Atelectasis predicts poor prognosis in pediatric macrolides-unresponsive Mycoplasma pneumoniae pneumonia with A2063/2064G mutations treated with azithromycin by Jie Cheng, Ya Liu, Guangli Zhang, Yuanyuan Li, Xiaoyin Tian, Liping Tan, Zhengxiu Luo

“…ObjectiveWe aimed to investigate prognostic indicators for pediatric macrolides-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP) cases with A2063/2064G mutations with azithromycin therapy.MethodsThis was a retrospective observational cohort study conducted at the Children’s Hospital of Chongqing Medical University. …”
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Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model by Jinyu Hu, Yanmei Zeng, Liying Tang, Lei Ye, Cheng Chen, Qian Ling, Xiaoyu Wang, Liangqi He, Xu Chen, Yixin Wang, Qianmin Ge, Yi Shao

“…The aim of this experiment was to investigate the therapeutic effect of VitB6 eye drops on particulate matter 2.5 (PM2.5)-induced dry eye in mice. <b>Methods</b>: Mice induced with the dry eye group were first induced using PM2.5 eye drops in a standard environment for 14 days, and then treated with different concentrations of VitB6 eye drops for 14 consecutive days. …”
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Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients by Ping Zhang, Shilong Xiang, Bicheng Liu, Xiaohui Wang, Xiaoping Yang, Chaoyang Ye, Zunsong Wang, Yanlin Li, Li Zhou, Caili Wang, Hongbo Li, Jian Huang, Ai Peng, Xiaoping Wang, Deguang Wang, Jie Xiao, Wenli Chen, Hong Cheng, Nan Mao, Jianqin Wang, Lin Yang, Jianghua Chen

“…Our present bridging study aimed to evaluate the efficacy and safety of nalfurafine in Chinese cohort with refractory CKD-aP.Methods In this phase III, multicenter bridging study conducted at 22 sites in China, 141 Chinese cases with refractory CKD-aP were randomly (2:2:1) assigned to receive 5 μg, 2.5 μg of nalfurafine or a placebo orally for 14 days in a double-blind manner. …”
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Safety Profile of Antipsychotics as Predictors of the Quality of Life in Patients with Schizophrenia—An Inpatient Welfare Institution-Based Cross-Sectional Study by Aleksandra D. Petrovic, Ana M. Barjaktarevic, Olivera Z. Kostic, Sara S. Mijailovic, Slobodan M. Jankovic, Marija V. Andjelkovic, Marijana S. Stanojevic Pirkovic, Katarina D. Parezanovic Ilic, Vladimir S. Janjic, Jana Mojsilovic, Jana Arsenijevic, Danijela B. Jovanovic, Sanja Knezevic, Nevena Folic, Milovan Stevic, Dejana Ruzic Zecevic, Nemanja Z. Petrovic, Marina J. Kostic

“…The primary objective of this study was to identify and evaluate the adverse effects of antipsychotics in patients diagnosed with schizophrenia who were treated at the social welfare institution, as well as to analyze the impact of these adverse effects on patients’ overall quality of life. <b>Methods</b>: A clinical, observational cross-sectional study was conducted, involving a sample of 278 patients diagnosed with schizophrenia. …”
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Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospect... by Willem A Bemelman, Pieter J Tanis, Lianne Koens, Vivian P Bastiaenen, Bartholomeus JGA Corten, Elise AJ de Savornin Lohman, Joske de Jonge, Anne C Kraima, Hilko A Swank, Jaap LP van Vliet, Gijs JD van Acker, Anna AW van Geloven, Klaas H in 't Hof, Philip R de Reuver, Charles C van Rossem, Gerrit D Slooter, Valeska Terpstra, Marcel GW Dijkgraaf

“…The aim of the selective histopathological examination Following AppeNdicectomy and CholecystectomY (FANCY) study is to investigate the oncological safety and potential cost savings of selective histopathological examination based on macroscopic assessment performed by the surgeon.Methods and analysis This is a Dutch multicentre prospective observational study, in which removed appendices and gallbladders will be systematically assessed by the operating surgeon for macroscopic abnormalities suspicious for malignant neoplasms. …”
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Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS by Zehra Özsoy, Şerife Asya Germe, Gizem Ayan, Güllü Sandal Uzun, Mustafa Ekici, Erdinç Ünaldı, Levent Kılıç, Ali Akdoğan, Şule Apras Bilgen, Sedat Kiraz, Ali İhsan Ertenli

“…This study aimed to compare the demographic, clinical characteristics, treatment choices, and treatment responses of seronegative (SN) and seropositive (SP) RA patients who were receiving or newly started biological treatment. Methods: The files and records of patients registered with Hacettepe University Biological Database with RA diagnosis who were planned to use biological disease-modifying antirheumatic drugs (b-DMARDs) between 2010-2024 were scanned. …”
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N-Butyl-2-Cyanoacrylate Adhesive Versus Absorbable Tacks in Laparoscopic Groin Hernia Repair: A Multicenter Randomized Clinical Trial by Clayton C. Petro, MD, Benjamin K. Poulose, MD, Michael J. Rosen, MD, Alfredo M. Carbonell, II, DO, Adel G. El-Ghazzawy, MD, Jeremy A. Warren, MD, Emanuele Lo Menzo, MD, Ajita S. Prabhu, MD, David M. Krpata, MD, Samuel Szomstein, MD, Vimal Narula, MD, Crystal F. Totten, MD, Kelly R. Haisley, MD, Andrew C. Bernard, MD, Henrik O. Berdel, MD, Jessica K. Reynolds, MD, Zachary D. Warriner, MD, John S. Roth, MD

“…The primary outcome was improvement in pain (visual analog scale [VAS]) at 6 months. The noninferiority margin was 0.9 (α = 0.025; β = 80%). …”
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Investigating the effects of mobile bottom fishing on benthic carbon processing and storage: a systematic review protocol by Stacey L. Felgate, John Aldridge, Stefan G. Bolam, Sarah Breimann, Emil de Borger, Jolien Claes, Jochen Depestele, Graham Epstein, Clement Garcia, Natalie Hicks, Michel Kaiser, Jack H. Laverick, Gennadi Lessin, Finbarr G. O’Neill, Sarah Paradis, Ruth Parker, Ryan Pereira, Alex J. Poulton, Claire Powell, Craig Smeaton, Paul Snelgrove, Justin Tiano, Johan van der Molen, Sebastiaan van de Velde, Marija Sciberras

“…This is primarily due to a lack of quantitative understanding of how trawling mixes and resuspends sediments, how it alters bioturbation, bioirrigation, and oxygenation rates, and how these processes translate into carbon fluxes into or out of sediments. Methods The primary question addressed by this review protocol is: how does mobile bottom fishing affect benthic carbon processing and storage? …”
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Effectiveness of Local Wound Infiltration with Morphine, Ketorolac, and Bupivacaine Compared to Bupivacaine Alone Following Tibial Osteotomy in Pediatric Patients: A Randomized Con... by Piyanuch Musikachart, Thanase Ariyawatkul, Jidapa Wongcharoenwatana, Nath Adulkasem, Perajit Eamsobhana

“… Objective: To compare postoperative pain in children receiving ketorolac plus morphine local wound infiltration as adjunct analgesic agents with bupivacaine for local wound infiltration following tibial osteotomy. Materials and Methods: This randomized, double-blind, placebo-controlled trial included patients aged 7-15 years who underwent tibial osteotomy. …”
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Efficacy and safety of first-line or second-line selective laser trabeculoplasty for normal-tension glaucoma: a multicentre cohort study by Tomoko Naito, Kazuyuki Hirooka, Toru Nakazawa, Masaki Tanito, Shiro Mizoue, Katsuyoshi Suzuki, Keiji Yoshikawa, Itaru Kimura, Yasushi Ikuno, Takako Miki, Kazuhisa Sugiyama, Tairo Kimura, Akiko Narita, Tadashi Nakano, Tomoyuki Watanabe, Koji Nitta, Kae Sugihara, Maki Katai, Takuji Matsuda, Hiroaki Ozaki, Kaori Komatsu, Yoshiaki Saito, Takeshi Sagara, Aika Tsutsui, Akiko Ishida, Satoru Tsuda, Toyoaki Tsumura, Naoki Tojo, Naoto Tokuda, Kenji Nakamoto, Naka Shiratori, Mami Nanno, Naoya Nezu, Yoshitaka Tasaka, Shigeru Mori, Shigeki Yamabayashi, Kimihito Konno, Miyuki Domoto

“…Background/aims This study aimed to investigate and compare the efficacy and safety of first-line and second-line selective laser trabeculoplasty (SLT) in Japanese patients with normal-tension glaucoma (NTG).Methods 100 patients with NTG were enrolled in this study. …”
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Individual-level characteristics and geospatial factors associated with cervical cancer screening participation in Alberta, Canada: a population-based cross-sectional study by Jessica Law, Geneviève Jessiman-Perreault, Amanda Alberga Machado, Linan Xu, Bonnie Chiang, Huiming Yang, Lisa Allen Scott, Rizwan Shahid, Curtis Mabilangan, Alvin Li, Kamala Adhikari, Gary Teare

“…This study aimed to identify these characteristics related to cervical cancer screening status. Methods The study population included women between the ages of 28 to 69 years in Alberta. …”
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Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging by Qian-Qian Zeng, Shi-Zhe An, Chao-Nan Chen, Zhen Wang, Jia-Cheng Liu, Ming-Xi Wan, Yu-Jin Zong, Xiao-Hua Jian, Jie Yu, Ping Liang

“…Methods Patients with FLLs between June 2022 and February 2023 were prospectively screened. …”
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Combinations of polymorphisms in the regulatory regions of cytokine genes are associated with diabetic retinopathy in type 2 diabetic patients by V. I. Konenkov, A. V. Shevchenko, V. F. Prokof`ev, V. V. Klimontov, N. V. Tyan, V. V. Chernykh, D. V. Chernykh, A. V. Eremina, A. N. Trunov

“…Accordingly, we aimed to assess the frequencies of combinations of SNPs from promoters of cytokine genes in type 2 diabetic subjects with and without DR.Materials and methods: We enrolled 201 caucasian subjects with type 2 diabetes, including 90 ones with non-proliferative or preproliferative retinopathy and 111 subjects without DR. …”
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The Swiss Endometriosis Database: a retrospective multicentre cohort study on pain levels and multimodal treatment needs of endometriosis patients by Sara Imboden, Selina Lang, Antonalla Martino, Peter Martin Fehr, Lea Duempelmann, Cloé Vaineau, Heike Willi, Nicolas Samartzis, Simone Kamm, Dimitri Sarlos, Stephanie Verta, Tina Rohrbach, Christian Polli, Alexandra Kochanowski, Michael Mueller

“… STUDY AIMS: This study aimed to deepen the understanding of endometriosis symptoms, types, and therapy recommendations for Swiss endometriosis patients in Swiss-certified endometriosis centres in 2022. METHODS:In this exploratory retrospective multicentre cohort study, data from 3538 women who had their first consultation at a certified endometriosis centre in Switzerland in 2022 were analysed retrospectively. …”
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Erector spinae plane block versus transversus abdominis plane block with rectus sheath block for postoperative analgesia in laparoscopic hepatectomy: a randomized clinical trial by Mengke Liu, Xuan Mo, Ruonan Zhan, Han Wang, Yangxi Zhao, Yi Zhang

“…This study aims to compare the efficacy of bilateral ultrasound-guided ESPB versus subcostal TAPB with RSB for postoperative analgesia, addressing the gap in current research and optimizing pain management strategies for this procedure. Methods Sixty patients scheduled for laparoscopic hepatectomy were randomly divided into two groups: E group received ultrasound-guided ESPB, while the TR group received subcostal TAPB with RSB. …”
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Am I attached? A patient-partnered approach to creating infographics about attachment to primary care in Ontario, Canada by Maggie MacNeil, Aya Tagami, Peter Sheffield, Vivian R. Ramsden, Joan Barker, Jennifer Boyle, Clare Cruickshank, Eliot Frymire, Richard H. Glazier, Anita Gombos Hill, Michael E. Green, Mary Huang, Marijke Jurriaans, Caron Leid, Melissa McCallum, Sarah Precious, Jo-Ann Stans, Julie Vizza, Murray Walz, Sue Wilkins, Rebecca Ganann

“…Our approach to engaging patients prevented both oversimplification and unnecessary complexity in a public-facing visual about attachment to primary care.…”
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The Effect of Polymorphisms in the CYP2D6 and CYP2C9 Genes on the Clinical Efficacy of Tramadol and Ketorolac When Using the Accelerated Recovery Protocol in Patients With Uncompli... by A. A. Muradyan, D. A. Blagovestnov, D. A. Sychev, P. A. Yartsev, M. L. Rogal, L. N. Kerimova, V. T. Koroshvili, I. A. Yepifanova

“…Analgesic efficacy was assessed using a visual analog scale (VAS) and McGill Pain Questionnaire.Results. …”
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Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study by Xiaobo Liu, Bin Wan, Xi-Han Zhang, Ruifang Cui, Siyu Long, Ruiyang Ge, Lang Liu, Jinming Xiao, Zhen-Qi Liu, Jiadong Yan, Ke Xie, Meng Yao, Xin Wen, Sanwang Wang, Yujun Gao

“…The mBD showed expanded visual and prefrontal regions but compressed motor and precuneus regions. …”
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Melanin-concentrating hormone attenuates the hedonic feeding induced by orexin-A in the ventral tegmental area of high-fat diet male mice by Xiaoning Liu, Xiaoning Liu, Helin Yang, Wenguang Xu, Xuezhe Wang, Wenhui Tang, Xiaoxuan Wang, Yang Jiao, Xinchi Luan, Pengmeng Li, Feifei Guo

“…This study aims to investigate the modulatory role of MCH and OX-A in hedonic feeding within the VTA of high-fat diet (HFD) mice.MethodsMale mice were subjected to an 8-week high-fat diet. …”
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Comparison of clinical effectiveness between stapled transanal rectal resection and procedure for prolapse and hemorrhoids for young male patients with prolapsed hemorrhoids by Pei Yan, Gao Jihua, Qi Wenyue, Tian Maosheng, Wu Qiong, Duan Bingqian, Wang Ran, Liu Ziyi

“…[Objectives] To compare the clinical effectiveness between stapled transanal rectal resection (STARR) and procedure for prolapse and hemorrhoids (PPH) for young male patients with prolapsed hemorrhoids. [Methods] This was a retrospective analysis of 84 young male patients with prolapsed hemorrhoids who were treated at the Department of Colorectal Surgery, The First Affiliated Hospital of Hebei College of Chinese Medicine, between January 2019 and December 2019. …”
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