Adeno-associated virus-clustered regularly interspaced short palindromic repeats/cas9‑mediated ovarian cancer treatment targeting PD-L1 by Tamaki Yahata, Saori Toujima, Izumi Sasaki, Naoyuki Iwahashi, Megumi Fujino, Kaho Nishioka, Tomoko Noguchi, Yuko Tanizaki-Horiuchi, Tsuneyasu Kaisho, Kazuhiko Ino

“…Abstract The response rate of antibody therapy targeting immune checkpoint molecules in ovarian cancer is insufficient. This study aimed to develop a novel gene immunotherapy model targeting programmed death ligand 1 (PD-L1) in vivo in ovarian cancer using adeno-associated virus (AAV)-clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and investigate its efficacy. …”
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Fractional Calculus Approach for Variational Problems: Characterization of Sufficient Optimality Conditions and Duality by Ved Prakash Dubey, Devendra Kumar, Jagdev Singh, Dumitru Baleanu

“…These applications and results generalize other important duality results of VPs and also provide results connected to duality with generalized invexity in mathematical programming. Several conventional results can also be seen as a special case of the obtained results in this work. 2010 Mathematics Subject Classification: 90C29; 90C46; 26A33…”
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Tallow tree biological control and beekeeping: Assessing the misconceptions and possible resolutions to protect native ecosystems by Alexander M. Gaffke, Daijiang Li, Veronica Manrique, Anthony P. Abbate, Gregory S. Wheeler, Rodrigo Diaz

“…Plans to release biological control agents developed for the invasive tree Chinese tallow, Triadica sebifera (L.) …”
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Study on residual strength of oil and gas pipeline with corrosion defects under bending load by Song Chenxi, Shu Jie, Chen Han, Shi Tong, Wu Xiatong, Liu Xiaoben

“…To accurately evaluate the pipeline’s bearing capacity and safety, the study developed a nonlinear numerical simulation software called ABAQUS, utilising the Python programming language for analysis. …”
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Leveraging survival analysis and machine learning for accurate prediction of breast cancer recurrence and metastasis by Shahd M. Noman, Youssef M. Fadel, Mayar T. Henedak, Nada A. Attia, Malak Essam, Sarah Elmaasarawii, Fayrouz A. Fouad, Esraa G. Eltasawi, Walid Al-Atabany

“…We merged datasets from the Molecular Taxonomy of Breast Cancer International Consortium, Memorial Sloan Kettering Cancer Center, Duke University, and the SEER program, creating a comprehensive dataset of 272, 252 rows and 23 columns. …”
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Real time wire rope detection method based on Rockchip RK3588 by Mengpeng Qian, Yong Wang, Shaoqing Liu, Zhanghou Xu, Zhenshan Ji, Ming Chen, Hailong Wu, Zuchao Zhang

“…To enhance non-destructive wire rope inspection, a Mini-YOLO model was developed by integrating MobileNetV3, the Coordinate Attention (CA) mechanism, and a novel loss function, Inner-IoU, into the YOLOv8 framework. …”
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Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy by Man Fang, Lei Cao, Zhao Zhang, Zhen Yu, Yue Shen, Jieqi Chen, Juan Chen, Yue-Qin Li, Zhaoqian Liu, Yingcai Meng, Haihua Xiao, Qiang Qu, Ji-Ye Yin, Xiang-Ping Li

“…In light of previous research into drug conjugation, this study was to develop a combined chemo-immunotherapy approach. The HSA@Pt demonstrated high efficacy and low toxicity, with targeted tumor accumulation. …”
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Molecular Docking Analysis of Flavonoid from Strobilanthes crispus L. as Potential Inhibitors of Mycobacterium tuberculosis Targeted Proteins by Rita Arbianti, Linatri Purwati Latifah, Graciella Sisila, Tania Surya Utami, Ibnu Maulana Hidayatullah, Fatimah Azizah Riyadi, Yuswan Muharam

“…Since Multidrug Resistant Tuberculosis (MDR-TB) accounts for 78% of the 10 million total cases identified globally, there is an urgent need to develop new anti-tuberculosis drugs. Flavonoid compounds are promising in counteracting antibiotic resistance and enhancing the efficacy of existing anti-tuberculosis treatments. …”
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In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage by Yibin Zhang, Peisen Yao, Fuxiang Chen, Shufa Zheng, Xuegang Niu, Haojie Wang, Yuanxiang Lin, Bin Gao, Dezhi Kang

“…Furthermore, a novel “in situ proliferation” strategy is proposed and a flexible multi‐target peptide nanoparticle is developed through co‐assembling matrix metalloproteinase‐2 responsive cationic peptide and glutathione peroxidase‐mimicking peptide (GPXP). …”
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Artificial intelligence-based digital pathology using H&E-stained whole slide images in immuno-oncology: from immune biomarker detection to immunotherapy response prediction by Yeseul Kim, Eugene Kim, Young Kwang Chae, Jaeyoun Choi, Chan Mi Jung, Christmann Low, Ju Young Lee, Jonghanne Park, Sukjoo Cho, Lee Cooper, Jessica Zhang, Horyun Choi, Allen Cho, Emma J Yu, Jeffrey H Chuang

“…Immune biomarkers, such as programmed death-ligand 1, microsatellite instability/defective mismatch repair, and tumor mutational burden have been developed for patient selection and stratification for ICIs, though their predictive abilities remain limited. …”
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Exploring the Landscape of Operating Room Scheduling: A Bibliometric Analysis of Recent Advancements and Future Prospects by Md Al Amin, Majed Hadid, Adel Elomri, Rabah Ismaen, Ismail Dergaa, Hind Alashi, Amal Jobran Al-Hajaji, Moustafa Alkhalil, Omar M Aboumarzouk, Abdelfatteh EL Omri

“…Results: ORS publications steadily rose, notably post-2013, led by developed nations like the UK, Australia, the US, France, and Germany. …”
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Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer by Lili Jiang, Tong Wu, Xinyu Qu, Shuqi Li, Qi’an Jiang, Tingting Ren, Jiali Liang, Yan Ding, Keqin Hua, Zhongmin Tang, Junjun Qiu

“…What was more, we have developed a liposome containing POM-1, which effectively enhanced the anti-tumor effect of POM-1. …”
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Knowledge and confidence regarding pressure ulcer prevention among caregivers of high-risk individuals: A pre- and post-education assessment in a single-center by Maram T. Alkhatieb, Rahaf W. Shigdar, Zainab A. Alkhalifah, Hussain A. Alkhalifah, Hanan F. Alsabri, Lama W. Attar, Hana Z. Fatani, Haifa M. Alnahdi

“…Objective: We aimed to measure the effect of implementing a pressure ulcer (PU) educational program on the knowledge and confidence of caregivers taking care of bedridden patients or patients with limited mobility. …”
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Hybrid model predictive control-based integration of handling stability control for distributed drive electric vehicles by Shu Wang, Zichen Zheng, Xuan Zhao, Zhaoke Li, Jia Tian

“…A mixed integer quadratic programming method is employed to track the target value and determine the additional yaw moment and active steering angle. …”
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Numerical Simulation Study of Thermal Performance in Hot Water Storage Tanks with External and Internal Heat Exchangers by Yelizaveta Karlina, Yelnar Yerdesh, Amankeldy Toleukhanov, Yerzhan Belyayev, Hua Sheng Wang, Olivier Botella

“…The numerical model is developed by solving a system of ordinary differential equations using the 4th-order Runge–Kutta method, implemented in the Python programming language. …”
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Radiotherapy-Induced Lung Cancer Risk in Breast Cancer Patients: A Retrospective Comparison of Hypofractionated and Standard Fractionated 3D-CRT Treatments by Alessia D’Anna, Giuseppe Stella, Elisa Bonanno, Giuseppina Rita Borzì, Nina Cavalli, Andrea Girlando, Anna Maria Gueli, Martina Pace, Lucia Zirone, Carmelo Marino

“…An Eclipse™ plug-in script was developed using the Eclipse Scripting Application Programming Interface (ESAPI) to extract patient and treatment data from the Treatment Planning System and compute Organ At Risk (OAR) volume, Organ Equivalent Dose (OED), Excess Absolute Risk (EAR), and Lifetime Attributable Risk (LAR) using the Schneider Mechanistic Model and reference data from regional populations, A-bomb survivors, and patients with Hodgkin’s Disease (HD). …”
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Investigating the effects of alkalization on mechanical properties of enset fibers using digital image correlation technique by Abebayehu Abdela, Bart Buffel, Belete Sirahbizu, Frederik Desplentere

“…The characterization of fiber level tensile properties is vital for conducting micromechanical analyses and developing mechanical models of materials and their composites. …”
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Measurement of apoptosis by SCAN©, a system for counting and analysis of fluorescently labelled nuclei by Neta Shlezinger, Elad Eizner, Stas Dubinchik, Anna Minz-Dub, Rachel Tetroashvili, Adi Reider, Amir Sharon

“…Apoptosis-like programmed cell death (A-PCD) is a universal process common to all types of eukaryotic organisms. …”
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Identification of new hub- ferroptosis-related genes in Lupus Nephritis by Xiao-Jie Zheng, Ying Chen, Li Yao, Xiao-Li Li, Da Sun, Yan-Qiu Li

“…Background: Lupus Nephritis (LN) is the primary causation of kidney injury in systemic lupus erythematosus (SLE). Ferroptosis is a programmed cell death. Therefore, understanding the crosstalk between LN and ferroptosis is still a significant challenge. …”
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Tricuspid Valve Replacement in a Patient with a Leadless Cardiac Pacemaker: Current Guidelines and Recommendations for Perioperative Management by River Hames, J. W. Awori Hayanga, Diane Schmidt-Krings, Timothy Goldhardt, John Bozek, Donald Siddoway, Stanley Schmidt, John Lobban, Heather K. Hayanga

“…Leadless cardiac pacemakers were developed to reduce complications associated with conventional transvenous pacemakers. …”
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