Aneurysm Wall Enhancement and Systemic Inflammation Jointly Contribute to Cognitive Dysfunction in Untreated Unruptured Intracranial Aneurysm Patients by Wu XB, Luo B, Guo X, Liu CC, Liu YA, Ye JS, Fan SY, Li QJ, Wang SW

“…We assessed cognitive function and its association with inflammatory markers in UIA patients.Methods: The study included 120 consecutive patients with UIAs diagnosed between September 2018 and December 2023 and a control group of 27 healthy adults at our institution. …”
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Simulating the risk of heat stress on grain maize production under arid and semi-arid conditions by Khosro Azizi, Sajjad Rahimi-Moghaddam

“…Furthermore, the risk window for maize flowering in each region was equal to the first day of the year with a temperature of over 36 °C until the last day of the year with a temperature above 36 °C. …”
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Photothermal Antibacterial Effect of Gold Nanostars Coating on Titanium Implant and Its Osteogenic Performance by Li L, Wu J, Liu L, Zhang P, Zhang Y, Zhou Z, Gao X, Sun S

“…The research aimed to enhance osseointegration through surface modification while leveraging GNS’s photothermal effect for on-demand antibacterial activity, offering a dual-functional strategy to improve implant performance.Methods: GNSs were synthesized and anchored onto titanium surfaces through surface modification via silanization. …”
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Evaluation of Luteolin Nanosuspensions on Pharmacokinetics of Atorvastatin: Drug-Drug Interactions Using Rat Models by Liang Y, Sun B, Yang M, Meng X, Wang M, Yang L, AI-Hamyari B, Zhang Y, Shen Y, Meng S

“…This study aims to explore the pharmacokinetic (PK) drug-drug interactions (DDIs) of LUT toward ATV and the influencing mechanisms involving CYP450s and OATPs, and using the physiologically based pharmacokinetic (PBPK) models extrapolated to humans to optimize the DDIs dosage regimens for subsequent research.Methods: Luteolin nanosuspensions lyophilized powder (LUT-NS-LP) were prepared for improving LUT’s solubility and bioavailability, the effects of both LUT on the ATV CYP450s enzyme kinetics and LUT-NS-LP/LUT on the PK behavior of ATV in rats were further studied by UPLC. …”
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Association Between Sleep and Vertigo Severity in Benign Paroxysmal Positional Vertigo: Mediating Role of Psychological Factors by Xing J, Xu X, Shan H, Wu J, Liu P, Shi W, Ren P, Liu J, Huang Y, Mi B

“…Juanli Xing,1,* Xinyu Xu,2– 4,* Hongying Shan,2 Jiaqian Wu,4 Peiyu Liu,5 Wenyan Shi,4 Peihua Ren,2 JinLing Liu,4 Yuge Huang,2 Baibing Mi2 1Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China; 3Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 4Department of Health Science Center, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 5Department of Health Science Center, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Baibing Mi, Department of Epidemiology and Biostatistics Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China, Email xjtu.mi@xjtu.edu.cnObjective: To investigate the relationship between sleep quality and vertigo severity among patients with benign paroxysmal positional vertigo (BPPV) and to elucidate the mediating effects of anxiety and depression on this association.Methods: We analyzed baseline data from an ongoing cohort study of 1056 BPPV patients in Northwest China. …”
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Efficacy of a 6-month supported online programme (Feeling Safer) for the treatment of persecutory delusions: protocol for a randomised controlled trial by Richard Emsley, Verity Westgate, Daniel Freeman, Thomas Kabir, José Leal, Anthony Morrison, Kate Chapman, Robert Dudley, Laina Rosebrock, Felicity Waite, Louise Isham, Jason Freeman, Stephanie Common, Alex Kenny, Ariane Beckley, Natalie Rouse, Megan McGovern

“…We will also test whether Feeling Safer works equally across gender, age, ethnicity and cognitive functioning (moderation) and whether Feeling Safer works via the targeted psychological processes (mediation).Methods and analysis The study design is a multicentre, single-blind (outcome assessor), parallel, four-arm randomised controlled trial; 484 patients with persistent persecutory delusions will be randomised to one of the four conditions (1:1:1:1): Feeling Safer (added to treatment as usual (TAU)) supported by peer-support workers, or Feeling Safer (added to TAU) supported by graduate mental health workers including assistant psychologists, or Feeling Safer (added to TAU) supported by CBT therapists or TAU. …”
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FDG PET/CT AND PSMA PET/CT IN MUSCULOSKELETAL SOFT TISSUE SARCOMAS by Ellen Nogueira Lima, Thaisa Ramos Freire, Mayara Branco E. Silva, Natalia Tobar Toledo Prudente Silva, Thiago Alves, Allan Santos, Mariana Lima, José Carvalheira, Mauricio Etchebehere, Elba Etchebehere

“…Objectives: Evaluate the potential of PSMA PET/CT in diagnosing different types of STSs compared to FDG PET/CT, with the aim of expanding the clinical management of these patients and the potential of a Theranostics strategy with radiolabeled PSMA. Materials and Methods: Forty-four participants (20 females) with STS were prospectively enrolled and submitted to FDG PET/CT and PSMA PET/CT for primary staging, with a 48-hour interval between studies. …”
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Plasma Exosomal miR-17-5p Regulates Macrophage Polarization by Targeting Bcl11b in Sepsis-Induced Lung Injury by Xian Y, Sun Y, Wang L, Lin L, Wu Z, Zhang K, Chen R

“…The transcription factor Bcl11b, previously linked to immune cell regulation, has not yet been studied in the context of sepsis-associated macrophage reprogramming.Methods: Extracellular vehicles (EVs) were isolated from the plasma of sepsis patients and healthy controls. …”
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Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis by Chen Y, Wang C, Wu Y, Zeng Y, Xie S, Weng J, Guo L, Fu J, Zhou T, Zhang X, Zhou Z

“…This study aims to elucidate how alectinib induces liver injury and to explore a potential protective strategy.Methods: In vitro, AML-12 hepatocytes were incubated with alectinib to determine cell viability and morphology by using CCK-8 assay and optical microscopy, respectively. …”
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Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification by Wu Q, Wang H, Wang YH, Du J, Li B, Gan XN, Liu CY, Liang J, Liu C, Cao M

“…Qiong Wu,1,* Hao Wang,2,* You Hua Wang,1 Jun Du,3 Bo Li,3 Xiao-Na Gan,3 Chen-Yang Liu,2 Jing Liang,2 Chang Liu,2 Min Cao2 1Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Nutrilite Health Institute, Amway (China) R&D Center, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chang Liu, Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Xunhui, 725 South Wan-Ping Road, Shanghai, 200032, People’s Republic of China, Tel +862164385700, Email doctorlchang@163.com Min Cao, Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Xunhui, 725 South Wan-Ping Road, Shanghai, 200032, People’s Republic of China, Tel +862164385700, Email caomin_cm@163.comObjective: This study aimed to elucidate the mechanisms underlying the protective effects of Zhenxin Formula (ZXF) against doxorubicin (Dox)-induced HF through the integration of network pharmacology, phospho-antibody array analysis, and experimental validation.Methods: The active components and potential targets of ZXF were identified via the Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform, while HF-associated target genes were retrieved from the OMIM, Genecards, and TTD databases. …”
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Prevalence of CYP2C19 Variants in Patients with Cardiovascular Disease from the Yunnan-Guizhou Plateau in Southwestern China by Li XP, Wang JL, Lei SX, Chen BY, Ma X, He F, Yue CF, Liu HX, Hu JP, Xiong Q, Ji T, Zhang ZF, Sun Y, Li HW

“…Here, differences in CYP2C19 alleles, genotypes, and phenotypes in patients with cardiovascular disease from the Yunnan-Guizhou Plateau were systematically surveyed to provide a reference for appropriate treatment approaches.Methods: The CYP2C19*2, *3, and *17 variants were determined by RT-qPCR in 1934 patients with cardiovascular disease from 10 different areas of the Yunnan-Guizhou Plateau. …”
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Continuous Flow Ventilatory Support (Clinical Experience) by Pavol Török, Peter Сandík, Ján Šalantay, Milan Májek, Ján Kolník

“…Despite the use of different forms of ventilatory support, disconnection of patients from artificial ventilation is unsuccessful in 10—30% of cases despite the fact that the clinical and biochemical criteria are met.Objective: to discuss the efficiency of the new ventilation regime — continuous flow ventilatory support in the clinical setting.Methods: continuous flow ventilatory support with an original licensed multi-jet insufflation catheter or a terminal one-orifice catheter nasally inserted into the trachea was applied to 70 patients. …”
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Optimal Utilization of Donors Aged ≥65 Y in Lung Transplantation to Increase Donor Availability While Maintaining Comparable Posttransplant Outcomes by Marniker A. Wijesinha, PhD, Maksim Korotun, DO, Michael L. Terrin, MD, Craig J. Fryman, MD, Manish R. Mohanka, MD, Si M. Pham, MD, Aldo T. Iacono, MD

“…Utilizing older donors (≥65 y) in lung transplantation can greatly expand donor availability while potentially maintaining typical survival outcomes in certain subpopulations, such as older recipients, especially compared to survival with single lung transplants (which comprise ~20%–25% of US lung transplants according to recent data). Methods. This study included US adult lung transplants from 2010 to 2021 in the Scientific Registry for Transplant Recipients. …”
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Predictive Significance of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio in Post-Percutaneous Coronary Intervention Contrast-Induced Nephropathy Among Patients with Co... by Lin A, Peng Y, Shao J, Chen L, Lin Y

“…Aijie Lin,1,* Yanchun Peng,2,* Jiayi Shao,1 Liangwan Chen,3 Yanjuan Lin2,4 1School of Nursing, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 3Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 4Department of Cardiac Surgery Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liangwan Chen, Department of Cardiac Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, Fujian, 350001, People’s Republic of China, Email fjxhlwc@163.com Yanjuan Lin, Department of Nursing, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, Fujian, 350001, People’s Republic of China, Email fjxhyjl@163.comPurpose: This study aimed to examine the connection between monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and contrast-induced nephropathy (CIN) and to introduce a novel perspective to early clinical diagnosis of CIN.Patients and Methods: This single-center bidirectional cohort study included 1771 patients with coronary artery disease (CAD) who underwent elective percutaneous coronary intervention (PCI) from January 2017 to July 2022 at the Fujian Medical University Union Hospital. …”
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Clinical Characteristics and Independent Risk Factors for Multidrug-Resistant Klebsiella pneumoniae Bloodstream Infections: A Retrospective Analysis from China by Xu P, Mao Y, Chen Q, Luo X, Lin R, Zheng C

“…Panpan Xu,1,* Yifeng Mao,1,* Qingqing Chen,2,3,* Xinhua Luo,4 Ronghai Lin,1 Cheng Zheng1 1Department of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China; 2Rehabilitation Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, 318000, People’s Republic of China; 3Neurorehabilitation Center, Taizhou Rehabilitation Hospital, Taizhou Enze Medical Center (Group), Taizhou, Zhejiang, 318000, People’s Republic of China; 4Department of Clinical Microbiology Laboratory, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cheng Zheng, Department of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China, Email dr.zhengcheng@foxmail.com Ronghai Lin, Department of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China, Email tylinrh@163.comPurpose: This study aimed to analyze the clinical characteristics and risk factors of multidrug-resistant Klebsiella pneumoniae bloodstream infections (MDR KP-BSI) compared to non-MDR KP-BSI among adult patients in China, providing guidance for clinicians to prevent MDR KP-BSI.Patients and Methods: A retrospective analysis of 240 adult patients with KP-BSI (2019– 2023) was conducted. …”
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COTE and Pulmonary Comorbidities Predict Moderate-to-Severe Acute Exacerbation and Hospitalization in COPD by Chen Q, Wang X, Yao X, Zhang L, Liu X

“…Qinglin Chen,1,* Xinmao Wang,1,* Xiujuan Yao,1 Luo Zhang,2– 4 Xiaofang Liu1 1Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission, Beijing, People’s Republic of China; 3Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education of China, Beijing Institute of Otolaryngology, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaofang Liu, Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, No.2, Xinanhuan Road, Yizhuang District, Beijing, 100176, China, Email xfliutrhos@163.com Luo Zhang, Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University; Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education of China, Beijing Institute of Otolaryngology, No. 17, Hougou Hutong, Chongnei, Dongcheng District, Beijing, 100730, China, Email dr.luozhang@139.comPurpose: The aim of this study was to explore the predictive value of the chronic obstructive pulmonary disease (COPD) specific comorbidity test index (COTE) and pulmonary comorbidities for moderate-to-severe acute exacerbation and hospitalization in COPD patients.Patients and Methods: This was a retrospective cohort study. …”
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Impact of COVID-19 lockdown-associated visitor restrictions on mother-child interaction and emotional state of women in the puerperium – a retrospective cohort study by Irina Höhn, Anett Hernadi, Reto Zihlmann, Christina Coelius, Katharina Walter, Amr Hamza, Nicole Ochsenbein-Kölble, Leonhard Schäffer

“…As secondary endpoints, we defined the influence of the restrictions on breastfeeding, the length of hospital stay, patient satisfaction during the inpatient stay due to the reduced number of visitors, and postpartum complications after discharge. MATERIALS AND METHODS:The study was conducted at a university-affiliated teaching hospital in Switzerland. …”
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Survival Benefit of Adjuvant Treatment with Huaier Granules Plus Lenvatinib in Hepatocellular Carcinoma Patients with Tumors Greater Than 5 cm After Radical Hepatectomy by Liu C, Bai Y, Bai Q, Parra MA, Zhao L, Zou J, Cao Q, Liu H, Yang H

“…This study investigated potential adjuvant treatment strategies for HCC patients who exhibit multiple recurrence factors after radical resection.Methods: A retrospective analysis was conducted on data from 243 patients who underwent radical resection for HCC and exhibited high recurrence factors at the First Affiliated Hospital of Harbin Medical University. …”
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Spatial Epidemiologic Analysis of Fetal Birth Defects in Guangxi, China by Peng Z, Huang X, Wei J, Chen B, Liang L, Feng B, Wei Q, He S

“…Zhenren Peng,1– 5,* Xiuning Huang,4,5,* Jie Wei,4,5,* Biyan Chen,4,5 Lifang Liang,4,5 Baoying Feng,4,5 Qiufen Wei,1– 5 Sheng He1– 5 1Birth Defects Research Laboratory, Guangxi Clinical Research Center for Birth Defects, Nanning, 530002, People’s Republic of China; 2Birth Defects Research Laboratory, Guangxi Key Laboratory of Reproductive Health and Birth Defect Prevention, Nanning, 530002, People’s Republic of China; 3Birth Defects Research Laboratory, Guangxi Clinical Research Center for Pediatric Diseases, Nanning, 530002, People’s Republic of China; 4Birth Defects Research Laboratory, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, 530002, People’s Republic of China; 5Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiufen Wei, Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, No. 59 Xiangzhu Avenue, Nanning, Guangxi Zhuang Autonomous Region, 530002, People’s Republic of China, Email Wqf2024@163.com Sheng He, Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, No. 59 Xiangzhu Avenue, Nanning, Guangxi Zhuang Autonomous Region, 530002, People’s Republic of China, Email heshengbiol@163.comPurpose: To apply various spatial epidemiological approaches to detect spatial trends and geographical clusters of birth defects (BDs) prevalence in Guangxi, China, and to explore the risk factors for BDs.Methods: Between 2016 and 2022, the Guangxi Birth Defects Monitoring Network (GXBDMN) monitored a total of 4.57 million fetuses in this study. …”
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RGD-Functionalized Ginsenoside Rg3 Liposomes for Alleviating Oxidative Stress and Choroidal Neovascularization in Age-Related Macular Degeneration by Zhou J, Zhao D, Niu S, Meng W, Chen Z, Li H, Liu Y, Zou L, Li W

“…This study aimed to develop a multitargeted therapeutic strategy for AMD by leveraging the antioxidant and anti-angiogenic properties of ginsenoside Rg3 (Rg3).Methods: RGD-Rg3@Lips was formulated to encapsulate Rg3 and modified with (Arginine-Glycine-Aspartic Acid, RGD) peptides for targeted delivery. …”
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