HIV-phyloTSI: subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data by Tanya Golubchik, Lucie Abeler-Dörner, Matthew Hall, Chris Wymant, David Bonsall, George Macintyre-Cockett, Laura Thomson, Jared M. Baeten, Connie L. Celum, Ronald M. Galiwango, Barry Kosloff, Mohammed Limbada, Andrew Mujugira, Nelly R. Mugo, Astrid Gall, François Blanquart, Margreet Bakker, Daniela Bezemer, Swee Hoe Ong, Jan Albert, Norbert Bannert, Jacques Fellay, Barbara Gunsenheimer-Bartmeyer, Huldrych F. Günthard, Pia Kivelä, Roger D. Kouyos, Laurence Meyer, Kholoud Porter, Ard van Sighem, Mark van der Valk, Ben Berkhout, Paul Kellam, Marion Cornelissen, Peter Reiss, Helen Ayles, David N. Burns, Sarah Fidler, Mary Kate Grabowski, Richard Hayes, Joshua T. Herbeck, Joseph Kagaayi, Pontiano Kaleebu, Jairam R. Lingappa, Deogratius Ssemwanga, Susan H. Eshleman, Myron S. Cohen, Oliver Ratmann, Oliver Laeyendecker, Christophe Fraser, the HPTN 071 (PopART) Phylogenetics protocol team, the BEEHIVE consortium and the PANGEA consortium

“…Abstract Background Estimating the time since HIV infection (TSI) at population level is essential for tracking changes in the global HIV epidemic. Most methods for determining TSI give a binary classification of infections as recent or non-recent within a window of several months, and cannot assess the cumulative impact of an intervention. …”
Get full text

Influence of dendritic cells on corneal nerve morphological analysis and clinical relevance in chronic dry eye disease after femtosecond laser-assisted laser in situ keratomileusis by Yilin Liu, Yilin Liu, Baikai Ma, Baikai Ma, Lu Zhao, Hongshuo Li, Wenlong Li, Wenlong Li, Zhengze Sun, Zhengze Sun, Hongyu Duan, Hongyu Duan, Yitian Zhao, Hong Qi, Hong Qi

Get full text

Rapid detection of SARS-CoV-2 RNA using a one-step fast multiplex RT-PCR coupled to lateral flow immunoassay by Insaf Bel Hadj Ali, Hejer Souguir, Mouna Melliti, Mohamed Vall Taleb Mohamed, Monia Ardhaoui, Kaouther Ayouni, Sondes Haddad-Boubaker, Yusr Saadi Ben Aoun, Henda Triki, Ikram Guizani

“…Methods We developed various simplex fast-PCRs for screening sets of primer pairs newly designed or selected from literature or from validated WHO diagnostics, targeting S, N, E, RdRp or ORF1ab genes. …”
Get full text

Pointwise Structure–Function Analysis of the Ellipsoid Zone in Retinitis Pigmentosa Using an Artificial Intelligence-Assisted OCT and Microperimetry Overlay by Jesse A. Most, BA, An D. Le, MS, PhD, Melanie D. Tran, BS, Evan H. Walker, MS, Aneesh Swamy, Dirk-Uwe G. Bartsch, PhD, William R. Freeman, MD, Truong Nguyen, PhD, Cheolhong An, PhD, Shyamanga Borooah, MBBS, PhD

“…Subjects: Patients with clinically confirmed RP. Methods: Same-day spectral-domain OCT (SD-OCT) and microperimetry near-infrared images were overlaid in patients with confirmed RP. …”
Get full text

Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for... by Emmanuel Futier, Bruno Pereira, Russell Chabanne, Elodie Caumon, Dominique Morand, Audrey De Jong, Jean-Michel Constantin, Matthieu Jabaudon, Thomas Godet, Benjamin Andanson, Pierre Borrel, Leo Astier, Nathalie Bourguignon, Lise Laclautre

“…The Brain-Injured Patients Extubation Readiness (BIPER) study is an ongoing multicentre stepped-wedge cluster-randomised controlled trial aiming to test one of these scores as an intervention protocol to decrease extubation failure in neurocritical care patients with residual disorder of consciousness.Methods and analysis Trial design: Stepped-wedge cluster-randomised controlled trial with five groups of three to six clusters (20 ICUs). …”
Get full text

Clinical characteristics and risk factors of bacillary layer detachment in central serous chorioretinopathy: a comparative multicenter study by Antonio M. Casella, Raphaela M. Fuganti, Ahmad M. Mansour, José Ignácio Fernández-Vigo, Suthasinee Sinawat, Ali Osman Saatci, Jay Chhablani, Arman Zarnegar, Juliana Prazeres, Igor Kozak, Lorenzo López Guajardo, Michel E. Farah, Claudio Zett, Francisco Rodriguez, William E. Smiddy, Janet L. Davis, Philip J. Rosenfeld, Stephen G. Schwartz, Luiz H. Lima, Maurício Maia

“…Purpose Compare the clinical characteristics, risk factors, and optical coherence tomography (OCT) findings in patients with Central Serous Chorioretinopathy (CSC) with and without Bacillary Layer Detachment (BALAD), and to identify the distinguishing features and associated conditions of CSC with BALAD. Methods This observational, retrospective, multicenter case–control study collected data from 12 retina centers worldwide on patients with central serous chorioretinopathy (CSC) from December 1, 2022, to April 1, 2023. …”
Get full text

Comparative Efficacy of Bone Graft Materials in Transforaminal Lumbar Interbody Fusion: A Systematic Review and Meta-Analysis by Sami Al Eissa, Fahad Al Helal, Majed Abaalkhail, Abdullah Al Shehri, Raed Al Mousa, Abdullah Bin Shabib, Hussam Al Angari, Abdulrahman M. AlJahani, Dana W. AlDughiman

“…Aim This study aims to compare the efficacy and safety of different bone graft materials used in TLIF surgeries by analyzing fusion rates, clinical outcomes, and complication rates across various studies. Methods A systematic search was conducted on PubMed and Google Scholar for studies related to TLIF and bone graft materials up to December 2023. …”
Get full text

Association between out-of-pocket expenditure and health-related quality of life among patients receiving cancer treatment: a cross-sectional study from Nepal by Pratik Khanal, Suman Sapkota, Nirmal Poudel, Achyut Raj Pandey, Bidwata Bhattarai, Etna Khatiwada, Ravi Kant Mishra, Biraj Man Karmacharya, Shiva Raj Adhikari, Kjell Arne Johansson, Krishna Kumar Aryal

“…We further investigate the association of out-of-pocket expenditure (OOPE) with HRQoL. Methods A cross-sectional survey was conducted from April to May 2024 among 353 patients undergoing cancer treatment in two tertiary cancer hospitals in Nepal. …”
Get full text

Effects of exercise and exercise timing on energy intake and appetite control in Danish individuals with overweight or obesity with and without type 2 diabetes: a protocol for a ra... by Louise Groth Grunnet, Martin Bæk Blond, Jonas Salling Quist, Kristine Beaulieu, Graham Finlayson, Kristine Færch, Lea Jalking, Natja Poder Launbo, Marie Møller Jensen, Hanne Enghoff Pedersen, Marina Kjærgaard Gerstenberg

“…Introduction The aim of this study is to investigate the effects of acute exercise on appetite control and whether this differs between morning and late afternoon in individuals with overweight/obesity with or without type 2 diabetes (T2D).Methods and analysis The hedonic and homeostatic appetite control in obesity and type 2 diabetes in the context of meal and exercise timing (TIMEX) study is a randomised, controlled, cross-over trial. …”
Get full text

Efficiency and safety of leflunomide in rheumatoid arthritis: Results of a Russian observational multicenter of trial by R. M. Balabanova, T. V. Dubinina, D. V. Goryachev, O. N. Anoshenkova, E. A. Antonova, I. Yu. Ilyevsky, O. V. Semagina, N. V. Yasyukevih

“…In 2011, the Russian Federation registered and since it has been successfully using leflunomide**.Objective: to evaluate the efficacy and tolerability of leflunomide** used to treat RA in routine clinical practice.Subjects and methods.The investigation enrolled patients with varying duration of RA that met the 1987 classification criteria. …”
Get full text

Dynamical network-based evaluation for neuromuscular dysfunction in stroke-induced hemiplegia during standing by Jinping Li, Na Zhang, Ying Xu, Juan Wang, Xianglian Kang, Runing Ji, Ke Li, Ying Hou

“…This study aimed to investigate the hemiplegia-linked neuromuscular dysfunction during standing from the perspective of multi-muscle dynamical coordination by utilizing a novel network approach – weighted recurrence network (WRN). Methods Ten male hemiplegic patients with first-ever stroke and 10 age-matched healthy male adults were instructed to stand on a platform quietly for 30 s with eyes opened and eyes closed, respectively. …”
Get full text

Effect of holistic nursing interventions for patients undergoing Laser-assisted tympanostomy under otoendoscopy for secretory otitis media (分泌性中耳炎耳内镜下鼓膜激光打孔治疗中整体护理干预的应用效果)... by ZHOU Xiaojing (周晓静), ZHANG Yi (张燚), CHEN Xiaoping (陈晓平), GUAN Li (管丽)

“…Objective To investigate the effect of holistic nursing intervention for patients undergoing Laser-assisted tympanostomy under otoendoscopy for secretory otitis media. Methods Totally 126 (155 ears) patients with secretory otitis media were randomly divided into the observation group and the control group, with 63 cases in each group. …”
Get full text

Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults by Tjard Sattler, Sophie Gottschalk, Hans-Helmut König, Tobias Braun, Gisela Büchele, Michael Denkinger, Tim Fleiner, Corinna Nerz, Kilian Rapp, Martina Schäufele, Christian Werner, Judith Dams

“…Unlike previous studies that examined only few mediating variables, this study aimed to develop a more comprehensive path model explaining the association between FoF and HrQoL. Methods A theoretical path model was developed based on existing evidence and expert feedback and fitted to cross-sectional baseline data on 385 community-dwelling (pre-)frail older adults from the PromeTheus randomized controlled trial using robust weighted least squares estimation. …”
Get full text

Percutaneous unilateral biportal endoscopic discectomy for symptomatic lumbar disc herniation in geriatric patients by Rongqing Qin, Rongqing Qin, Anhong Guan, Anhong Guan, Min Zhu, Pin Zhou, Bing Zhou, Bing Zhou, Ruihua Zhou, Ruihua Zhou, Zaiyong Guan, Zaiyong Guan

“…PurposeThe purpose of this study is to investigate the surgical efficacy and safety of percutaneous unilateral biportal endoscopic discectomy (UBED) for symptomatic lumbar disc herniation (LDH) in geriatric patients.MethodsSeventy-two geriatric patients, aged 65–86 years (mean age: 73.2 years), with single or two-level LDH who underwent UBED from January 2020 to September 2022 were retrospectively analyzed. …”
Get full text

Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma by Junjue Chen, Huimin Zhong, Bingqiao Shen, Huan Yu, Yang Zhang, Ruiqi Han, Ping Huang, Shouyue Huang, Yisheng Zhong

“…Thioredoxin-interacting protein (TXNIP) is involved in glucose and lipid metabolism, and associated with oxidative stress and inflammation, however, not known whether to be involved in glaucoma neuropathy and its underlying mechanisms. Methods To establish the chronic ocular hypertension (COH) mice model. …”
Get full text

AI-Based Noise-Reduction Filter for Whole-Body Planar Bone Scintigraphy Reliably Improves Low-Count Images by Csaba Csikos, Sándor Barna, Ákos Kovács, Péter Czina, Ádám Budai, Melinda Szoliková, Iván Gábor Nagy, Borbála Husztik, Gábor Kiszler, Ildikó Garai

“…This study aimed to assess the performance of an AI-based bone scan noise-reduction filter on noisy, low-count images in a routine clinical environment. <b>Methods</b>: The performance of the AI bone-scan filter (BS-AI filter) in question was retrospectively evaluated on 47 different patients’ ^99mTc-MDP bone scintigraphy image pairs (anterior- and posterior-view images), which were obtained in such a manner as to represent the diverse characteristics of the general patient population. …”
Get full text

A Closer Look at Periocular Necrotizing Fasciitis: A Systematic Review of Literature by David Oliver-Gutierrez, Elena Ros-Sanchez, Gloria Segura-Duch, Tirso Alonso, Miguel Ángel Arcediano, Alejandra Herranz-Cabarcos, Jessica Matas, Roberto Castro Seco, R. L. P. van der Veen, Anna Boixadera, José García-Arumí, Joan Oliveres

“…To address this critical issue, we conducted the largest and most comprehensive systematic review to date, providing valuable insights into the diagnosis and treatment of PNF to improve clinical practice and patient prognosis. <b>Methods</b>: A search on Pubmed, Scopus, Embase, and WOS from January 2013 to August 2024 was performed. …”
Get full text

Multidisciplinary, Clinical Assessment of Accelerated Deep-Learning MRI Protocols at 1.5 T and 3 T After Intracranial Tumor Surgery and Their Influence on Residual Tumor Perception by Christer Ruff, Till-Karsten Hauser, Constantin Roder, Daniel Feucht, Paula Bombach, Leonie Zerweck, Deborah Staber, Frank Paulsen, Ulrike Ernemann, Georg Gohla

“…This study evaluates accelerated deep learning reconstruction (DLR) versus standard clinical protocols for early postoperative MRI following tumor resection. <b>Methods</b>: This study uses a multidisciplinary approach involving a neuroradiologist, neurosurgeon, neuro-oncologist, and radiotherapist to evaluate qualitative aspects using a 5-point Likert scale, the preferred reconstruction variant and potential residual tumor of DLR and conventional reconstruction (CR) of FLAIR, T1-weighted non-contrast and contrast-enhanced (T1), and coronal T2-weighted (T2) sequences for 1.5 and 3 T MRI. …”
Get full text

Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Subjects and participants: Fourteen healthy individuals (28 eyes, age range: 22-54 years) underwent TRT measurements using both Old and New OCT models, with each eye receiving three consecutive scans per visit. Methods and testing: TRT measurements were performed using the Posterior Pole Algorithm (PPA) and Early Treatment Diabetic Retinopathy Study (ETDRS) grid protocols. …”
Get full text

Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis by Binh T Nguyen, Edward Hulten, Venkatesh L Murthy, Tarin Phillips, Gregory M Blake, Jonathan A Aun, Lisa M Conte, Ritika Gadodia, Aakash Tuli, Sara L Robinson, Travis E Harrell

“…Publication bias was assessed by visual inspection of funnel plots and formal testing by Egger’s and Begg’s tests. …”
Get full text