Venous Sinus Stenting Using a Ledge‐Reducing Catheter, 0.088‐in. Catheter‐Extender With an External Single Point of Control: Technique and Multicenter Clinical Experience by Oded Goren, Fabio Settecase, George Luh, Tareq Kass‐Hout, Rami Morsi, Coleman O. Martin, Ahmad K. Almekkawi, Nicholas A. Telischak, Matthew D. Alexander, Michael G. Abraham, Sivani Lingam, Ramesh Grandhi, M. Shazam Hussain, Tudor G. Jovin, Priyank Khandelwal, Thanh T. Nguyen, Piers Klein, Joey D. English, Mohamad K. Abdalkader

“…In this study, we describe the MS technique for VSS and our multicenter clinical experience. Methods We retrospectively reviewed consecutive patients who underwent VSS with the MS from 2022 to 2023 for intracranial hypertension and/or pulsatile tinnitus at 13 sites. …”
Get full text

Epidemiological trends of hepatitis C incidence and death in Mainland China between 2004 and 2018 and its predictions to 2030 by Guo Tian, Yang Zheng, Yinghua He, Can Chen, Xiaobao Zhang, Yuxia Du, Shigui Yang, Tianan Jiang, Lanjuan Li

“…Abstract Introduction This study aimed to evaluate the epidemiological trends and spatial-temporal distribution of hepatitis C virus (HCV) in mainland China. Methods HCV monthly incidence surveillance data from 2004 to 2018 was mainly available from the Public Health Sciences Data Center of China. …”
Get full text

Varied cellular abnormalities in thin vs. normal endometrium in recurrent implantation failure by single-cell transcriptomics by Xiaoying Fu, Xiaoyan Guo, Han Xu, Yini Li, Bihui Jin, Xirong Zhang, Chongyi Shu, Yuhang Fan, Yiqi Yu, Yuqing Tian, Jiao Tian, Jing Shu

“…In order to elucidate differences between these two types of endometrial defects in terms of molecular signatures, cellular interactions, and structural changes, we systematically investigated the single-cell transcriptomic atlas across three distinct groups: RIF patients with thin endometrium (≤ 6 mm, TE-RIF), RIF patients with normal endometrium thickness (≥ 8 mm, NE-RIF), and fertile individuals (Control). Methods The late proliferative and mid-secretory phases of the endometrium were collected from three individuals in the TE-RIF group, two in the NE-RIF group, and three in the control group. …”
Get full text

Effect of fusion and arthroplasty for cervical degenerative disc disease in patients with physically demanding occupations by Harjot Uppal, MBA, George Abdelmalek, MD, Neil Patel, MD, Daniel Coban, MD, Stuart Changoor, MD, Nikhil Sahai, MD, Kumar Sinha, MD, Ki Hwang, MD, Arash Emami, MD

“…Therefore, the purpose of this study is to compare the outcomes of CDA versus ACDF in patients with labor-intensive jobs and to assess how workers' compensation (WC) status influences these outcomes. Methods: In this prospective cohort study, 300 (CDA: 150, ACDF: 150) patients with 1- or 2-level cervical DDD with labor-intensive jobs were enrolled, including a subgroup of 60 WC patients (CDA: 30, ACDF: 30). …”
Get full text

Predicting the risk of postoperative avascular necrosis in patients with talar fractures based on an interpretable machine learning model by Jian Zhang, Jian Zhang, Jian Zhang, Jihai Xu, Jihai Xu, Jiapei Yu, Jiapei Yu, Jiapei Yu, Hong Chen, Hong Chen, Xin Hong, Songou Zhang, Xin Wang, Xin Wang, Chengchun Shen, Chengchun Shen, Chengchun Shen

“…PurposeThis study aims to develop and validate an interpretable machine learning model for predicting avascular necrosis (AVN) following talar fracture, thereby aiding in personalized prevention and treatment.MethodsA retrospective cohort study included patients undergoing surgical intervention for talar fractures at Ningbo No.6 Hospital between January 2018 and December 2023. …”
Get full text

Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues by Adam Glaser, Jayaram Chandrashekar, Sonya Vasquez, Cameron Arshadi, Rajvi Javeri, Naveen Ouellette, Xiaoyun Jiang, Judith Baka, Gabor Kovacs, Micah Woodard, Shamishtaa Seshamani, Kevin Cao, Nathan Clack, Andrew Recknagel, Anna Grim, Pooja Balaram, Emily Turschak, Marcus Hooper, Alan Liddell, John Rohde, Ayana Hellevik, Kevin Takasaki, Lindsey Erion Barner, Molly Logsdon, Chris Chronopoulos, Saskia EJ de Vries, Jonathan T Ting, Steven Perlmutter, Brian E Kalmbach, Nikolai Dembrow, Bosiljka Tasic, R Clay Reid, David Feng, Karel Svoboda

“…Combined with new tissue clearing and expansion methods, the microscope allows imaging centimeter-scale samples with 375 nm lateral and 750 nm axial resolution (4× expansion), including entire mouse brains, with high contrast and without sectioning. …”
Get full text

[68Ga]Ga-FAPI-46 PET/CT for Staging Suspected/Confirmed Lung Cancer: Results on the Surgical Cohort Within a Monocentric Prospective Trial by Lucia Zanoni, Emilia Fortunati, Giulia Cuzzani, Claudio Malizia, Filippo Lodi, Veronica Serena Cabitza, Irene Brusa, Stefano Emiliani, Marta Assenza, Filippo Antonacci, Francesca Giunchi, Alessio Degiovanni, Marco Ferrari, Filippo Natali, Thomas Galasso, Gian Piero Bandelli, Simona Civollani, Piero Candoli, Antonietta D’Errico, Piergiorgio Solli, Stefano Fanti, Cristina Nanni

“…To evaluate T&N-staging diagnostic performance of [68Ga]Ga-FAPI-46 PET/CT (FAPI) in a suspected/confirmed lung cancer surgical cohort. Methods: Patients were enrolled in a prospective monocentric trial (EudraCT: 2021-006570-23) to perform FAPI, in addition to conventional-staging-flow-chart (including [18F]F-FDG PET/CT-FDG). …”
Get full text

Association of autoantibodies with the IFN signature and NETosis in patients with systemic lupus erythematosus by Ellen D. Kaan, Tammo E. Brunekreef, Julia Drylewicz, Lucas L. van den Hoogen, Maarten van der Linden, Helen L. Leavis, Jacob M. van Laar, Michiel van der Vlist, Henny G. Otten, Maarten Limper

“…Here we studied the association between autoantibodies, the IFN signature, NET release, and clinical manifestations in patients with SLE. Methods: We performed principal component analysis (PCA) and hierarchical clustering of 57 SLE-related autoantibodies in 25 patients with SLE. …”
Get full text

Time to endovascular thrombectomy for acute ischaemic stroke in language other than English (LOTE) communities in South-Western Sydney by Dennis Cordato, Peter Thomas, Alan McDougall, Cecilia Cappelen-Smith, Christopher Blair, Nathan Manning, Jing ji, Longting Lin, Mark Parsons, Andrew K Cheung, Daniel Wardman, Chushuang Chen, Suzanne J Hodgkinson, Helen Badge, Vivek Pidugun, Timmy Pham

“…Patients requiring interpreters equally exhibited shorter ATP times (152 vs 170 min; p=0.01) and higher stroke severity. …”
Get full text

Effect of vitamin D on proteinuria, lipid status, glicoregulation and C-reactive protein in patients with type-2 diabetes mellitus by Petrović Marijana, Dragović Tamara, Petrović Stanko, Obrenčević Katarina, Rančić Nemanja, Đurašinović Tatjana, Petrović Dejan, Ignjatović Ljiljana, Rabrenović Violeta, Nenezić Nemanja, Marinković Dejan, Maksić Đoko

“…The aim of this study was to examine the influence of vitamin D supplementation on proteinuria, cholesterol, triglycerides, C-reactive protein (CRP) and hemoglobin A1c in patients with type-2 DM and vitamin D insufficiency/ deficiency. Methods. This prospective, cohort study included 90 patients with type-2 DM and vitamin D insufficiency/ deficiency divided into 3 equal groups: with normal proteinura, with microproteinuria and with macroproteinuria. …”
Get full text

Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis by Yong-Li Zhao, Yi-Ning Hao, Yi-Jun Ge, Yi Zhang, Lang-Yu Huang, Yan Fu, Dan-Dan Zhang, Ya-Nan Ou, Xi-Peng Cao, Jian-Feng Feng, Wei Cheng, Lan Tan, Jin-Tai Yu

“…We aimed to determine the variables influencing cognitive function. Methods Our study included 164,463 non-demented adults (89,644 [54.51%] female; mean [SD] age, 56.69 [8.14] years) from the UK Biobank who completed four cognitive assessments at baseline. 364 variables were finally extracted for analysis through a rigorous screening process. …”
Get full text

A Program for Master of Science in Environment and Natural Resources (MENR) by Kabale University

“…Utilize their skills to analyse relationships between agricultural production, natural resource depletion, climate change, pollution and land degradation and develop innovative methods and mitigate their effects. iii. Promote professional development through multidisciplinary approaches to solve challenges in environment and natural resources.…”
Get full text

Photothermal‐Responsive Soluble Microneedle Patches for Meibomian Gland Dysfunction Therapy by Fei Yu, Xuan Zhao, Qian Wang, Yifei Niu, Peng Xiao, Jinze Zhang, Keyi Fei, Yuancong Huang, Liu Liu, Po‐Han Fang, Xinyue Du, Weihua Li, Dalian He, Tingting Zhang, Saiqun Li, Jin Yuan

Get full text

Turtle Study: A Phase 2 Study of Durvalumab Plus Carboplatin and Etoposide in Elderly Patients With Extensive-Stage SCLC (LOGiK 2003) by Hidenobu Ishii, MD, PhD, Koichi Azuma, MD, PhD, Yuta Yamanaka, MD, Hiroshige Yoshioka, MD, PhD, Yukihiro Toi, MD, Naoki Shingu, MD, Katsuhiko Naoki, MD, PhD, Masaki Okamoto, MD, PhD, Yuko Tsuchiya-Kawano, MD, PhD, Taishi Harada, MD, Hiroyuki Inoue, MD, PhD, Hiroshi Ishii, MD, PhD, Kazunori Tobino, MD, PhD, Chiho Nakashima, MD, PhD, Yoshifusa Koreeda, MD, Yasushi Hisamatsu, MD, Shinsuke Tsumura, MD, Takashi Inagaki, MD, Keiko Mizuno, MD, PhD, Takayuki Shimose, MMath, Isamu Okamoto, MD, PhD

“…We evaluated the safety and efficacy of durvalumab plus carboplatin and etoposide in elderly patients with ES-SCLC. Methods: In this prospective, single-arm, multicenter, phase 2 clinical trial, patients with ES-SCLC aged above or equal to 75 years received chemotherapy with up to four cycles of durvalumab 1500 mg on day 1, carboplatin at a dose equivalent to an area under the curve of 5 on day 1, and etoposide 80 mg/m2 on days 1 to 3 every 3 weeks as induction therapy. …”
Get full text

Global burden of breast cancer and application of patient-reported outcomes in clinical trials: a systematic analysis based on the global burden of disease study 2021 and WHO inter... by Jiaxin Hao, Jiaxin Hao, Yijia Gong, Yijia Gong, Xiaowen Zhang, Xiaowen Zhang, Xiaowen Zhang, Minghong Du, Minghong Du, Minghong Du, Huan Wang, Huan Wang, Huan Wang, Guolin Guo, Mengqing Zhou, Tian Tian, Hongguo Rong, Hongguo Rong, Hongguo Rong

“…This study aims to evaluate the global burden and the application of patient-reported outcomes (PROs) in clinical trials of breast cancer.MethodsData of breast cancer burden is extracted from the Global Burden of Disease Study (GBD) 2021 database. …”
Get full text

Acute Pharmacological Effects of Two Synthetic Cathinones in Humans: An Observational Study of <i>N</i>-Ethylhexedrone and <i>N</i>-Ethyl-nor-pentedrone by Melani Núñez-Montero, Clara Pérez-Mañá, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Georgina De la Rosa, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Nunzia La Maida, Annagiulia Di Trana, Silvia Graziano, Simona Pichini, Magì Farré, Esther Papaseit

“…However, still, little is known with regard to their pharmacological effects in humans. <b>Methods</b>: For the first time, we conducted a naturalistic, prospective observational study in 16 participants (7 women and 9 men) with a previous history of psychostimulant recreational use. …”
Get full text

Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial CellsSUMMARY by Siyuan Ma, Nawras W. Habash, Mrunal K. Dehankar, Nidhi Jalan-Sakrikar, Shawna A. Cooper, Abid A. Anwar, Sofia Jerez, Papawee Sutthirat, Jinhang Gao, Tamir Diamond, Jing Jiao, Caixin Qiu, Jingchun Yang, Sumera I. Ilyas, Markcus Lee, Usman Yaqoob, Sheng Cao, Rebecca G. Wells, Vijay H. Shah, Moira B. Hilscher

“…We studied spatial changes in immune cells in the sinusoid that contribute to congestive fibrosis and portal hypertension (PHTN). Methods: To visualize the distribution of immune cells in congestive hepatopathy (CH), we performed imaging mass cytometry (IMC) on liver tissue from patients with CH, Fontan-associated liver disease (FALD), and controls. …”
Get full text

Model of superior semicircular canal dehiscence: asymmetrical vestibular dysfunction induces reversible balance impairment by Sean S. Hong, P. Ashley Wackym, P. Ashley Wackym, Damian J. Murphy, Eran Peci, Matthew Y. Kiel, Aaron Tucker, Nicolas L. Carayannopoulos, Shrivaishnavi C. Chandrasekar, Nikhil Suresh, Umut A. Utku, Justin D. Yao, Justin D. Yao, Todd M. Mowery, Todd M. Mowery

“…In this study, we completed our assessment of this model to include reversible asymmetrical vestibular impairments that interfere with balance.MethodsAdult Mongolian gerbils (N = 6) were trained to complete a balance beam task. …”
Get full text

Catheter-associated urinary tract infections in urethral stricture patients indwelling suprapubic catheter: Insights from a retrospective investigation into specific antibiogram an... by Jiahao Lin, Changhao Hou, Yubo Gu, Wei Yuan, Xianjie Xiu, Zhenwei Yu, Ruihang Zhang, Guangyu Mao, Qiang Fu, Lujie Song

“…Objectives: This study aimed to evaluate the incidence and risk factors of suprapubic catheter-associated bacteriuria (SPCAB) and multidrug-resistant bacteria (MDRB) in patients with urethral strictures, and compare antimicrobial resistance patterns between pathogens isolated from urinary samples and suprapubic catheters. Methods: A retrospective analysis was performed on patients with urethral strictures who had urethral reconstructive surgery with suprapubic catheters from January 2010 to June 2023. …”
Get full text

The Connection between Galaxy Mergers, Star Formation, and Active Galactic Nuclei Activity in the HSC-SSP by Kiyoaki Christopher Omori, Connor Bottrell, Sabine Bellstedt, Aaron S. G. Robotham, Hassen M. Yesuf, Andy D. Goulding, Marcin Sawicki, Tohru Nagao, Tsutomu T. Takeuchi

“…We quantitatively examine the merger–SFR–AGN connection using Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) galaxies using novel methods for both galaxy classification and property measurements. …”
Get full text