A “rotating menu” of medical uncertainty for families affected by telomere biology disorders: A qualitative interview study by Emily E. Pearce, Alina Majid, Toniya Brown, Catherine Wilsnack, Camella Rising, Ashley S. Thompson, Rowan Forbes Shepherd, Arman Niknafs, Allison Werner-Lin, Melissa B. Gilkey, Kurt M. Ribisl, Sadie P. Hutson, Paul K.J. Han, Sharon A. Savage

Get full text

Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8 by Udo S Gaipl, Carol I Geppert, Arndt Hartmann, Benjamin Frey, Markus Eckstein, Markus Hecht, Antoniu Oreste Gostian, Sandra Rutzner, Jens von der Grün, Thomas Illmer, Matthias G Hautmann, Gunther Klautke, Simon Laban, Thomas Brunner, Axel Hinke, Ina Becker, Sabine Semrau, Panagiotis Balermpas, Wilfried Budach, Heinrich Iro, Rainer Fietkau

“…Adverse event (AE) grade 3–4 appeared in 38 patients (68%) and mainly consisted of leukopenia (43%) and infections (29%). Six patients (11%) developed grade 3–4 immune-related AE. Univariate analysis computed p16 positivity, programmed death ligand 1 immune cell area and intratumoral CD8+ cell density as predictors of pCR. …”
Get full text

Phase 1 trial of durvalumab (anti–PD-L1) combined with lenalidomide in relapsed/refractory cutaneous T-cell lymphoma by Christiane Querfeld, Joycelynne Palmer, Zhen Han, Xiwei Wu, Yate-Ching Yuan, Min-Hsuan Chen, Chingyu Su, Ni-Chun Tsai, D. Lynne Smith, Samantha N. Hammond, Liliana Crisan, Joo Y. Song, Raju Pillai, Steven T. Rosen, Jasmine Zain

“…Abstract: Selective targeting of the functionally exhausted malignant T cells in cutaneous T-cell lymphoma (CTCL) and distinct cells within the tumor microenvironment (TME) via programmed cell death 1/programmed cell death ligand 1 blockade (durvalumab) may restore an antitumor immune response. …”
Get full text

Bridging the procedures skill gap from medical school to residency: a simulation-based mastery learning curriculum by Lauren D. Branditz, Andrew P. Kendle, Cynthia G. Leung, Christopher E. San Miguel, David P. Way, Ashish R. Panchal, Jennifer Yee

“…To prepare our graduating students for their internship in emergency medicine, we developed a simulation-based mastery learning curriculum housed within a specialty-specific program. …”
Get full text

An approach to the quantitative determination of endogenous substances in biological fluids by a chromatographic method using a mathematical apparatus by V. V. Smirnov, L. M. Krasnykh, G. V. Ramenskaya, S. B. Kazanbekov

“…To confirm the reliability of the developed method of quantitative determination, the convergence of the results obtained by this method using deuterated standards is established. …”
Get full text

Why and how should we simulate platform trials? Learnings from EU-PEARL by Elias Laurin Meyer, Tobias Mielke, Marta Bofill Roig, Michaela Maria Freitag, Peter Jacko, Pavla Krotka, Peter Mesenbrink, Tom Parke, Sonja Zehetmayer, Dario Zocholl, Franz König

“…We addressed the functionality limitations of existing software as well as the unavailability of the coding therein by developing a suite of open-source software to use in simulating platform trials based on the R programming language. …”
Get full text

TECHNIQUE OF CONSTRUCTION AND ANALYSIS OF GLONASS FIELDS OF ACCURACY IN THE GIVEN ZONE OF AIRSPACE by O. N. Skrypnik, R. O. Aref`ev, N. G. Astrakhanceva

“…Based on the usage of LabView’s developed program of orbital motion modeling and the choice of satellite’s working constellation, the methodology of building-up the fields of potential accuracy GLONASS in the given airspace has been proposed. …”
Get full text

Allocation algorithms for multicore partitioned mixed-criticality real-time systems by Luis Ortiz, Ana Guasque, Patricia Balbastre, José Simó

“…As these systems are increasingly finding application in critical domains, it arises a necessity to develop novel methodologies for their efficient resource allocation. …”
Get full text

Optimization Methods for Customized Bus Routes in Random Environments by Fangyuan Gong, Chuanjun Jia, Xu Wu

“…Therefore, this paper investigates the optimization problem of customized bus routes considering random vehicle travel times and the capability to respond to dynamic requests in real time. We developed a stochastic programming model that minimizes total cost and passenger travel time. …”
Get full text

Research on Dynamic Storage Location Assignment of Picker-to-Parts Picking Systems under Traversing Routing Method by Xiangbin Xu, Chenhao Ren

“…Finally, the computer program is developed to simulate the whole process. …”
Get full text

Peningkatan Keterampilan Kitabah Arabiyah Mahasiswa Melalui Metode Tutor Sebaya by Syamsi Setiadi

“… Abstract: The learning of Arabic writing at Universitas Negeri Jakarta still faced some difficultiesin order to develop the students’ skill. The purpose of this study is to empirically examine the effectiveness of peer teaching method on the skills of students in Arabic writing. …”
Get full text

Evaluation of an Adaptive Multimedia Streaming in Mobile Cloud Computing for Slow-Speed Networks by Oluwafolake Ojo, Olufunke Oyinloye, Alaba Adejimi, Tobiloba Adejumo

“…The adaption logic concept was used to develop the scheme, which was then put into practice utilising the Java programming language and cloud computing. …”
Get full text

Resilience-Uncertainty Nexus in Building Energy Management Integrated With Solar System and Battery Storage by Hasan Mehrjerdi

“…The stochastic mixed integer linear programming is implemented to minimize the objective functions. …”
Get full text

The Republic of Türkiye's Diplomatic Stance from the Perspective of Public Diplomacy and its Response to Disinformation: Israeli-Palestinian Conflict by Ahmet Koçyiğit

“…In this context, the Republic of Türkiye has established the Directorate of Communications, Center for Countering Disinformation. It is aimed to develop an effective strategy to combat disinformation both nationally and internationally. …”
Get full text

Algorithm of Forming the Category Management in the Diy Market Segment by Yevgeny Romat, Yuliia Biliavska

“…The implementation of category management program is not always perceived by the staff as it is a relatively new area of work. …”
Get full text

The Effect of Sustainability Education Integrated with the e-Book on the Environmental Attitudes of Preschool Children by Yasemin AKKAYA ALICI, Ebru DERETARLA GÜL

“…In the research, it was concluded that sustainability educaton integrated with e-Book is efectve in developing positve attudes towards the environment.…”
Get full text

Ukraine – EU Cooperation for Post-War Recovery and Eurointegration by Oleksandr Sharov

“…This objective should be taken into account when developing pre-accession financial aid schemes, which are usually provided to candidate countries. …”
Get full text

A COMPUTER TECHNIQUE FOR ANALYZING RADIO‐TELEMETRY DATA by Gregory. T. Koeln

“…Abstract An interactive computer system to analyze radio‐telemetry data has been developed and used on turkey observations. The program calculates home range by the convex polygon, capture radius, and non‐circular home range methods. …”
Get full text

CYBERSECURITY ISSUES IN JOURNALISM BASED ON ARTIFICIAL INTELLIGENCE TECHNOLOGIES by Sunbul Zalova

“…Proposals are made for solving cybersecurity issues and a conceptual model is developed.…”
Get full text

South Africa’s Battle Against COVID-19 Pandemic by Ke Yan Loo, Jodi Woan-Fei Law, Loh Teng Hern Tan, Vengadesh Letchumanan

“…The local government has done as much as possible to control the spread of the virus in the local communities by quickly implementing lockdowns and enforcing movement restrictions. An eight-stage program to combat COVID-19 and a national vaccination strategy was also developed soon to manage the Coronavirus spread in the country better. …”
Get full text