Cifoplastia con silicona (elastoplastia) versus cifoplastia tradicional con cemento para fracturas vertebrales osteoporóticas. ¿Esta nueva técnica reduce las complicaciones? by R. Luque, D. Garríguez, P. Checa Betegon, M. Sanchez, M. Olvera, J.L. Perez Gonzalez, I. Dominguez Esteban

“…This study's objective is to compare the results between kyphoplasty with bone cement and with the VK100 silicone. Materials and methods: This is a comparative, prospective study involving 64 patients, 23 treated using VK100 and 41 with PMMA. …”
Get full text

Acupuncture Modulates Spatiotemporal Neuronal Dynamics in Mild Cognitive Impairment: A Protocol for Simultaneous EEG-fMRI Study by Li YQ, Chen ZW, He H, Liu YW, Ye F, Yang ZQ, Li DH, Bao QN, Zhang XY, Zhong WQ, Wu KX, Yao J, Xu P, Yang SQ, Wang ZW, Yin ZH, Liang FR

“…However, no studies have investigated the detailed mechanisms underlying this effect.Methods: This randomized controlled neuroimaging trial will enroll 60 patients with MCI, who will be randomly assigned to one of two groups: a real acupuncture (RA) group or a sham acupuncture (SA) group. …”
Get full text

Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…We aimed to explore the applicability of tNGS in the co-detection of the responsible pathogens, antimicrobial resistance (AMR) genes, and virulence genes in patients with pneumonia.Methods: A prospective study was conducted among patients with suspected pneumonia at Ruijin Hospital from March 1 to May 31, 2023. …”
Get full text

Effect of Different Doses of Intrathecal Nalbuphine as Adjuvant to Hyperbaric Bupivacaine on Characteristics of Subarachnoid Block in Pelvic and Lower Limb Orthopaedic Surgeries: A... by Anupama Kumari, Shraddha Jogani, Nilesh Shah, Sara Mary Thomas

“…Aim: To compare the sensory and motor blockade, time of two-segment regression, time for rescue analgesia, haemodynamic effects and sedative effects between hyperbaric 0.5% levobupivacaine and hyperbaric 0.75% ropivacaine. Materials and Methods: This prospective, double-blinded and randomised clinical study was conducted in the Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre (a tertiary care institute), Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India, from September 2023 to July 2024, with a sample size of 40 patients. …”
Get full text

Second Victim Syndrome Among Healthcare Professionals: A Systematic Review of Interventions and Outcomes by Ong TSK, Goh CN, Tan EKYE, Sivanathan KA, Tang ASP, Tan HK, Ng QX

“…This systematic review aimed to synthesize the evidence on the outcomes of available interventions targeting SVS.Methods: We systematically searched MEDLINE, Embase, and the Cochrane Library databases, covering all records up to July 7, 2024. …”
Get full text

Effects of exercise intensity on soleus muscle myostatin and follistatin levels of hyperglycaemic rats (Efectos de la intensidad del ejercicio sobre la miostatina y folistatina de... by Sepideh Azhir, Eidy Alijani, Sergio Francisco Martínez Huenchullán, Hamid Amni, Julien Baker, Farid Farhani

“…The purpose of this study was to compare two training programs, moderate-intensity constant (MICT) and high-intensity interval training (HIIT), on soleus mRNA levels of Mstn and Fs in an animal model of hyperglycaemia. Material and Methods: 36 male Wistar rats, were divided into control (n=18) and hyperglycaemic (HG, n=18; induced by a single intraperitoneal dose of Streptozotocin) groups. …”
Get full text

TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function by Li Y, Xu W, Zhao G, Guo Y, Wang L, Du Q, Fei Y, Hu X, Hu H, Chen L, Xu Y

“…Tumor necrosis factor-associated protein 1 (TRAP1), a mitochondrial chaperone regulating stress responses, remains unexplored in DR pathogenesis.Methods: We established in vivo and in vitro models of DR. …”
Get full text

Investigation into the Efficacy of Formic Acid Fumigation for Inactivating Clinically Isolated Filamentous Fungi by Yuan K, Tian B, Zhan A, Chen Z, Ye L, Ling Y, Liu S, Bai X, Zhao Y

“…We aim to develop an efficient inactivation protocol for molds and provide valuable insights into laboratory techniques for fungal inactivation.Methods: Initially, 238 clinical isolates from 23 species of molds were evaluated for the inactivation efficacy of formic acid, formaldehyde, and peracetic acid. …”
Get full text

Chinese Massage (Tuina) Attenuates Knee Osteoarthritis by Modulating Autophagy-Related Cytokines: A Multidisciplinary Methodological Investigation by Wang Z, Zhao C, Li M, Zhang L, Diao J, Wu Y, Yang T, Shi M, Lei Y, Wang Y, Li M, Bian Y, Zhou Y, Xu H

“…Zhen Wang,1,* Chi Zhao,1,2,* Mengmeng Li,1,2,* Lili Zhang,1,* Jieyao Diao,1 Yiming Wu,2 Tao Yang,2 Mingwei Shi,2 Yang Lei,2 Yu Wang,3 Miaoxiu Li,4 Yanqin Bian,5 Yunfeng Zhou,1 Hui Xu1,2 1College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Acupuncture and Massage Department, The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 3College of Computer Science, Xidian University, Xian, People’s Republic of China; 4College of Acupuncture and Massage, Shanghai University of Chinese Medicine, Shanghai, People’s Republic of China; 5Orthopaedic Research Laboratory, University of California, Davis, CA, USA*These authors contributed equally to this workCorrespondence: Hui Xu, Email 15036065036@163.comBackground: Tuina therapy has demonstrated its potential in modulating autophagy-related factors in knee osteoarthritis (KOA); however, its core therapeutic targets and specific mechanisms require systematic elucidation through interdisciplinary research.Objective: This study investigated the mechanism by which Tuina alleviates KOA progression using multidimensional approaches, including Mendelian randomization (MR), in vivo experiments, and machine learning.Methods: Genetic data from genome-wide association studies of 60 cytokines and KOA were analyzed using MR analysis to identify autophagy-related factors significantly associated with KOA. …”
Get full text

Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model by Zhang K, Zhou F, Zhu C, Yuan L, Li D, Wang J, Lu W

“…Therefore, in the present study, we chose digoxin as the inhibitor to investigate whether HIF-1α contributes to the progression in a mouse model of COPD and possible mechanism.Methods: The COPD model was established by cigarette smoke (CS) exposed; animals were intragastrically treated with vehicle or different doses of digoxin (0.02 mg/kg and 0.1 mg/kg). …”
Get full text

Uso de Moodle para fortalecer competencias ciudadanas en estudiantes de fisioterapia: un diseño pretest-postest (Use of Moodle to strengthen citizenship competencies in physiother... by Milena Boneth-Collante, Jorge Salazar-Rodríguez, Adriana Angarita-Fonseca

“…Objective: To improve citizenship competencies through a pedagogical strategy in the Moodle platform in students registered in the training courses of clinical/administrative physiotherapy practice at the University of Santander, Bucaramanga, Colombia. Methods: A pretest-posttest design was carried out. …”
Get full text

Xietu Hemu Prescription Improves Metabolic Dysfunction-Associated Steatotic Liver Disease: A Real-World Cohort Study by Xiang LL, Cao YT, Wang XX, Wang GX, Zhang YJ, Li RH, Qi F, Huai JX, Sun J, He XJ, Zhou XQ

“…Liu-lan Xiang,1,2,* Yu-tian Cao,1,2,* Xiao-xiao Wang,3,* Gao-xiang Wang,1,* Yu-juan Zhang,4 Rui-han Li,1,2 Fang Qi,5 Jia-xuan Huai,1,2 Jing Sun,1,2 Xiao-jin He,3 Xi-qiao Zhou1 1Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China; 2The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China; 4Department of Endocrinology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 5Department of Geriatrics, Panjin Liao-Oil Field Gem Flower Hospital, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xi-qiao Zhou, Email zhouxiqiao@njucm.edu.cn Xiao-jin He, Email xomaestro@163.comPurpose: This study aims to evaluate the efficacy of the Xietu Hemu prescription (XHP) in improving metabolic dysfunction-associated steatotic liver disease (MASLD) through a Real World Study approach.Methods: This was a single-center, prospective, real-world cohort study of 262 patients with MASLD who met the inclusion and exclusion criteria from November 2021 to November 2023 at Jiangsu Provincial Hospital of Traditional Chinese Medicine. …”
Get full text

Adverse drug reactions and contributing factors in patients with drug-resistant tuberculosis: A 7-year retrospective cohort study in Addis Ababa, Ethiopia by Bisrat Solomon, Yimtubezinash Woldeamanuel, Tigest Ajeme, Mbazi Senkoro, Tsegahun Manyazewal

“…This study aimed to assess the incidence of adverse drug reactions and contributing factors in patients on drug-resistant tuberculosis treatment in Addis Ababa, Ethiopia. Methods: A facility-based, retrospective cohort study was conducted on patients with drug-resistant tuberculosis who were followed up in two major drug-resistant tuberculosis treatment sites, St. …”
Get full text

The observance of maternal rights charter in labor with postpartum anxiety in mothers delivering at maternity hospitals by Marziye Shahpari, Mahnaz Zarshenas, Marzieh Akbarzadeh

“…The present study aimed to determine the relationship between maternal rights charter observance during labor and postpartum anxiety. Materials and methods: This was a cross-sectional study. We investigated the observance of maternal rights charter using a researcher-made questionnaire. …”
Get full text

Predicting Sleeping Disorders After mTBI: A Role for Inflammation and Brain Network Biomarkers by Du R, Yu Y, Zhu X, Wang R, Yang Y, Li Y, Zhang S, Su H

“…Rui Du,1,* Yue Yu,1– 4,* Xiwen Zhu,2 Ranchao Wang,1 Yu Yang,1 Yang Li,1 Subo Zhang,3 Hui Su4 1Department of Radiology, Zhenjiang First People’s Hospital, Zhenjiang, Jiangsu, People’s Republic of China; 2Department of Surgery, Lishui People’s Hospital, Nanjing, Jiangsu, People’s Republic of China; 3Department of Radiology, The Second People’s Hospital of Lianyungang, Lianyungang, Jiangsu, People’s Republic of China; 4Department of Radiology, Gaoyou People’s Hospital, Yangzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Subo Zhang, Department of Radiology, The Second People’s Hospital of Lianyungang, No. 41 Hailian East Road, Haizhou District, Lianyungang, Jiangsu, People’s Republic of China, Tel +0518-85775003, Email zhangsubolyg@126.com Hui Su, Department of Radiology, Gaoyou People’s Hospital, No. 10, Dongyuan Road, Gaoyou, Jiangsu, People’s Republic of China, Tel +86 18852869930, Email 18852869930@163.comPurpose: To predict the occurrence of sleeping disorders (SD) in patients with mild traumatic brain injury (mTBI) 3 months after injury.Methods: This study recruited a total of 232 patients with mTBI and underwent a three-month follow-up period. …”
Get full text

PPIH Expression Correlates with Tumor Aggressiveness and Immune Dysregulation in Hepatocellular Carcinoma by Bei J, Sun Z, Fu R, Huang X, Huang J, Luo Y, Li Y, Chen Y, Wei Z

“…This study investigates the role of Peptidyl-prolyl isomerase H (PPIH) in HCC by analyzing its expression, prognosis, methylation levels, and relationship with immune cell infiltration.Methods: We utilized bulk sequencing and clinical data from UCSC Xena and the GTEx database for preprocessing and subsequent differential expression analysis of PPIH in tumor and adjacent normal tissues, evaluating prognostic parameters like overall survival and disease-free interval between low and high PPIH expression groups. …”
Get full text

Dietary Habits, Anthropometric Values, and Microvascular Reactivity in Older Persons of Both Sexes Living at Retirement Home in Osijek, Croatia by Drenjančević I, Prošić I, Firi L, Stupin A, Jukić I

“…Huttlera 4, Osijek, 31000, Croatia, Tel +385912241406, Email ines.drenjancevic@mefos.hrPurpose: To examine the correlation between dietary habits, anthropometric measurements, and microvascular reactivity with respect to sex in older adults (aged > 65 years) residing in organized accommodation within retirement homes.Patients and Methods: Sixty-nine older persons who live in a retirement home in Osijek, Croatia volunteered to participate (34 men and 35 women) in this observational cross-sectional study. …”
Get full text

Prevalence of iron deficiency in acute and chronic heart failure according to different clinical definitions by Lukas Lanser, Gerhard Pölzl, Moritz Messner, Maria Ungericht, Marc‐Michael Zaruba, Jakob Hirsch, Stefan Hechenberger, Stefan Obersteiner, Bernhard Koller, David Haschka, Hanno Ulmer, Guenter Weiss

“…The aim of this analysis was to assess the true ID prevalence in HF patients on the basis of different ID definitions. Methods We performed a retrospective analysis of 329 AHF and 613 CHF patients, recruited between 02/2021 and 05/2022 at the Innsbruck Medical University (47%/32% female, median age 81/64 years). …”
Get full text

Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) on Oxygenation in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome by Wu T, Wang T, Jiang J, Tang Y, Zhang L, Jiang Z, Liu F, Kong G, Zhou T, Liu R, Guo H, Xiao J, Sun W, Li Y, Zhu Y, Liu Q, Xie W, Qu Y, Wang X

“…This trial aimed to evaluate the effect of sivelestat sodium on oxygenation in patients with sepsis-induced ARDS.Methods: We conducted a multicenter, double-blind, randomized, placebo-controlled trial enrolling patients diagnosed with sepsis-induced ARDS admitted within 48 hours of the advent of symptoms. …”
Get full text

Selective Deletion of HLA-B, and -C Class I Genes Promotes Immunocompatibility of Humanized Skin Graft Model by Cobos-Figueroa L, Notario L, Mir C, Molpeceres C, Lauzurica S, López D, Lorente E, Lauzurica P

“…Laura Cobos-Figueroa,1,2,* Laura Notario,1,* Carmen Mir,1 Carlos Molpeceres,2 Sara Lauzurica,2 Daniel López,1 Elena Lorente,1,* Pilar Lauzurica1,* 1Centro Nacional de Microbiología, Insituto de Salud Carlos III, Majadahonda, Madrid, Spain; 2Centro Láser, Universidad Politécnica de Madrid, Madrid, Madrid, Spain*These authors contributed equally to this workCorrespondence: Laura Notario, Centro Nacional de Microbiología, Insituto de Salud Carlos III, Ctra. de Pozuelo, 28, Majadahonda, Madrid, 28222, Spain, Tel +34 918223718, Email lnotario@isciii.esBackground: The treatment of extensive burns requires rapid allogeneic skin transplantation, but HLA diversity poses a significant challenge in finding histocompatible donor-recipient matches.Methods: In this study, we developed a humanized skin graft model using HLA class I transgenic mice to closely examine the HLA-mediated immune response in skin transplantation. …”
Get full text