Insulin-Like Growth Factor Binding Protein, Acid-Labile Subunit Serum Level During the Acute and Convalescent Stage of SARS-CoV-2 Infection Depicted in a Longitudinal Study of 72 P... by Gad H, Mahmoud MA, Antar M, Sayed Ahmed A, Laudanski K

“…Here, we investigate if serum IGFALS during the acute response to SARS-CoV-2 will not be likely to accompany immune response during acute phase and convalescence.Patients and Methods: We recruited patients hospitalized with PCR-confirmed SARS-CoV-2 infection in 2020 and have blood collected after securing consent (tadm), at 48 hours (t48hrs), 7 days (t7d), and after discharge from hospital (tlong). …”
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The contribution of personalized video feedback to robotic partial nephrectomy training in realistic 3D tumor kidney models: design, production and implementation by Ahmet Furkan Sarıkaya, Kayhan Tarım, Ersin Köseoğlu, Arif Özkan, İbrahim Can Aykanat, Baris Esen, Umut Can Karaarslan, Mustafa Müdüroğlu, Şevval Kanlı, Murat Can Kiremit, Yakup Kordan, Mevlana Derya Balbay, Tarık Esen, Serdar Aydın, Serdar Aydın, Abdullah Erdem Canda, Abdullah Erdem Canda

“…This study investigates the impact of 3D-printed renal models and video-based feedback on skill acquisition in robotic partial nephrectomy training.MethodsForty urology residents without prior robotic surgery experience participated in this study. …”
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Analysis of Cardiotoxicity and Risk Factors of Breast Cancer Chemotherapy Drugs: A Five-Year Single-Centre Retrospective Study in Early Breast Cancer by Ju F, Gu H, Yu L, Zhao G, Liu Y, Yin D, Niu J, Xue T, Yin C, Jiao L, Li C, Wu J, Ji Y

“…Feng Ju,1,* Hong Gu,1,* Lijiang Yu,2 Guangyu Zhao,1 Yin Liu,1 Dengyang Yin,1 Jiali Niu,1 Ting Xue,1 Chunxia Yin,1 Lingyun Jiao,1 Chaoqun Li,1 Jian Wu,3 Yong Ji4 1Department of Pharmaceutical Administration, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 2Department of Oncology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 3Department of Rehabilitation, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 4Department of General Surgery, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Wu, Department of Rehabilitation, Jingjiang People’s Hospital Affiliated to Yangzhou University, No. 28, Zhongzhou Road, Jingjiang, Jiangsu, 214500, People’s Republic of China, Tel +86 0523-84995225, Email wu_wuwujianhh1201@21cn.com Yong Ji, Department of General Surgery, Jingjiang People’s Hospital Affiliated to Yangzhou University, No. 28, Zhongzhou Road, Jingjiang, Jiangsu, 214500, People’s Republic of China, Tel +86 0523-84995225, Email jiyong_jy615@163.comObjective: To investigate the cardiotoxicity of breast cancer (BC) chemotherapy drugs and analyse their risk factors.Methods: Through the electronic medical record system, the data of 415 patients with early BC (EBC) who had undergone a complete chemotherapy cycle were retrospectively collected within 5 years from the beginning of chemotherapy. …”
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Impact of Subsequent Treatment on Clinical Outcomes in Patients with EGFR-Mutant Non-Small Cell Lung Cancer Transformed to Small-Cell Lung Cancer by Chen CY, Ko HW, Hu PW, Chang CY, Chen CY, Chang SC, Chiu YC, Wei YF

“…This study aimed to investigate the clinical factors and treatments associated with outcomes in this group.Patients and Methods: This retrospective multicenter study enrolled patients with SCLC transformed from advanced NSCLC after progression on EGFR-TKI treatment. …”
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A Statistical Approach to Assess Biological Equivalent Mean Organ Dose (MOD) for Different Fractionations in Thoracic Radiotherapy by Siyao Zhong, Guangshan Wang, Xiaohang Qin, Yinghui Li, Bin Sun, Feng-Ming (Spring) Kong, Yuyan Gao, Jian-Yue Jin

“…<b>Purpose:</b> This study aims to provide an approach that can reasonably estimate the possibility of toxicity using a biological equivalent mean organ dose (MOD)-based model from the 2 Gy per fraction era for various fractionations. <b>Methods and Materials:</b> The dose volume histograms (DVHs) of 272 patients treated with radiotherapy for lung cancer at a prescribed dose of 2 Gy × 30 f were used for analysis. …”
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Adherence to Medical Treatment in Elderly Patients with Coronary Artery Disease in the Settings of Primary Outpatient Care by S. K. Zyryanov, S. B. Fitilev, A. V. Vozzhaev, I. I. Shkrebneva, N. N. Shindryaeva, D. A. Klyuev, L. N. Stepanyan, A. M. Lutsenko, A. T. Tsai, A. A. Danilova

“…To study medication adherence in elderly patients with coronary artery disease (CAD) in primary care practice.Material and methods. The study conducted in out-patient clinic of Moscow city. 293 elderly (≥65 years) patients with established CAD included. …”
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Distinct Airway Microbiome and Metabolite Profiles in Eosinophilic and Neutrophilic Asthma by Liu S, Lin Z, Zhou J, Yang X, You L, Yang Q, Li T, Hu Z, Zhan X, Jiang Y, Sun B

“…While allergen triggers are well-known, the role of the airway microbiome and metabolites in asthma exacerbations remains poorly understood.Methods: We recruited 64 participants (24 EA, 20 NEA, 20 healthy controls [HC]) for the discovery cohort, with validation in an external cohort (10 EA, 8 NEA, 8 HC). …”
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Comparing cervical cerclage, pessary and vaginal progesterone for prevention of preterm birth in women with a short cervix (SuPPoRT): A multicentre randomised controlled trial. by Natasha L Hezelgrave, Natalie Suff, Paul Seed, Vicky Robinson, Jenny Carter, Helena Watson, Alexandra Ridout, Anna L David, Susana Pereira, Fatemeh Hoveyda, Joanna Girling, Latha Vinayakarao, Rachel M Tribe, Andrew H Shennan, SuPPoRT Collaborating Team

“…The SuPPoRT "Stitch, Pessary, or Progesterone Randomised Trial" was designed to compare the rate of PTB <37 weeks between each intervention in women who develop a short cervix in pregnancy.<h4>Methods and findings</h4>SuPPoRT was a multicentre, open label 3-arm randomised controlled trial designed to demonstrate equivalence (equivalence margin 20%) conducted from 1 July 2015 to 1 July 2021 in 19 obstetric units in the United Kingdom. …”
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Rapid Initiation of Antiretroviral Therapy Suppresses T Cell Pathological Proliferation and Improves Immune Recovery in People Living with HIV by Ji J, Guo C, Li Z, Cai M, Wang R, Chen X, Zhang Y, Wu H, Zhang T, Zhang Y

“…The objective of this research is to examine how rapid ART affects T-cell pathological proliferation, immune recovery, and systemic inflammation in PWH.Patients and Methods: In this cross-sectional study (conducted at Beijing Youan Hospital, Capital Medical University, China, from April 1 to September 18, 2022), we recruited 39 PWH, including 23 in the rapid ART group (within 30 days) and 16 in the non-rapid ART group (after 180 days). …”
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Immunological Efficacy and Safety of a New Pneumococcal Polysaccharide Conjugated Thirteen-Valent Vaccine in the Immunization of Adults and Children (Results of Clinical Studies in... by I. V. Feldblium, M. H. Alyeva, A. V. Bikmieva, V. V. Romanenko, O. A. Rychkova, A. N. Galustyan

“…To evaluate the immunological efficacy and safety of the pneumococcal polysaccharide conjugate adsorbed thirteen-valent (PCV13) vaccine in the immunization of adults and children in theRussian Federation.Materials and methods. The immunological efficacy and safety of the pneumococcal polysaccharide conjugated adsorbed thirteen-valent vaccine were studied in a prospective comparative randomized double-blind study in parallel groups in adult volunteers aged 18 to 65 years and a multicenter open comparative study in parallel groups in young children. …”
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Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…To predict its therapeutic targets via network pharmacology and verify the therapeutic effect and the mechanism of BB against influenza virus in vitro and in vivo.Material and Methods: The potential active and underlying mechanism of BB in the treatment of influenza virus was predicted through network pharmacological strategies and Molecular Docking. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…Leveraging the radiosensitizing ability of Deruxtecan (DXd) and the internal radiation therapy of 131I for tumors, we aimed to develop the first radio-antibody-drug conjugates (RADCs) for the treatment of gastric cancer.Methods: The CLDN18.2-specific antibody HLX58 was conjugated with the payload DXd through a cleavable maleimide glycynglycyn-phenylalanyn-glycyn (GGFG) peptide linker. …”
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Spleen Volume Dynamics and Survival Outcomes in HCC Patients Undergoing Immune Checkpoint Inhibitors: A Retrospective Analysis by Fu X, Jiang S, Li Y, Guo Y, Gong B, Lou J, Li Y, Wang S, Sun Y, Ren Y, Chen Q, Yang L

“…This study investigated the prognostic impact of spleen volume (SV) on the survival in hepatocellular carcinoma (HCC) patients receiving immune checkpoint inhibitors (ICIs).Patients and Methods: This retrospective study included 224 HCC patients treated with ICIs, categorized into Higher and Lower SV groups by median SV and further into SV increased and Non-SV increased groups based on changes in SV at 3 months after ICIs. …”
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Narrow-Margin Treatment with Modified Mohs Microsurgery for Extramammary Paget&amp;rsquo;s Disease: A Retrospective Clinical Analysis by Yang J, Yan J, Luo H, Li L, Jiang L, Chen X, Wu L, Chai J, Xue H, Gan L, Liu Y, Chen J, Fei W, Bai Y, Zhu Q, Chen Z, Guo L, Chen Y

“…Jing Yang,1,&amp;ast; Jianna Yan,1,&amp;ast; Hao Luo,1 Liang Li,1 Long Jiang,1 Xuewen Chen,1 Ling Wu,1 Jingxiu Chai,1 Huan Xue,1 Leimeng Gan,1 Yeqiang Liu,2 Jia Chen,3 Wu Fei,2 Yun Bai,4 Quangang Zhu,5 Zhongjian Chen,5 Lehang Guo,6 Yuchong Chen1 1Department of Surgery, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 2Department of Pathology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 3Department of Rheumatology and Immunology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 4Department of Central Laboratory, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 5Department of Pharmacy, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 6Department of Ultrasonography, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yuchong Chen, Department of Dermatologic Surgery Division, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China, Email 973309637@qq.comBackground: To investigate the clinical efficacy of narrow-margin modified Mohs microsurgery (mMMS) in the treatment of extramammary Paget’s disease (EMPD).Methods: A retrospective cohort review was conducted on 52 patients with EMPD who were treated at the Skin Disease Hospital of Tongji University in Shanghai between 2017 and 2023. …”
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Real-World Efficacy and Safety of Anti-PD-1 Antibody Plus Apatinib and Temozolomide for Advanced Acral Melanoma by Zhang J, Tian H, Mao L, Li C, Wei X, Gu J, Wang X, Zhou L, Lian B, Tang B, Yan X, Li S, Cui C, Chi Z, Sheng X, Guo J, Si L

“…The aim of this retrospective study was to evaluate the efficacy and safety of the triplet regimen for advanced AM in the real-world setting.Methods: The data of patients with advanced AM who received anti-PD-1 antibody plus apatinib and temozolomide at Peking University Cancer Hospital and Institute between September 2019 and December 2023 were analyzed. …”
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Predictive Potential of CRTP5 and SII for Coronary Artery Severity and Myocardial Fibrosis in Patients with NSTE-ACS: An Exploratory Biomarker Study by Ji J, Qiao M, Ding Y, Wei X, Wan D, Wu L, Liu H

“…Jinrui Ji,1,2,&amp;ast; Mu Qiao,3,4,&amp;ast; Ya’nan Ding,1,2,&amp;ast; Xiaoyun Wei,1,2,&amp;ast; Dongyu Wan,1,2,&amp;ast; Lei Wu,1,2,&amp;ast; Hengliang Liu1,2,&amp;ast; 1Clinical Medical Department, Faculty of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 2Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 3Department of Cardiology, Seventh People’s Hospital of Zhengzhou, Zhengzhou, 450000, People’s Republic of China; 4Department of Cardiology, Zhengzhou Cardiovascular Institute, Zhengzhou, 450000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Hengliang Liu, Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China, Email hnzzjjr@163.comPurpose: Findings from this research aim to enhance clinical assessments of coronary artery disease severity and myocardial fibrosis (MF).Methods: A total of 523 eligible non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients were included. …”
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Effectiveness of isoniazid preventive treatment among patients on antiretroviral treatment in Southeast Nigeria: A retrospective cohort study by Chukwuma David Umeokonkwo, Bello Segun, Patrick Nguku, Muhammad Shakir Balogun, Peter Nsubuga, Lilian Bulage, Adanna Anthonia Umeokonkwo, Olufunmilayo Ibitola Fawole

“…We compared the incidence of TB among adult HIV patients on ART who had received IPT for 6 months with those who had not received IPT and identified factors associated with the development of TB to in our operational context. Methods: We conducted a retrospective cohort study on adult HIV patients who commenced ART from January 2010 to December 2016. …”
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IN VITRO STUDY OF SUPERFICIAL ENAMEL LAYER OF PERMANENT TEETH DURING STAGE OF SECONDARY MINERALIZATION by G.M. Grigorenko, L.A. Khomenko, G.V. Sorochenko, L.M. Kapitanchuk

“…The aim of the research - in vitro study of the chemical composition and morphological structure of the superficial enamel layer of permanent teeth immediately after their eruption and 12 months later. Object and methods of the research. We used for the study 15 samples of enamel of permanent teeth (erupted not later than 6 months ago premolars of 11-13 years old children). …”
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Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling by Lv P, Zhang Y, Zhao Z, Wu W, Zhou Y, Liu Z, Wang H, Jiang X, Li S, Yan P, Huang X, Xiang W, Fu P

“…This study aimed to explore the effects and mechanisms of GaMSCs-derived exosomal miRNA-191-5p on the PMT of glioblastoma.Methods and Results: Conditioned medium from three independently established GaMSCs lines (GaMSCs-CM) significantly enhanced the tumorigenicity of glioma cells. …”
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Protective Effect of Resveratrol on Exercise-induced Kidney Injury in Rats by Regulating Keap1-Nrf2 Signaling Pathway by Haitao ZHOU, Ge HU, Jing ZHANG, Qiyun ZHOU, Fei QIN

“…Objective: To investigate the protective mechanism of resveratrol on exercise-induced kidney injury in rats. Methods: Thirty-two 7-week-old SPF-grade male SD rats were randomly assigned to four groups: control group (CONT, n=8), resveratrol group (RESV, n=8), exercise-induced kidney injury model group (EIKIM, n=8), and resveratrol-treated exercise-induced kidney injury group (REIKIM, n=8). …”
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