NanoAbLLaMA: construction of nanobody libraries with protein large language models by Xin Wang, Haotian Chen, Bo Chen, Lixin Liang, Fengcheng Mei, Bingding Huang

“…This study introduces a novel approach leveraging protein large language models (LLMs) to generate germline-specific nanobody sequences, enabling efficient library construction through statistical analysis.MethodsWe developed NanoAbLLaMA, a protein LLM based on LLaMA2, fine-tuned using low-rank adaptation (LoRA) on 120,000 curated nanobody sequences. …”
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Microbiota and Cytokine Modulation: Innovations in Enhancing Anticancer Immunity and Personalized Cancer Therapies by Hamidreza Farhadi Rad, Hamed Tahmasebi, Samaneh Javani, Maral Hemati, Darya Zakerhamidi, Masoomeh Hosseini, Farnaz Alibabaei, Seyedeh Zahra Banihashemian, Valentyn Oksenych, Majid Eslami

“…Cytokines including TGF-β, IL-6, and IL-10 promote tumor development by inhibiting efficient immune surveillance. The gut microbiome exhibits a delicate balance between pro- and anti-tumorigenic factors, as evidenced by the enhancement of anti-tumor immunity by cytokines such as IL-12 and IFN-γ. …”
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Spot Urine PCR as an Independent Predictor of Renal Disease in Patients with Essential Hypertension by Spoorthi P. Yadagudde, Jayannan Jayasenan, Anbarasu Duraisamy

“…Spot urine PCR proved to be an effective and cost-efficient tool for early detection of kidney impairment in hypertensive patients. …”
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Response Analysis of an Experimental Study on the Effect of Speed and Premixed Fuel Ratio on Performance and Emissions in RCCI Engine by Habtamu Deresso Disassa, Venkata Ramayya Ancha, Ramesh Babu Nallamothu, Bisrat Yoseph, Getachew Alemayehu

“…Even though CI engines are more efficient than SI engines due to their ability to operate at a greater compression ratio, a leaner charge, and lower throttle losses, they have higher PM and nitrogen oxide emissions. …”
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Real-Time Triage, Position, and Documentation (TriPoD) During Medical Response to Major Incidents: Protocol for an Action Research Study by Monica Rådestad, Torkel Kanfjäll, Veronica Lindström

“…ConclusionsThis protocol includes several methods for data collection that will form the basis for the design and development process of a digital solution for real-time information sharing to support efficient management in major incidents based on the experiences and requirements of end users. …”
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A Comparative Evaluation of Bubble Breath Play Therapy and Hand-held Video Gaming Used in Reducing Dental Anxiety among Children by Shital Kiran Davangere Padmanabh, Omkar R Bhise

“…Clinical significance: Hand-held video gaming and bubble breath are efficient in children to reduce the dental anxiety.…”
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Enhancing the low concentration CO2-capture abilities of aminium ionic liquids through blending with acetate ionic liquids by Yu Nagai Kanasaki, Yuki Kohno, Takashi Makino

“…The efficient capture of low-concentration CO2 is essential for achieving carbon neutrality and recycling. …”
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The impact of a risk assessment tool on hospital pressure injury prevalence and prevention: a quantitative pre-post evaluation by Ragnar Seton, Elisabeth Wetzer, Lisa Hultin

“…The use of an evidence-based risk assessment instrument is, therefore, crucial to enable efficient, effective, and reliable assessments. Objective: The evidence-based pressure injury risk assessment instrument PURPOSE T was widely introduced at a university hospital in 2021, replacing another commonly used assessment tool, the Modified Norton Scale. …”
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DVCW-YOLO for Printed Circuit Board Surface Defect Detection by Pei Shi, Yuyang Zhang, Yunqin Cao, Jiadong Sun, Deji Chen, Liang Kuang

“…The accurate and efficient detection of printed circuit board (PCB) surface defects is crucial to the electronic information manufacturing industry. …”
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Activated Sawdust-Based Adsorbent for the Removal of Basic Blue 3 and Methylene Green from Aqueous Media by Najeeb Ur Rahman, Wasim Bahadar, Sultan Alam, Muhammad Zahoor, Ivar Zekker, Farhat Ali Khan, Riaz Ullah, Essam A. Ali, H. C. Ananda Murthy

“…Although activated carbon is an efficient adsorbent for dye reclamation from effluents, its expressive nature renders its use on large commercial scales. …”
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Unsupervised evaluation of pre-trained DNA language model embeddings by Raghav Awasthi, Gayan Samuditha Mend Mend Arachchige, Xiaofeng Zhu

“…Conclusion This study introduces a computationally efficient framework for evaluating DLMs. Our results show that GENA-LM, DNA-BERT2, and Nucleotide Transformer frequently outperform HyenaDNA and Mistral across both unsupervised and supervised evaluations. …”
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Impact of taxation policy on tobacco consumption in Saudi Arabia by Hawazin Fahad Alotaibi, Nasser Abdullah Alsanea

“…BACKGROUND: Taxes on tobacco products that increase the price and target demand-reduction have been shown to be an efficient means of reducing tobacco consumption. A new policy introduced in 2017 has increased the price of a 20-cigarette pack of the most popular brand to 27.50 SAR (7.33 USD) with the tax portion being 68.09%, which is within the yardstick recommended by the World Bank. …”
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Trust-driven approach to enhance early forest fire detection using machine learning by Tayyab Khan, Karan Singh, Bhoopesh Singh Bhati, Khaleel Ahmad, Amal Al-Rasheed, Masresha Getahun, Ben Othman Soufiene

“…The detrimental impacts of forest fires, such as the exacerbation of the greenhouse effect, the hastening of global warming, and the modification of climatic patterns, underscore the urgent necessity for the creation of efficient detection systems. …”
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Research on the Instability Mechanism and Control Technology of Gob-Side Entry in Deep Mines with Soft Rock by Lu Ma, Luyi Xing, Chang Liu, Tongyuan Cui, Xi Qiao, Wang Miao, Peng Kong

“…This complexity leads to challenges in roadway stability control which greatly affects the coal mine production succession and safe and efficient mining. This paper takes the gob-side entry in Liuzhuang Coal Mine as the background. …”
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Comparison of genomic prediction accuracies in dairy cattle lactation traits using five classes of functional variants versus generic SNP by Setegn Worku Alemu, Thomas J. Lopdell, Alexander J. Trevarton, Russell G. Snell, Mathew D. Littlejohn, Dorian J. Garrick

“…This highlights the potential for the development of more efficient, trait-focused SNP panels utilizing functional variants.…”
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Progress in functional covalent organic frameworks as advanced materials for sample pretreatment by Hui Cao, WeiKang Guo, Ke Liu, Qin Shuai, Lijin Huang, Zhaochu Hu

“…The review begins by examining two primary strategies for functionalizing COF: ''bottom-up'' and ''post-synthetic modification''. Subsequently, the interaction mechanisms and analytical performances of methods based on functionalized COFs are critically analyzed, emphasizing their extraction efficiency and selectivity. …”
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U-Net-based VGG19 model for improved facial expression recognition by Xiaohu ZHAO, Jingyi ZHANG, Mingzhi JIAO, Lixun XIE, Lanfei WANG, Weiqing SUN, Di ZHANG

“…The use of feature cropping and stitching techniques allows the model to efficiently integrate multi-scale features, thereby enhancing the robustness and effectiveness of facial expression recognition tasks. …”
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Agricultural Waste–Derived Biochar for Antibiotics Removal in Aqueous Environment: A Comprehensive Outlook by Varalakshmi Varatharajan, Karthik V., Selvakumar Periyasamy

“…Biochar form agricultural waste can efficiently remove antibiotics from aquatic environments and is a renewable and cost-effective adsorbent. …”
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Miniature enOsCas12f1 Enables Targeted Genome Editing in Rice by Junjie Wang, Qiangbing Xuan, Biaobiao Cheng, Beibei Lv, Weihong Liang

“…The editing efficiencies of TTT and TTC PAMs were 6.21% and 44.21%, respectively. …”
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P39 | NEW PERSPECTIVES FOR THE EXPLOITATION OF FEMALE REPRODUCTIVE POTENTIAL IN MAMMALS: GENERATION OF GRANULOSA-LIKE CELLS FROM HUMAN ADIPOSE MESENCHYMAL STEM CELLS

“…To verify their functional state, hiPSC-GLCs and hASC-GLCs were aggregated with 12.5 dpc mouse primordial germ cells (mPGCs) to have organoids in which, after 4 weeks of culture, significant number of germ cells, likely growing oocytes, were found, but with low efficiency. For this reason, two recent protocols3,4 developed in mouse were employed, with some modifications to adapt to our cells. …”
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