Automatic vessel segmentation and reformation of non-contrast coronary magnetic resonance angiography using transfer learning-based three-dimensional U-net with attention mechanism by Lu Lin, Yijia Zheng, Yanyu Li, Difei Jiang, Jian Cao, Jian Wang, Yueting Xiao, Xinsheng Mao, Chao Zheng, Yining Wang

“…The sensitivity, specificity, and accuracy at patient-based analysis were 94%, 71%, and 88%, respectively, by AI post-processed whole-heart CMRA. …”
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Multi-Comparison of Different Ocular Imaging Modality-based Deep Learning Models for Visually Significant Cataract Detection by Jocelyn Hui Lin Goh, BEng, Xiaofeng Lei, MSc, Miao-Li Chee, MPH, Yiming Qian, PhD, Marco Yu, PhD, Tyler Hyungtaek Rim, MD, PhD, Simon Nusinovici, PhD, David Ziyou Chen, MBBS, FRCOphth, Kai Hui Koh, BSc, Samantha Min Er Yew, BSc, Yibing Chen, BEng, Victor Teck Chang Koh, MBBS, MMed, Charumathi Sabanayagam, MD, PhD, Tien Yin Wong, MD, PhD, Xinxing Xu, PhD, Rick Siow Mong Goh, PhD, Yong Liu, PhD, Ching-Yu Cheng, MD, PhD, Yih-Chung Tham, PhD

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Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment by Xianzhu Zhang, Wei Jiang, Xinyu Wu, Chang Xie, Yi Zhang, Liying Li, Yuqing Gu, Zihao Hu, Xinrang Zhai, Renjie Liang, Tao Zhang, Wei Sun, Jinchun Ye, Wei Wei, Xiaozhao Wang, Yi Hong, Shufang Zhang, Youzhi Cai, Xiaohui Zou, Yihe Hu, Hongwei Ouyang

“…Furthermore, cross-species comparisons employing machine learning reveal high resemblance of the relative Krt8+ SSCs/Has1+ MFs composition in bone regeneration with that in public data from developmental bone tissues. …”
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Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy by Louis Boon, Matheus H W Crommentuijn, Sjoerd T T Schetters, Laura J W Kruijssen, Yvette van Kooyk, Ernesto Rodriguez, Jan Van den Bossche, Joke M M Den Haan

“…We additionally analyzed existing single cell RNA sequencing data of the myeloid compartment of patients with melanoma undergoing αPD1 ICB. …”
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Macleaya cordata extract improves egg quality by altering gut health and microbiota in laying hens by Guoxin Zhang, Bochen Song, Xue Pan, Chake Keerqin, Okasha Hamada, Zhigang Song

“…Furthermore, the dietary supplementation of MCE led to a significant enhancement in eggshell thickness and Haugh unit at wk 8 and the data showed a statistically significant linear and quadratic increase (P < 0.05). …”
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Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension by M. A. Manukyan, A. Yu. Falkovskaya, V. F. Mordovin, I. V. Zyubanova, V. A. Lichikaki, E. I. Solonskaya, A. A. Vtorushina, S. A. Khunkhinova, I. A. Skomkina, V. V. Rudenko, T. Yu. Rebrova, E. F. Muslimova, S. A. Afanasyev

“…The compared groups did not differ in sex and age composition, prevalence of T2D and basic clinical data. …”
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Immune cell topography of head and neck cancer by Bernard A Fox, Rieneke van de Ven, Carmen Ballesteros-Merino, Tara Muijlwijk, Sonja H Ganzevles, Ruud H Brakenhoff, Jos B Poell, Dennis N L M Nijenhuis, C René Leemans, Laura A N Peferoen, Elisabeth Bloemena, Fatima Ekhlas

“…Also, the fraction of T cells within 10 µm of CD163+macrophages was lowest in OCSCC, indicating fewer myeloid/T-cell suppressive interactions in OCSCC.Conclusions We comprehensively described the TIME of HNSCC using a unique data set of resection specimens. We discovered that the composition, as well as the relative localization of immune cells in the TIME, differed in distinct anatomical sites of the head and neck.…”
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Anticoagulation therapy and related outcomes among Asian patients after bioprosthetic valve replacement by Tang-Yu Liu, Yi‐Hsin Chan, Victor Chien-Chia Wu, Dong-Yi Chen, Kuo-Chun Hung, Fu-Chih Hsiao, Ying-Chang Tung, Chia-Pin Lin, Pao-Hsien Chu, Shao-Wei Chen

“…Main outcomes and measures The outcomes of primary and secondary interest were composite thromboembolic events and bleeding events during the 1-year follow-up, respectively. …”
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Modified double-row suture bridge technique for anterior colliculus fractures combined with deltoid ligament injury: a retrospective study by Jianlong Ni, Zhihao Chen, Wang Wei, Ruiying Li, Dazhi Wang, Dongjian Wang, Zenan Tian, Zhikun Jia, Qichun Song, Meng Feng, Zhibin Shi

“…For clinical outcome evaluation, objective data are presented through clinical examination findings; radiographic assessments, including X-rays and computed tomography (CT); and follow-up analysis utilizing American Orthopaedic Foot & Ankle Society ankle‒hindfoot (AOFAS) scores, Olerud Molander Ankle Scores (OMAS), and visual analogue scale (VAS) scores. …”
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The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical an... by Michael G. Fehlings, Karlo M. Pedro, Mohammed Ali Alvi, Ali Moghaddamjou, James S. Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Paul M. Arnold, James D. Guest, Shekar N. Kurpad, James M. Schuster, Ahmad N. Nassr, Karl M. Schmitt, Jefferson R. Wilson, Darrel S. Brodke, Faiz U. Ahmad, Albert Yee, Wilson Z. Ray, Nathaniel P. Brooks, Jason Wilson, Diana S-L. Chow, Elizabeth G. Toups, Kevin E. Thorpe, Jiaxin Huang, Peng Huang

“…The overall probability of improvement was computed using a summary estimate, the global treatment effect (GTE). …”
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Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas by Ziyan Xu, Yunzhi Wang, Tao Xie, Rongkui Luo, Heng-Li Ni, Hang Xiang, Shaoshuai Tang, Subei Tan, Rundong Fang, Peng Ran, Qiao Zhang, Xiaomeng Xu, Sha Tian, Fuchu He, Wenjun Yang, Chen Ding

“…Through integrative analysis with single-cell transcriptomic data, we elucidated the cellular composition and cell–cell communications in a spatial context. …”
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Chemical characterization of menstrual and intimate care products: An extractables &amp; leachables investigation by Quinten Marcelis, Eric Deconinck, Vera Rogiers, Heidi Demaegdt, Mélanie Di Mario, Tamara Vanhaecke, Bart Desmedt

“…Conclusion: This study provides new insights into the chemical composition of MICPs. Furthermore, it demonstrates that the majority of hazardous chemicals present in the studied MICPs are not detected under realistic use conditions; however exposure to phthalates, fragrances and other chemical constituents remains possible.…”
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The impact of participation status on the colorectal cancer incidence, stage and survival outcomes in the Shanghai colorectal cancer screening program by PENG Peng, DOU Jianming, WU Chunxiao, PANG Yi, GONG Yangming, WU Mengyin, SHI Yan, GU Kai

“…The registered residents in Shanghai from 2013 to 2017 who met the screening age range were divided into screening group and non-screening group. The data of colorectal cancer cases after being included in groups were obtained from the Population Based Cancer Registry. …”
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Biological activities of optimized biosynthesized selenium nanoparticles using Proteus mirabilis PQ350419 alone or combined with chitosan and ampicillin against common multidrug-re... by Laila A. Elshikiby, Zakaria A.M. Baka, Mohamed M. El-Zahed

“…The absorption peaks for Se NPs and Se/CS/AMP were identified to be between 350 and 360 nm. The XRD data revealed the crystalline composition of the Se NPs loaded with CS and AMP. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. Particle size distribution, quantification and zeta-potential was measured with nanoparticle tracking analysis. …”
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Longitudinal characterization of the metabolome of dairy cows transitioning from one lactation to the next: Investigations in fecal samples by M.H. Ghaffari, H. Sauerwein, H. Sadri, S. Schuchardt, J. Martín-Tereso, J.H. Doelman, J.B. Daniel

“…These results underscore the value of this data set in advancing the application of fecal metabolome profiling to investigate metabolic changes during critical transitions in the lactation cycle of dairy cows.…”
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Prospective comparison of the digestive tract resistome and microbiota in cattle raised in grass-fed versus grain-fed production systems by Jiye Kwon, Windy Tanner, Yong Kong, Martina Wade, Chad Bitler, Marilia B. Chiavegato, Melinda M. Pettigrew

“…Beta-diversity estimates indicated overlap in the pre-weaning resistome and microbiota in both systems, which diverged post-weaning, with increases in several medically important ARGs when system B cattle transitioned to a grain diet. Analysis of compositions of microbiomes with bias correction indicated that levels of tetracycline, macrolide, aminoglycoside, beta-lactam, and bacitracin ARGs were significantly higher in system B cattle pre-harvest. …”
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Prediabetes: prevalence, associations with cardiovascular risk factors and contribution to survival in the Russian population by Yu. A. Balanova, S. A. Shalnova, A. E. Imaeva, V. A. Kutsenko, A. V. Kapustina, S. E. Evstifeeva, G. A. Muromtseva, R. V. Ievlev, R. N. Shepel, O. M. Drapkina

“…Prediabetes and T2D demonstrated a significant decrease of survival, including cardiovascular survival, and the occurrence of a composite endpoint. However, multivariate analysis adjusted for sex, age, and region of residence indicates a significant contribution of T2D, but not IFG.Conclusion. …”
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Lipidomic profile of seminal plasma in non-obstructive azoospermia with sperm maturation arrest by S. I. Gamidov, T. V. Shatylko, A. Kh. Tambiev, A. O. Tokareva, V. V. Chagovets, T. B. Bitsoev, N. L. Starodubtseva, A. Yu. Popova, V. E. Frankevich

“…Samples of seminal plasma for lipid composition of 24 men with normozoospermia and 64 men with azoospermia were studied. …”
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Prevalence and factors associated with poor umbilical cord care among postpartum mothers in South Western Uganda: a cross sectional study by Brian Mugoya, James K. Tumwine, Emmanuel Ategeka, Timothy Nduhukire, Valence Mfitumukiza, Munezero Tamu, Amito Paula Mary, Christiana Nkiru Okafor, Jane Turyasingura, Kabami Jane, Mandera Immaculate, Alex Tumusiime, Kenyange Grace, Agnes Napyo

“…Methods The cross-sectional study was done at the Young Child Clinic in Kabale regional referral hospital among postpartum mothers with infants aged 6weeks to 6 months of age. Data was collected, entered into excel and exported to Stata version 14 (StataCorp, College Station, Texas, U.S.A) for analysis. …”
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