OKEN: A Supervised Evolutionary Optimizable Dimensionality Reduction Framework for Whole Slide Image Classification by Soroush Oskouei, André Pedersen, Marit Valla, Vibeke Grotnes Dale, Sissel Gyrid Freim Wahl, Mats Dehli Haugum, Thomas Langø, Maria Paula Ramnefjell, Lars Andreas Akslen, Gabriel Kiss, Hanne Sorger

“…The aim of this study was to develop a WSI classification framework utilizing an optimizable kernel to encode features from each patch from a WSI into a desirable and adjustable latent space using an evolutionary algorithm. The encoded data can then be used for classification and segmentation while being computationally more efficient. …”
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Association of rs556621 Polymorphism with Development of Stroke in Patients with Cardiovascular Pathology by S. Yu. Nikulina, V. A. Shulman, A. A. Chernova, S. V. Prokopenko, D. A. Nikulin, I. M. Platunova, S. S. Tretyakova, V. N. Maksimov, A. A. Gurazheva

“…The examination of the main group included: collection of complaints, anamnesis, clinical examination, computed tomography of the brain, electrocardiography, echocardioscopy, ultrasound duplex scanning of extracranial brachiocephalic arteries, daily blood pressure and heart rate monitoring, analysis of the blood coagulation system. …”
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High-dose vitamin D3 to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan: a double-blind randomised controlled trial (ViDiSAM) by Javeria Saleem, Rubeena Zakar, Muhammad Salman Butt, Rameeza Kaleem, Asif Chaudhary, Jaya Chandna, David A. Jolliffe, Joseph Piper, Zaigham Abbas, Jonathan C. Y. Tang, William D. Fraser, Nick Freemantle, Andrew J. Prendergast, Adrian R. Martineau

“…The trial has now completed. 259 children were randomised (128 to vitamin D, 131 to placebo), of whom 251 (96.9%) contributed data to analysis of the primary outcome (123 allocated to vitamin D, 128 to placebo). …”
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Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker by Jason-Alexander Hörauf, Amit Singh, Maika Voth, Hamed Moheimani, Cora Rebecca Schindler, Borna Relja, Liudmila Leppik, Ingo Marzi, Dirk Henrich

“…<b>Methods</b>: A retrospective analysis of prospectively collected data and blood samples from 26 trauma patients was conducted. …”
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Intensification of Natural Disasters in the State of Pará and the Triggering Mechanisms Across the Eastern Amazon by Everaldo B. de Souza, Douglas B. S. Ferreira, Luciano J. S. Anjos, Alan C. Cunha, João Athaydes Silva, Eliane C. Coutinho, Adriano M. L. Sousa, Paulo J. O. P. Souza, Waleria P. Monteiro Correa, Thaiane S. Silva Dias, Alexandre M. C. do Carmo, Carlos B. B. Gutierrez, Giordani R. C. Sodré, Aline M. M. Lima, Edson J. P. Rocha, Bergson C. Moraes, Luciano P. Pezzi, Tercio Ambrizzi

“…Furthermore, we conducted a comprehensive composite analysis on the tropical ocean–atmosphere dynamic structure that elucidated the various triggering mechanisms of disasters arising from Inundations, Droughts, and Forest fires (on seasonal scale), and Flash floods and Heavy rainfall (on sub-monthly scale) in Pará. …”
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PETRO- AND PALEOMAGNETIC STUDIES OF BASALTS OF THE UPPER DEVONIAN APPAINSKAYA SUITE (WESTERN YAKUTIA) by К. M. Konstantinov, М. D. Tomshin, Sh. Z. Ibragimov, М. Z. Khuzin, I. K. Konstantinov, A. A. Yakovlev, E. V. Artemova

“…A correct paleomagnetic pole (PMP) can be obtained from the data of geochronological and paleomagnetic studies conducted in one and the same geological object, such as a suite, an intrusive complex etc. …”
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In silico study of biological activity of 2-[5-(furan-2-yl)-4-phenyl-4n-1,2,4-triazol-3-ylthio]-1-(4-chlorophenylethanone) by N. M. Borysenko, I. V. Bushuyeva, V. V. Parchenko, O. P. Shmatenko, А. М. Solomennyi, O. K. Yerenko, O. P. Kileyeva

“…For screening, the crystallographic structures of GABAA receptors –“4COF,” “6D6T,” and “6X3U” - obtained from the RCSB Protein Data Bank were used. Visualization of the results was conducted using Schrödinger Release 2018-1: Schrödinger, LLC, New York, NY, 2018. …”
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Simple Renal Cysts in Marfan Syndrome by Claire Bouleti, MD, PhD, Noemie Tence, MD, Raphael Thuillier, MD, PhD, Florence Nicot, MD, Nicoletta Pasi, MD, Benjamin Alos, MD, Gaspard Suc, MD, Olivier Milleron, MD, Florence Arnoult, MD, Maria Tchitchinadze, MD, Maud Langeois, Catherine Boileau, MD, PhD, Laurent Gouya, MD, PhD, Phalla Ou, MD, PhD, Guillaume Jondeau, MD, PhD

“…Marfan syndrome (MFS) is associated with severe aortic disease, but very few data on SRCs exist in this population. Objectives: The objectives were to evaluate: 1) the prevalence of SRCs in patients with MFS, compared to matched controls; and 2) the association between SRCs and aortic events in patients with MFS. …”
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Impact of ambient air pollution exposure during preconception and pregnancy on risk of gestational diabetes mellitus: A retrospective cohort study in China by Min Li, Jiayi Shi, Xiaoping Fei, Xiaohong Chen, Yupei Shen, Qianxi Zhu, Zhaofeng Zhang, Yanyan Mao, Difei Wang, Siyu Yi, Rui Zhao, Yixiang Zhu, Jing Du

“…The first trimester was identified as a critical exposure window using distributed lag non-linear models. Quantile-based g-computation analysis revealed that exposure to a mixture of the five pollutants during the first trimester was significantly associated with GDM risk. …”
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Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter study by Tomofumi Mizuno, MD, Nobuhiro Nishii, MD, PhD, Hiroshi Morita, MD, PhD, Takuro Masuda, MD, Akira Ueoka, MD, PhD, Saori Asada, MD, PhD, Yoshimasa Morimoto, MD, Masakazu Miyamoto, MD, Satoshi Kawada, MD, PhD, Tadashi Wada, MD, PhD, Shigeki Hiramatsu, MD, PhD, Keisuke Okawa, MD, Motoki Kubo, MD, PhD, Koji Nakagawa, MD, PhD, Atsuyuki Watanabe, MD, PhD, Kazufumi Nakamura, MD, PhD, Shinsuke Yuasa, MD, PhD

“…Methods: Patients diagnosed with IVF or BrS and receiving ICDs in 6 hospitals were enrolled between February 1997 and July 2020 to compute data regarding the incidence of ATAs, appropriate/inappropriate ICD therapy frequency, and independent predictors of ATAs. …”
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Clinical characteristics associated with peripartum maternal bloodstream infection by Xiao-Li Gao, Xiao-Li Gao, Yang Li, Yang Li, Su-Juan Hou, Su-Juan Hou, Wen-Jun Fan, Wen-Jun Fan, Ling-Yi Fang, Ling-Yi Fang, Shi-Jun Ni, Shi-Jun Ni, Ye Yan, Ye Yan, Jie Li, Jie Li, Cha Han, Cha Han

“…ObjectiveBloodstream infection (BSI) during the peripartum period is a major cause of maternal morbidity and mortality. However, data on maternal BSI during hospitalization for delivery are limited. …”
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BACES score: a predictor of health-related quality of life and associated factors in patients with nontuberculous mycobacterial pulmonary disease by Youngmok Park, Nakwon Kwak, Hyeontaek Hwang, Doosoo Jeon, Byung Woo Jhun, Kyung-Wook Jo, Young Ae Kang, Hyung-Jun Kim, Joong-Yub Kim, Young Ran Kim, Yong-Soo Kwon, Jae Ho Lee, Tae Sun Shim, Hojoon Sohn, Jake Whang, Jayoun Kim, Nanhee Park, Gyeong In Lee, Jae-Joon Yim, Jeongha Mok

“…We assessed whether the BACES score reflects HRQOL and associated factors in these patients. Data were collected from the nationwide NTM-KOREA prospective cohort of patients with NTM-PD who started antibiotic treatment and included symptoms, Quality of Life–Bronchiectasis (QOL-B) questionnaire, nutritional status using the Mini Nutritional Assessment–Short Form (MNA-SF) and Prognostic Nutritional Index (PNI), physical activity, body composition, spirometry, handgrip strength, and 6-min walking distance. …”
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Pediatric Adenotonsillectomy Trial for Snoring (PATS): protocol for a randomised controlled trial to evaluate the effect of adenotonsillectomy in treating mild obstructive sleep-di... by Rui Wang, Jessie P. Bakker, Ronald D. Chervin, Susan L. Garetz, Fauziya Hassan, Stacey L. Ishman, Ron B. Mitchell, Michael G. Morrical, Syed K. Naqvi, Jerilynn Radcliffe, Emily I. Riggan, Carol L. Rosen, Kristie Ross, Michael Rueschman, Ignacio E. Tapia, H. Gerry Taylor, David A. Zopf

“…The results will be published in peer-reviewed journals and presented at academic conferences. The data collected from the PATS study will be deposited in a repository (National Sleep Research Resource, sleepdata.org) after completion of the study to maximise use by the scientific community.Trial registration number NCT02562040; Pre-results.…”
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Impact of meteorological factors on transmission of respiratory viruses across all age groups in the hot arid climate in Qatar by May Husein, May Husein, Salma Younes, Muthanna Samara, M. Rami Alfarra, Abdullatif Al Khal, Muna Al Maslamani, Gheyath K. Nasrallah, Einas Al Kuwari, Ali Al-kinani, Peter V. Coyle, Peter V. Coyle, Nader Al-Dewik, Nader Al-Dewik, Nader Al-Dewik

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Enabling new insights from old scans by repurposing clinical MRI archives for multiple sclerosis research by Philipp Goebl, Jed Wingrove, Omar Abdelmannan, Barbara Brito Vega, Jonathan Stutters, Silvia Da Graca Ramos, Owain Kenway, Thomas Rossor, Evangeline Wassmer, Douglas L. Arnold, D. Louis Collins, Cheryl Hemingway, Sridar Narayanan, Jeremy Chataway, Declan Chard, Juan Eugenio Iglesias, Frederik Barkhof, Geoff J. M. Parker, Neil P. Oxtoby, Yael Hacohen, Alan Thompson, Daniel C. Alexander, Olga Ciccarelli, Arman Eshaghi

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Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Rachel Warren, Erin Macdonald, Ba Pham, Milan Patel, Fatemeh Yazdi, Amruta Radhakrishnan, Marco Ghassemi, Patricia Rios, Chantal Williams, Naveeta Ramkissoon, Matthew P Muller, Nazia Darvesh, Gordon V Cormack, Maura R Grossman, Melissa Kampman, Reid Robson

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An Approach to, and Tool for, Predicting the Time Course of an Infectious Disease Outbreak as a Function of Behavioral Interventions by Abebe HT, Siraj A, Berhane K, Siraj D, Van Breukelen GJ

“…Haftom Temesgen Abebe,1,2 Amir Siraj,3 Kiros Berhane,4 Dawd Siraj,5 Gerard JP Van Breukelen6 1Department of Biostatistics, Mekelle University College of Health Sciences, Mekelle, Tigray, Ethiopia; 2Laboratory Interdisciplinary Statistical Data Analysis, Mekelle University College of Health Sciences, Mekelle, Tigray, Ethiopia; 3Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA; 4Department of Biostatistics, Columbia University, New York, NY, USA; 5Division of Infectious Diseases, University of Wisconsin-Madison, Madison, WI, USA; 6Department of Methodology and Statistics, School CAPHRI Care and Public Health Research Institute and Graduate School of Psychology and Neuroscience, University of Maastricht, Maastricht, The NetherlandsCorrespondence: Haftom Temesgen Abebe, Department of Biostatistics, Mekelle University College of Health Sciences, P.O. …”
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Improved mental health outcomes and normalised spontaneous EEG activity in veterans reporting a history of traumatic brain injuries following participation in a psilocybin retreat by Grace Blest-Hopley, Giuseppe Pasculli, Giuseppe Pasculli, Simon G. D. Ruffell, WaiFung Tsang, Olateju Emmanuel, Kathryn M. Pate, Hannes Kettner, Hannes Kettner, Leor Roseman, David Erritzoe, Robin Carhart-Harris, Robin Carhart-Harris

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Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility by Careen A. Schroeter, Anna Gorlova, Michael Sicker, Aleksei Umriukhin, Alisa Burova, Boris Shulgin, Sergey Morozov, Joao P. Costa-Nunes, Tatyana Strekalova

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Deep Learning-Based Identification of Echocardiographic Abnormalities From Electrocardiograms by Goro Fujiki, MD, Satoshi Kodera, MD, PhD, Naoto Setoguchi, MD, Kengo Tanabe, MD, PhD, Kotaro Miyaji, MD, PhD, Shunichi Kushida, MD, PhD, Mike Saji, MD, PhD, Mamoru Nanasato, MD, PhD, Hisataka Maki, MD, PhD, Hideo Fujita, MD, PhD, Nahoko Kato, MD, PhD, Hiroyuki Watanabe, MD, PhD, Minami Suzuki, MD, Masao Takahashi, MD, PhD, Naoko Sawada, MD, PhD, Jiro Ando, MD, Masataka Sato, MD, Shinnosuke Sawano, MD, PhD, Susumu Katsushika, MD, PhD, Hiroki Shinohara, MD, PhD, Norifumi Takeda, MD, PhD, Katsuhito Fujiu, MD, PhD, Hiroshi Akazawa, MD, PhD, Hiroyuki Morita, MD, PhD, Issei Komuro, MD, PhD

“…Conclusions: We have developed convolutional neural network models that predict a wide range of echocardiographic findings, including left-sided cardiac abnormalities, valvular heart diseases, and right-sided cardiac abnormalities from ECGs and created a model to predict a composite findings label by logistic regression analysis. …”
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