Gadoxetic acid-enhanced MRI for identifying cholangiocyte phenotype hepatocellular carcinoma by interpretable machine learning: individual application of SHAP by Wei Liu, Zhiping Cai, Yifan Chen, Xingqun Guan, Jieying Feng, Haixiong Chen, Baoliang Guo, Fusheng OuYang, Chun Luo, Rong Zhang, Xinjie Chen, Xiaohong Li, Cuiru Zhou, Shaomin Yang, Ziwei Liu, Qiugen Hu

“…This study aims to develop and validate an optimal machine learning model to predict cholangiocyte phenotype HCC based on T1 mapping gadoxetic acid-enhanced MRI and to implement individual applications via the Shapley Additive explanation (SHAP). Methods We included 180 patients with histologically confirmed HCC from two institutions. …”
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Post-exertional malaise in Long COVID: subjective reporting versus objective assessment by Barbara Stussman, Nathan Camarillo, Gayle McCrossin, Marybeth Stockman, Gina Norato, C. Stephenie Vetter, Alenka Ferrufino, Ashade Adedamola, Nicholas Grayson, Avindra Nath, Leighton Chan, Brian Walitt, Lisa M. K. Chin

“…Secondarily, Long COVID symptom responses to exercise were compared to those of ME/CFS and healthy volunteers.MethodsData from three registered clinical trials comprised four cohorts in this study: Long COVID Questionnaire Cohort (QC; n = 244), Long COVID Exercise Cohort (EC; n = 34), ME/CFS cohort (n = 9), and healthy volunteers (HV; n = 9). …”
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EFFICIENCY OF DYNAMIC ELECTRONEUROSTIMULATION IN KNEE OSTEOARTHRITIS: RESULTS OF A MULTICENTER RANDOMIZED STUDY by O. M. Lesnyak, E. Yu. Kadochnikova, L. I. Alekseeva, I. G. Dydykina, O. B. Ershova, E. M. Zaitseva, T. A. Korotkova, T. A. Popova, M. L. Sukhareva, E. A. Taskina, V. N. Khodyrev, E. P. Sharapova, A. G. Solodovnikov, A. A. Vlasov

“…Dynamic electroneurostimulation (DENS) is a type of percutaneous electroneurostimulation with a differentiation approach to choosing exposure areas and to optimizing electrocutaneous therapeutic action on the reflexogenic areas and acupuncture points for analgesia and for the treatment of functional disorders.Objective: to study the clinical efficiency and safety of therapy using a DiaDENS-PC apparatus in the treatment of knee osteoarthritis (OA).Subjects and methods. A multicenter randomized double-blind placebo-controlled study was conducted in 132 knee OA patients with pain value above 40 mm on visual analogue scale (VAS) and Lequesne’s index of 4–12. …”
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The effect of taurine supplementation on markers of muscle damage and muscle pain in an athletic population: A systematic review and meta-analysis of randomized controlled trials a... by Elaheh Dehghani, Fatemeh Naeini, Sakineh Shab Bidar, Mohammad Beba, Erfan Mortezapour, Ruhollah Nourian, Khashayar Danandeh, Zahra Gohari Dezfuli, Kurosh Djafarian

“…This systematic review and meta-analysis examines the effects of TS on EIMD and muscle pain in athletes. Methods: PubMed, Scopus, and Web of Science were systematically searched for randomized controlled trials (RCTs) on TS in athletic populations until March 2025. …”
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Circulating DNA methylation level of CXCR5 correlates with inflammation in patients with rheumatoid arthritis by Yiming Shi, Cen Chang, Lingxia Xu, Ping Jiang, Kai Wei, Jianan Zhao, Linshuai Xu, Yehua Jin, Runrun Zhang, Huijuan Wang, Yi Qian, Yingying Qin, Qin Ding, Ting Jiang, Shicheng Guo, Rongsheng Wang, Dongyi He

“…Abstract Objectives To assess the differences in circulating DNA methylation levels of CXCR5 between rheumatoid arthritis (RA) and osteoarthritis (OA) and healthy controls (HC), and the correlation of methylation changes with clinical characteristics of RA patients. Methods Peripheral blood samples were collected from 239 RA patients, 30 patients with OA, and 29 HC. …”
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Implementing a Common Data Model in Ophthalmology: Mapping Structured Electronic Health Record Ophthalmic Examination Data to Standard Vocabularies by Justin C. Quon, MD, Christopher P. Long, MD, William Halfpenny, MBBS, MEng, Amy Chuang, MS, Cindy X. Cai, MD, MS, Sally L. Baxter, MD, MSc, Vamsi Daketi, MS, Amanda Schmitz, BS, Neil Bahroos, MS, Benjamin Y. Xu, MD, PhD, Brian C. Toy, MD

“…Subjects: Not applicable. Methods: Source eye examination data elements from the default Cerner Model Experience EHR and a local implementation of the Cerner Millennium EHR were extracted, classified into one of 8 subject categories, and mapped to the semantically closest standard concept in the OMOP CDM. …”
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Evidence of functional connectivity disruptions between auditory and non-auditory regions in adolescents living with HIV by Joanah Madzime, Joanah Madzime, Marcin Jankiewicz, Marcin Jankiewicz, Marcin Jankiewicz, Ernesta M. Meintjes, Ernesta M. Meintjes, Ernesta M. Meintjes, Peter Torre, Barbara Laughton, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes, Martha J. Holmes

“…Investigating the functional connectivity (FC) within the CAS and between the CAS and non-auditory regions may reveal the influence of HIV on regions involved in auditory function.MethodsWithin a Bayesian statistical framework, we used resting-state functional magnetic resonance imaging to map FC in the CAS as well as between CAS regions and non-auditory regions of 11-year-old CPHIV. …”
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Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…As group therapy has proven to be a valuable and effective treatment option for managing anxiety and depression, the aim of this study was to determine its effects on patients with CHD and anxious–depressive symptoms. <i>Methods</i>: We used non-pharmacological psychological group intervention, of six weekly sessions of 90 min each, administered by trained personnel, in adult patients with CHD. …”
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Searching for Axion Dark Matter Gegenschein of the Vela Supernova Remnant with FAST by Wenxiu Yang, Yitian Sun, Yougang Wang, Katelin Schutz, Yichao Li, Calvin Leung, Wenkai Hu, Shuanghao Shu, Kiyoshi Masui, Xuelei Chen

“…Based on our observation strategy, data processing methods, and results, the expected sensitivity will reach ∼10 ^−11 GeV ^−1 with ∼2000 hr of observation in the future.…”
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Conventional and Conformal Radiotherapy with and without Beam Intensity Modulation in Patients with Stage II Hodgkin’s Lymphoma with Supradiaphragmal Lesions by YuN Vinogradova, EI Ivanova, AI Chumachenko, EV Smirnova, GI Andreev, AM Kalesnik, NA Vorob’ev, NV Il’in

“…Overall 5- and 10-year survival (OS) was equal and accounted for 98.0 ± 1.4 %, the disease-free survival (DFS) was also equal between groups and accounted for 85.9 ± 1.3 %. …”
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A Comparative Analysis of Energy Efficiency of Two Sprinkler Irrigation Systems for Wheat Cultivation (Case Study: Dehgolan Plains, Kurdistan) by P. Tahmasbi, F. Dalvand, S.A. Hosseini, B. Karimi, H. Ghadrshnas

“…The main objective of this study is to evaluate the energy consumption indexes of wheat in farms under fixed-mobile sprinkler classic and Willet rain irrigation systems. Materials and MethodsThis study was conducted in the farms of Dehgolan plains where the energy consumption trend of input factors in two irrigation systems was investigated. …”
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Partial volume effect correction impairs the diagnostic utility of [18F]-THK-5351 PET in nonfluent-agrammatic variant primary progressive aphasia by Patrick J. Sommer, Sebastian Schuster, Oliver Goldhardt, Nobuyuki Okamura, Felix Mueller-Sarnowski, Maximilian Scheifele, Florian Eckenweber, Annika Kreuzer, Maria Griessl, Peter Bartenstein, Thomas Wegehaupt, Lucas Wolski, Josef Priller, Axel Rominger, Leonie Beyer, Timo Grimmer, Matthias Brendel

“…The aim of this study was to challenge partial volume effect correction (PVEC) in patients with nonfluent-agrammatic variant primary progressive aphasia (nfv-PPA) imaged with [18F]-THK-5351 PET a marker of reactive neuroinflammatory astrogliosis as well as tau-binding. Methods: Patients with nfv-PPA (n = 20) were imaged with [18F]-THK-5351 PET accompanied by structural magnetic resonance tomography imaging (MRI). …”
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Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respirator... by Mike Clarke, Marc Chikhani, Cliona McDowell, Ranjit Lall, Michael McKelvey, Margaret McFarland, Brenda O'Neill, Cecilia O'Kane, Murali Shyamsundar, Gavin Perkins, Clifford C Taggart, Gordon Sturmey, Barry Williams, John Warburton, Paul Dark, Bronwen Connolly, Ashley Agus, Naomi Dickson, Mark Borthwick, Bronagh Blackwood, Daniel F McAuley, Christina Campbell, Judy Bradley

“…Participants will be equally allocated across four trial arms. All participants will receive usual airway clearance management. …”
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HPV genotyping agreement between paired cervical cytological sample and biopsy across lesion severity and vaccination by Shimin Chen, Qiaoyun Du, Jian Yin, Xiaoqian Xu, Wen Chen, Qinjing Pan, Xun Zhang, Ying Hong, Wenhua Zhang, Bin Liu, Jianfeng Cui, Shangying Hu, Fanghui Zhao

“…Thus, investigating genotyping agreement between these two sample types and potential influence of lesion severity and vaccination status on their degree of concordance is essential for understanding their diagnostic reliability. Methods Paired cervical cytological samples and formalin-fixed paraffin-embedded (FFPE) biopsies from 392 cervical intraepithelial neoplasia or cancer (CIN+) cases (187 CIN1, 111 CIN2, 94 CIN3+; 262 unvaccinated, 130 vaccinated) were genotyped using SPF10-DEIA-LiPA25 detection system. …”
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From rural practice to scientific evidence: synergistic antiplasmodial and antioxidant properties of combined Ageratum conyzoides and Bidens pilosa extracts by Patrick Valere Tsouh Fokou, Courthney Akwi Mboh, Kenneth Lifoter Navti, Marius Jaurès Tsakem Nangap, Raoul Kemzeu, Canis Parfait Donbou Djiotie, Aubin Youbi Kamche, Hubert Nana Djigang, Arnold Tegen Tah, Mariscal Brice Tchatat Tali, Lauve Rachel Tchokouaha Yamthe, Vincent Ngouana, Fabrice Fekam Boyom

“…Aim: This study evaluates the in vitro and in vivo antiplasmodial, hemolytic, and antioxidant activities of a combined extract of Ageratum conyzoides (A. conyzoides) and Bidens pilosa (B. pilosa), a traditionally used but scientifically unvalidated combination. Methods: Plant leaves were extracted via aqueous decoction and cold maceration, combining equal parts to mimic traditional preparation. …”
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Efficacy of Kegan Liyan oral liquid vs. Lianhuaqingwen capsules for patients with mild COVID-19: a double-blinded, randomized, controlled, non-inferiority trial by Yuewei Li, Yihe Chi, Mengting Zhu, Feiting Fan, Zhongyang Deng, Jingmin Xiao, Shaohan Jin, Luoqi Lin, Xiaochun Chen, Ruhong Xu, Long Fan, Xuhua Yu, Ziyao Liang, Jingyu Quan, Shangzhao Li, Xinying Peng, Yuanbin Chen, Yuanbin Chen, Yuanbin Chen, Lin Lin, Lin Lin, Lin Lin, Lei Wu, Lei Wu, Lei Wu

“…This trial aims to assess whether KGLY is non-inferior to LHQW in treating mild COVID-19.MethodsA total of 127 participants (63 in KGLY group and 64 in LHQW group) were randomly allocated to receive either KGLY therapy or LHQW therapy in a 1:1 ratio. …”
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Deep Learning to Predict the Future Growth of Geographic Atrophy from Fundus Autofluorescence by Anish Salvi, MS, Julia Cluceru, PhD, Simon S. Gao, PhD, Christina Rabe, PhD, Courtney Schiffman, PhD, Qi Yang, PhD, Aaron Y. Lee, MD, MSCI, Pearse A. Keane, MD, FRCOphth, Srinivas R. Sadda, MD, Frank G. Holz, MD, Daniela Ferrara, MD, PhD, Neha Anegondi, MTech

“…Purpose: The region of growth (ROG) of geographic atrophy (GA) throughout the macular area has an impact on visual outcomes. Here, we developed multiple deep learning models to predict the 1-year ROG of GA lesions using fundus autofluorescence (FAF) images. …”
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Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study by Jaesub Park, Jaesub Park, Woo Jung Kim, Woo Jung Kim, Han Wool Jung, Han Wool Jung, Jae-Jin Kim, Jae-Jin Kim, Jin Young Park, Jin Young Park, Jin Young Park

“…This study aimed to explore the relationship between regional EEG abnormalities and amyloid deposition in patients with mild cognitive impairment (MCI).MethodsWe recruited 24 older adults with MCI from a community center for dementia prevention, and 21 participants were included in the final analysis. …”
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Ibuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats by Brandon M. Roberts, Alyssa V. Geddis, Alexandra Ciuciu, Marinaliz Reynoso, Nikhil Mehta, Alyssa N. Varanoske, Alyssa M. Kelley, Maximus C. Leiss, Alexander L. Kolb, Julie M. Hughes, Marshall A. Naimo, Ryan E. Tomlinson, Jeffery S. Staab

“…The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6 weeks of aerobic exercise. Methods Nine‐week‐old male Wistar rats (n = 80) were randomized to either exercise (EX) or no‐exercise control (CON) conditions and treated with naproxen, ibuprofen (IBU), flurbiprofen (FLU) or placebo (PLA). …”
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Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry by Jae Myeong Kang, Manchumad Manjavong, Chengshi Jin, Adam Diaz, Miriam T. Ashford, Joseph Eichenbaum, Emily Thorp, Elizabeth Wragg, Kenton H. Zavitz, Francesca Cormack, Anna Aaronson, R. Scott Mackin, Rachana Tank, Bernard Landavazo, Erika Cavallone, Diana Truran, Sarah Tomaszewski Farias, Michael W. Weiner, Rachel L. Nosheny

“…We hypothesized that the Everyday Cognition Scale (ECog), a subjective change measure, predicts longitudinal change in cognition in the Brain Health Registry (BHR), an online registry for neuroscience research. Methods This study included BHR participants aged 55 + who completed both the baseline ECog and repeated administrations of the CANTAB® Paired Associates Learning (PAL) visual learning and memory test. …”
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