CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation by Juan Juan Chen, Zhang Ze Lu, Yu Xin Jing, Xing Mei Nong, Yi Qin, Jin Yang Huang, Na Lin, Jie Wei

“…Herein, we investigated the differential expression biomarkers between RSV infected hospitalized patients, healthy groups and RSV infected outpatients.MethodsTwo publicly available transcriptomic datasets (GSE77087 and GSE188427) were retrieved from the Gene Expression Omnibus (GEO) database. …”
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Kirjeldamisest lavastamiseni. Loovuurimuslik vaade / From Describing to Staging: A Practice-as-Research Look by Karl Saks, Hedi-Liis Toome, Anu Sööt, Ele Viskus

“…The research shows that using ekphrasis and thin and thick description—methods used in other fields—is a fruitful practice and the description based exercises are later useful in their professional career as directors. …”
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Evaluation of the efficacy of high molecular weight hyaluronic acid with chondroitin sulfate in post-traumatic knee osteoarthritis by E. I. Bialik, M. A. Makarov, V. A. Nesterenko, V. E. Bialik, A. E. Karateev, A. A. Bialik, V. I. Stadnik

“…Objective: to evaluate the efficacy of a single or double administration of a preparation of high molecular weight hyaluronic acid (HLA) with chondroitin sulfate (CS) in post-traumatic knee osteoarthritis (OA). Material and methods. The study included 91 patients with stage III post-traumatic knee OA. …”
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Damage to the Cardiovascular System in Patients with SARS-CoV-2 Coronavirus Infection. Part 2: Correction of Myocardial Systolic Dysfunction by V. I. Podzolkov, A. I. Tarzimanova, A. E. Bragina, I. I. Shvedov, E. E. Bykova, A. A. Ivannikov, L. V. Vasilyeva

“…To study changes in myocardial contractile function when prescribing mineralocorticoid receptor antagonists of spironolactone in patients after coronavirus infection SARS-CoV-2 with symptoms of chronic heart failure (CHF).Materials and methods. The study included 90 hospitalized patients with a diagnosis of SARS-CoV-2 coronavirus infection. …”
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Overcoming challenges and achieving high HPV vaccination uptake in Cameroon: lessons learned from a gender-neutral and single-dose program and community engagement by Andreas Ateke Njoh, Dur-E-Nayab Waheed, Tchokfe Shalom Ndoula Josue Kedakse, Lionel Junior Ebongue, Eugene Justine Kongnyuy, Adidja Amani, Afizu Chrakoh Tambasho, Yauba Saidu, Mohamed II Kaba, Clovis Nchinjoh Sangwe, Herman Kenfack, Judith Seungue, Daniel Nebongo, Nadege Edwige Nnang, Alex Vorsters, Laurent Cleenewerck de Kiev

“…This paper highlights the challenges, lessons learned, and progress in HPV vaccination as part of Cameroon’s gender-neutral-single-dose approach and the periodic intensification of routine immunization (PIRI). Methods This ecological cross-sectional study, conducted from July to December 2023, examines the introduction of the HPV vaccine in Cameroon, along with associated challenges, strategies, and progress. …”
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Exploring the shared molecular mechanisms of primary hypertension and IgA vasculitis through a case report and combining bioinformatics analysis by Qijiao Wei, Jiayan Feng, Yifei Mu, Qian Shen, Hong Xu, Li Sun, Haimei Liu

“…This study aims to report this unusual case and investigate the biological mechanisms associated with the differentially expressed genes (DEGs) related to PHTN and IgAV through the application of bioinformatics tools.MethodsWe present the case of a boy diagnosed with PHTN and IgAV. …”
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Musical Expertise Reshapes Cross-Domain Semantic Integration: ERP Evidence from Language and Music Processing by Xing Wang, Tao Zeng

“…This event-related potential (ERP) study investigated whether Chinese sentences and musical chord sequences share semantic processing mechanisms and how musical expertise modulates these mechanisms. <b>Methods:</b> This study recruited 46 college students (22 musicians and 24 non-musicians). …”
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The association between vision impairment and multi-site pain in middle-aged and older adults in China: results from the China health and retirement longitudinal study by Tianyi Luo, Cunzi Li, Lan Zhou, Lan Zhou, Yingrui Liu, Hongyan Sun, Ming Ming Yang

“…BackgroundPrevious research on the association between vision impairment (VI) and multi-site pain has been sparse, and no studies have specifically examined this relationship in low- and middle-income countries (LMICs).ObjectiveThis study aims to investigate the relationship between VI and the coexistence of pain in 15 different body sites and multi-site pain among middle-aged and older adults in China using nationally representative survey data.MethodsWe conducted a cross-sectional study using data from the 2020 China Health and Retirement Longitudinal Study (CHARLS), which included 10,240 participants. …”
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[18F]F-FMISO and [18F]F-FLT PET/CT dual-nuclide imaging for in vivo prediction of drug resistance in pancreatic cancer by SUN Chenwei, HAI Wangxi, QU Qian, XI Yun

“…Objective·[18F]F-FMISO and [18F]F-FLT are specific PET imaging agents for detecting the hypoxia microenvironment and cell proliferation, respectively. This study aims to visualize and monitor the impact of drug resistance in pancreatic cancer on the hypoxia microenvironment and cell proliferation through [18F]F-FMISO and [18F]F-FLT PET/CT dual-nuclide imaging, with the goal of providing a theoretical basis for clinical application.Methods·The CCK-8 assay was conducted to assess drug resistance in the PANC-1/R (PR) pancreatic cancer cell line compared to the parental PANC-1 (P) cell line. …”
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Implantation of a long biological patch in classical carotid endarterectomy for extended atherosclerotic lesions. Long-term outcomes by A. N. Kazantsev, M. A. Chernyavsky, R. A. Vinogradov, V. N. Kravchuk, D. V. Shmatov, A. A. Sorokin, S. V. Artyukhov, V. V. Matusevich, V. A. Porkhanov, G. G. Khubulava

“…Objective: to analyze the in-hospital and long-term outcomes of classical carotid endarterectomy (CEE) in extended atherosclerotic lesions in comparison with the outcomes of this operation in local atherosclerotic plaque (AP). Materials and Methods. This study, which lasted from January 2010 to December 2020, included 148 patients with extended AP and hemodynamically significant internal carotid artery (ICA) stenosis. …”
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Outcomes of Cooled Radiofrequency Ablation of Lumbar Nerves as Treatment for Chronic Low Back Pain by Alaa Abd-Elsayed, Trevor N. Johnson, Kylie K. Ruprecht, Tristan R. Argall, Lukas J. Henjum, Kenneth J. Fiala

“…This study investigates whether patients receiving CRFA for relief of chronic low back pain caused by lumbar facet arthropathy experience a reduction in pain scores, the length of this reduction in pain scores, and the magnitude of this reduction in pain. Methods This study was a retrospective analysis of data extracted from UW-Health Electronic Medical Health records (EMR), encompassing lumbar CRFA procedures performed from 2015 through April of 2024. …”
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Extended-view totally extraperitoneal approach for midline primary and incisional ventral hernia repair: Initial results and experience from a single institution in Vietnam by Van Phu La, Vinh Phuc La, Hai Duong Tong, Minh Dien Tran, Tuan Tu Duong, Vimal Kumar Vasudeavan, Hadinata Prana, Anh Vu Doan

“…This study aimed to evaluate the initial outcomes and institutional experience of the e-TEP technique for midline primary and incisional ventral hernia repair at a tertiary center in Vietnam. Methods: This prospective descriptive study was conducted on 65 patients with midline primary or incisional ventral hernias who underwent e-TEP repair between June 2022 and August 2024. …”
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H‐Shaped Anatomical Titanium Plate: Biomechanical Validation and Clinical Application in the Treatment of Complex Posterior Wall/Column Acetabular Fractures by Qiaoli Zhang, Liang Jin, Xiaorui Hao, Weijie Zheng, Fei Zhou, Shuxin Zhang, Tianfeng Li, Xiaohui Xiong, Yihan He, Xiaojie Chen, Jiexin Huang

“…This study aims to conduct biomechanical testing and clinical evaluation of HTP to assess its stability and efficacy in treating these fractures. Methods In the biomechanical research, posterior column with posterior wall fractures was created on nine acetabular models procured from Sawbones, USA and were allocated to three fixation groups: (1) a single reconstruction plate combined with a single cortical screw (PCS), (2) double parallel reconstruction plates (2P), (3) HTP. …”
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The safe lowest effective power of subthreshold micropulse laser treatment in Chinese patients with acute or chronic central serous chorioretinopathy by Ting Xie, Ting Xie, Wangting Li, Linli Wang, Jiafeng Ning, Zhi Li, Yulei Chen, Xifeng Lin, Shaolin Du, Qingshan Chen

“…PurposeTo assess the safe, lowest effective laser power of subthreshold micropulse laser (SML) for treating acute and chronic central serous chorioretinopathy (CSC) in Chinese patients.MethodsPatients were distinguished with acute or chronic CSC based on focal or diffuse retinal pigment epithelium (RPE) leakage on fundus fluorescein angiography (FFA), with or without widespread RPE decompensation. …”
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Systemic inflammatory and oxidative stress biomarkers as predictors of pain in sequential bilateral phacoemulsification for age-related cataract by Peng Yin, Peng Yin, Liyuan Wang, Yongsheng Hou, Yang Huang, Dawei Sun, Dewang Shao

“…This study investigated whether systemic inflammatory biomarkers and oxidative stress indicators could predict and explain the differential pain experience in sequential bilateral phacoemulsification for age-related cataract.MethodsIn this prospective, single-blinded case-control study, we enrolled 80 patients with age-related cataract undergoing sequential bilateral phacoemulsification. …”
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Sociodemographic factors associated with health-related quality of life in UK healthcare workers: a cross-sectional study by Christopher A. Martin, Rebecca F. Baggaley, Lucy Teece, Daniel Pan, Joshua Nazareth, Luke Bryant, Carol Rivas, Katherine Woolf, Manish Pareek, The UK-REACH study collaborative group

“…We also examined EQ-5D-5L visual analogue scale (VAS) scores using linear regression. …”
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Effectiveness of Platelet-rich Plasma Therapy and Limberg Flap Reconstruction in the Management of Pilonidal Sinus Disease: A Prospective Observational Study by S Vinith Balaji, K Thinagaran, Reegan Jose, Najeem Fazil, Mohana Vamsi, Arafath Iqbal

“…Aim: To compare the wound healing duration, postoperative pain levels, recurrence rates and postoperative complications between PRP therapy and Limberg flap reconstruction in the management of PSD. Materials and Methods: A prospective observational study was conducted in the Department of General Surgery at SRM Medical College Hospital and Research Institute, Chennai, Tamil Nadu, India from January to December 2024, involving 62 patients. …”
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ENABLE—App-Based Digital Capture and Intervention of Patient-Reported Quality of Life, Adverse Events, and Treatment Satisfaction in Breast Cancer: Protocol for a Randomized Contro... by Thomas M Deutsch, Léa L Volmer, Manuel Feisst, Laura Bodenbeck, Kathrin Hassdenteufel, Lara Tretschock, Christiane Breit, Stefan Stefanovic, Armin Bauer, Carolin Anders, Lina Weinert, Tobias Engler, Andreas D Hartkopf, Nico Pfeifer, Pascal Escher, Marc Mausch, Oliver Heinze, Marc Suetterlin, Sara Y Brucker, Andreas Schneeweiss, Markus Wallwiener

“…Additionally, it assessed the impact of a patient-reported outcome–based intervention across various therapy settings. MethodsPatients with breast cancer were eligible to participate in the study before neoadjuvant, adjuvant, postneoadjuvant, or palliative systemic therapy against breast cancer was initiated at the Heidelberg, Mannheim, and Tuebingen, Germany, university hospitals. …”
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Effect of Floating Needle Perfusion Therapy combined with Joint Mobilization on Shoulder Pain of Hemiplegia after Stroke by Xin WANG, Hu LI, Xiuyan LU

“…Objective:To observe the effect of floating needle perfusion therapy combined with joint mobilization on shoulder pain of hemiplegia after stroke. Methods: A total of 90 hemiplegia patients with shoulder pain after stroke in the department of rehabilitation medicine of Shandong Provincial Third Hospital from February to December 2019, which were divided into the control group, the floating needle group and the comprehensive group according to the random number table, with 30 cases in each group. …”
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The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial by Sewar Khatib, Yuval Palgi, Yoni K Ashar, Natalya Polyvyannaya, Pavel Goldstein

“…ObjectiveThis randomized controlled trial examines the specific and combined effects of brief SS and TS interventions on older adults’ physical and mental health and pain intensity levels, among individuals living in nursing homes. MethodsA total of 96 patients aged 65-99 years from a nursing home were randomly assigned to 3 groups: SS, TS, and combined SS+TS interventions, each delivered as four 20-minute sessions. …”
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