Nitrogen dioxide exposure attenuates or even reverses the association between physical activity and fasting plasma glucose levels in non-diabetic elderly Chinese adults by Chen Zhang, Qingsi Wu, Xuqiu Cheng, Ziwei Tian, Junzhe Li, Qiang Liu, Yan Zhang, Xianwei Guo, Guimei Chen, Huaibiao Li, Changliu Liang, Bing Hu, Dongmei Zhang, Chunmei Liang, Jie Sheng, Fangbiao Tao, Jun Wang, Yuyou Yao, Linsheng Yang

“…This study aimed to examine whether long-term exposure to NO2 attenuates the association between PA and FPG levels in non-diabetic older adults. Methods A total of 2600 non-diabetic elderly Chinese adults were included in this cross-sectional study. …”
Get full text

Development and validation of an early diagnosis model for severe mycoplasma pneumonia in children based on interpretable machine learning by Si Xie, Mo Wu, Yu Shang, Wenbin Tuo, Jun Wang, Qinzhen Cai, Chunhui Yuan, Cong Yao, Yun Xiang

“…Therefore, there is an urgent need to establish an early warning model for SMPP to improve the prognosis of pediatric pneumonia. Methods The study comprised 597 SMPP patients aged between 1 month and 18 years. …”
Get full text

Identification of anoikis-related genes classification patterns and immune infiltration characterization in chronic rhinosinusitis with nasal polyps based on machine learning by Ziqi Chen, Lingmei Qu, Qing Hao, Shuang Teng, Shuo Liu, Qin Wu, Hongtian Yi, Xianji Shen, Liang Li, Zhaonan Xu, Yanan Sun

“…Although anoikis is implicated in immune regulation and CRSwNP pathogenesis, its specific mechanistic role remains poorly defined.MethodsThe GSE136825 and GSE179625 datasets were obtained from the GEO database and 338 anoikis-related genes (ARGs) were extracted from the literature and databases. …”
Get full text

The association and impact of radiographic, pathological emphysema and spirometric airway obstruction on patients with resectable lung adenocarcinoma by Yixiao Zhang, Lu Lang, Xiaojuan Guo, Kewu Huang, Jiawen Yi, Yuan Yuan, Min Zhu, Shu Zhang, Bin Hu, Xue Li, Yuhui Zhang

“…Thus, this study aimed to examine the association among radiographic, pathological emphysema and spirometric airway obstruction in patients with resectable lung cancer as well as explore their impact on postoperative pulmonary complications (PPCs) and long-term prognosis. Methods Lung adenocarcinoma (LUAD) patients who performed chest CT, spirometry, and curative resection were included from a prospective three-institution database. …”
Get full text

Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa: study protocol... by David Macleod, Einoti Matayan, William Makupa, Jeremy John Hoffman, Simon Arunga, Francis Orishaba, Abel Ebong, Reena Yadav, Astrid Leck, Muna Elisante, Tara Mtuy, Sandip Das Sanyam, Victor H Hu, Matthew J Burton

“…The contrasting findings necessitate a comprehensive RCT to investigate the potential benefit of adding topical chlorhexidine 0.2% alongside natamycin 5% in the management of FK. Methods We will test the hypothesis that topical natamycin 5% in combination with chlorhexidine 0.2% is superior to topical natamycin 5% alone in a two-arm, single-masked RCT (ISRCTN, ISRCTN87195453, registered 27/08/2020, https://www.isrctn.com/ISRCTN87195453). …”
Get full text

SMART accelerates rate of cognitive gains in service members with mTBI and PTSD by Erin Venza, Jeffrey S. Spence, Jennifer Zientz, Cole Devlin, Jason Bailie, Jason Bailie, Jason Bailie, Andrew Darr, Andrew Darr, Andrew Darr, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Bond Chapman

“…The study also examined the relationship between PTSD symptom severity and cognitive outcomes.MethodsA total of 148 ADSMs with mTBI and persistent cognitive complaints were randomized to receive either SMART (20 h over 4 weeks) or SCORE (60 h over 6 weeks). …”
Get full text

Test-retest reliability of diffusion kurtosis imaging metrics in the healthy adult brain by Liu-Yang Wu, Yao Xu, Lan-Lan Chen, Wen-Rui Yang, Yan Li, Song-An Shang, Xian-Fu Luo, Wei Xia, Jing Xia, Hong-Ying Zhang

“…Purpose: To evaluate the reliability of magnetic resonance imaging (MRI) diffusion kurtosis imaging (DKI) derived metrics from the human brain as well as the effect of spatial smoothing preprocess on measurement reliability through test-retest measurements. Materials and methods: A total of 23 healthy volunteers who underwent MRI DKI scanning during two sessions performed at an interval of two weeks were enrolled in the study. …”
Get full text

Investigation of early-stage cardiovascular-kidney-metabolic syndrome on retinal structure and function evaluated by optical coherence tomography angiography by Yunyi Liang, Congbi Liang, Jianping Yang, Wanhua Li, Runyi Liang, Kun Li, Jingfeng Zhang, Peiqiong Lao, Junhua Zhu, Lin An, Zhaohao Liang, Chubin Ou

“…This study aimed to investigate retinal structural and vascular alterations in the early-stage CKM using OCTA and explore its potential as a biomarker tool.MethodsA cross-sectional study included 2,153 participants undergoing OCTA during health checks (2023–2024). …”
Get full text

Non-inferiority comparison of medical glue and hook-wire for preoperative localization of multiple pulmonary nodules by Zexin Xie, Zexin Xie, Ran Ma, Ran Ma, Tao Gao, Tao Gao, Jingsong Liu, Jingsong Liu, Kewei Zhang, Kewei Zhang, Jun Li, Jun Li, Xiaotong Zhou, Xiaotong Zhou, Hao Zhang, Hao Zhang

“…However, precisely localizing deep-seated or poorly visualized nodules remains a prominent challenge. This study aims to compare the effectiveness and safety of medical glue vs. hook-wire in the CT-guided localization of multiple pulmonary nodules.MethodsA prospective cohort of patients scheduled for CT-guided localization of multiple pulmonary nodules between February 2024 and August 2024 was enrolled. …”
Get full text

Primary deltoid ligament repair versus trans-syndesmotic fixation for acute bimalleolar equivalent ankle fractures: A meta-analysis of comparative studies by Osama Z. Alzobi, Hammam Kayali, Loay Salman, Mohamed Kenawey, Ashraf Hantouly, Motasem Salameh, Bashir Zikria, Pieter D'Hooghe, Vinod Panchbhavi, Mohamed Mekhaimar, Salah AlBurdeni, Jasim Alsaei

“…The goal of this meta-analysis is to compare clinical outcomes after acute deltoid ligament repair and trans-syndesmotic screw fixation following fibula fixation for management of bimalleolar equivalent fractures. Methods: Five databases were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines until April 1, 2023. …”
Get full text

Psychological correlates of COVID-19 vaccine attitudes among medical professionals: An exploratory data analysis by Aldo SITIBONDO, Aanuoluwapo AFOLABI, Jamel HAJJI, Abdulmohsen Mohammed Abdullah ALKHULAYFI, Izaddin Ahmad AZIZ, Zane Asher GREEN, Francesca BRUNO, Martina BARBERA, Murat YLDIRIM

“…This study aims to assess the relationship between emotional states—particularly anxiety-related feelings—and COVID-19 vaccination status among Italian medical professionals. Methods: A cross-sectional analysis was conducted using data from 160 healthcare workers who completed a structured questionnaire. …”
Get full text

Exome sequencing revealed a novel homozygous variant in TRMT61 A in a multiplex family with atypical Cornelia de Lange Syndrome from Rwanda by Esther Uwibambe, Abdoulaye Yalcouyé, Elvis Twumasi Aboagye, Lettilia Xhakaza, Kalinka Popel, Norbert Dukuze, Thashi Bharadwaj, Carmen de Kock, Isabelle Schrauwen, Suzanne M. Leal, Leon Mutesa, Ambroise Wonkam

“…We performed a molecular characterization of CdLS in a multiplex Rwandan family. Methods After a clinical evaluation of two affected siblings, DNA isolated from peripheral whole blood of the affected patients and their parents underwent Exome Sequencing (ES). …”
Get full text

De novo variant in GUCY2D gene causing atypical cone-rod dystrophy in a consanguineous family and literature review by Xin-He Fang, Fa-Yong Ke, Wen-Qing Zou, De-Jun Zhu, Mei-Jiao Ma, Yuan-Yuan Lian, Xue-Li Wu, Rui-Hua Wei, Xun-Lun Sheng

“…AIM: To analyze the pathogenicity and clinical features of patients in a consanguineous cone-rod dystrophy (CRD) family due to heterozygous variants in the GUCY2D gene. METHODS: Whole exome sequencing was used to screen for pathogenic genes and candidate pathogenic variants were obtained by bioinformatics analysis. …”
Get full text

Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study by Yin Sun, Longteng Ma, Song Wang, Caohui Duan, Xinyu Wang, Xiangbing Bian, Shuqing Wang, Deqi Zhai, Siyuan Xie, Shuhua Zhang, Yingyuan Liu, Xiaoxue Lin, Ruobing Wang, Xiu Liu, Shengyuan Yu, Xin Lou, Zhao Dong

“…This study employs multimodal MRI—combining structural, diffusion tensor, and functional imaging—to characterize brain abnormalities in CM patients with and without MOH, while investigating the relationship between acute analgesic use frequency and these changes. Methods The study employed comparative analyses to examine differences in gray matter volume, white matter integrity, and spontaneous brain activity between CM patients with (CM + MOH) and without (CM − MOH) medication overuse headache, as well as healthy controls. …”
Get full text

Comparison of low-pressure and standard-pressure pneumoperitoneum laparoscopic cholecystectomy in patients with cardiopulmonary comorbidities: a double blinded randomized clinical... by Feng Tian, Xiaowei Sun, Yang Yu, Ning Zhang, Tao Hong, Lu Liang, Bihui Yao, Lei Song, Changhong Pei, Yu Wang, Wenlong Lu, Qiang Qu, Junchao Guo, Taiping Zhang, Xiaodong He

“…This study aimed to explore the feasibility and pulmonary effects of LPLC in patients with cardiopulmonary comorbidities. Methods This was a multicenter, parallel, double-blind, randomized controlled trial. …”
Get full text

Short-term use of ceftriaxone sodium leads to intestinal barrier disruption and ultrastructural changes of kidney in SD rats by Wenli Zou, Yueming Liu, Wei Zhang, Bo Lin, Wei Shen, Yiwen Li, Qiang He, Juan Jin

“…The aim of this study was to evaluate and visualize the impact of antibiotics on colonic mucus and the microbial community, and to assess whether intestinal dysbacteriosis is involved in the pathogenesis and progression of extraintestinal diseases in vivo.Materials and Methods Twenty-one SD rats were randomly assigned into three groups followed by different experimental treatments. …”
Get full text

A predictive model for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis by Rui Huang, Rui Huang, Dan Wu, Dan Wu, Ling Wang, Ling Wang, Ping Liu, Ping Liu, Xiaoru Zhu, Xiaoru Zhu, Leqiu Huang, Leqiu Huang, Mengmeng Chen, Mengmeng Chen, Xin Lv, Xin Lv

“…The outcome of this study carries important clinical value for early diagnosis and treatment of EBV-HLH.MethodsA retrospective analysis was conducted on 60 patients diagnosed with EBV-HLH and 221 patients diagnosed with EBV-IM at our hospital between November 2018 and January 2024. …”
Get full text

A Study of Multimodality Imaging Features of Brown Tumor or Osteitis Fibrosa Cystica by Dhruv Patel, Abhijeet Ashok Salunke, Nandlal Bharwani, Ritesh Suthar, Umank Tripathi, M. Varun, Dipesh Dave, Keval Patel, Vikas Warikoo, Jebin Aron, Rahul Shah, Shashank J. Pandya

“…Despite its rarity, Brown tumor poses diagnostic challenges due to its varied clinical presentations and radiographic features, often mimicking other bone lesions such as giant cell tumors or metastatic disease. Material and Methods In this study, we present a retrospective analysis of 6 cases of Brown tumor diagnosed and managed at our institution over a 12 months period from April 2022 to April 2023. …”
Get full text

The potential for dementia prevention in Brazil: a population attributable fraction calculation for 14 modifiable risk factorsResearch in context by Claudia K. Suemoto, Wyllians V. Borelli, Ismael L. Calandri, Laiss Bertola, Raphael M. Castilhos, Paulo Caramelli, Ricardo Nitrini, Sonia M.D. Brucki, Jerson Laks, Naaheed Mukadam, Gill Livingston, Cleusa P. Ferri

“…This study aims to provide the first LMIC figure for the potential for dementia prevention in Brazil attributed to 14 modifiable risk factors. Methods: Data was retrieved from 9949 participants aged 50 years or older from the nationally representative second wave of the Brazilian Longitudinal Study of Aging (ELSI-Brazil) conducted between 2019 and 2021. …”
Get full text

Unravelling Metazoan and Fish Community Patterns in Yujiang River, China: Insights from Beta Diversity Partitioning and Co-Occurrence Network by Yusen Li, Dapeng Wang, Yuying Huang, Jun Shi, Weijun Wu, Chang Yuan, Shiqiong Nong, Chuanbo Guo, Wenjian Chen, Lei Zhou

“…However, traditional survey methods often fail to comprehensively capture species diversity, particularly for low-abundance taxa. …”
Get full text