Can a delayed sowing date improve the eating and cooking quality of mechanically transplanted rice in the Sichuan Basin, China? by Yuxin He, Fei Deng, Chi Zhang, Qiuping Li, Xiaofan Huang, Chenyan He, Xiaofeng Ai, Yujie Yuan, Li Wang, Hong Cheng, Tao Wang, Youfeng Tao, Wei Zhou, Xiaolong Lei, Yong Chen, Wanjun Ren

“…In conclusion, DS might contribute to a significant deterioration in ECQ in machine-transplanted rice in the Sichuan Basin. …”
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Selenium nanoparticle loaded on PVA/chitosan biofilm synthesized from orange peels: antimicrobial and antioxidant properties for plum preservation by Hamza T. O. Abdelaziz, Eldin M. Seif Mohamed, Samir K. A. Younis, Nada Ahmed, Mary N. Michaeel, Samah H. Abu-Hussien, Ashraf Bakry, Naglaa M. Ebeed, Mohamed A. Nasser, Mohamed K. Abou El-Nasr, Mahmoud A. A. Ali, Bahaa Hemdan, Mahmoud Salah, Salwa M. El-Sayed

“…HPLC analysis of orange peel extract identified high levels of rutin (546.46 mg/kg), quercetin (217.45 mg/kg), and chlorogenic acid (72.75 mg/kg), which likely contributed to the observed antioxidant properties. …”
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Mitochondria from huntington´s disease striatal astrocytes are hypermetabolic and compromise neuronal branching by Laura López-Molina, Alba Pereda-Velarde, Nadia di Franco, Imme Aerts, Elisa Sebastià, Laura Valls-Roca, Mariona Guitart-Mampel, Gloria Garrabou, Silvia Gines

“…Beyond these neuron-intrinsic factor, increasing evidence suggest that non-neuronal mechanisms, particularly astrocytic dysfunction involving disrupted homeostasis and metabolic support also contribute to disease progression. These findings underscore the critical role of metabolic crosstalk between neurons and astrocytes in maintaining striatal integrity. …”
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Chlorogenic acid alters ileal microbiota and metabolites in broiler chickens under immune stress by Ziwei Wang, Wenrui Zhen, Yi Zhang, Caifang Guo, Xiaodie Zhao, Penghui Ma, Koichi ito, Bingkun Zhang, Cai Zhang, Dongying Bai, Yanbo Ma

“…In this study, CGA altered gut microbiota and metabolites associated with alleviating immune stress were provided, which will provide new insights into strategies to target gut microbiota and metabolites to relieve immune stress in broilers. These findings contribute to a better understanding of the mechanism of action of CGA on the attenuation of immune stress and provide new approaches to immune stress therapy by regulating gut microbiota and metabolites.…”
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Long COVID-19 alters muscle architecture and muscle-tendon force transmission: a one-year longitudinal study by Leandro Gomes de Jesus Ferreira, Leandro Gomes de Jesus Ferreira, Isabella da Silva Almeida, Isabella da Silva Almeida, Rochelle Rocha Costa, Gabrielle Vieira Roriz, Gabrielle Vieira Roriz, Jeam Marcel Geremia, João Luiz Quagliotti Durigan, João Luiz Quagliotti Durigan, Rita de Cássia Marqueti, Rita de Cássia Marqueti

“…Additionally, torque played a crucial role in influencing PA in both muscles, at rest and during contraction.ConclusionParticipants with severe COVID-19 exhibited alterations in muscle architecture, which may contribute to persistent muscular weakness even one-year post-infection. …”
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Unravelling the Role of PIEZO1 in Adipogenesis of Fibrogenic/Adipogenic Progenitors for Muscle Fat Infiltration After Rotator Cuff Tear by Xingzuan Lin, Qingfa Song, Amila Kuati, Zhanghua Li, Hao Zhou, Shujing Feng, Minhui Wang, Siyuan Zhu, Guoqing Cui, Jianhua Wang, Xiexiang Shao

“…Conclusions Our findings indicate that the downregulation of PIEZO1 expression contributes to the enhanced adipogenesis capacity of FAPs after RCT by inhibiting ERK/KLF4 signalling. …”
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A multinational cross-sectional study on the prevalence and predictors of long COVID across 33 countries by Mohamed Sayed Zaazouee, Eman Ayman Nada, Mohammed Al-kafarna, Ahmed Shaheen, Shivabalan Kathavarayan Ramu, Abdelrahman H. Hafez, Sajeda Ghassan Matar, Ahmed Assar, Mohamed Elshennawy, Hazem Abu El-Enien, Hala Jamal Redwan, Sarah Makram Elsayed, Maha Jabir Omran, Omar Hammam Salloum, Hossam Almadhoon, Mohamed Mamdouh, Engy A. Wahsh, Anas Zakarya Nourelden, Alaa Ahmed Elshanbary, Walid Abdel-Aziz, Hivan Haji Rashid, Iman Basheti, Khaled Mohamed Ragab, Ahmed Taher Masoud, Abdelrahman I. Abushouk, Long-COVID International Team (LCIT)

“…Following the removal of multicollinear variables, a generalized linear model was established to estimate the contribution of different predictors to LC occurrence. …”
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Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease by Fatma Saaoud, Mohammed Ben Issa, Lu Liu, Keman Xu, Yifan Lu, Ying Shao, Baosheng Han, Xiaohua Jiang, Xiaohua Jiang, Xiaolei Liu, Avrum Gillespie, Jin Jun Luo, Laisel Martinez, Roberto Vazquez-Padron, Sadia Mohsin, Beata Kosmider, Hong Wang, Silvia Fossati, Xiaofeng Yang, Xiaofeng Yang

“…IntroductionEndothelial-to-mesenchymal transition (EndoMT), cell death, and fibrosis are increasingly recognized as contributing factors to Alzheimer’s disease (AD) pathology, but the underlying transcriptomic mechanisms remain poorly defined. …”
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Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi From Patients and Small Mammals in Xiangyun County, Yunnan Province, China by Li Chen, Yi‐Chen Kong, Jia‐Wei Tian, Pei‐Yu Han, Song Wu, Chen‐Jie He, Ti‐Lian Ren, Bo Wang, Lian Qin, Yun‐Zhi Zhang

“…Recombination analysis revealed genetic overlap among strains of similar or different genotypes, suggesting that genetic diversity may contribute to the increased incidence of scrub typhus. …”
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BdNRT2A and BdNRT3.2 Are the Major Components of the High‐Affinity Nitrate Transport System in Brachypodium distachyon by Laure C. David, Mathilde Grégoire, Patrick Berquin, Anne Marmagne, Marion Dalmais, Abdelhafid Bendahmane, Tony J. Miller, Anne Krapp, Françoise Daniel‐Vedele, Thomas Girin, Sylvie Ferrario‐Méry

“…ABSTRACT An efficient nitrate uptake system contributes to the improvement of crop nitrogen use efficiency under low nitrogen availability. …”
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Branched-chain amino acids induce hyperammonemia via gut-liver axis-mediated ammonia overproduction in laying hens by Huafeng Jian, Mengru Xu, Fang Liu, Libo Zhang, Qiuming Huang, Jiangang Ma, Xiaoting Zou, Xinyang Dong

“…Excessive ammonia cannot be entirely detoxified through the hepatic urea cycle; instead, it stimulates SCAP to dissociate ammonia contributing to hyperammonemia and resulting in decreased productive performance.…”
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Cohort profile: the Korean National Health Examination Baseline (KNHEB) cohort for longitudinal health monitoring in South Korea by Suyoung Jo, Eunsil Cheon, Heewon Kang, Min Kyung Lim, Wankyo Chung, Sun Ha Jee, Keum Ji Jung, Yeun Soo Yang, Seong Yong Park, Sunmi Lee, Jin-Kyoung Oh, Kyoungin Na, Soyeon Kim, Jieun Hwang, Sung-il Cho

“…Conclusions The KNHEB cohort provides a large-scale, population-based dataset that supports comprehensive analyses of the long-term effects of modifiable risk factors on NCDs. Its findings contribute to evidence-based policymaking in South Korea and offer comparative insights for global research on chronic disease prevention and risk factor management. …”
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<i>ZmNLR</i><i>-7</i>-Mediated Synergistic Regulation of ROS, Hormonal Signaling, and Defense Gene Networks Drives Maize Immunity to Southern Corn Leaf Blight by Bo Su, Xiaolan Yang, Rui Zhang, Shijie Dong, Ying Liu, Hubiao Jiang, Guichun Wu, Ting Ding

“…The rapid evolution of pathogens and the limited genetic diversity of hosts are two major factors contributing to the plant pathogenic phenomenon known as the loss of disease resistance in maize (<i>Zea mays</i> L.). …”
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Comparing weight loss rates between males and females: a preliminary analysis by Valentina Rodriguez Da Silva, Ryan Singh, Valeria V. Silva Ramirez, Daniel Arevalo, Eric T. Trexler, Landon Shannahan, John Solis, Samuel Blanke, Samuel Evers, Talon Westervelt, John Holtje, Bill I. Campbell

“…Future research should explore the factors contributing to this variability and include more balanced samples for validation.…”
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Ellagic acid on milk production performance, blood and milk hormones, antioxidant capacity and fecal microbial communities in lactating Yili mares by Xinxin Huang, Xinxin Huang, Linjiao He, Linjiao He, Jun Ma, Yuqi Li, Jiahao Li, Jiahao Li, Changjiang Zang, Changjiang Zang, Min Hou, Xiaobin Li, Xiaobin Li

“…Ellagic acid (EA), a natural polyphenol, exerts potent antioxidant and anti-inflammatory effects in humans and other animals, while contributing to intestinal microbiota homeostasis. This study investigated the impact of EA supplementation on milk production, hormone secretion, antioxidant activity, and gut microbiota in lactating Yili mares. …”
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Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients by Tzu-Chun Cheng, Mien-Chie Hung, Lu-Hai Wang, Shih-Hsin Tu, Chih-Hsiung Wu, Yun Yen, Chi-Long Chen, Jacqueline Whang-Peng, Wen-Jui Lee, You-Cheng Liao, Yu-Ching Lee, Min-Hsiung Pan, Hui-Kuan Lin, Huey-En Tzeng, Peixuan Guo, Cheng-Ying Chu, Li-Ching Chen, Yuan-Soon Ho

“…Mechanistic studies revealed that the interaction between HNMT and HER2 contributes to increased HER2 protein expression at the transcriptional level, thereby impacting the efficacy of anti-HER2 therapy. …”
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Are there inequalities in the attendance at and effectiveness of behavioural weight management interventions for adults in the UK? An individual participant data meta-analysis by Annie S Anderson, Martin White, Stephen J Sharp, Beth Stuart, Paul Aveyard, Alex McConnachie, Rebecca J Beeken, Sarah Damery, Colin Greaves, Simon J Griffin, Rebecca A Jones, Amy L Ahern, Julia Mueller, Michael P Kelly, Susan Jebb, Kiran Nanchahal, Nerys Astbury, Jack M Birch, Angela Craigie

“…Objectives Interventions for obesity that require individual behaviour change, such as behavioural weight management interventions, may contribute to health inequalities. We explored if there was evidence of inequalities in the attendance at and effectiveness of behavioural weight management interventions in adults.Design Two-stage individual participant data meta-analysis.Data sources Eligible studies were extracted from a previous systematic review and an updated search was completed on PubMed.Eligibility criteria UK-based randomised controlled trials of behavioural weight management interventions suitable for use in primary care, published until 31 December 2021.Data extraction and synthesis Multivariable regression analyses were conducted with weight at 12-month follow-up as the primary outcome and included an interaction between inequality characteristic and trial arm (control or intervention). …”
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Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy by Hongmei Wang, Maribel Beaumont, Wendy Blumenschein, Laurence Fayadat-Dilman, Mingmei Cai, Jing Yuan, Douglas Wilson, Thierry O Fischmann, Jeanne Baker, Tanya Keenan, Daniel Malashock, Eunseon Ahn, Komal Pradhan, Jeffery Grein, Srishti Chakravorty, Soheila Bahmanjah, David Ban, Ellen Chien, Mark Hsieh, Todd Mayhood, Janica C Wong, Mark A McCoy, Sybil M G Williams, Wolfgang Seghezzi, Jin-Hwan Han

“…Biacore-based binding data indicate that both vibostolimab and tiragolumab bind on TIGIT with comparable binding affinity (KD), but different binding kinetics characterized by faster on and off rates, which may contribute to enhanced T-cell activation with vibostolimab, as evidenced by greater IL-2 production in an in vitro cell-based assay. …”
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Microgliosis, neuronal death, minor behavioral abnormalities and reduced endurance performance in alpha-ketoglutarate dehydrogenase complex deficient mice by Márton Kokas, András Budai, Andrea Kádár, Soroosh Mozaffaritabar, Lei Zhou, Tímea Téglás, Rebeka Sára Orova, Dániel Gáspár, Kristóf Németh, Daniel Marton Toth, Nabil V. Sayour, Csenger Kovácsházi, Andrea Xue, Réka Zsuzsanna Szatmári, Beáta Törőcsik, Domokos Máthé, Noémi Kovács, Krisztián Szigeti, Péter Nagy, Ildikó Szatmári, Csaba Fekete, Tamás Arányi, Zoltán V. Varga, Péter Ferdinandy, Zsolt Radák, Andrey V. Kozlov, László Tretter, Tímea Komlódi, Attila Ambrus

“…Additionally, KGDHc is also capable of generating reactive oxygen species, which contribute to mitochondrial oxidative stress. Hence, the KGDHc and its dysfunction are implicated in various pathological conditions, including selected neurodegenerative diseases. …”
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Bacterial type IV secretion system induces specific and nonspecific protective immunity by Fernanda V. S. Castanheira, Marcelo S. F. Pereira, Marco A. Ataide, Danielle P. A. Mascarenhas, Rhanoica O. Guerra, Gustavo F. S. Quirino, Fausto Almeida, Dario S. Zamboni

“…CCR2+ monocytes and CD4+ T cells were partially involved in T4SS-induced responses that conferred protection against secondary infections with L. pneumophila, Legionella longbeachae, and the pathogenic fungus Cryptococcus neoformans. Our findings contribute to the identification of pathogen determinants that induce specific and nonspecific immunity, a process central to understanding host-pathogen interactions and with potential implications for vaccine development.IMPORTANCEUnderstanding how bacteria interact with the immune system is crucial for developing better treatments and vaccines. …”
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