E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer by Ligang Chen, Mingyi Wang, Yunge Gao, Yanhong Lv, Lianghao Zhai, Jian Dong, Yan Chen, Xia Li, Xin Guo, Biliang Chen, Yi Ru, Xiaohui Lv

“…The increased degradation of S100A11 led to less efficient DNA damage repair, which in turn contributed to increased PARPi-induced DNA damage. …”
Get full text

New Insights into the Adsorption Mechanism of Vanadium Through Quaternary Ammonium Salt-Functionalized SiO₂: Synergistic Experiments Utilizing Energy Decomposition Analy... by Qiang Fu, Jianhua Tian, Jinjun Yang, Jie Wang, Meitong Li, Gangzhen Jiao, Yuhong Xie, Wenjiao Yuan, Cuihong Wang

“…SiO₂@DMOA maintained efficient adsorption performance over five repeated cycles. …”
Get full text

Architecture of Ti–6Al–4V thin-walled microthrusters fabricated via laser powder bed fusion by Jeongrak Lee, Junghoon Lee, Rae Eon Kim, Seonghyeon Kim, Kyungtae Kim, Youngsam Kwon, Hongjae Kang, Gunsu Yun, Dongsik Kim, Anna Lee, Hyoung Seop Kim

“…Propulsion efficiencies were also high, with characteristic-velocity and specific-impulse efficiencies reaching 84.3% and 91.7%, respectively. …”
Get full text

Double-blinded, randomized tolerance study of a biologically enhanced Nanogel with endothelin-1 and bradykinin receptor antagonist peptides via intra-articular injection for osteoa... by Antoinette Terlinden, Sandrine Jacquet, Seng Manivong, Aurélie Cullier, Frédéric Cassé, Florence Legendre, Araceli Ac Garcia, Gaëlle Roullin, Florina Moldovan, Pierre Sirois, Xavier Banquy, Philippe Galéra, Fabrice Audigié, Magali Demoor, Lélia Bertoni

“…The purpose of this double-blinded randomized tolerance study versus negative control was to evaluate the response of healthy joints to a single injection of the expected efficient dose (further referred to as the trial dose) and overdose of nanogels composed of chitosan and hyaluronic acid and featuring a type A endothelin receptor antagonist and a type B1 bradykinin receptor antagonist. …”
Get full text

Normothermic ex vivo heart and lung autoperfusion: assessment of functional status and metabolism by A. R. Tarkova, I. S. Zykov, M. O. Zhulkov, A. V. Protopopov, Ya. M. Smirnov, A.  G. Makaev, A. V. Guseva, F. Yu. Kosimov, M. N. Murtazaliev, A. D. Limansky, D. A. Sirota, E.  E. Kliver, V. E.  Kliver, А. M. Volkov, A. M. Chernyavsky

“…In the control group, the heart pumping function was restored after 6-hour cold cardioplegia using Bretschneider’s solution. The efficiency of graft preservation was assessed by measuring hemodynamic parameters, myocardial contractile function, and myocardial oxygen consumption.Results. …”
Get full text

Development and validation of a gut motility based model for predicting bowel preparation quality by Hongjiao Wu, Rui Wu, Yunyun Zhang, Xinyi Lu, Wei Zhao, Biyun Xu, Jun Liu, Nina Zhang

“…This model provides a practical, motility-informed approach for risk stratification and personalized preparation regimens, offering potential to enhance the effectiveness and efficiency of colonoscopy in diverse clinical settings.…”
Get full text

Identification of Hotspot Regions for Candidate Genes Associated with Peanut (<i>Arachis hypogaea</i> L.) Pod and Seed Size on Chromosome A05 by Xiaoji Zhang, Luhuan Wang, Qimei Liu, Xiaoyu Zhang, Yuexia Tian, Yunyun Xue, Huiqi Zhang, Na Li, Xin Zhang, Dongmei Bai

“…The size of peanut pods and seeds, which directly affects yield and quality, also has significant implications for mechanized production and market efficiency. Identifying relevant loci and mining candidate genes is crucial for cultivating high-yield peanut varieties. …”
Get full text

Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis by E. Lopez-Soley, E. Martinez-Heras, F. Vivo, A. Calvi, S. Alba-Arbalat, L. Romero-Pinel, S. Martínez-Yélamos, C. Ramo-Tello, S. Presas-Rodríguez, E. Munteis, J.E. Martínez-Rodríguez, J. Sastre-Garriga, E. Anglada, E.R. Meza-Murillo, M.J. Arévalo, R. Sánchez-Carrión, R. Pelayo, M. Bernabeu, N. Sola-Valls, M. Hervas, M. Sepulveda, A. Saiz, Y. Blanco, E. Solana, S. Llufriu

“…Brain MRI pre- and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. …”
Get full text

Analisa Tingkat Kematangan Literasi Tik Pada Tenaga Kesehatan Dalam Pelayanan Kesehatan Berbasis TIKDi Puskesmas Kota Palembang by Istiqomah Febrianty, Darius Antoni, Dedy Syamsuar, Diana Diana

“…While social media is at Level 2 (Repeatable) with an average maturity index between 0,65 – 0,70.   …”
Get full text

X-linked spinal and bulbar muscular atrophy (Kennedy's disease) with long-term electrophysiological evaluation: case report Atrofia muscular bulbo-espinal ligada ao cromossomo X (d... by João Aris Kouyoumdjian, Maria da Penha Ananias Morita, Rogério Gayer Machado de Araújo

“…PCR techniques of DNA analysis showed an abnormal number of CAG repeats, found to be 44 (normal 11-34). Our case revealed an acute and asymmetric clinical presentation related to bulbar motoneurons; low amplitude/absent SNAP with mild asymmetry; a sub-clinical or subtle involvement of proximal/distal muscles of both upper and lower limbs; and a probable evolution with bouts of acute dennervation, followed by an efficient reinnervation.…”
Get full text

InvarNet: Molecular property prediction via rotation invariant graph neural networks by Danyan Chen, Gaoxiang Duan, Dengbao Miao, Xiaoying Zheng, Yongxin Zhu

“…Recently, deep learning methods, particularly Graph Neural Networks (GNNs), have significantly improved efficiency by capturing molecular structures’ invariance under translation, rotation, and permutation. …”
Get full text

Callus culture-derived regeneration and molecular characterization of regenerated Stevia rebaudiana: implications for steviol glycoside production and genetic stability by Pritom Biswas, Ankita Kumari, Arpan Modi, Amiya Priyam, Rizwanul Haque, Mohammad Shamsul Ola, Sanjeev Kumar, Nitish Kumar

“…MS medium containing NAA and 6-Benzylaminopurine (BAP) was most effective for shoot regeneration, yielding the highest shoot induction rate (87.77%) and robust plant growth. Rooting efficiency was significantly enhanced by using a quarter-strength MS medium with Indole-3-acetic acid (IAA), which produced the highest rooting percentage (88.40%) and longest roots (3.41 cm). …”
Get full text

Crop rotation combined with bionematicides for Pratylenchus brachyurus management in soybean by Guilherme Tarini, Eduarda Thais Sonda, Monique Thiara Rodrigues e Silva, Raiane Pereira Schwengber, Angélica Miamoto, Simone de Melo Santana-Gomes, Angélica Calandrelli, Cláudia Regina Dias-Arieira

“…This study assessed the efficiency of cover crops combined with bionematicides in managing Pratylenchus brachyurus in soybean. …”
Get full text

Plasma-Activated Water Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i> and Vancomycin-Resistant <i>Enterococcus faecalis</i> by Dragana Vuković, Maja Miletić, Boško Toljić, Nikola Milojević, Olivera Jovanović, Jovana Kuzmanović Pfićer, Nikola Škoro, Nevena Puač

“…Time-dependent significant inactivation efficiency against <i>K. pneumoniae</i> was observed (log reduction 6.92 ± 0.24 after 60 min exposure), while effects on <i>E. faecalis</i> were limited. …”
Get full text

Spatial and temporal predictability drive foraging movements of coastal birds by Madeleine Foley, Kimberly A. Lato, Matthew Fuirst, Richard R. Veit, Robert M. Cerrato, Lesley H. Thorne

“…Abstract Background Temporal and spatial predictability of food resources are critical to the foraging efficiency of central place foragers. While site fidelity is often assessed in this context, route fidelity, or the repeated use of the same path while traveling, and temporal aspects of habitat predictability have received less attention. …”
Get full text

Endoscopic Prophylaxis and Treatment of Portal-Genesis Oesophageal Haemorrhage by B. Kh. Bebezov, R. A. Sultangaziev, T. A. Abdykadyrov

“…In early postoperative period, 2 patients developed recurrent bleeding, with haemostasis re-achieved by a repeated vein ligation below bleeding.Conclusion. Hence, small invasiveness and minor traumatism coupled with high efficiency and lesser complications render endoscopic ligation the method of choice in primary and secondary prophylaxis and treatment of OV. …”
Get full text

Study protocol for a stepped-wedge, randomized controlled trial to evaluate implementation of a suicide risk identification model among behavioral health patients in three large he... by Scott P. Stumbo, Stephanie A. Hooker, Rebecca C. Rossom, Kathleen Miley, Brian K. Ahmedani, Elizabeth Lockhart, Hsueh-Han Yeh, Bobbi Jo H. Yarborough

“…A stepped-wedge design using repeated measures pre/post-implementation maximizes statistical efficiency and power with fewer participants compared to a parallel design while allowing all clinics to participate. …”
Get full text

Intraoperative oximetry of hollow organs in case of gunshot injuries of the abdomen by I. V. Sobko

“…In phase III of DCS, intraoperative oximetry was performed to assess the viability of questionable areas of both sutured wounds and intestinal stumps after obstructive resections. Results. The high efficiency of intraoperative oximetry in penetrating gunshot injuries of the abdomen in phase I of DCS tactics has been proven. …”
Get full text

Genetic Assessment and Positioning of Algerian Barley Landraces with Respect to Landraces from the Middle East and Europe Using RAPD and SSR Markers by Hamama Guetteche, Ali Jarrar, Sascha Wetters, Leila Rouabah, Abdelkader Rouabah, Abdelkader Benbelkacem, Ruzanna Sadoyan, Adnan Kanbar, Peter Nick

“…Landraces are a critical genetic resource for resilience breeding, offering solutions to prepare agriculture for the challenges posed by climate change. Their efficient utilisation depends on understanding their history and genetic relationships. …”
Get full text

Effects of sustained cold and heat stress on energy intake, growth and mitochondrial function of broiler chickens by Shao-shuai ZHANG, Hong-guang SU, Ying ZHOU, Xiu-mei LI, Jing-hai FENG, Min-hong ZHANG

“…And these could provide the theoretical basis on the high efficient production.…”
Get full text