-Olov Adami, Demetrius Albanes, Ana Babic, Matt Barnett, David Bogumil, Hui Cai, Chu Chen, A Heather Eliassen, Jo L Freudenheim, Gretchen Gierach, Edward L Giovannucci, Marc J Gunter, Niclas Håkansson, Mayo Hirabayashi, Tao Hou, Brian Z Huang, Wen-Yi Huang, Harindra Jayasekara, Michael E Jones, Verena A Katzke, Woon-Puay Koh, James V Lacey, Ylva Trolle Lagerros, Susanna C Larsson, Linda M Liao, Kenneth Lo, Erikka Loftfield, Robert J MacInnis, Satu Männistö, Marjorie L McCullough, Anthony Miller, Roger L Milne, Steven C Moore, Lorelei A Mucci, Marian L Neuhouser, Alpa V Patel, Elizabeth A Platz, Anna Prizment, Kim Robien, Thomas E Rohan, Carlotta Sacerdote, Sven Sandin, Norie Sawada, Minouk Schoemaker, Xiao-Ou Shu, Rashmi Sinha, Linda Snetselaar, Meir J Stampfer, Rachael Stolzenberg-Solomon, Cynthia A Thomson, Anne Tjønneland, Caroline Y Um, Piet A van den Brandt, Kala Visvanathan, Sophia S Wang, Renwei Wang, Elisabete Weiderpass, Stephanie J Weinstein, Emily White, Walter Willett, Alicja Woslk, Brian M Wolpin, Shiaw-Shyuan S Yaun, Chen Yuan, Jian-Min Yuan, Wei Zheng, Paul Brennan, Stephanie A Smith-Warner, Pietro Ferrari

“…We examined the association between alcohol intake and pancreatic cancer risk in a large consortium of prospective studies.<h4>Methods and findings</h4>Population-based individual-level data was pooled from 30 cohorts across four continents, including Asia, Australia, Europe, and North America. …”
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Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi by Ahmed M. Elgendy, Mohamed S. Nafie, Zohour I. Nabil, Nahla S. El-Shenawy, Heba N. Gad El-Hak

“…The study aimed to reveal the antiurolithiatic potential of two benzene sulfonamide derivatives (SBCl and SBF; A and B, respectively) against ethylene glycol-induced kidney stones. Methods: The rats were divided into two main groups: the first group consisted of 20 rats with induced kidney stones, and the second group included 15 control rats. …”
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Characterizing ECOPD Phenotypes: Associations with In-Hospital Outcomes and Immunoinflammatory Mechanisms by Wang Q, Wang L, Zhang L, Zhao C, Liu Y, Liu L, Yuan L, Feng M, Wang G, Li L, Zhang S, Yuan Y, Kang D, Zhang X

“…We sought to explore the underlying mechanisms that contribute to the relationship between ECOPD phenotypes and these outcomes.Methods: A k-means cluster analysis was conducted on 20,890 recruited patients hospitalized for ECOPD. …”
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The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report by Jakopin NE, Lanjewar SN, Garzon A, Gross P, Holubkov R, Moghekar A, Preston J, Romanoski M, Shannon CN, Tamber MS, Van der Willigen T, Sloan M, Chau MJ, Koschnitzky JE

“…This publication introduces the registry by highlighting the demographics, etiology, treatments, symptom profiles, and diagnosed comorbidities of the participants.Methods: The Hydrocephalus Association and a 10-member steering committee developed HAPPIER. …”
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DS-Modified Paeoniflorin pH-Responsive Lipid&amp;ndash;Polymer Hybrid Nanoparticles for Targeted Macrophage Polarization in a Rat Model of Rheumatoid Arthritis by Zhang J, Yang J, Yu Z, Bai H, Wang Y, Wang R

“…Simultaneously, dextran sulfate serves as a ligand to actively target Scavenger receptor class A type I overexpressed on activated macrophages in RA synovium, achieving dual-targeted delivery via environmental responsiveness and ligand-receptor interaction.Methods: We developed dextran sulfate-modified Pae–PPNPs–DS, which exhibits dual capabilities of active macrophage targeting and pH-triggered drug release, to deliver paeoniflorin to macrophages and improve drug delivery at the joint inflammation site. …”
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Evaluating Digital Rehabilitation Outcomes in Chronic Musculoskeletal Conditions Across Non-Obesity, Obesity, and Severe Obesity by Pereira AP, Janela D, Areias AC, Molinos M, Tong X, Bento V, Yanamadala V, Cohen SP, Correia FD, Costa F

“…The rising prevalence of obesity calls for scalable solutions to address MSK conditions in this population, given their complex clinical profile and barriers to accessing care.Purpose: To evaluate the engagement and clinical outcomes of a fully remote digital care program in patients with MSK conditions, focusing on those with and without comorbid obesity.Patients and Methods: A post-hoc analysis of a prospective, longitudinal, single-arm observational home-based study conducted between August, 2023, and August, 2024. …”
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Safety and efficacy of low-dose esketamine weakly opioidized anesthesia in elderly patients with lumbar spinal stenosis undergoing surgery: a prospective, double-blind randomized c... by Ni-Na Hou, Meng-Yun Zhang, Yu-Wei Zhang, Hong-Jing Wu, Hong Luo, Heng Yang

“…We aimed to evaluate the intraoperative safety and efficacy of weak opioidized anesthesia with low-dose esketamine in the treatment of elderly patients with lumbar spinal stenosis undergoing total laminectomy with complete decompression and interbody implant fusion. Methods In total, 90 elderly patients were randomized into three groups: the esketamine HS group (0.2 mg/kg induction, 0.25 mg/(kg·h) infusion), the esketamine LS group (0.2 mg/kg induction, 0.125 mg/(kg·h) infusion), and the control group (group C receiving an equal volume of saline). …”
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Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress by Guan H, Huang L, Liu Y, Zhu E, Chen L, Li W, Wu H, Zhang X, Qin R, Zheng J, Mo Y, Zhong M, Xu B, Dai X, Wei Q, Chen Y, Wang Q, Zheng Z, Ma K, Tang C

“…In this study, we aimed to explore the effector mechanisms of PS immune-complex during lupus development.Patients and Methods: Serological profiles of immune-complexes in SLE patients were analyzed. …”
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Studying Spatiotemporal Changeability of Oak Forests in Zagros in Response to Rainfall Variation by Zahra Alirezai, Amir Gandomkar, Morteza khodagholi, Alireza Abbasi

“…Borhan et al., 2015). 2-Materials and Methods In this study, two categories of data were used. …”
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Social Media Behavior Guidelines for Healthcare Professionals: An American Society of Pain and Neuroscience NEURON Project by Giuffrida A, Saia-Owenby C, Andriano C, Beall D, Bailey-Classen A, Buchanan P, Budwany R, Desai MJ, Comer A, Dudas A, Tieppo Francio V, Grace W, Gill B, Grunch B, Goldblum A, Garcia RA, Lee DW, Lavender C, Lawandy M, Mandell L, Mata R, Rabii M, Patel K, Patel RG, Patel AA, Sayed D, Singh G, Strand N, Tate J, Schatman ME, Deer T

“…As part of the broader initiatives on Spine and Nerve practice, the executive board of ASPN has decided it would be beneficial to include comprehensive guidance for healthcare providers when engaging on social media.Methods: A panel of experts was chosen based on expertise, publications, diversity, and their social media presence. …”
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A caffeine and theacrine combination improves cognitive performance in tactical personnel under physically fatiguing conditions by Blaine S. Lints, Adam T. Harrison, Sten O. Stray-Gundersen, Gianna F. Mastrofini, Riccardo F. Romersi, Noah K. Nakagawa, Mackenzie B. Yoder, Chimaobim E. Martin-Diala, Alexa J. Chandler, R. Davis Moore, Shawn M. Arent

“…Theacrine, a purine alkaloid similar in structure to caffeine but with a longer half-life, less habituation, and fewer side effects, is proposed as a caffeine-alternative to enhance cognitive resilience.Methods Tactically trained participants (n = 20; F = 5; M = 16; age = 21.5 ± 3.8 y) completed one baseline and three experimental visits. …”
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