Does the number of drain tubes influence the formation of postoperative spinal epidural hematoma following biportal endoscopic unilateral laminotomy for bilateral decompression (BE... by Zhuolin Zhong, Jingjing Ying, Shaohua Zhang, Kaili Cai, Xiaowei Jing, Zhengyu Xu, Lejian Jiang, Tianxin Wu, Guojun Wei, Qingfeng Hu

“…The objective of this study is to investigate the potential impact of the number of drain tubes on POSEH following biportal endoscopic unilateral laminotomy for bilateral decompression (BE-ULBD) in patients of two-level adjacent lumbar spinal stenosis. Methods A prospective randomized study was conducted involving 89 patients with two-level adjacent lumbar spinal stenosis who underwent BE-ULBD. …”
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Opioid versus opioid-free analgesia after surgical discharge: protocol for a systematic review and meta-analysis by Charbel El-Kefraoui, Ghadeer Olleik, Marc-Aurele Chay, Araz Kouyoumdjian, Philip Nguyen-Powanda, Fateme Rajabiyazdi, Uyen Do, Alexa Derksen, Tara Landry, Alexandre Amar-Zifkin, Agnihotram V. Ramanakumar, Marc-Olivier Martel, Gabriele Baldini, Liane Feldman, Julio F Fiore Jr

“…We propose a systematic review and meta-analysis to assess the extent to which opioid analgesia impact postoperative pain intensity and adverse events in comparison to opioid-free analgesia in patients discharged after surgery.Methods and analysis Major electronic databases (MEDLINE, Embase, Cochrane Library, Scopus, AMED, BIOSIS, CINAHL and PsycINFO) will be searched for multi-dose randomised-trials examining the comparative effectiveness of opioid versus opioid-free analgesia after surgical discharge. …”
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Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…Introduction Myopia and its complications can lead to irreversible visual impairment and even blindness, making this a worldwide public health concern for the 21st century. …”
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Hyperuricemia predicts adverse clinical outcomes after arthroscopic microfracture of osteochondral lesions of the talus by Yuanqiang Li, Zhenyu Wang, Guo Zheng, Lin Ma, Xin Xin Li, Yan Liang, Xinyu Xie, Xiaolin Zhang, Chengsong Yuan, Wan Chen

“…Purpose: To investigate the correlation of serum uric acid levels with the clinical outcomes of arthroscopic microfracture in osteochondral lesions of the talus (OLTs) and determine the cut-off point for predicting outcomes. Methods: A total of 134 OLTs patients who underwent arthroscopic microfracture from November 2008 to June 2019 were included: 42 in the hyperuricemia group (≥ 420 μmol/L) and 92 in the non-hyperuricemia group (< 420 μmol/L). …”
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Low density of intratumoral M1-macrophage infiltration may correlate with worse prognosis in low-grade early-stage uterine endometrioid carcinoma by Michiko Nagamine, Hiroshi Ogi, Maki Hirai, Ikoi Omatsu, Sanzo Moriwaki, Saya Shibata, Satoru Yasukawa, Kaori Yoriki, Motohiro Kojima, Taisuke Mori, Kyoko Itoh, Eiichi Konishi

“…Our objective was to explore the differences in tumor immune microenvironment (TIME) between recurrent and cured low-grade early-stage endometrioid carcinoma cases. Methods: We retrospectively examined the TIME in recurrent (n = 11) and non-recurrent (cured, n = 10) cases of low-grade, early-stage endometrioid carcinoma. …”
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Contemporary carotid artery stenting practices and peri-procedural outcomes in different European countries: ROADSAVER study multicentric insights by Stefan Müller-Hülsbeck, Zsolt Vajda, Piotr Odrowąż-Pieniążek, Zoltán Ruzsa, Roel Beelen, Aleksandar Gjoreski, Koen Deloose, Sérgio Castro, Benjamin Faurie, Alejandro Tomasello Weitz, Arne Schwindt, Paweł Latacz, Antonio Orgaz Pérez-Grueso, Vladimir Cvetić, Ralf Langhoff, Sasko Kedev, all ROADSAVER study investigators

“…However, their impact on procedural outcomes, especially with the use of dual-layer micromesh stents, is not fully understood. Methods This prospective, multi-center observational study included 1965 patients with asymptomatic or symptomatic carotid artery stenosis treated with the Roadsaver dual-layer micromesh stent. …”
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Characterisation of combined abiotic and biotic stresses effects on lettuce plants via a multi-analysis approach by Roberta Bulgari, Roberta Bulgari, Jouhaina Riahi, Riccardo Cecire, Riccardo Cecire, Luisella Celi, Mery Malandrino, Gica Stefanescu Miralles, Gica Stefanescu Miralles, Lorenzo Comba, Luca Alfarano, Luca Alfarano, Massimo Pugliese, Massimo Pugliese

“…These findings pave the way to the development of proactive, reliable, and effective methods for stress detection in lettuce cultivation, also including non-destructive optical approaches.…”
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Improvement in long-term survival with mesenchymal stem cell transplantation in systemic sclerosis patients: a propensity score-matched cohort study by Wenyi Yuan, Mian Liu, Dapeng Yang, Yirui Shi, Zhikang Wang, Xuan Cao, Jun Liang, Linyu Geng, Huayong Zhang, Xuebing Feng, Ziyi Jin, Dandan Wang, Lingyun Sun

“…While several studies have investigated the therapeutic potential of mesenchymal stem cell transplantation (MSCT), the clarity of its long-term outcomes for SSc patients is still lacking. Methods Data on MSCT were extracted from the medical records of inpatients at Nanjing Drum Tower Hospital between January 2013 and December 2022. …”
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Proportional representation and incidence rate of repeat visits in ethnic minorities compared to native Dutch people under the age of 25 years in the Netherlands by Y.J. Evers, A. Verhaegh, A. Ibrahim, C. Peters, N.H.T.M. Dukers-Muijrers, R. Reijs, C.J.P.A. Hoebe

“…In this study, we aimed to determine the proportional representation of first- and second generation EMs under 25 years at Dutch Sexual Health Centers (SHCs) compared to native Dutch citizens. Methods: In this retrospective cohort study, coded health records data of 270,927 persons in the age group of 15 till 24 years visiting SHCs between 2016 and 2021 were included. …”
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Effect of traditional Chinese medicine combined with conventional Western medicine for patients with severe/very severe chronic obstructive pulmonary disease: a multi-center, rando... by Jiansheng Li, Yang Xie, Minghang Wang, Suyun Li, Xuefeng Yu, Nianzhi Zhang, Zhengang Zhu, Wei Zhang, Jihong Feng, Zikai Sun, Lin Lin, Zhijia Sun, Hailong Zhang, Xueqing Yu

“…This study aimed to evaluate the clinical efficacy of comprehensive therapy based on TCM patterns for patients with stable, severe to very severe COPD. Methods A multicenter, randomised, double-blind, placebo-controlled trial was conducted. …”
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Diagnostic work-up of lipomatous tumors: a decision-making analysis among European sarcoma centers by Ali Naimi, Paul Martin Putora, Christian Rothermundt, Antonia Digklia, Jose Manuel Asencio, Sylvie Bonvalot, Florian Bösch, Anant Desai, Amer James Durrani, Haim Gutman, Daphne Hompes, Jens Jakob, Wolfram Trudo Knoefel, Elisabetta Pennacchioli, Piotr Rutkowski, Winan J. van Houdt, Barbara L. van Leeuwen, Stephan Waelti, Tim Steffen Fischer, Stefan Markart, Simon Wildermuth, Tobias Johannes Dietrich

“…The aim of this work was to compare standard operating procedures (SOPs) for the diagnostic management of lipomatous soft-tissue tumors among European academic centers. Methods Experts of the Soft Tissue and Bone Sarcoma Group of the European Organization for Research and Treatment of Cancer were asked for their SOPs in the diagnosis of adipocytic soft-tissue tumors in an otherwise healthy patient. …”
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Ensemble Computational Intelligent for Insomnia Sleep Stage Detection via the Sleep ECG Signal by Pragati Tripathi, M. A. Ansari, Tapan Kumar Gandhi, Rajat Mehrotra, Md Belal Bin Heyat, Faijan Akhtar, Chiagoziem C. Ukwuoma, Abdullah Y. Muaad, Yasser M. Kadah, Mugahed A. Al-Antari, Jian Ping Li

“…The traditional insomnia detection methods are time-consuming, cumbersome, and more expensive because they demand a long time from a trained neurophysiologist, and they are prone to human error, hence, the accuracy of diagnosis gets compromised. …”
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Heterogeneous treatment effects of stress ulcer prophylaxis among ICU patients at risk for gastrointestinal bleeding by Yongpeng Xie, Yao Yan, Qixiang Hong, Hui Zheng, Lijuan Cao, Xiaoming Li, Songqiao Liu, Hui Chen

“…Understanding HTE is crucial for tailoring SUP to individual treatment. Methods This cohort study included patients admitted to intensive care unit (ICU) with at least one risk factor for clinically important gastrointestinal bleeding (GIB). …”
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Using Human-Centered Design to Bridge Zero-Dose Vaccine Gap: A Case Study of Ilala District in Tanzania by Simon Martin Nzilibili, Hellen Maziku, Awet Araya, Ruthbetha Kateule, Millenium Anthony Malamla, Suna Salum, Furaha Kyesi, Lotalis Gadau, Tumaini Menson Haonga, Florian Tinuga, Rashid Mfaume, Zaitun Hamza, Georgina Joachim, Alice Geofrey Mwiru, Alex Benson, Oscar Kapela, Ona Machangu, Norman Jonas, Ntuli Kapologwe

“…As a result, 67,145 houses, equal to 104%, were reached, surpassing the initial target of 64,800 houses, and 131,088 families, equal to 83% of the targeted 156,995 households, were sensitized through a home-to-home campaign approach. …”
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Study of Concentration of Angiotensin-Converting Enzyme 2 Receptor Proteins in Different Age-groups and Genders with Reference to Susceptibility toward Severe Acute Respiratory Syn... by Shareef M Buvvaji, Vinod Joshi, Bennet Angel, Annette Angel, Poorna Khaneja, Monika Dheer, Bhawna Sharma, Neha Singh, Shilpa Barthwal, Ramesh Joshi, Ambreen S Khan, Nuzhat M Peer, Khushbu Kumari, Reshu Chauhan, Aarya Chitransh

“…The present study aimed to find whether age-specific disease severity was due to different concentrations of ACE2 in the patients. Materials and methods: Nasopharyngeal swab samples of different age-groups and gender from infected COVID-19 patients and healthy individuals were subjected to Enzyme-Linked Immunosorbent Assay (ELISA) for quantitative estimation of ACE2 in the upper respiratory tract. …”
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Greater pain and functional impairment in chronic erosive hand osteoarthritis compared to treated rheumatoid arthritis: A comparative study by S. Berkani, S. Tuffet, A. Rousseau, N. Rincheval, E. Maheu, B. Combes, A. Saraux, B. Fautrel, L. Gossec, F. Berenbaum, J. Sellam, A. Courties

“…Objectives: To compare the burden of established chronic rheumatoid arthritis (RA) and erosive hand osteoarthritis (EHOA), in terms of pain, functional impairment, comorbidities, and cardiometabolic diseases (CMD). Methods: This study included EHOA patients from the inclusion visit of the DIGICOD cohort and RA patients from the 10th year visit of the ESPOIR cohort. …”
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A pilot study to explore utility of electronic informed consent in a low- income setting; the case of a Controlled human infection study in Blantyre, Malawi [version 2; peer review... by Clara Ngoliwa, Joel Gondwe, Chikondi Chakwiya, Anthony E. Chirwa, Pemphero Liwonde, Evaristar Kudowa, Vitumbiko Nkhoma, Linda Chantunga, Modesta Reuben, Edward Mangani, Tiferanji Sochera, Neema Toto, Lumbani Makhaza, Dingase Dula, Stephen B. Gordon, Ben Morton, Tarsizio Chikaonda, Marc Y.R. Henrion, Edna Nsomba

“…Objectives We aimed to explore the utility of electronic consent (e-consent) in an ongoing human infection study in Blantyre, Malawi. Methods The approved paper consent forms were digitized using Open Data Kit (ODK). …”
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Scleral Buckling for Primary Retinal Detachment: Outcomes of Scleral Tunnels versus Scleral Sutures by Matthew R. Starr, Edwin H. Ryan, Anthony Obeid, Claire Ryan, Xinxiao Gao, Malika L. Madhava, Sean M. Maloney, Adam Z. Adika, Krishi V. Peddada, Kareem Sioufi, Luv G. Patel, Michael J. Ammar, Nora J. Forbes, Antonio Capone Jr., Geoffrey G. Emerson, Daniel P. Joseph, Dean Eliott, Carl D. Regillo, Jason Hsu, Omesh P. Gupta, Yoshihiro Yonekawa, for the Primary Retinal Detachment Outcomes (PRO) Study Group

“…Abstract Purpose: There are primarily two techniques for affixing the scleral buckle (SB) to the sclera in the repair of rhegmatogenous retinal detachment (RRD): scleral tunnels or scleral sutures. Methods: This retrospective study examined all patients with primary RRD who were treated with primary SB or SB combined with vitrectomy from January 1, 2015 through December 31, 2015 across six sites. …”
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Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial by SoYoung Ahn, Parivash Jamrasi, Byunggul Lim, Ji-won Seo, Xinxing Li, Shu Jiang, Yunho Sung, Seo Hyun Ahn, Chaeyoung Shin, Dongjin Noh, Bora Jin, Seonjoo Lee, Ki Won Lee, Jin Soo Kim, Young Tae Koo, Wook Song

“…Therefore, this study aimed to investigate the effects of the CAA herbal complex on muscle fatigue and endurance capacity in a randomized, placebo-controlled, double-blind trial. Methods: In an 8-week trial, 80 patients with chronic fatigue symptoms were randomly assigned to the CAA (43.5 ± 1.2 years) or placebo group (41.8 ± 1.3 years). …”
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Clinical manifestation and management of severe blepharokeratoconjunctivitis combined with corneal perforation by Xu Li, Ping Hou, Xiao-Lin Qi, Su-Xia Li, Wei-Yun Shi, Hua Gao, Ting Zhang

“…AIM: To investigate the clinical signs of blepharokeratoconjunctivitis (BKC) and evaluate the efficacy of penetrating keratoplasty (PKP) for the disease. METHODS: Sixteen patients (16 eyes) with BKC complicated by corneal perforation hospitalised at Shandong Eye Hospital were retrospectively analyzed. …”
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