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2561
Mechanism of modified mRNA structure in COVID-19 vaccines for inducing neutralizing antibodies
Published 2024-10-01“… The development of SARS-CoV-2 mRNA vaccines is closely linked to advancements in mRNA manufacturing technology. Structural modifications, such as replacing uridine with 1-methylpseudouridine (1mψ), enhance translation efficiency and help the mRNA evade immune detection. …”
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2562
The first ornithocheiromorph humerus from Wuerho (Urho), China, with a new isotopic age of the Tugulu Group
Published 2025-01-01“…The new finding here also suggests that Ornithocheiromorpha had rapidly diversified and achieved a global distribution during the earliest Cretaceous, presumably through a series of modifications on the locomotor apparatus including the warped deltopectoral crest of the humerus, which might substantially improve their flight efficiency.…”
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2563
A semantic segmentation framework with UNet-pyramid for landslide prediction using remote sensing data
Published 2024-12-01“…Currently, Deep Learning is constrained by the lack of applicability, lack of data, and low efficiency in landslide detection but with recent advancement in deep learning-based solutions for landslide detection has sparked considerable advantages over traditional techniques. …”
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2564
Immunogenicity induced by biologicals in the treatment of psoriasis and psoriatic arthritis: View of the problem
Published 2016-01-01“…The antibodies to most BAs, except drugs based on soluble tumor necrosis factor-α receptors (etanercept), are neutralizing, i.e. they affect the efficiency of therapy, particularly when used over a long period of time.The results of trials evaluating the impact of antibodies to BAs on their clinical value are considered. …”
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2565
Towards a Unified Management Interface for 5G Sensor Networks: Interoperability between Yet Another Next Generation and Open Platform Communication Unified Architecture
Published 2024-09-01“…The key finding of this research is that the proposed solution enables seamless interoperability without requiring modifications to the private 5G sensor network components, thus enhancing the efficiency and reliability of industrial automation systems. …”
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2566
Experimental Evaluation of Mechanical Properties in Transmission Mechanisms of Electromechanical Actuators
Published 2025-03-01“…This shift involves a transition from hydraulic to electric actuation, which promises to reduce the overall weight of aircraft while increasing system efficiency. However, the use of EMAs is currently limited to non-safety-critical functions due to the still limited understanding of their behavior. …”
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2567
2024 FDA TIDES (Peptides and Oligonucleotides) Harvest
Published 2025-02-01“…In addition, it highlights how the prodrug strategy has improved targeting efficiency and extended the half-lives of the active drugs.…”
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2568
Functional analysis of metabolic channeling and regulation in lignin biosynthesis: a computational approach.
Published 2012-01-01“…Lignin is a polymer in secondary cell walls of plants that is known to have negative impacts on forage digestibility, pulping efficiency, and sugar release from cellulosic biomass. …”
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2569
Engineering the moss Physcomitrium patens to produce proteins with paucimannosidic glycans
Published 2025-07-01“…Our data confirm that the finely tuned expression and cellular localization of the glycosylation machinery can improve the efficiency of glyco-engineering. We also exploit the assembly of DNA fragments in vivo, which overcomes the limitations of traditional knock-in methods and facilitates the screening of different genetic elements. …”
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2570
Heat Stress from Calving to Mating: Mechanisms and Impact on Cattle Fertility
Published 2025-06-01“…Considering the impact of ambient-temperature-induced HS, developing strategies to improve fertility—namely through the selection of thermotolerant breeds allied to environmental management measures—can improve cattle production efficiency and reduce resource use, thereby reducing the carbon footprint. …”
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2571
Effect of Preload on Box-Section Steel Columns Filled with Concrete under Axial Load: A Numerical Study
Published 2024-09-01“…External loads applied to a box-section steel column before it is filled with concrete to increase its efficiency due to modifications in structural systems or design errors may reduce its ultimate capacity and change its structural behavior. …”
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2572
Is the Smart cities of hybrid model of local government - The type III cities: Four possible answers
Published 2018-03-01“… Using historical analysis and practice, this paper finds that the past many years structural modifications and adaptations by world cities have generally followed the mayor-council and council-manager cities theories, increasing their administrative efficiency more or later. …”
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2573
Effect of fuel injection timing on engine characteristics with an equal volume of 1-heptanol/diesel blend in a CRDI CI engine
Published 2025-06-01“…Research suggests a 50 % blend of 1-Heptanol as a promising renewable fuel for diesel engines, with slight modifications.…”
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2574
Exploring the Potential of Mitochondria-Targeted Drug Delivery for Enhanced Breast Cancer Therapy
Published 2025-01-01“…These therapies have improved the efficiency of mitochondria-targeted cancer treatment due to their advantageous properties of minimal toxicity, noninvasiveness, reduced drug resistance, and a safer profile. …”
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2575
Simulation Based Performance Assessment of Developing Heterarchical Control for a Flexible Assembly System
Published 2025-03-01“…The purpose of this study is to assess and enhance the efficiency, adaptability, and overall efficacy of the control system. …”
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2576
Cost-Effective and Reliable Sidechain Approach for Managing Small-Scale Digital Asset Trading Platforms
Published 2025-05-01“…The proposed sidechain, termed the <i>platform chain</i> in this paper, inherits the security and trust of the reference chain, while reducing operational costs and requiring no modifications to it. To enhance efficiency and privacy, the proposed method introduces a dual-sidechain architecture. …”
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2577
Neural Network-Based Sentiment Classification of Russian Sentences into Four Classes
Published 2022-06-01“…The experimental comparison of the efficiency of various neural networks were performed on three corpora of Russian sentences. …”
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2578
Validation of improved cytochrome c oxidase I (COI) primers for comprehensive biodiversity assessment of ascidians
Published 2025-07-01“…Analysis of penalty scores showed the improved efficiency of the redesigned AscCOI2 pair, with ascidians scoring less than 150 points for both forward and reverse primers and the non-target groups maintaining a score above 480. …”
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2579
Shaping viral immunotherapy towards cancer-targeted immunological cell death
Published 2025-07-01“…We also examine the mechanisms of ICD and viral modifications that contribute to efficient cancer cell death and modulation of cancer-specific immunity. …”
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2580
Study of Stage Gap for a 2-bladed 2-stage Savonius-like-hydro-kinetic Turbine Performance Involving End Plates and Overlapping
Published 2025-02-01“…However, for its operation at such sites, efficiency is to be improved by design modifications and flow control. …”
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