Apatinib plus camrelizumab (anti-PD1 therapy, SHR-1210) for advanced osteosarcoma (APFAO) progressing after chemotherapy: a single-arm, open-label, phase 2 trial by Xin Sun, Yuan Li, Jie Xu, Wei Guo, Yi Huang, Lu Xie, Jin Gu, Kuisheng Liu, Bingxin Zheng, Tingting Ren, Xiaodong Tang, Taiqiang Yan, Rongli Yang, Kunkun Sun, Danhua Shen

Get full text

Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind c... by Una Martin, Timothy Barrett, Susan Mollan, Karen E Morrison, Ruth Evans, Isabelle Meunier, Rajat Gupta, Andrew Peet, Martin Wilson, Sulev Koks, Wojciech Młynarski, Patrick Yu-Wai-Man, Agathe Roubertie, Darren Barton, Dewi Astuti, Renuka P Dias, Lucinda Billingham, Kun Hu, Malgorzata Zatyka, Archana Kulkarni, Benjamin Wright, Kristian Brock, Victoria Homer, Rebecca Malpass, Heather Rose, Christophe Orssaud, Zsuzsanna Nagy, Tracy Lynch, Sabrina Cronier, Amandip Malhi, Pooja Takhar, Amy Lamb, Gema Esteban-Bueno

“…To date, there have been no multicentre randomised controlled trials investigating the efficacy of treatments for neurodegeneration in patients with Wolfram syndrome.Methods and analysis TREATWOLFRAM is an international, multicentre, double-blind, placebo-controlled, randomised clinical trial designed to investigate whether 36-month treatment with up to 40 mg/kg/day of sodium valproate will slow the rate of loss of visual acuity as a biomarker for neurodegeneration in patients with Wolfram syndrome. …”
Get full text

Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial by Kristine Godziuk, Mary Forhan, Flavio T. Vieira, Joao F. Mota, Jason Werle, John A. Batsis, Lorenzo M. Donini, Mario Siervo, Carla M. Prado

“…We investigated the feasibility and efficacy of a multimodal behavioural intervention compared to usual care to enhance physical function and muscle mass in this population. Methods The POMELO (Prevention Of MusclE Loss in Osteoarthritis) study is a two‐arm pilot randomized controlled trial; NCT05026385. …”
Get full text

Comparison of the efficacy and safety of various anti-inflammatory drugs in urate-lowering therapy initiation in patients with gout (preliminary data) by M. N. Chikina, M. S. Eliseev, O. V. Zhelyabina

“…Non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and glucocorticoids (GC) are used to prevent arthritis attacks in gout, but data on their comparative effectiveness is lacking.Objective: to compare the efficacy and safety of various anti-inflammatory drugs at the start of treatment in patients with gout.Patients and methods. Of the 108 patients with gout, observed in the V.A. …”
Get full text

User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…ObjectiveThis study aimed to clarify how a digital behavioral intervention for people with chronic pain can be developed through a user-centered approach to address the needs and preferences of the target population. MethodsThis study used a multimethod approach involving end users, namely, patients with chronic pain and therapists, to develop prototypes for a digital behavioral intervention across 3 phases. …”
Get full text

Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity by Linrong He, Xiaoming Shu, Xia Liu, Yongpeng Ge, Sizhao Li, Xin Lu, Guochun Wang

“…To investigate the role of soluble interleukin-2R (sIL-2R) in idiopathic inflammatory myopathies (IIM). Methods. Serum sIL-2R levels were measured in 74 dermatomyositis (DM), 16 immune-mediated necrotizing myopathy (IMNM), 24 rheumatoid arthritis (RA), 20 systemic lupus erythematosus (SLE), and 20 healthy controls (HCs) by chemiluminescent immunometric assay. …”
Get full text

The first experience of using upadacitinib in the treatment of rheumatoid arthritis in real clinical practice (results of the multicenter project “RACURS”) by V. N. Amirjanova, A. E. Karateev, E. Y. Pogozheva, A. A. Baranov, V. I. Mazurov, R. R. Samigullina, O. N. Anoshenkova, N. A. Lapkina, T. Yu. Grineva, E. L. Nasonov, A. M. Lila

“…During the first week of taking the drug, there was a marked decrease in pain from 60 to 30 mm on a visual analogue scale, which lasted until the third month of therapy. …”
Get full text

Differential correlations of refractive error, axial length, and axial length-to-corneal curvature ratio with anterior segment biometrics in myopic refractive surgery candidates by Jian Zhang, Youlin Zhu, Ping Yuan, Xiaojuan Dong, Manyun Xie, Zongrui Ma, Rong Tian

Get full text

Age-related features of calcium pyrophosphate deposition disease by M. S. Eliseev, O. V. Zhelyabina, M. N. Chikina

“…The age-related features of the disease have not been studied.Objective: to study age-related features of CPPD.Subjects and methods. A total of 113 patients (54 men and 59 women) who had received inpatient or outpatient treatment at the V.A. …”
Get full text

Comparison of the effects of IMRT and IMPT on MRI features of normal brain tissue: a retrospective study by Jian Xu, Lili Zhang, Tingting Liu, Qingzeng Liu, Jian Zhu

“…And evaluate the potential application value of radiomic features in dose optimization and biological dose assessment. Methods A retrospective analysis included 113 patients undergoing brain-target radiotherapy: 44 receiving IMPT (average total dose: 5713.63 ± 774.32 cGy) and 69 receiving IMRT (average total dose: 5489.86 ± 627.05 cGy). …”
Get full text

The i‐gel® supraglottic airway device compared to endotracheal intubation as the initial prehospital advanced airway device: A natural experiment during the COVID‐19 pandemic by Daniel B. Levi, Joris Hoogendoorn, Shenae Samuels, Lindsay Maguire, Ruben Troncoso, Scott Gunn, Matthew Katz, Christine VanDillen, Susan A. Miller, Jay L. Falk, Steven H. Katz, Linda Papa

“…The objective was to compare first‐pass success and timing to successful airway placement between ETI and the i‐gel® SGA under extenuating circumstances. Methods This pre/post study compared airway placement metrics in prehospital patients requiring advance airway management for non‐trauma‐related conditions. …”
Get full text

Triple positivity for autoantibodies in patients with rheumatoid arthritis is associated with a severe course of the disease but not with bone turnover markers by Tomasz Budlewski, Joanna Sarnik, Olga Brzezinska, Anna Lewandowska-Polak, Tomasz Poplawski, Joanna Samanta Makowska

“…This study aimed to evaluate the correlation between autoantibody profiles, disease activity, bone turnover markers, and selected SNPs in a cohort of Polish RA patients. Material and methods A total of 138 RA patients from the Department of Rheumatology, Medical University of Lodz, were enrolled. …”
Get full text

Evaluating the Efficacy and Safety of 48-Week Low-Dose Dienogest Administration in Patients With Dysmenorrhea Caused by Endometriosis: Protocol for a Randomized, Open-Label, Parall... by Kyoko Kikuno, Ryuta Asada, Takuma Ishihara, Yoshimasa Bomoto, Saki Murase, Yoko Ueda, Tomomi Shiga, Yoh Hayasaki, Tatsuro Furui, Satoko Matsuzaki, Masahiko Takemura, Kazutoshi Matsunami, Makoto Kubo, Naoki Ito, Masanori Isobe, Ken-ichirou Morishige

“…The primary endpoint is the change in the pain visual analog scale (VAS) score from baseline to 48 weeks. …”
Get full text

Patient-specific computational flow simulation reveals significant differences in paravisceral aortic hemodynamics between fenestrated and branched endovascular aneurysm repair by Kenneth Tran, MD, Celine Deslarzes-Dubuis, MD, Sebastien DeGlise, MD, Adrien Kaladji, MD, Weiguang Yang, PhD, Alison L. Marsden, PhD, Jason T. Lee, MD

“…This study sought to use patient-specific computational flow simulation (CFS) to assess differences in postoperative hemodynamic effects associated with fEVAR vs bEVAR. Methods: Patients from two institutions who underwent four-vessel fEVAR with the Cook Zenith Fenestrated platform and bEVAR with the Jotec E-xtra Design platform were retrospectively selected. …”
Get full text

In vitro Study of Fungus-Like Organisms Peronospora ficariae and Wilsoniana bliti as Potential Inhalant Allergens by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…This research sought to explore the potential of two fungus-like species from the Peronosporales (Peronospora ficariae) and Albuginales (Wilsoniana bliti) to induce a proinflammatory response in vitro models of the upper and lower respiratory tract.Materials and Methods: BEAS-2B and A549 cell lines were used to mimic upper and lower respiratory epithelial cells. …”
Get full text

Expression characteristics of miR-502-5p/p53/NF-κB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodolo... by Xiaozhe Zhang, Kesong Shi, Anmin Ruan, Pu Chen, Tao Zhang, Qingpu Wang

“…This study aimed to investigate the expression patterns and correlations of the miR-502-5p/p53/NF-κB signaling pathway in KOA synovial tissue across different disease severities. Methods This cross-sectional observational study enrolled 80 KOA patients undergoing knee arthroscopy from March 2019 to October 2019, stratified by Kellgren-Lawrence (KL) grades (20 patients per grade). …”
Get full text

Acupuncture effects of post-stroke thalamic pain: a systematic review and meta-analysis of randomized controlled trials by Tianwei Zhang, Tianwei Zhang, Junying Zhai, Junying Zhai, Ling Cheng, Ling Cheng, Kaixin Jiang, Kaixin Jiang, Dayang Wang, Huawei Shi, Bin Wang, Xing Chen, Xinglu Dong, Li Zhou

“…This systematic review and meta-analysis aimed to evaluate the efficacy and safety of acupuncture treatment for PS-TP.MethodsAccording to the established search strategy, randomized controlled trials (RCTs) of acupuncture therapy for PS-TP were retrieved from eight Chinese and English databases as well as two clinical trial registration platforms, up to February 2024. …”
Get full text

Capabilities of Dynamic Magnetic Resonance Angiography in Patients With Cerebral Aneurysms in the Postoperative Period by D. O. Kardailskaya, E. I. Zyablova, T. N. Trofimova, I. N. Sever, D. V. Litvinenko, V. V. Tkachev, V. A. Pоrhanov

“…Magnetic resonance angiography (MRA) has recently become increasingly attractive for the follow-up of surgically treated CAs because it is noninvasive, does not require hospitalization, and reduces complications associated with the frequent use of cerebral angiography.Objective: To evaluate capabilities of dynamic MRA in postoperative monitoring of patients with CAs.Materials and methods: The study was conducted at the premises of the Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1 (Krasnodar, Russian Federation). …”
Get full text

Application of auricular acupoint scraping therapy in postoperative patients with lower extremity fracture (耳穴推刮术在下肢骨折术后患者中的应用) by GUI Huiqiong (桂辉琼), WANG Yihua (王一华), YUAN Qingna (袁庆娜), JI Chen (冀晨), YANG Yihua (杨毅华)

“…Objective To observe the effect of auricular acupoint scraping therapy on postoperative pain and sleep quality of patients with lower extremity fracture. Methods Totally 70 cases of patients undergoing surgery for lower limb fracture were randomly divided into control group and observation group, with 35 cases in each group. …”
Get full text

Effect of bagging on nutritional quality and mineral element content of peach fruit in different varieties by CHEN Meng, ZHANG Xue, LI Yue, LI Yong, CHEN Xiaolong, CHEN Jian, YU Xiangyang

“…The study aimed to evaluate the impact of bagging on the nutritional quality and mineral element content of peach fruit in various varieties. [Methods] Three peach varieties from Jiangsu including Baifeng, Xiacui, and Xiahui were tested. …”
Get full text