Comparative evaluation of three polymerase chain reaction primer sets for accurate molecular detection of Trypanosoma lewisi in wild rodents in Indonesia by Aditya Yudhana, Gusti Ayu Illiyin Putri Santosa, April Hari Wardhana, Frenky Laksana Putra, Ryanka Edila, Dyah Haryuningtyas Sawitri, Ratih Novita Praja, Muhammad Aqil Kurnianto, Aldi Gusnizar Rizaldy Tanjung, Marc Desquesnes, Makoto Matsubayashi

“…This study aimed to compare the diagnostic performance of three published PCR primer sets–TC121/TC122, CATLew F/CATLew R, and LEW1S/LEW1R–for the detection of T. lewisi in wild Rattus spp. in Indonesia and determine the most reliable tool for field application. Materials and Methods: One hundred rat blood samples obtained from the Badan Riset dan Inovasi Nasional (BRIN), Research Center for Veterinary Science, Bogor, West Java Province, Indonesia were analyzed through PCR using the three primer sets under optimized thermal cycling conditions. …”
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“Koshimagari Exercise” for Adult Spinal Deformity in Older Adults: Assessment of Home-Based Exercise Outcomes in a Prospective Multicenter Study by Hidetomi Terai, Shinji Takahashi, Masatoshi Hoshino, Hiroshi Taniwaki, Koji Tamai, Toshimitsu Ohmine, Tamotsu Nakatsuchi, Goya Shinbashi, Masatoshi Teraguchi, Masakazu Minetama, Kei Watanabe, Naritoshi Sato, Takuya Kitamura, Masaru Kanda, Tadao Tsujio, Yuichi Takeuchi, Tatsuki Mizouchi, Katsuhito Ishizu, Toshihito Ebina, Yasunari Muraoka, Tomonori Sodeyama, Hiroshi Mikami, Yuji Kasukawa, Takahiko Hyakumachi, Kazuhiro Ishida, Kazufumi Miyagishima, Yosuke Oishi, Kiyonori Yo, Ryota Kimura, Hiromichi Sato, Keiji Nagata, Yu Yamato, Ko Matsudaira, Naohisa Miyakoshi, Yukihiro Matsuyama, Hirotaka Haro, Hiroshi Hashizume, Hiroshi Yamada, Takashi Kaito, Project Committee of the Japanese Society for Spine Surgery and Related Research (JSSR)

“…This study aimed to investigate the impact of “Koshimagari exercise,” a specific home-based exercise regimen designed for patients with ASD, and to evaluate its effects on clinical outcomes in older adults. Methods: A total of 144 participants aged 50-80 years with chronic low back pain (LBP) due to spinal deformities were included in this multicenter prospective study. …”
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Platelet-rich plasma therapy for knee osteoarthritis: Insights from real-world clinical data in Japan by Yoshitomo Saita, Yohei Kobayashi, Sayuri Uchino, Hirofumi Nishio, Takanori Wakayama, Shin Fukusato, Yasumasa Momoi, Ryosuke Nakajima, Nanako Yamamoto, Shinnosuke Hada, Haruka Kaneko, Muneaki Ishijima

“…This study aimed to analyze patient characteristics and treatment outcomes of PRP therapy for KOA in our hospital registered in NRMD database and to identify factors that influence therapeutic effectiveness. Methods: This retrospective observational study analyzed PRP treatment data for KOA in our hospital from January 2020 to May 2024 which was registered in the NRMD. …”
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White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease by Mariyemuguli Reheman, Sagar Buch, Naying He, Pei Huang, Qiurong Yu, Xinhui Wang, Yu Liu, Youmin Zhang, Zhijia Jin, Yan Li, Peng Liu, Shengdi Chen, E. Mark Haacke, Fuhua Yan

“…This study integrates T2-FLAIR and quantitative MRI (qMRI) to investigate burden, spatial distribution, and extent of tissue alterations in WMH, aiming to elucidate their role in cognitive decline among PD patients. Methods: A total of 122 age- and sex-matched PD patients and 65 healthy controls (HC) were recruited, with PD patients grouped by Montreal Cognitive Assessment (MoCA) score including normal, mild cognitive impairment (MCI) or PD with dementia (PDD). …”
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Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD by Ahmad Moolla, Toryn Poolman, Nantia Othonos, Jiawen Dong, Kieran Smith, Thomas Cornfield, Sarah White, David W. Ray, Sofia Mouchti, Ferenc E. Mózes, Helena Thomaides-Brears, Stefan Neubauer, Jeremy F. Cobbold, Leanne Hodson, Jeremy W. Tomlinson

“…To dissect the mechanisms underpinning their benefits, we conducted a prospective, randomised, experimental medicine study in people with MASLD, comparing GLP-1RA treatment (liraglutide) to matched lifestyle-induced weight loss and assessed the impact of treatment withdrawal. Methods: Twenty-nine participants with MASLD, without type 2 diabetes underwent metabolic phenotyping including measurement de novo lipogenesis (DNL), liver magnetic resonance imaging, body composition, adipose tissue RNA sequencing, circulating proteome, and stool microbiome analysis. …”
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Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk? by Komodo Matta, Vivian Viallon, Anastasia Chrysovalantou Chatziioannou, Nivonirina Robinot, Roland Wedekind, Christina C. Dahm, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Therese Truong, Chloé Marques, Pauline Frenoy, Rudolf Kaaks, Renée Turzanski Fortner, Matthias B. Schulze, Sabrina Sieri, Mario Fordellone, Rosario Tumino, Fulvio Ricceri, Tonje Braaten, Therese Haugdahl Nøst, Maria-Jose Sánchez, Olatz Mokoroa-Carollo, Sandra Colorado-Yohar, Camino Trobajo-Sanmartín, Keren Papier, Rhea Harewood, Kostas Tsilidis, Salvatore Vaccarella, Mattias Johansson, Elisabete Weiderpass, Cyrille Delpierre, Sebastien Lamy, Kristin Benjaminsen Borch, Pekka Keski-Rahkonen, Elio Riboli, Heinz Freisling, Marc Gunter, Pietro Ferrari

“…Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer. Methods Lifestyle and untargeted metabolomic data were available from a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 1,067 colon cancer cases and 1,067 controls matched on age, sex, study centre, and blood collection time. …”
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Exploring the impact of a daily sport uniform policy in primary schools: a qualitative study with students and teachers by Carly Gardner, Carly Gardner, Carly Gardner, Carly Gardner, Cassandra Lane, Cassandra Lane, Cassandra Lane, Cassandra Lane, Alix Hall, Alix Hall, Alix Hall, Alix Hall, Nicole McCarthy, Nicole McCarthy, Nicole McCarthy, Nicole McCarthy, Emma Pollock, Emma Pollock, Emma Pollock, Emma Pollock, Rachel Sutherland, Rachel Sutherland, Rachel Sutherland, Rachel Sutherland, Luke Wolfenden, Luke Wolfenden, Luke Wolfenden, Luke Wolfenden, Nicole Nathan, Nicole Nathan, Nicole Nathan, Nicole Nathan

“…This qualitative study explored the perspectives of students and teachers at primary schools (elementary schools) where a daily sport uniform policy had been implemented.MethodsWe used a pragmatic, exploratory qualitative study design with data collected from participants in the intervention arm of a randomised controlled trial. …”
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Research progress in intracranial artery dissections over past 25 years: a review and bibliometric analysis by Zixuan Zhou, Zixuan Zhou, Zixuan Zhou, Bingyang Qin, Yang Chen, Yang Chen, Yang Chen, Ren Li, Ren Li, Ren Li, Biao Yang, Biao Yang, Biao Yang, Ziao Li, Ziao Li, Ziao Li, Yongqiang Wu, Yongqiang Wu, Yongqiang Wu, Xiaogang Wang, Xiaogang Wang, Xiaogang Wang, Xiaolong Guo, Xiaolong Guo, Xiaolong Guo, Wenju Zhang, Wenju Zhang, Wenju Zhang, Yuanli Zhao, Geng Guo, Geng Guo, Geng Guo, Geng Guo, Geng Guo

“…BackgroundA bibliometric and visual analysis of articles related to intracranial artery dissection (IAD) was performed to reveal the academic developments in this research field, to better assist researchers in reviewing previous research results, exploring current scientific research hotspots and cutting-edge trends, and obtaining a global perspective on IAD research.MethodsArticles on IAD published from January 1, 2000 to March 15, 2025 were searched, screened, and downloaded using the Web of Science Core Collection (WoSCC). …”
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Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes by Janet Mei, Hamza Adel Salim, Dhairya A. Lakhani, Licia Luna, Aneri Balar, Mona Shahriari, Nathan Z. Hyson, Francis Deng, Adam A. Dmytriw, Adrien Guenego, Vaibhav Vagal, Victor C. Urrutia, Elisabeth B. Marsh, Hanzhang Lu, Risheng Xu, Rich Leigh, Dylan Wolman, Gaurang Shah, Benjamin Pulli, Kambiz Nael, Gregory W. Albers, Max Wintermark, Jeremy J. Heit, Tobias D. Faizy, Argye E. Hillis, Raf Llinas, Vivek Yedavalli

“…This study investigates the association between PVT and percent change on the National Institutes of Health Stroke Scale (NIHSS) among AIS‐LVO patients who have undergone successful reperfusion. Methods We performed a retrospective analysis of prospectively collected data from consecutive adult AIS‐LVO patients with successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b/2c/3). …”
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Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis by Mark Simmonds, Matthew Walton, Rob Hodgson, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, John Lawrenson, Tunde Peto, David Steel

“…Anti-vascular endothelial growth factor drugs are used to treat various eye conditions and may be beneficial for people with proliferative or non-proliferative retinopathy. Methods The Anti-VEGF In Diabetes project sought to investigate the clinical and cost-effectiveness of using anti-vascular endothelial growth factor to prevent retinopathy progression when compared to panretinal photocoagulation or no treatment. …”
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Assessment of the thoracic aorta after aortic root replacement and/or ascending aortic surgery using 3D relaxation-enhanced angiography without contrast and triggering by Carsten Gietzen, Jan Paul Janssen, Juliana Tristram, Burak Cagman, Kenan Kaya, Robert Terzis, Roman Gertz, Thorsten Gietzen, Henry Pennig, Alexander C. Bunck, David Maintz, Thorsten Persigehl, Navid Mader, Kilian Weiss, Lenhard Pennig

“…The purpose of this study was to evaluate the performance of REACT after surgery of the aortic root and/or ascending aorta by performing an intraindividual comparison to CE-MRA.Material and methodsThis retrospective single center study included 58 MRI studies of 34 patients [mean age at first examination 45.64 ± 11.13 years, 31 (53.44%) female] after ascending aortic surgery. …”
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A Comprehensive Analysis of Spitzer 4.5 μm Phase Curves of Hot Jupiters by Lisa Dang, Taylor J. Bell, Ying (Zoe) Shu, Nicolas B. Cowan, Jacob L. Bean, Drake Deming, Eliza M.-R. Kempton, Megan Weiner Mansfield, Emily Rauscher, Vivien Parmentier, Alexandra Rochon, Kevin B. Stevenson, Mark Swain, Laura Kreidberg, Tiffany Kataria, Jean-Michel Désert, Robert Zellem, Jonathan J. Fortney, Nikole K. Lewis, Michael Line, Caroline Morley, Adam Showman

“…The analysis, performed with the Spitzer Phase Curve Analysis pipeline, confirms that BLISS mapping is the best detrending scheme of the three independent schemes we tested for most, but not all, observations. Visual inspection remains necessary to ensure consistency across detrending methods due to the diversity of phase-curve data and systematics. …”
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A systematic review of the cost-effectiveness of anti-VEGF drugs for the treatment of diabetic retinopathy by Robert Hodgson, Matthew Walton, Helen Fulbright, Laura Bojke, Ruth Walker, Alexis Llewellyn, Sofia Dias, Lesley Stewart, David Steel, John Lawrenson, Tunde Peto, Mark Simmonds

“…Objective To systematically review the evidence supporting the cost-effectiveness of alternative treatments for diabetic retinopathy. Methods A systematic review of all comparative cost-effectiveness studies evaluating any treatment for diabetic retinopathy was conducted. …”
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Effectiveness of Chemical Management for Broadleaf Weeds in Autumn-Sown Chickpea (Cicer arietinum L.) by Mozhgan Veisi, Mehdi Minbashi Moeini, Sepideh Hatami, Mohammad Saleh Mansouri

“…In this regard, the purpose of this study was to compare new PRE-herbicide (flumioxazin) with different rates as IBS, PRE, and early-post with previously used herbicides, in terms of weed control and subsequently increase grain yield of chickpea. Materials and MethodsThis experiment was carried out in Kermanshah, West Azerbaijan and Hamadan during crop year 2021-2022, Iran. …”
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Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and meta-analysis by Mark Simmonds, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Matthew Walton, Rob Hodgson, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, John G Lawrenson, Tunde Peto, David Steel

“…Objective To investigate the efficacy and safety of anti-vascular endothelial growth factor therapy for the treatment of diabetic retinopathy when compared to panretinal photocoagulation. Methods A systematic review and network meta-analysis of all published randomised controlled trials comparing anti-vascular endothelial growth factor (alone or in combination with panretinal photocoagulation) to panretinal photocoagulation in people with diabetic retinopathy. …”
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Development and validation of a predictive nomogram for differentiating diabetic nephropathy from non-diabetic nephropathy in patients with T2DM: a multicenter study by Zishan Lin, Zishan Lin, Zishan Lin, Tao Hong, Tao Hong, Tao Hong, Wenfeng Wang, Wenfeng Wang, Wenfeng Wang, Shidong Xie, Shidong Xie, Shidong Xie, Caiming Chen, Caiming Chen, Caiming Chen, Feng Yang, Dewen Jiang, Dewen Jiang, Dewen Jiang, Jianxin Wan, Jianxin Wan, Jianxin Wan, Zugang Xie, Yanfang Xu, Yanfang Xu, Yanfang Xu

“…This multicenter study aims to develop a non-invasive diagnostic model to distinguish DN from NDN in T2DM patients.MethodsFrom January 2014 to December 2023, T2DM patients undergoing percutaneous renal biopsies at three hospitals in Fujian were enrolled. …”
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Key indicators for guiding tocilizumab therapy to prevent orbital decompression surgery in hormone-resistant dysthyroid optic neuropathy by Wenjun Shu, Wenjun Shu, Wenjun Shu, Wenjun Shu, Mingxu Yan, Mingxu Yan, Mingxu Yan, Mingxu Yan, Lu Gan, Lu Gan, Lu Gan, Lu Li, Hongyue Tao, Zhiyu Peng, Zhiyu Peng, Zhiyu Peng, Zhiyu Peng, Jinghan Wang, Jinghan Wang, Jinghan Wang, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Xintong Lin, Xintong Lin, Xintong Lin, Haifeng Chen, Haifeng Chen, Haifeng Chen, Jie Guo, Jie Guo, Jie Guo, Kang Xue, Kang Xue, Kang Xue, Hongguang Cui, Heng Lou, Heng Lou, Heng Lou, Binbin Xu, Binbin Xu, Binbin Xu, Jinwei Cheng, Jinwei Cheng, Jinwei Cheng, Hongying Ye, Yiming Li, Jiang Qian, Jiang Qian, Jiang Qian, Rui Zhang, Rui Zhang, Rui Zhang, Ruiqi Ma, Ruiqi Ma, Ruiqi Ma, Fangfang Zeng

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Acupuncture as adjunctive therapy for acute cerebral infarction: a randomized clinical trial by Jiang-Peng Cao, Jiang-Peng Cao, Jiang-Peng Cao, Xin-Yue Du, Xiao-Xi Liu, Xiao-Xi Liu, Meng-Han Li, Meng-Han Li, Man Zhang, Sheng-Xuan Guo, Sheng-Xuan Guo, Qiu-Han Cai, Qiu-Han Cai, Jia-Xin Zhang, Jia-Xin Zhang, Jia-Xin Zhang, Shan-Shan Sun, Shan-Shan Sun, Shan-Shan Sun, Jia-Wei Han, Lin-Ling Chen, Na Zheng, Lan-Yu Jia, Gui-Ping Li, Gui-Ping Li, Yuan-Hao Du, Yuan-Hao Du

“…We aimed to investigate the efficacy and safety of acupuncture as adjunctive therapy to improve neurological function in patients with ACI.MethodsThe multicenter, sham-controlled, patient- and assessor-blinded randomized controlled trial was conducted in 4 tertiary hospitals in China from January to September 2024. …”
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Risk Analysis of Retinal Hemangioblastomas in Nonadvanced Stages of von Hippel–Lindau Syndrome Using Ultra-widefield Imaging: The ULTRA von Hippel–Lindau Study by Sebastiano Del Fabbro, MD, Maria Vittoria Cicinelli, MD, Rosangela Lattanzio, MD, Soufiane Bousyf, MD, Lorenza Bruno, MD, Alessio Antropoli, MD, Lorenzo Bianco, MD, Elena Bruschi, MD, Alessandro Arrigo, MD, Giovanni Pipitone, MD, Francesco Cei, MD, Lucia Salerno, MD, Alessandro Larcher, MD, Andrea Salonia, MD, Francesco Bandello, MD, Maurizio Battaglia Parodi, MD

“…Subjects: Caucasian patients with genetically confirmed VHL syndrome. Methods: Annual evaluations included dilated fundus examinations, UWF pseudocolor fundus retinal images, UWF fluorescein angiography, and OCT. …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe by Deborah De Moortel, Michelle C Turner, Ella Arensman, Alex Binh Vinh Duc Nguyen, Víctor Gonzalez

“…The project is a collaboration between five countries (Austria, Belgium, Greece, the UK, and Sweden) and entails a cross-national mixed-methods intervention study with an embedded process and impact evaluation. …”
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