Trends in the disease burden of early-onset cancers in China from 1990 to 2021: a systematic analysis of the 2021 Global Burden of Disease study by Jicun Zhu, Tiandong Li, Jiajun Chen, Wenhua Xue, Shuhong Liang, Chen Xie, Xiting Han, Weiwei Hao, Yixin He, Gaoxing Qiao, Xiaoran Duan, Lifeng Li, Jie Zhao

“…The age-standardized average annual percentage change (AAPC) was estimated using the Joinpoint regression program. Results From 1990 to 2021, the incidence rate of all early-onset cancers in China increased by 150.72 per 100,000, while the mortality and DALY rates decreased by 4.30 per 100,000 and 279.34 per 100,000, respectively. …”
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DAILY – A personalized circadian Zeitgeber therapy as an adjunctive treatment for alcohol use disorder patients: results of a pilot trial by Naomi Springer, Naomi Springer, Lisa Echtler, Lisa Echtler, Paul Volkmann, Anisja Hühne-Landgraf, Anisja Hühne-Landgraf, Jasmin Hochenbleicher, Eva Hoch, Eva Hoch, Gabi Koller, Dominic Landgraf

“…Recurring activities such as sleep, activity, and meals represent time cues, so called Zeitgebers, that synchronize the circadian system. With our newly developed therapy approach for AUD patients, we aim to reduce relapses and alcohol consumption in AUD patients undergoing a withdrawal program by strengthening their circadian rhythms.Methods/DesignWe aim to achieve the improvement of circadian rhythms with personalized structure plans for daily Zeitgeber activities, which are used in parallel with the standard therapy at our clinic. …”
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Low transthyretin is associated with the poor prognosis of colorectal cancer by Zhe Zhang, Zhe Zhang, Zhe Zhang, Chenhao Hu, Chenhao Hu, Chenhao Hu, Feiyu Shi, Feiyu Shi, Feiyu Shi, Lei Zhang, Lei Zhang, Lei Zhang, Ya Wang, Ya Wang, Yujie Zhang, Yujie Zhang, Yujie Zhang, Xiaojiang Zhang, Xiaojiang Zhang, Xiaojiang Zhang, Junjun She, Junjun She, Junjun She

“…The preoperative TTR level, clinicopathological data, and follow-up data were recorded. The X-tile program was used to determine the optimal cut-off value. …”
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Impact of a demand-side integrated WASH and nutrition community-based care group intervention on behavioural change: a randomised controlled trial in western Kenya by Matthew C Freeman, Katie Micek, Amy Webb Girard, Anna S Ellis, Emily Awino Ogutu, Bethany A Caruso, Molly Linabarger, Richard Muga, Breanna K Wodnik, Kimberly Jacob Arriola

“…We developed an intervention targeting practices relating to food hygiene, mealtime and feeding, and compound cleanliness, each using various behavioural change techniques to influence the uptake of targeted behaviours. …”
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Cemiplimab and diabetic ketoacidosis: a case report of a rare endocrinopathy associated with immune checkpoint inhibitors by Anna Arecco, Cristian Petolicchio, Alessandro Pastorino, Enrica Teresa Tanda, Enrica Teresa Tanda, Lara Vera, Mara Boschetti, Mara Boschetti, Francesco Cocchiara, Davide Carlo Maggi, Davide Carlo Maggi, Diego Ferone, Diego Ferone, Federico Gatto, Federico Gatto

“…ICIs are antibodies blocking several immune checkpoint pathways, as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) with its ligand PD-L1. …”
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The effectiveness of the REAL™, a school-based, virtual reality-integrated social emotional learning intervention to promote mental health for early Malaysian adolescents by Aimi Nur Athira Putri Baharuddin, Nik Ruzyanei Nik Jaafar, Normala Ibrahim, Abdul Rahman Ahmad Badayai, Hajar Mohd Salleh Sahimi, Nurul Ain Mohamad Kamal, Nur Husna Ismail, Ely Salwana, Mohd Pilus Abdullah, Mohd ‘Ammar Ihsan Ahmad Zamzuri

“…Background: The REAL™ module was developed to impart social and emotional learning (SEL) skills to early Malaysian adolescents using virtual reality (VR) components at school within the local social and cultural dynamics. …”
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Complex treatment of patellofemoral pain syndrome in athletes after reconstruction of the anterior cruciate ligament of the knee joint by V. V. Arkov, A. A. Dmitriev, O. N. Milenin, Z. G. Ordzhonikidze, N. V. Sichinava, V. A. Badtieva, L. I. Alekseeva, A. M. Lila

“…Intramuscular SYSADOA injection therapy, which was used as part of a rehabilitation program, reduced pain and improved the function of the knee joint and had a positive effect on statokinetic stability in athletes after ACL reconstruction.…”
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Machine learning analysis of pathological images to predict 1-year progression-free survival of immunotherapy in patients with small-cell lung cancer by Hirotaka Matsumoto, Hiroaki Akamatsu, Nobuyuki Yamamoto, Yuki Sato, Daichi Fujimoto, Yoshihiko Taniguchi, Motohiro Tamiya, Yasuhiro Koh, Junya Fukuoka, Hisashi Tanaka, Naoki Furuya, Ryota Shibaki, Tsukasa Nozawa, Akira Sano, Yuka Kitamura, Takashi Kijima, Toshihide Yokoyama, Satoru Miura, Akito Hata, Jun Sugisaka

“…We trained a model to predict 1-year progression-free survival (PFS) using pathological images (H&E, programmed cell death-ligand 1 (PD-L1), and double immunohistochemical assay (cluster of differentiation 8 (CD8) and forkhead box P3 (FoxP3)) and patient information. …”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Anoikis is a type of programmed cell death that occurs when cells lose their attachment to the extracellular matrix (ECM), and it plays a crucial role in tumor metastasis. …”
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Immune composition of the mononuclear cell fraction of human umbilical cord blood by Karen Kikuta, Esmond Lee, Esmond Lee, Esmond Lee, Talia Menezes, Hannah Fung, Alvaro Amorin, Aditi Agrawal, Theodore L. Roth, Matthew Porteus, Matthew Porteus, Matthew Porteus

“…Overall, our findings provide a robust characterization of MNC UCB immune subsets and insights into how immune function develops from birth to adulthood.…”
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RUBIES: JWST/NIRSpec Confirmation of an Infrared-luminous, Broad-line Little Red Dot with an Ionized Outflow by Bingjie Wang, Anna de Graaff, Rebecca L. Davies, Jenny E. Greene, Joel Leja, Gabriel B. Brammer, Andy D. Goulding, Tim B. Miller, Katherine A. Suess, Andrea Weibel, Christina C. Williams, Rachel Bezanson, Leindert A. Boogaard, Nikko J. Cleri, Michaela Hirschmann, Harley Katz, Ivo Labbé, Michael V. Maseda, Jorryt Matthee, Ian McConachie, Rohan P. Naidu, Pascal A. Oesch, Hans-Walter Rix, David J. Setton, Katherine E. Whitaker

“…We develop a new joint galaxy and active galactic nucleus (AGN) model within the Prospector Bayesian inference framework and perform spectrophotometric modeling using NIRCam, MIRI, and NIRSpec/Prism observations. …”
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Improving contraceptive agency through peer social support: findings from a longitudinal qualitative evaluation of the I-CAN intervention in Uganda by Erica Sedlander, Beth Phillips, Isabelle Thapar, Catherine Birabwa, Lauren Suchman, Madeline Griffith, Dinah Amongin, Ronald Wasswa, Lynn Atuyambe, Jenny Liu, Peter Waiswa, Kelsey Holt

“…BackgroundSexual and reproductive health organizations have been advocating for a human rights-based approach to contraceptive programming for many years, but progress has been slow. …”
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Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET by T. Elise Potthoff, Carolin Walter, Daniela Jeising, Daniel Münter, Archana Verma, Eric Suero Molina, Walter Stummer, Martin Dugas, Wolfgang Hartmann, Matthias Dottermusch, Lea Altendorf, Ulrich Schüller, Sophia Scheuermann, Christian Seitz, Thomas K. Albert, Kornelius Kerl

“…Regarding the treatment of drug-resistant lactotroph PitNET, proliferative lymphocytes, CD8+ T, and NK cells could represent potentially valuable targets for developing new cancer immunotherapies.…”
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Stochastic population models to identify optimal and cost‐effective harvest strategies for feral pig eradication by Peter W. Hamnett, Frédérik Saltré, Brad Page, Myall Tarran, Matt Korcz, Kate Fielder, Lindell Andrews, Corey J. A. Bradshaw

“…We developed a stochastic Leslie matrix with compensatory density feedback on survival to project population trajectories from an initial population (N0) of 250 female pigs with an estimated island‐wide carrying capacity (K) of 2500 over 3 and 10 years for populations subjected to an annual harvest of 35%–95%. …”
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Epidemiological Characteristics of Injuries Among Rowing Athletes Based on Gender and Age: A Retrospective Study by Huiru Ma, Xiao Zhou, Kazuhiro Imai, Ziwen Mu, Yixin Deng, Hongtao Zeng, Shaoshuai Shen, Laihong Wan, Yueying Hu, Hengrui Yu

“…To develop a prevention program for rowing-related injuries, it is crucial to study the epidemiological characteristics of injuries among Chinese rowing athletes. …”
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Can Ileostomy Reversal Be Safely Performed by Surgical Residents? by Michał Kisielewski, Magdalena Pisarska-Adamczyk, Natalia Dowgiałło-Gornowicz, Łukasz Nawacki, Wojciech Serednicki, Mateusz Wierdak, Jerzy Wilczek, Kamil Safiejko, Marcin Juchimiuk, Marian Domurat, Jacek Pierko, Mateusz Mucha, Wojciech Fiedorowicz, Michał Wysocki, Maurycy Ladziński, Michał Zdrojewski, Tomasz Sachańbiński, Tomasz Wojewoda, Victoria Chochla, Karol Tkaczyński, Michał Jankowski, Wojciech M. Wysocki

“…Despite the negative impact of the COVID-19 pandemic on surgical training, recent changes in the Polish surgical training program have increased the number of intestinal procedures required to be completed by residents. …”
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Odense-Oxford PET Image Analysis (OPETIA): An FSL-based toolbox for multimodal neuroimaging by Mohammadtaha Parsayan, Sasan Andalib, Thomas Lund Andersen, Habib Ganjgahi, Poul Flemming Høilund-Carlsen, Abass Alavi, Mojtaba Zarei

“…Most clinical software lack accurate quantification. Here we developed a user-friendly multimodal neuroimage analysis toolbox, named Odense-Oxford PET Image Analysis (OPETIA), based on Functional Magnetic Resonance Imaging of the Brain Software Library (FSL) and Python programming language. …”
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5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia by Zuowei Yuan, Guoyun Jiang, Ying Yuan, Qian Liang, Yaxin Hou, Wenyao Zhang, Lujia Tang, Kelong Fan, Wenli Feng

“…Pyroptosis, a form of programmed cell death, has emerged as a promising strategy in cancer therapy due to its ability to eliminate tumor cells while stimulating antitumor immunity. …”
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Unlocking the in vivo therapeutic potential of radiation-activated photodynamic therapy for locally advanced rectal cancer with lymph node involvementResearch in context by Rui Sang, Sheri Nixdorf, Tzongtyng Hung, Carl Power, Fei Deng, Thuy Anh Bui, Alexander Engel, Ewa M. Goldys, Wei Deng

“…In this study, a therapeutic strategy, radiation-activated photodynamic therapy (RA-PDT), for the treatment of LARC with lymph node-positive tumours was developed and evaluated. Methods: RA-PDT was achieved by using a lipid-polymer hybrid nanoplatform loaded with verteporfin (VP) and functionalised with folic acid (FA) as a targeting molecule. …”
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A synchronous virtual surgical lecture series on cardiothoracic, vascular, oncology, and transplant surgery for surgical trainees in Sub-Saharan Africa: the COSECSA learner perspec... by Abebe Bekele, Oluwaseun Ojomo, Jules Iradukunda, Niraj Bachheta, Callum Forbes, Pierrette Ngutete Mukundwa, Victor Mithi, Michael Mwachiro, Robert Riviello, Dereje Gulilat, Stella Itungu, Barnabas Tobi Alayande

“…Abstract Introduction The College of Surgeons of East, Central, and Southern Africa (COSECSA) training program requires completion of a mandatory rotation in vascular and cardiothoracic surgery. …”
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