Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis by Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

“…Xiangran Gu,1,* Yuan Chen,2,* Xinyue Hu,1,* Yunhui Li,3 Renlong Zhu,2 Hongxu Li,1 Zhengrong Yuan,1 Yajie Wang2,3 1College of Biological Sciences and Technology, Beijing Forestry University, Beijing, People’s Republic of China; 2Department of Clinical Laboratory, Peking University Ditan Teaching Hospital, Beijing, People’s Republic of China; 3Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengrong Yuan, College of Biological Sciences and Technology, Beijing Forestry University, No. 35 Tsinghua East Road, Haidian District, Beijing, 100083, People’s Republic of China, Email zryuan@bjfu.edu.cn Yajie Wang, Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China, Email wangyajie@ccmu.edu.cnObjective: This study aimed to identify autophagy-related genes (ARGs) with prognostic significance in hepatocellular carcinoma (HCC) using bioinformatics and survival analysis.Materials and Methods: ARGs were sourced from multiple references, including the Human Autophagy Database (HADb), relevant literatures, the Gene Set Enrichment Analysis (GSEA), and a final list was confirmed after eliminating duplicate entries. …”
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Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection by Andrea A. Berry, Thomas L. Richie, L. W. Preston Church, Matthew B. Laurens, Colleen Boyce, Natasha KC, Sudhaunshu Joshi, Abra Rachida Koudjra, Lauryn Butler, Mei-Chun Chen, Yonas Abebe, Tooba Murshedkar, Eric R. James, Peter F. Billingsley, B. Kim Lee Sim, Stephen L. Hoffman, Kirsten E. Lyke

“…Attenuated P. falciparum sporozoites (PfSPZ) are being developed as a traveller’s vaccine and to fulfill WHO’s call for high-level efficacy in endemic countries to support malaria elimination. Methods PfSPZ Vaccine, comprised of radiation-attenuated PfSPZ, was compared with normal saline placebo in a randomized, double-blind trial targeting 60 malaria-naive US adults to assess safety, tolerability, immunogenicity, and efficacy against heterologous controlled human malaria infection three and twelve weeks after immunization. …”
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Correlation of Novel Inflammation Index with Postoperative Acute Kidney Injury in Patients with Joint Arthroplasty: A Retrospective Cohort Study by Yan YT, Liu R, Liu J, Zhang WJ, Wang S, Tang TY, Lei YQ, Zhu XY, Liu KX, Zheng QJ, Liu HM

“…This study investigated the association between novel inflammation indices and postoperative AKI.Methods: This retrospective cohort study included 1434 patients who underwent hip or knee arthroplasty, with 1225 patients comprising the complete case analysis dataset. …”
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Real-World Assessment of the Association Between PCSK9i Adherence and LDL Reduction and Variability in a Chinese Clinical Practice by Ye X, Zhang S, Zhong X, Li M, Liu M, Zhuang X, Liao X

“…Xiaomin Ye,1,2,* Shaozhao Zhang,1,2,* Xiangbin Zhong,1,2 Miaohong Li,1,2 Menghui Liu,1,2 Xiaodong Zhuang,1,2 Xinxue Liao1,2 1Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinxue Liao, Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People’s Republic of China, Tel +86-13903063724, Fax +86-020-28823388, Email liaoxinx@mail.sysu.edu.cn Xiaodong Zhuang, Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People’s Republic of China, Tel +86-13760755035, Email zhuangxd3@mail.sysu.edu.cnBackground: Real-world evidence about adherence to proprotein convertase subtilisin/kexin type-9 inhibition (PCSK9i) is needed in Chinese population.Objective: We aimed to evaluate the adherence patterns using anti-PCSK9 monoclonal antibody in Chinese clinical practice and explored the association between adherence to PCSK9i and low-density lipoprotein cholesterol (LDL-C) reduction ratio and variability.Methods: A total of 5373 patients initiating PCSK9i in the First Affiliated Hospital of Sun Yat-sen University were included as sub-analysis of the RED-CARPET registry. …”
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Spatial variation and associated factors of home delivery among reproductive age group women in Ethiopia, evidence from Performance Monitoring for Action Ethiopia Survey 2019, spat... by Ermias Bekele Enyew, Kokeb Ayele, Lakew Asmare, Fekade Demeke Bayou, Mastewal Arefaynie, Yawkal Tsega, Abel Endawkie, Shimelis Derso Kebede, Abiyu Abadi Tareke, Kaleab Mesfine Abera, Natnael Kebede, Mahider Shimelis Feyisa, Mengistu Mera Mihiretu

“…Therefore, this study aims to investigate the spatial distributions of home birth and associated factors in Ethiopia using the Performance Monitoring for Action Survey (PMAS) 2019) to get information that helps to take geographic-based interventions and can assist health planners and policymakers in developing particular measures to reduce home deliveries.MethodIn PMA-ET 2019, a community-based cross-sectional study was conducted in collaboration with Addis Ababa University, Johns Hopkins University, and the Federal Ministry of Health from September 2019 to December 2019, in Ethiopia. …”
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Mapping the key players in Kawasaki disease; role of inflammatory genes and protein-protein interactions by Wael Hafez, Feras Al-Obeidat, Asrar Rashid, Afsheen Raza, Nouran Hamza, Nesma Ahmed, Marwa M. Abdeljawad, Raziya Kadwa, Abdelhameed Elmesery, Muneir Gador, Dina Khair, Gihan Zina, fatema Abdulaal, Mina Wassef Girgiss, Maha Abdelhadi, Ahmed Abdelrahman, Mahmad Anwar Ibrahim, Mohamed El Sherbiny

“…Objective: This study aimed to identify the genetic patterns and molecular mechanisms associated with KD using a comprehensive gene expression analysis. Methods: RNA sequencing and microarray genomic datasets were retrieved from the NCBI Gene Expression Omnibus (GEO). …”
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Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort... by Adrián Borja-Flores, Salvador I. Macías-Hernández, Gabriela Hernández-Molina, Andric Perez-Ortiz, Eloy Reyes-Martínez, José Belzazar-Castillo de la Torre, Laura Ávila-Jiménez, María Cristina Vázquez-Bello, Marco Antonio León-Mazón, Janette Furuzawa-Carballeda, Gonzalo Torres-Villalobos, Fernanda Romero-Hernández, Cidronio Albavera-Hernández, Jesús Pérez-Correa, Hilda A. Castro-Rocha

“…The aim was to evaluate the effect of intra-articular injections (IAIs) of polymerized-collagen among patients with symptomatic knee osteoarthritis (OA) in delaying or preventing joint replacement surgery. Patients and Methods. This was a cohort study of 309 patients with knee OA. …”
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Postoperative pain and influencing factors after prophylactic extraction of impacted mandibular third molars: a multicenter prospective cohort study by Zhiwei Cao, Chengzhi Zhao, Renyi Wang, Qianxing Du, Kun Zhang, Jihong Zhao, Yang Xue, Bing Han, Jiuyan Jiang, Liwei Hu, Xuejuan Liao, Jian Pan

“…Abstract Objective This study aims to investigate factors influencing postoperative pain after prophylactic third molar extraction to provide evidence-based recommendations for clinical practice. Methods This study enrolled 804 patients undergoing prophylactic third molar extraction. …”
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Non-tuberculous mycobacteria and other acid fast bacilli pathogens identification by qPCR and MALDI-ToF MS in tuberculosis-like lesions of slaughtered cattle from Ecuador by Solon Alberto Orlando, Solon Alberto Orlando, Leila Estefania Vera Loor, Joselyn Calderón, Melissa Joseth Carvajal-Capa, Fabrizio Arcos Alcívar, Pablo Torres-Lasso, W. Favián Maza Valle, Oliverio N. Vargas González, Naomi Mora-Jaramillo, Ariana León-Sosa, Ariana Rivera, Angel Sebastián Rodríguez-Pazmiño, Bernardo Castro-Rodriguez, Greta Franco Sotomayor, Greta Franco Sotomayor, Sandra Uruchima-Campoverde, Manuel Gonzalez, Jose Manuel Benitez-Medina, Natalia Jimenez-Pizarro, Javier Hermoso de Mendoza, Henry Parra-Vera, Miguel Angel Garcia-Bereguiain

“…While the importance of NTM in opportunistic infections in humans has been gaining attention, surveillance and control programs for cattle health and production remain predominantly focused on bovine tuberculosis (BTB) that it is caused exclusively by MTBC.MethodsIn this study, we conducted a comprehensive inspection of 5,803 cattle carcasses destined for human consumption across 22 abattoirs in five provinces of Ecuador’s coastal region, searching for lesions visually compatible with BTB (BTB-like lesions).ResultsA high prevalence of 13.4% (CI 95%: 12.8–14.6) for BTB-like lesions and 3.1% (CI 95%: 2.6–3.5) for acid-fast bacilli (AFB) presence in lesions was observed. …”
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Comparison of intraoperative and postoperative outcomes between open, wiltse, and percutaneous approach to traumatic thoracolumbar spine fractures without neurological injury: A sy... by Abdulrahman O. Al-Naseem, MB ChB (Hons), MSc, Yusuf Mehkri, MD, Sachiv Chakravarti, MD, Eli Johnson, MD, Margot Kelly-Hedrick, MD, Cathleen Kuo, MD, Melissa Erickson, MD, MBA, Khoi D. Than, MD, Brett Rocos, MD, BSc (Hons), MB, ChB, Deb Bhowmick, MD, Christopher I. Shaffrey, MD, Norah Foster, MD, Ali Baaj, MD, Nader Dahdaleh, MD, C. Rory Goodwin, MD, PhD, Theresa L. Williamson, MD, Yi Lu, MD, PhD, Muhammad M. Abd-El-Barr, MD, PhD

“…This systematic review and meta-analysis aims to compare perioperative outcomes between these approaches. Methods: PubMed, Web of Science, Scopus, Embase, and the Cochrane Library were searched for all relevant observational comparative studies. …”
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Long-Shaft Vitrectomy Probe for Vitreoretinal Diseases in Highly Myopic Eyes: A Randomized Controlled Trial by Yun Hsia, MD, MS, Cheng-Yung Lee, MD, Mei-Chi Tsui, MD, Shih-Wen Wang, MD, Chien-Jung Huang, MD, I-Hsin Ma, MD, MS, Kuo-Chi Hung, MD, Muh-Shy Chen, MD, PhD, Zih-Wei Yang, MD, Bo-Da Huang, MD, Ting-Chieh Ko, MD, Tzyy-Chang Ho, MD

“…Subjects: Highly myopic eyes (axial length [AL] >26 mm) with epiretinal membrane (ERM), myopic tractional maculopathy, and retinal detachment. Methods: The enrolled eyes were randomly assigned to a study group (UltraVit 25 Ga, 31.75 mm, Alcon) and a control group (UltraVit 25 Ga+, 27 mm, Alcon). …”
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Cognition and behavior in adults with neurofibromatosis type 1 by Anja Bos-Roubos, Anja Bos-Roubos, Anja Bos-Roubos, Hanneke van Leeuwen, Hanneke van Leeuwen, Hanneke van Leeuwen, Ellen Wingbermühle, Ellen Wingbermühle, Ellen Wingbermühle, Ellen Wingbermühle, Louisa van den Bosch, Lindsey Ossewaarde, Walter Taal, Walter Taal, Laura de Graaff, Laura de Graaff, Laura de Graaff, Jos Egger, Jos Egger, Jos Egger, Jos Egger, Jos Egger

“…The present study describes the neuropsychological phenotype of adults with NF1 based on comprehensive clinical examination of cognition and behavior across multiple functions.MethodsParticipants were 62 adults with NF1 (mean age 38.2 years; SD 13.4). …”
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Vaccination coverage, hesitancy and associated factors: a household survey of a cohort of children born in 2017 and 2018 in urban areas of state capital cities in the Brazilian Nor... by Ramon da Costa Saavedra, Martha Suely Itaparica de Carvalho Santiago, Maria da Glória Lima Cruz Teixeira, Maria Bernadete de Cerqueira Antunes, Rejane Christine de Sousa Queiroz, Luisa Helena de Oliveira Lima, Alberto Novaes Ramos Jr, Anderson Fuentes Ferreira, Adjoane Mauricio Silva Maciel, Jaqueline Caracas Barbosa, Ana Paula França, Carla Magda Allan Santos Domingues, José Cássio de Moraes, Adriana Ilha da Silva, Alberto Novaes Ramos Jr., Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Glória Lima Cruz Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo

“…ABSTRACT Objective To estimate vaccination coverage and analyze sociodemographic factors associated with non-vaccination in children born in 2017 and 2018 in the state capitals of Northeast Brazil. Methods A household survey using cluster sampling was conducted from 2020-2022 to estimate vaccination coverage and hesitancy. …”
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Long-Term Safety and Efficacy of Lenabasum, a Cannabinoid Receptor Type 2 Agonist, in Patients with Dermatomyositis with Refractory Skin Disease: Follow-Up Data from a 3-Year Open-... by Caroline J. Stone, Geeta Ahuja, Lais Lopes Almeida Gomes, Joy Poroye, Daniella Forman Faden, Lillian Xie, Rui Feng, Barbara White, Victoria P. Werth

“…Key aims include evaluating the drug’s long-term effectiveness and assessing disease manifestation recurrence. Methods: The phase 2 lenabasum trial enrolled patients with treatment-resistant, skin-predominant DM. …”
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Monitoring Anthropogenically Disturbed Parcels with Soil Erosion Dynamics Change Based on an Improved SegFormer by Zhenqiang Li, Jialin Li, Jie Li, Zhangxuan Li, Kuncheng Jiang, Yuyang Ma, Chuli Hu

“…Currently, traditional methods for change detection, such as field surveys and visual interpretation, suffer from time inefficiencies, complexity, and high resource consumption. …”
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Key motor and non-motor features in early dementia with Lewy bodies by Anna Planas-Ballvé, Anna Planas-Ballvé, José Rios, Lourdes Ispierto, Mireia Gea, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vilas, Dolores Vilas

“…ObjectiveThe objective of our study was to characterize early-stage dementia with Lewy bodies (DLB) focusing on motor and non-motor symptoms.MethodsThis cross-sectional study prospectively included newly diagnosed DLB patients within 3 years of cognitive symptom onset. …”
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Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…Participants: The study included 29 healthy subjects (51 eyes) and 62 DED patients (95 eyes). Methods: All subjects underwent comprehensive ophthalmic examinations, dry eye tests, and in vivo confocal microscopy to visualize the whorl-like corneal nerve at the inferior whorl (IW) region and the straight nerve at the central cornea. …”
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Exploring family physicians’ mental health referrals via centralized referral systems in Quebec, Canada: a qualitative descriptive study by Jessica Spagnolo, Marie Beauséjour, Marie-Josée Fleury, Jean-François Clément, Claire Gamache, Lyne Couture, Carine Sauvé, Shane Knight, Christine Gilbert, Richard Fleet, Helen-Maria Vasiliadis

“…Methods: A qualitative descriptive study with 20 participants working in the healthcare sector was conducted. …”
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The efficacy and safety of glycosaminoglycan-peptide complex in patients with knee osteoarthritis and comorbidity: a multicenter prospective study by L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, E. P. Sharapova, E. A. Strebkova, S. G. Anikin, N. V. Chichasova, T. A. Raskina, E. V. Zonova, E. N. Otteva, E. I. Shmidt, S. P. Yakupova, I. B. Vinogradova, O. N. Ivanova, V. A. Lila, B. V. Zavadovsky, P. A. Shesternya, A. M. Lila

“…Objective: to evaluate the efficacy and safety of glycosaminoglycan-peptide complex (GPC, Rumalon) used in patients with knee osteoarthritis (OA) and comorbidities (hypertension and/or type 2 diabetes mellitus (T2DM).Patients and methods: A 10-month multicenter (13 centers from 10 subjects of the Russian Federation) prospective study included 179 patients with Stages II–III primary tibiofemoral knee OA and comorbidity, a walking pain intensity of ≥40 mm on a visual analogue scale (VAS), and a need for nonsteroidal anti-inflammatory drugs (for at least 30 days in the previous 3 months). …”
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Machine Learning Model Based on Prognostic Nutritional Index for Predicting Long‐Term Outcomes in Patients With HCC Undergoing Ablation by Nan Zhang, Ke Lin, Bin Qiao, Liwei Yan, Dongdong Jin, Daopeng Yang, Yue Yang, Xiaohua Xie, Xiaoyan Xie, Bowen Zhuang

“…ABSTRACT Aims To develop multiple machine learning (ML) models based on the prognostic nutritional index (PNI) and determine the optimal model for predicting long‐term survival outcomes in hepatocellular carcinoma (HCC) patients after local ablation. Methods From January 2009 to December 2019, we analyzed data from 848 primary HCC patients who underwent local ablation. …”
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