Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemothera... by Arndt Hartmann, Bernd Wullich, Markus Eckstein, Pamela Strissel, Reiner Strick, Veronika Weyerer, Ralph Wirtz, Carolin Pfannstiel, Adrian Wullweber, Fabienne Lange, Philipp Erben, Robert Stoehr, Simone Bertz, Carol Imanuel Geppert, Nicole Fuhrich, Helge Taubert, Sven Wach, Johannes Breyer, Wolfgang Otto, Maximilian Burger, Christian Bolenz, Bastian Keck, Danijel Sikic

“…We conducted this study to develop a clinically applicable immune gene expression assay to predict prognosis and adjuvant chemotherapy benefit.Patients and methods Gene expression of CD3Z, CD8A and CXCL9, immune cell (IC) populations including stromal tumor infiltrating lymphocytes (sTILs), T-cells, natural killer cells (NK-cells), macrophages, Programmed cell death protein 1 positive (PD-1) IC and tumor subtypes (MD Anderson Cancer Center/MDACC-approach) were assessed in 187 MIBC patients (Comprehensive Cancer Center Erlangen-EMN/CCC-EMN-cohort). …”
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Virtual reality-based exposure with 360° video as part of cognitive behavioral therapy for social anxiety disorder: a three-arm randomized controlled trial by Per Trads Ørskov, Eik Runge, Trine Theresa Holmberg Sainte-Marie, Trine Theresa Holmberg Sainte-Marie, Mathias Torp Ernst, Mathias Torp Ernst, Lars Clemmensen, Lars Clemmensen, Caroline Høier Dalsgaard, Mia Beck Lichtenstein, Mia Beck Lichtenstein, Stéphane Bouchard, Stéphane Bouchard, Stéphane Bouchard

“…Virtual reality (VR)-based exposure using 360° video offers a promising way to deliver exposure therapy.ObjectiveTo develop a complete psychotherapeutic treatment program including CBT with VR-based exposure using 360° videos (CBT-ExpVR) for adult patients with SAD and to test the treatment effect using the Social Interaction Anxiety Scale (SIAS) as the primary outcome.MethodsThis three-arm randomized controlled trial involved 51 participants who were recruited through self-referral. …”
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First Russian experience in liver and kidney transplantation from donors with out-of-hospital cardiac arrest: 3 years’ results by O. N. Reznik, A. E. Skvortsov, V. S. Daineko, I. V. Loginov, A. A. Kutenkov, S. S. Komedev, V. M. Teplov, D. O. Kuzmin, A. N. Ananiev, I. V. Uliankina, D. V. Gogolev, A. A. Kukushkin, M. E. Malyshev, A. A. Boykov, V. E. Savello, A. N. Morozov, S. F. Bagnenko

“…In order to implement the program, round-the-clock ECMO and transplantation teams were organized at the inpatient emergency ward of Pavlov First St. …”
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Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy by Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Joanne Weidhaas, Mark Scholz, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Donatello Telesca

“…Treatment with the first drugs in this class, anti-programmed death 1 (anti-PD1)/programmed death-ligand 1 (PDL1) checkpoint therapies, results in grade 2 or higher irAEs in up to 25%–30% of patients, which occur most commonly within the first 6 months of treatment and can include arthralgias, rash, pruritus, pneumonitis, diarrhea and/or colitis, hepatitis, and endocrinopathies. …”
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Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study by Franziska Siche-Pantel, Manfred Mühlenberg, Rüdiger Buschfort, Heinke Michels, Rasmus Jakobsmeyer, Julian Oesterschlink, Claus Reinsberger

“…Variation in the routinely assessed standard parameters heart rate (HR) and blood pressure (BP) seem not well understood within the frame of sex-specific developments under therapy. Parameters of heart rate variability (RMSSD) and electrodermal activity (meanEDA) may assist the understanding of underlying autonomic developments. …”
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NEW GREENHOUSE TECHNOLOGIES FOR VEGETABLE PRODUCTION by S. M. Sirota, I. T. Balashova, E. G. Kozar, E. V. Pinchuk

“…Multi-tiered hydroponics on narrow benches has been developed since 2013 at VNIISSOK. Particularities of breeding program for multi-tiered hydroponics have been shown.…”
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Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma by David Kegyes, Anamaria Bancos, Adrian Bogdan Tigu, Ioana Rus, Delia Dima, Diana Cenariu, Madalina Nistor, Raluca Munteanu, Diana Gulei, Alina Tanase, Anca Colita, Anca Buzoianu, Cristina Iuga, Mihnea Zdrenghea, Evangelos Terpos, Stefan O. Ciurea, Aaron Ciechanover, Hermann Einsele, Ciprian Tomuleasa

“…In order to overcome intrinsic and acquired resistance mechanisms that frequently restrict the efficacy of single-agent therapies, drug combination strategies have been developed to simultaneously target multiple pathogenetic pathways. …”
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Utilizing loop-mediated isothermal amplification (LAMP) for detecting hemoglobin Constant Spring and hemoglobin Pakse mutations amidst the high prevalence and genetic heterogeneity... by Kasama Wongprachum, Nichakan Thitipoomdecha, Phakkamon Ananratanakit, Wattanakit Prakobkul, Unchasa Angkuranak, Nitchagan Sawangkul, Prapaporn Panichchob, Rossarin Karnpean, Wittaya Jomoui

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Translation and cross-cultural adaptation of the Get Active Questionnaire for Pregnancy (GAQ-P) to Spanish population by Eva Ferrer, Maia Brik, Margie Davenport, Ruben Barakat, Montse Palacio

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The Effect of Ventilation, Age, and Asthmatic Condition on Ultrafine Particle Deposition in Children by Hector A. Olvera, Daniel Perez, Juan W. Clague, Yung-Sung Cheng, Wen-Whai Li, Maria A. Amaya, Scott W. Burchiel, Marianne Berwick, Nicholas E. Pingitore

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JCV-specific cell-based assays for PML risk assessment in lupus and multiple sclerosis patients with and without natalizumab by Qi Wu, Qi Wu, Elizabeth A. Mills, Qin Wang, Guangmei Mao, Yang Mao-Draayer, Yang Mao-Draayer

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Simplified Model Characterization and Control of an Unmanned Surface Vehicle by Aldo Lovo-Ayala, Roosvel Soto-Diaz, Carlos Andres Gutierrez-Martinez, Jose Fernando Jimenez-Vargas, Javier Jiménez-Cabas, Jose Escorcía-Gutierrez

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Evaluating the disaster response capacity of the Korean citizen corps in rural areas: A System Dynamics–GIS approach by Jaejoon Lee, Moon-Soo Song, Jinsang Hwang, Seok Bum Hong

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Acute Limb Ischemia due to Arterial Thrombosis in a Patient with COVID-19 Pneumonia: A Case Report by Renata Primasari, Yetti Hernaningsih, Hartono Kahar, Bramantono Bramantono

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Synthesis of Novel Fluorescent Sensors Based on Naphthalimide Fluorophores for the Highly Selective Hg2+-Sensing by Yordkhuan Tachapermpon, Pornthip Piyanuch, Narupon Prapawattanapol, Kanjarat Sukrat, Kullatat Suwatpipat, Nantanit Wanichacheva

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Digital volumetric modeling reveals unique body plan experimentation in the Devonian tetrapod Ichthyostega by Catherine R.C. Strong, Peter J. Bishop, John R. Hutchinson, Stephanie E. Pierce

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Potential Increase in Hazard From Mediterranean Hurricane Activity With Global Warming by Juan J. González‐Alemán, Salvatore Pascale, Jesús Gutierrez‐Fernandez, Hiroyuki Murakami, Miguel A. Gaertner, Gabriel A. Vecchi

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Culture and sensitivity analysis in rhinitis atrophic: case series by Shelly Tjahyadewi, Rano Aditomo, Rahayu Rahayu, Agung Sulistyanto, Nurfauziati Pasaribu

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Bidirectional relationship between anxiety disorder and cancer: a longitudinal population-based cohort study by Sang-Hue Yen, Yi-Hsuan Hsu, Doreen Phiri, Chia-Chun Kuo, Hui-Fen Fang, Min-Huey Chung

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PENGEMBANGAN PERANGKAT PERKULIAHAN EKSPERIMEN FISIKA UNTUK MENINGKATKAN KREATIVITAS MAHASISWA CALON GURU DALAM MENDESAIN KEGIATAN PRAKTIKUM FISIKA DI SMA by H. S. Wattimena, A. Suhandi, A. Setiawan

“…</p><p>ABSTRACT</p><p>This study aimed to develop the lectures instrument of physics experiment to improve the creativity of preservice teachers in designing a high school physics lab activities. …”
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