Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer by Lin Shen, Xiaochen Zhao, Zhenghang Wang, Yuezong Bai, Feilong Zhao, Zhi Peng, Jinping Cai, Tong Xie, Shuang Tong, Xiaofan Wei

“…There were nearly significant differences in tumor mutational burden (TMB) level and SMARCA4 mutation frequency between the ICB response and non-response group.Conclusions We developed an efficient NGS-based EBV detection strategy, and this strategy-identified EBV infection was as effective as dMMR in predicting ICB efficacy in GC. …”
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Radiomic Model Associated with Tumor Microenvironment Predicts Immunotherapy Response and Prognosis in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma by Jie Sun, Xuewei Wu, Xiao Zhang, Weiyuan Huang, Xi Zhong, Xueyan Li, Kaiming Xue, Shuyi Liu, Xianjie Chen, Wenzhu Li, Xin Liu, Hui Shen, Jingjing You, Wenle He, Zhe Jin, Lijuan Yu, Yuange Li, Shuixing Zhang, Bin Zhang

“…We aimed to develop radiomic models using pre-immunotherapy MRI to predict the response to PD-1 inhibitors and the patient prognosis. …”
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Serum sPD-1 as a marker of T cell exhaustion in ART-naïve, ART-experienced, and intestinal parasite co-infected HIV-positive adults at the university of Gondar comprehensive specia... by Tadelo Wondmagegn, Wubet Birhan, Eseye Derb, Mulualem Lemma, Hana Yohannes, Degsew Ewunetie Anteneh, Alembante Bazezew, Kebebe Tadesse, Bewuketu Belete Alemu

“…While serum soluble programmed death protein 1 (sPD-1) may serve as a marker for immune exhaustion, its role in antiretroviral therapy (ART) and intestinal parasite (IP) co-infections remains underexplored, especially in developing countries like Ethiopia with high HIV and IP prevalence. …”
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Newborn screening facilitates early theranostics and improved spinal muscular atrophy outcome: five-year real-world evidence from Taiwan by Chen-Hua Wang, Ting-Rong Hsu, Mei-Ying Liu, Li-Yun Wang, I-Jun Chou, Wang-Tso Lee, Wen-Chen Liang, Inn-Chi Lee, Hsiao-Jan Chen, Shu-Min Kao, Hui-Chen Ho, Dau-Ming Niu, Kwang-Jen Hsiao, Ming-Yuh Chang, Hui-Min Hsieh, Yuh-Jyh Jong

“…All patients with two SMN2 copies developed symptoms within 62 days; those with three SMN2 copies experienced disease onset within 1 year. …”
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Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18 by Yu Liu, Yichi Zhang, Yayi Hou, Yan Cheng, Mengyu Zhang, Yuanhui Zhao, Dongge Xu, Weikang Sun, Yuqing Miao, Susu He, Dwayne Stupack, Erguang Li

“…Antitumor memory and synergistic effect with an anti-programmed cell death protein-1 (PD-1) antibody was evaluated. …”
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Age-stratified associations between radiotherapy and SPMs for FPHNC: a population-based cohort study by Yuan-Yuan Li, Qiong Liu, Si-Qi Ying, Xiu-Quan Wu, Xiao-Hui Zhang, Xiao-Mei Xie, Bing-Dong Sui, Yan Jin, Yang Jiao, Franklin R. Tay

“…Males were more likely to develop solid SPMs compared to females. Conclusions This study reveals an age-stratified association between radiotherapy and the risk of SPMs in HNC patients. …”
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A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images by Qianni Wu, Jianbo Li, Lanqin Zhao, Dong Liu, Jingyi Wen, Yunuo Wang, Yiqin Wang, Naya Huang, Lanping Jiang, Qinghua Liu, Hanming Lin, Pengxia Wan, Shicong Yang, Wenfang Chen, Hongjian Ye, Mohammed Haji Rashid Hassan, Ahmed Hassan Nur, Zefang Dai, Jie Guo, Shanshan Zhou, Jianwen Yu, Weixing Zhang, Wenben Chen, Ruiyang Li, Wai Cheng Iao, Juan-juan Feng, Yan Wang, Hua Hong, Peihong Yin, Qing Ye, Chao Xie, Min Zhu, Xiaoyi Liu, Yaozhong Kong, Jie Wang, Ruiying Ma, Yu Xiao, Guoguang Chen, Rongguo Fu, Yuhe Ke, Jasmine Ong Chiat Ling, Charumathi Sabanayagam, Daniel Shu Wei Ting, Kar Keung Cheng, Duoru Lin, Wei Chen, Haotian Lin

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Eradication of Biofilms on Catheters: Potentials of <i>Tamarix ericoides</i> Rottl. Bark Coating in Preventing Catheter-Associated Urinary Tract Infections (CAUTIs) by Mohammed H. Karrar Alsharif, Muhammad Musthafa Poyil, Salman Bin Dayel, Mohammed Saad Alqahtani, Ahmed Abdullah Albadrani, Zainab Mohammed M. Omar, Abdullah MR. Arafah, Tarig Gasim Mohamed Alarabi, Reda M. Fayyad, Abd El-Lateef Saeed Abd El-Lateef

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“They Know You Better Than the Transplant Team”: An Interpretive Description Study Exploring the Perspectives of Living Kidney Donors About Care Received From Family Physicians by Katya Loban, Charo Rodriguez, Antoine Przybylak-Brouillard, Elie Fadel, Heather Badenoch, Peter Nugus, Ann Bugeja, Justin Gill, Marie-Chantal Fortin, Emilie Trinh, Scott McKay, Shaifali Sandal

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Renoprotective Effects of Hydroxychloroquine and Folinic Acid via ET-1 and NLRP3 Modulation in Reducing Tubular Injury in A Rabbit Model of Methanol-induced Acute Kidney Injury by Prayuda Prayuda, I Gde Raka Widiana, Ketut Suega, Yenny Kandarini, Ni Wayan Winarti, Bambang Purwanto

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Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques by Lis de Weerd, Selina Hummel, Stephan A. Müller, Iñaki Paris, Thomas Sandmann, Marie Eichholtz, Robin Gröger, Amelie L. Englert, Stephan Wagner, Connie Ha, Sonnet S. Davis, Valerie Warkins, Dan Xia, Brigitte Nuscher, Anna Berghofer, Marvin Reich, Astrid F. Feiten, Kai Schlepckow, Michael Willem, Stefan F. Lichtenthaler, Joseph W. Lewcock, Kathryn M. Monroe, Matthias Brendel, Christian Haass

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Synthesizing evidence and identifying knowledge gaps in the role of swine in Japanese encephalitis virus transmission: a rapid systematic review of the literature by V. Horton, C. J. Hanthorn, A. L. Dixon, S. E. Edache, A. Thackrah, D. Mitzel, L. Noronha, L. W. Cohnstaedt, V. R. Brown, C. Mire, N. Cernicchiaro

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Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia by Richard White, Katherine L Fielding, Salome Charalambous, Nicola Foster, Degu Jerene, Andrew Mganga, Taye Letta, Job van Rest, Amare Worku Tadesse, Rein MGJ Houben, Ahmed Bedru, Kristian van Kalmthout, Christopher Finn McQuaid, Lara Goscé, Jense van der Wal, Martin J Harker, Norma Madden, Tofik Abdurhman, Demekech Gadissa, Tanyaradzwa N Dube, Jason Alacapa, Natasha Deyanova

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Individual variation in migration patterns of Iberian little bustards by Filipa Coutinho Soares, João Gameiro, Ana Teresa Marques, Gerard Bota, Eládio L. García de la Morena, Manuel B. Morales, Carlos Pacheco, David González del Portillo, Francesco Valerio, Francisco Moreira, Jorge M. Palmeirim, João Paulo Silva

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White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities by Jessica Alber, Suvarna Alladi, Hee‐Joon Bae, David A. Barton, Laurel A. Beckett, Joanne M. Bell, Sara E. Berman, Geert Jan Biessels, Sandra E. Black, Isabelle Bos, Gene L. Bowman, Emanuele Brai, Adam M. Brickman, Brandy L. Callahan, Roderick A. Corriveau, Silvia Fossati, Rebecca F. Gottesman, Deborah R. Gustafson, Vladimir Hachinski, Kathleen M. Hayden, Alex M. Helman, Timothy M. Hughes, Jeremy D. Isaacs, Angela L. Jefferson, Sterling C. Johnson, Alifiya Kapasi, Silke Kern, Jay C. Kwon, Juraj Kukolja, Athene Lee, Samuel N. Lockhart, Anne Murray, Katie E. Osborn, Melinda C. Power, Brittani R. Price, Hanneke F.M. Rhodius‐Meester, Jacqueline A. Rondeau, Allyson C. Rosen, Douglas L. Rosene, Julie A. Schneider, Henrieta Scholtzova, C. Elizabeth Shaaban, Narlon C.B.S. Silva, Heather M. Snyder, Walter Swardfager, Aron M. Troen, Susanne J. vanVeluw, Prashanthi Vemuri, Anders Wallin, Cheryl Wellington, Donna M. Wilcock, Sharon Xiangwen Xie, Atticus H. Hainsworth

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Multi-Stage Evaluation of Demolition and Reclamation Carbon Storage from "System Design-Construction-Quality Effect" Perspectives by Deng Pingping, Ye Changdong, Ke Chunpeng, Hu Yueming, Fu Xiaoping, Zhou Long

“…Guangdong Province was selected as a representative case study for developing a comprehensive multi-stage evaluation framework for carbon storage, structured across three sequential stages: System Design (SD), Construction (CO), and Quality Effect (QE). …”
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Level of matrix metalloproteinase-9 and myocardium remodeling in patients with acute postinfarction aneurism of left ventricle by V. D. Syvolap, S. M. Kyselov

“…Statistical analyses of the results was carried out on a personal computer with the help of a licensed program “Statistica” (version 6.0, Stat Soft Inc, USA). …”
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Community-Based Approaches to Healthy Aging: Lessons from Japanese Blue Zones by Hiroko Oe, Kai Weeks, Sitsada Sartamorn

“…Document analysis of municipal records, program evaluations, and demographic data provided institutional perspectives on healthy aging initiatives. …”
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Análisis sistémico del contexto mundial de gestión deportiva: aportes significativos de la revista retos (Systemic analysis of the world context of sports management: significant c... by William Alejandro Niebles Nuñez, José Ramón Sanabria Navarro, Yahilina Silveira Pérez

“…The articles published in Challenges provide an up-to-date and rigorous view of recent developments and best practices in these fields. Keywords. …”
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Anthracite nanoporous carbons obtained by nitric acid intercalation followed by alkaline activation by V. O. Kucherenko, Yu. V. Tamarkina, V. O. Sabierova, M. M. Nechitaylov

“…Activation of the starting anthracite poorly develops the surface (S ? 318 м2/г). The adsorption kinetics was found to obey a pseudo-second-order equation, and the isotherms are better approximated by the Langmuir model. …”
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