Neuropsychic manifestations in the Kyrgyz cohort of patients with systemic lupus erythematosus by G. M. Koylubaeva, T. M. Reshetnyak, E. A. Aseeva, K. S. Solovyov, A. S. Dzhumagulova, N. P. Tkachenko, E. R. Karimovа, A. Zh. Zhumakadyrova, E. Zh. Dzhishambaev, K. A. Dzhailobayeva, E. L. Nasonov

“…The aim of the investigation was to study neuropsychic manifestations (NPM) of systemic lupus erythematosus (SLE) in the Kyrgyz cohort of patients. Material and methods. The prospective study included 460 patients with a reliable diagnosis of SLE, verified according to the diagnostic criteria ACR (1997) and SLICC (2012), observed in the clinic of the Academician M. …”
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The median Effective Dose (ED50) and the 95% Effective Dose (ED95) of alfentanil in inhibiting responses to cervical dilation when combined with ciprofol during hysteroscopic proce... by Run Gao, Shu-Xi Li, Yan-Hong Zhou, Li Xing, Jin-Peng Fu, Jian-Jun Shen, Xin-Zhong Chen, Li-Li Xu

“…The requirement of ciprofol, the emergence time, the visual analogue scale score of pain at five time points, and the incidence of adverse events were recorded. …”
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Cross-sectional study of the perceived wellbeing of children in palliative care by Daniel Toro-Pérez, Ester Camprodon-Rosanas, Catalina Bolancé, Montserrat Guillen, Sergi Navarro Vilarrubí, Joaquin T. Limonero

“…Objective: To describe the perceived wellbeing (pWB) and the psychological characteristics of young people with life-limiting and life-threatening conditions (LLTCs). Methods: We conducted a cross-sectional study in young people aged 8 years or older with collection of data on demographic and disease-related variables from the health records. …”
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Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation by Xiaohu Wang, Mengxia Fu, Weiteng Wang, Songren Shu, Ningning Zhang, Ruojin Zhao, Xiao Chen, Xiumeng Hua, Xin Wang, Wei Feng, Xianqiang Wang, Jiangping Song

“…Therefore, we aimed to comprehensively examine the cellular and molecular components of mitral valves in patients with MR. Methods We conducted a single-cell RNA sequencing (scRNA-seq) analysis of mitral valve leaflets extracted from six patients who underwent heart transplantation. …”
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Clinical efficacy of Ni-Ti memory alloy four-corner arthrodesis concentrator in the treatment of scaphoid nonunion advanced collapse: a follow-up of over 10 years by Baochuang Qi, Minzheng Guo, Chen Meng, Teng Wang, Chuan Li, Yongqing Xu

“… Purpose: Exploring the therapeutic effects of Ni-Ti shape memory alloy four-corner arthrodesis concentrator (NT-FCAC) in treating scaphoid nonunion advanced collapse (SNAC) and providing a decade-long follow-up report. Materials and methods: Twenty-six patients with SNAC underwent scaphoidectomy, along with four-corner arthrodesis fusion involving the capitate, lunate, triquetrum, and hamate, using NT-MFCAC. …”
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Natural orifice transluminal endoscopic surgery in urology: The Chinese experience by Xiaofeng Zou, Guoxi Zhang, Tianpeng Xie, Yuanhu Yuan, Rihai Xiao, Gengqing Wu, Xiaoning Wang, Hui Xu, Folin Liu, Yuting Wu, Yunfeng Liao, Quanliang Liu, Yinghao Sun, Bo Yang, Linhui Wang, Chuanliang Xu, Xiaofeng Gao

“…Objective: To describe the Chinese experience of natural orifice transluminal endoscopic surgery (NOTES) in urology. Methods: From December 2008 to May 2017, 35 animal experiments and 305 clinical surgeries of NOTES or natural orifices specimen extractions (NOSE) were performed in China. …”
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The Potential Benefits of a Novel Food Supplement Based on Cannabis Sativa, Boswellia, and Fish Oil for Pain and Inflammation in Physical Activity: Unraveling the Role of Orexin-A... by Antonietta Messina, Antonietta Monda, Valentina Vassallo, Girolamo Di Maio, Rita Polito, Marco La Marra, Salvatore Allocca, Maria Casillo, Fiorenzo Moscatelli, Cristina Scavone, Francesco Taturi, Vincenzo Monda, Giovanni Messina, Chiara Schiraldi, Marcellino Monda

“…This study aimed to evaluate the effects of Flector Softgel FS Integratore, a multi-component food supplement, on joint pain, inflammatory markers, metabolic health, and orexin-A levels in physically active adults. Methods: In this randomized, controlled, low-intervention study, 25 adult participants (aged 30–60 years and amateur athletes engaging in at least 3 sessions/week of moderate physical activity) were assigned to either a treatment group (n = 15 received Flector Softgel FS for 14 days) or a placebo group (n = 10). …”
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Impact of postoperative depression and immune-inflammatory biomarkers on the prognosis of patients with esophageal cancer receiving minimally invasive esophagectomy: a retrospectiv... by Pei-xin Tan, Lin-xin Wu, Shuang Ma, Shi-jing Wei, Tai-hang Wang, Bing-chen Wang, Bing-bing Fu, Jia-shuo Yang, Qing Zhao, Qing Zhao, Li Sun, Yi Liu, Tao Yan

“…This study aimed to investigate the interrelationship between depression and prognosis in patients with EC, with a focus on immune-inflammatory biomarkers.MethodsThis single-center retrospective trial was conducted at the National Cancer Center/Cancer Hospital of the Chinese Academy of Medical Sciences. …”
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16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomiz... by Stephanie M. Van Riper, Jacob V. Ninneman, Jacob V. Ninneman, Aaron J. Stegner, Aaron J. Stegner, Brady A. Riedner, Brady A. Riedner, Laura D. Ellingson, Ryan J. Dougherty, Patrick J. O’Connor, Gunnar A. Roberge, Gunnar A. Roberge, Andrew L. Alexander, Andrew L. Alexander, Andrew L. Alexander, Doug C. Dean, Doug C. Dean, Doug C. Dean, Jill N. Barnes, Dane B. Cook, Dane B. Cook

“…This study tested the effects of 16 weeks of resistance exercise training (RET) on gray matter (GM) volume and white matter (WM) microstructure in Gulf War Veterans (GWVs) with CMP compared to GWV waitlist controls (WLC).MethodsFifty-four GWVs were randomly assigned to 16 weeks of RET (n = 28) or WLC (n = 26). …”
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Non-Invasive Ventilation Failure in Pediatric ICU: A Machine Learning Driven Prediction by Maria Vittoria Chiaruttini, Giulia Lorenzoni, Marco Daverio, Luca Marchetto, Francesca Izzo, Giovanna Chidini, Enzo Picconi, Claudio Nettuno, Elisa Zanonato, Raffaella Sagredini, Emanuele Rossetti, Maria Cristina Mondardini, Corrado Cecchetti, Pasquale Vitale, Nicola Alaimo, Denise Colosimo, Francesco Sacco, Giulia Genoni, Daniela Perrotta, Camilla Micalizzi, Silvia Moggia, Giosuè Chisari, Immacolata Rulli, Andrea Wolfler, Angela Amigoni, Dario Gregori

“…This study aims to identify predictors of first-attempt NIV failure in PICU patients by testing various machine learning techniques and comparing their predictive abilities. <b>Methods</b>: Data were sourced from the TIPNet registry, which comprised patients admitted to 23 Italian Paediatric Intensive Care Units (PICUs). …”
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Impact of Low Hand Grip Strength on Quality of Life, Utilization of Healthcare, and Mental Health in Individuals with Airflow Limitation by Kim SH, Zo S, Kong SA, Cho JH, Do JG, Shin SH, Park HY

“…However, data on the impact of sarcopenia on quality of life, utilization of healthcare, and mental health in individuals with AFL are limited.Patients and methods: We used data from the 2014– 2019 Korea National Health and Nutrition Examination Survey (KNHANES), and participants with AFL were included. …”
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An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningo... by Xiuwen Sui, Zhujun Shao, Yuanyuan Ji, Hairui Wang, Qingfu Xu, Bochao Wei, Zhuojun Duan, Chang Wang, Ying Yang, Jiayu Zhao, Tao Zhu

“…<b>Background</b>: The combined diphtheria–tetanus–acellular pertussis (three-component), <i>Haemophilus influenzae</i> type b (Hib, conjugate), and ACYW135 meningococcal (conjugate) vaccine (DTaP-Hib-MCV4) offers a promising alternative to single-component vaccines, potentially simplifying immunization schedules and improving vaccination coverage. <b>Methods</b>: We evaluated the safety, immunogenicity, and protective efficacy of DTaP-Hib-MCV4 in animal models. …”
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Prognostic Significance of Circulating Immune Subset Counts in Nasopharyngeal Carcinoma by Xie H, Zhang L, Chen L, Zhou W, Zhang L, Su Y, Li B, Ding P, Xiao Y, Lu T, Gong X, Li J

“…Honghui Xie,1– 3,&amp;ast; Lin Zhang,1,3,4,&amp;ast; Lizhi Chen,5,&amp;ast; Wenchao Zhou,1,6 Lijuan Zhang,1,3 Yong Su,1– 3 Bocheng Li,1,6 Peng Ding,1,6 Yun Xiao,1– 3 Tianzhu Lu,1,2,4,7 Xiaochang Gong,1,2,4,7 Jingao Li1,2,4,7 1NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 2Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 3Jiangxi Clinical Research Center for Cancer, Jiangxi Cancer Hospital &amp; Institute, The Second Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330029, People’s Republic of China; 4JXHC Key Laboratory of Tumour Metastasis, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China; 5Department of Oncology, Shangrao People’s Hospital, Shangrao, Jiangxi, 334000, People’s Republic of China; 6Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330064, People’s Republic of China; 7JXHC Key Laboratory of Tumor Microenvironment and Immunoregulation, Jiangxi Cancer Hospital, Nanchang, Jiangxi, 330029, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xiaochang Gong, NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, No. 519, Beijing East Road, Nanchang, Jiangxi, 330029, People’s Republic of China, Email gxcanddw@163.com Jingao Li, NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma, Jiangxi Cancer Hospital, No. 519, Beijing East Road, Nanchang, Jiangxi, 330029, People’s Republic of China, Email lijingao@hotmail.comPurpose: This study aimed to assess the prognostic value of circulating immune cells in newly diagnosed, non-metastatic nasopharyngeal carcinoma (NPC) and to develop a nomogram combining immune cell counts with clinical characteristics.Methods: In this retrospective study, patients with non-metastatic NPC treated between January 2015 and December 2018 were included. …”
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PEG-Coated Ceria-Zirconia Nanoparticle Prevent Weight Gain and Obesity-Related Organ Damage Through Autophagy Flux Activation and ROS Scavenging by Kim EK, Hong SE, Choi YS, Yu SL, Kang J, Park CG, Lee HY, Lee SK, Lee DC, Hwang WM, Yun SR, Park Y, Park MH, Lee J, Yoon KR, Lerman LO, Yoon SH

“…In this study, we examined the therapeutic efficacy of PEG-CZNPs against obesity-induced organ complications and investigated the associated intracellular mechanisms.Methods: Palmitate was used to establish a cellular model of obesity in HK-2 cells. …”
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Triple Therapy with Interventional Treatment, Donafenib, and Anti-PD-1 Antibodies in Unresectable Hepatocellular Carcinoma: A Retrospective Real-World Study in China by Ye Q, Song Z, Yu T, Li Y, Ai L, Yang G, Su K, Chen D, Zhao W, Ding R, Zha Y, Li G

“…Triple therapy combining interventional treatments, donafenib, and anti-PD-1 monoclonal antibodies has shown promise in recent studies, but real-world data remain limited.Objective: To evaluate the real-world efficacy and safety of triple therapy with interventional treatment, donafenib, and anti-PD-1 monoclonal antibodies in patients with uHCC.Methods: This retrospective study included 89 patients with uHCC who received donafenib, anti-PD-1 monoclonal antibodies (tislelizumab or sintilimab), and interventional therapies (TACE and/or HAIC) between March 2022 and December 2023. …”
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Influence of Socio-Demographic, Occupational and Lifestyle Variables on Sleep Time by Dutheil F, Saint-Arroman C, Clinchamps M, Flaudias V, Fantini ML, Pereira B, Berthon M, Laporte C, Baker JS, Charkhabi M, Cocco P, Lecca R, Puligheddu M, Figorilli M, Zak M, Ugbolue UC, Ubago-Guisado E, Gracia-Marco L, Bouillon-Minois JB, Vialatte L

“…Therefore, we aimed to evaluate the influence of those variables on sleep time, and to study risk factors of being a short sleeper.Methods: The COVISTRESS international study is an online questionnaire using the secure REDCap® software. …”
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Characteristics and Quality of Life of Patients with COPD with Different Degrees of Exercise-Induced Desaturation on Six-minute Walk Test by Gao B, Wang S, Zhao L, Liao H, Qumu S, Wang P, Yang T, Jiang S

“…Beiyao Gao,1,&amp;ast; Siyuan Wang,1,&amp;ast; Li Zhao,2– 5,&amp;ast; Hongbin Liao,6 Shiwei Qumu,4,5,7 Peijian Wang,1 Ting Yang,4,5,7 Shan Jiang1 1Department of Rehabilitation Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Lung Transplantation, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3National Center for Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 4National Clinical Research Center for Respiratory Diseases, Beijing, People’s Republic of China; 5Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; 6Department of Clinical Medicine, Peking University, Beijing, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Shan Jiang, Email landjiang@126.com Ting Yang, Email zryyyangting@163.comObjective: To identify predictive factors for different exercise-induced desaturation (EID) severities and evaluate health-related quality of life six months later in chronic obstructive pulmonary disease (COPD) patients.Methods: This retrospective study consecutively analyzed 116 COPD outpatients (male: 82.8% [96/116]; age: 63.48 ± 7.48 years; disease severity distribution: GOLD 1/2/3/4 = 55.8%/34.6%/7.7%/1.9%). …”
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European Beech (Fagus sylvatica L.): Quasi-Virgin Forest Stand of the Gorgany Mts.: Structure, Vascular Plants Diversity, Health Conditions by Yuriy Shparyk, Ivan Danylyk, Oleksandr Kuzyarin, Ivan Senchak, Nazar Kruk

“…The studies were carried out using traditional forest inventory methods in permanent and temporary experimental plots. …”
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Grinding power model for flute grinding of solid tools based on equivalent chip thickness by Lei REN, Jiangtao PAN, Daohui XIANG, Junjin MA, Xiaobin CUI

“…A grinding power model for flute grinding of solid tools is proposed based on equivalent chip thickness, aiming to achieve precise prediction and control of grinding power for flute grinding.MethodsA kinematic model for flute grinding is established using homogeneous coordinate transformation. …”
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Oxygen-Generating Biomimetic Nano-Herb System for Synergistic Therapy &amp;amp; Pain Relief in Triple-Negative Breast Cancer via HIF-1&amp;alpha;/VEGF Pathway by Cao DC, Liang Y, Guo Y, Wu DY, Wang NN, Li YM, Sun HF, Wang Q, Zhang X, Chi YL, Sun PP, Li YJ, Wang RR, Wang PY, Xie SY, Xie N

“…Dian-Chao Cao,1– 3,&amp;ast; Yan Liang,1,4,&amp;ast; Yang Guo,1 Dong-Yang Wu,1 Na-Na Wang,1 Yan-Mei Li,5 Hong-Fang Sun,1 Qin Wang,1 Xia Zhang,1 Yong-Liang Chi,6 Pei-Pei Sun,4 You-Jie Li,1 Ran-Ran Wang,7 Ping-Yu Wang,1,8 Shu-Yang Xie,1– 3 Ning Xie9 1Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China; 2Department of General Surgery, the second Medical College, Yantai Affiliated Hospital, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China; 3Shandong Laboratory of Advanced Materials and Green Manufacturing, Yantai, Shandong, 264000, People’s Republic of China; 4Department of Oncology, Binzhou Medical University Affiliated Hospital of Traditional Chinese Medicine, Binzhou, Shandong, 256600, People’s Republic of China; 5Department of Immune Rheumatism, Yantaishan Hospital, Yantai, Shandong, 264000, People’s Republic of China; 6Department of Anesthesiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China; 7Department of Rehabilitation Engineering, Institute of Rehabilitation Medicine, School of Rehabilitation Medicine, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China; 8Department of Epidemiology, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China; 9Department of Chest Surgery, Binzhou Medical University Affiliated Yantaishan Hospital, Yantai, Shandong, 264000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ning Xie, Department of Chest Surgery, Binzhou Medical University Affiliated Yantaishan Hospital, Yantai, Shandong, 264000, People’s Republic of China, Tel +86-0535-6913211, Fax +86 0535 6913163, Email sunnyvvv@163.com Shu-Yang Xie, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People’s Republic of China, Tel +86 0535 6913211, Fax +86 0535 6913163, Email xieshuyang@bzmc.edu.cnPurpose: This study aims to develop an innovative delivery system, (Q+M/MnOx)@Clip, to enhance the bioavailability and therapeutic efficacy of quercetin both in tumor treatment and pain alleviation.Methods: The (Q+M/MnOx)@Clip system was evaluated to enhance the release of quercetin, investigate its ability to target cancer cells, alleviate tumor hypoxia, and improve the efficacy of chemodynamic therapy (CDT). …”
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