The proportion of endometrial tumours associated with Lynch syndrome (PETALS): A prospective cross-sectional study. by Neil A J Ryan, Raymond McMahon, Simon Tobi, Tristan Snowsill, Shona Esquibel, Andrew J Wallace, Sancha Bunstone, Naomi Bowers, Ioana E Mosneag, Sarah J Kitson, Helena O'Flynn, Neal C Ramchander, Vanitha N Sivalingam, Ian M Frayling, James Bolton, Rhona J McVey, D Gareth Evans, Emma J Crosbie

“…The aim of this study was to establish the prevalence of LS and the diagnostic accuracy of LS testing strategies in an unselected EC population.<h4>Methods and findings</h4>This was a prospective cross-sectional study carried out at a large United Kingdom gynaecological cancer centre between October 2015 and January 2017. …”
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Comparison Between Low-Dose Esketamine and Dexmedetomidine on Postoperative Recovery Quality Among Patients Undergoing Humeral Trauma Surgery in Interscalene Brachial Plexus Block:... by Chen J, Qi Y, Zhang J, Sun B, Zhang M, Meng X, Zhou M, Wang L

“…In this report, we examined the effect of low-dose esketamine versus dexmedetomidine on postsurgical recovery among patients who underwent humerus surgery with interscalene brachial plexus block.Patients and Methods: In this prospective, randomized, controlled study, 141 patients aged 18 to 65 years who underwent humerus reduction and internal fixation were recruited. …”
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Development and Validation of a Predictive Nomogram for Myelosuppression Risk in Chronic Hepatitis B Patients Treated with Peginterferon by Fu J, Deng T, Zheng T, Shi P, Zhu W, Tao M, Wen Z, Wu X

“…In this study, we identified risk factors associated with increased myelosuppression, and incorporated them into a predictive nomogram.Patients and Methods: This study is designed as a case-control study. …”
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[Artículo traducido] Parámetros radiológicos preoperatorios correlacionados con la recidiva del hallux valgus después de una osteotomía en chevron distal by Y. Hernanz-González, J.C. Martínez-Ávila, E. Sánchez-Morata, A. Gómez-Sánchez, J.D. Serrano-Alonso, J. Vilá-Rico

“…The goal of this study was to analyze radiologic outcomes after distal chevron metatarsal osteotomy and to identify specific preoperative radiological parameters correlating with radiological recurrence. Materials and methods: One hundred twenty patients (134 feet) in patients with symptomatic moderate or severe HV deformity who underwent distal chevron metatarsal osteotomy at our hospital between 2014 and 2019 were included in the present study. …”
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Development and Validation of a Cost-Effective Machine Learning Model for Screening Potential Rheumatoid Arthritis in Primary Healthcare Clinics by Wu W, Hu X, Yan L, Li Z, Li B, Chen X, Lin Z, Zeng H, Li C, Mo Y, Wu Y, Wang Q

“…This study focuses on a screening model for primary healthcare, aiming to improve early RA screening accuracy and efficiency at a relatively lower cost, reducing delays in GPs’ recognition of RA.Methods: We randomly selected 2106 participants from the RA group or combined control group (comprising healthy individuals and patients with non-RA rheumatic diseases) at Peking University Shenzhen Hospital as the developing cohort. …”
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Effectiveness of Minimally Invasive Hepatectomy in Patients with Early or Intermediate-Stage Hepatocellular Carcinoma: A Multi-Institutional Cohort Study in an Asian Population by Chen HK, Chang KC, Shao SC, Soong RS, Chen YC, Wu CF, Wu TH, Chou TS, Chan SC, Lai ECC

“…However, the effectiveness of MIH has yet to be well established.Patients and Methods: This retrospective cohort study included patients aged 20 years and older, newly receiving MIH for HCC with Barcelona Clinic Liver Cancer (BCLC) classification stage 0, A or B from 2010 to 2019. …”
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Prognostic Factors and Nomogram for Klebsiella pneumoniae Infections in Intensive Care Unit by Du C, Zhang H, Zhang Y, Zhang H, Zheng J, Liu C, Lu F, Shen N

“…Therefore, we aimed to identify the risk factors for mortality in patients with K. pneumoniae infections and develop a nomogram model for prognosis.Methods: Patients diagnosed with K. pneumoniae infection were recruited from the intensive care unit of Peking University Third Hospital. …”
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Diffusion mechanisms of coal-measure helium and their implications for helium accumulation: A case study of the Taiyuan Formation, northern Qinshui Basin, China by Yong MA, Zhiyuan XIN, Jianfa CHEN, Yuhong LI, Xiutao ZHANG, Haojie JIANG, Zeya CHEN

“…This severely restricts further research on the accumulation patterns of coal-measure helium.MethodsThis study investigated a coal seam in the Taiyuan Formation in the northern Qinshui Basin and mudstones in the coal seam roof. …”
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Diffuse and Strong TTF-1 Expression Predicts Response to Pemetrexed-Based Immunochemotherapy in Advanced Lung Adenocarcinoma by Yamada J, Jimbo N, Yamasaki N, Hatakeyama Y, Kiriu T, Iwamoto N, Matsumura K, Katsurada M, Okuno K, Nakata K, Tachihara M

“…We evaluated the cut-off of TTF-1 considering the percentage of positive cells and staining intensity as a predictive factor.Patients and Methods: We conducted a retrospective multicenter study of patients with advanced lung adenocarcinoma or NSCLC favor adenocarcinoma treated with immunochemotherapy. …”
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Shu-Feng-Jie-Biao Formula Ameliorates Influenza A Virus-Induced Acute Lung Injury by Inhibiting NF-&amp;kappa;B and ERK MAPK Signaling Pathways by Lei B, Huang W, Peng W, Mu J, Liu Y, Zhou C, Cheng T, Wei X, Pan L, Zheng Y, Fang B

“…This study aimed to explore its mechanisms and effects for the treatment of influenza.Methods: Network pharmacology was used to explore the underlying mechanism of SFJBF against influenza. …”
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Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer by Xu Y, Chen X, Zhang L, Li P, He J, Zhu M, Makvandi P, Jin X

“…This study aimed to evaluate the therapeutic potential of nanomedicine-based delivery of the Aurora-A inhibitor Danusertib (Danu) in NSCLC treatment.Methods: Boron phenylalanine (BPA)-modified polydopamine (PDA) was used as a carrier to load Danu, preparing B-PDA@Danu nanoparticles. …”
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Major Predominant Serotypes and Virulence Genes and Antibiotic Resistance Characteristics of Klebsiella pneumoniae Clinical Isolates in Middle and East China by Pan WK, Chen SN, Yang MJ, Tao LP, Wang MQ, Zhang XW, Xu YH, Yan J, Qin JF, Sun AH

“…Predominant serotypes, virulence genes, and resistance characteristics of K. pneumoniae isolates from patients in different regions of China require further investigation.Methods: K. pneumoniae isolates from patients and healthy individuals in middle and east China were identified using an auto-bacterial detector. …”
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Induced Sputum Transcriptomics Profile and Serum C3 are Associated with Asthma Severity by Du F, Wang H, Chen Z, Xiong W, Wang Q, Li B, Li R, Li L, Shen Y, Zhu T

“…Then, this study aimed to explore asthma severity-associated transcriptomics profile and promising biomarkers for asthma severity prediction.Methods: In discovery cohort, induced sputum cells from 3 non-severe and 3 severe asthma patients were collected and analyzed using RNA-seq. …”
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Quercetin, a Compound of the Total Flavonoids of Periploca forrestii Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-&alpha; by Chen S, Xue W, Wu Z, Lu D, Zheng L, Zhou M, Li Y, Wang Y, Liu T

“…This study investigates the specific compounds of TFPF responsible for TNF-α inhibition and delineates their mechanism of action.Methods: L929 cells and luciferase-based assays were used to assess anti-TNF-α activity. …”
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Social Support, Quality of Life, and Financial Toxicity Among Patients with Hepatocellular Carcinoma by Liu S, Xie Y, Li T, Huang Y, Xu D, Cai L, Fu Y, Chen J, Zhang Y, Huang J, Hu Z

“…Shuyue Liu,1– 3,&amp;ast; Yawen Xie,1– 3,&amp;ast; Tiantian Li,1– 3,&amp;ast; Yanxia Huang,1– 3 Danting Xu,1– 3 Linli Cai,1– 3 Yizhen Fu,1– 3 Jinbin Chen,1– 3 Yaojun Zhang,1– 3 Jia Huang,4 Zili Hu1– 3 1Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 4Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510060, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Jia Huang, Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86 13828442672, Email hjia@mail.sysu.edu.cn Zili Hu, Department of Liver Surgery, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People’s Republic of China, Tel +86-20-87343115, Email huzl1@sysucc.org.cnBackground &amp; Aims: Despite the significant hepatocellular carcinoma (HCC) patient population, gaps exist in understanding their survivorship journey.Methods: Patients diagnosed with HCC at all stages were recruited at Sun Yat-sen University Cancer Center from August 1, 2023, to December 30, 2023. …”
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Leonurine Attenuates CCl4-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway by Wang P, Bai J, Ye M, Huang Z, Chen J, Sun L, Zhong X, Zheng Y, Ma T, Fu W, Du Y

“…This study aims to investigate the effect of Leo on liver fibrosis and clarify the mechanisms at play.Methods: We employed a mouse model of liver fibrosis induced by carbon tetrachloride (CCl4) and utilized LX-2 cells to investigate the mechanisms through which Leo exerts its effects.Results: Mice administered CCl4 displayed an elevated hepatic index, considerable necrosis as revealed by H&amp;E staining, and significantly heightened serum markers of liver injury (ALT and AST). …”
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Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study by Chen X, Wu X, Peng W, Liu L, Liu X, Wan X, Xu H, Zheng Y, Zhao H, Mao Y, Lu X, Sang X, Chang X, Zhou K, Pan J, Guan M, Hu D, Tan H, Zhang Y, Du S

“…This study evaluates the efficacy of different adjuvant treatments on disease-free survival (DFS) and overall survival (OS) in HCC patients with MVI following curative resection.Methods: A retrospective cohort of 409 HCC patients with MVI who underwent curative resection from three clinical centers between 2017 and 2024 was analyzed. …”
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Hyperspectral abdominal laparoscopy with real-time quantitative tissue oxygenation imaging: a live porcine study by Oscar MacCormac, Oscar MacCormac, Conor C. Horgan, Conor C. Horgan, Dale Waterhouse, Dale Waterhouse, Philip Noonan, Philip Noonan, Mirek Janatka, Mirek Janatka, Richard Miles, Richard Miles, Jaco Jacobs, Cameron Dockerill, Cameron Dockerill, Théo Trotouin, Théo Trotouin, Alexis Schizas, Barbara Seeliger, Barbara Seeliger, Barbara Seeliger, Sebastien Ourselin, Sebastien Ourselin, Michael Ebner, Michael Ebner, Tom Vercauteren, Tom Vercauteren, Jonathan Shapey, Jonathan Shapey, Jonathan Shapey

“…This system provides live, easy to interpret, tissue oxygenation (StO2) maps with associated quantitative values.MethodsWhite light view and tissue oxygenation maps were reconstructed from a protoype laparoscopic Hyperspectral Surgical System (HSS). …”
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Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy by Xuemei Li, Xuemei Li, Xuemei Li, Xuemei Li, Xuemei Li, Chao Xiong, Chao Xiong, Chao Xiong, Chao Xiong, Chao Xiong, Siyi Wang, Siyi Wang, Siyi Wang, Zhangjun Ren, Zhangjun Ren, Zhangjun Ren, Qi Jin, Qi Jin, Qi Jin, Jinhai Yu, Jinhai Yu, Jinhai Yu, Jinhai Yu, Jinhai Yu, Yunxiu Chen, Yunxiu Chen, Yunxiu Chen, Puying Gan, Puying Gan, Puying Gan, Puying Gan, Qihua Xu, Qihua Xu, Qihua Xu, Qihua Xu, Qihua Xu, Yaohua Wang, Yaohua Wang, Yaohua Wang, Yaohua Wang, Yaohua Wang, Hongfei Liao, Hongfei Liao, Hongfei Liao, Hongfei Liao, Hongfei Liao

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Geographical disparities in the prognosis of patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a large institution-based cohort study from... by Rui Sun, Hao Hu, Qi Yang, Liang Xu, Si-Ting Lin, Dong-Fang Meng, Li-Xia Peng, Li-Sheng Zheng, Yuan-Yuan Qiang, Yan Mei, Chang-Zhi Li, Xing-Si Peng, Yan-Hong Lang, Zhi-Jie Liu, Ming-Dian Wang, Hai-Feng Li, Bi-Jun Huang, Chao-Nan Qian

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