Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond by Jiaxin Wen, Yanfeng Wang, Song Wang, Yuxin Liang, Xiaozhen Hu, Qiuxiang Ou, Hua Bao, Kuo Zhao, Youyu Wang

“…Methods We analyzed genomic and transcriptomic data from pretreatment tumor samples of 342 melanoma patients treated with ICIs to identify mutations and expression signatures associated with ICI response and survival. …”
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Borreliosis and doxycycline treatment disrupt gut microbiota and immune responses in nonhuman primates by Ethan G. Napier, Isaac R. Cinco, Sheridan B. Wagner, Ethan V. Stuart, Qi Qiao, Joshua Taylor, Brian Stevenson, Ilhem Messaoudi

“…To address this knowledge gap, we longitudinally compared the immune response and gut microbial composition of Japanese macaques after intradermal infection with Bb strain 297 with or without doxycycline treatment. …”
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Blood profile as a health indicator in broiler chickens fed diets of different particle sizes supplemented with multienzyme by Kareem Damilola Uthman, Amos Adedoyin Titi, Idowu Olubukola Precious Adepeju, Bonagurio Lucas Pimentel, Idowu Olusegun Mark Obafemi

“…The blood indices of the chickens were evaluated. The data were subjected to Analysis of Variance (ANOVA), and means were compared using the Tukey Test at a 5 % probability level. …”
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Seasonal reversal in phytoplankton assembly mechanisms: stochastic dominance in autumn vs. deterministic control in spring within the middle and lower reaches of the Yellow River by Dahai Zeng, Dahai Zeng, Dahai Zeng, Houkuan Ding, Houkuan Ding, Houkuan Ding, Yuanyuan Tang, Yuanyuan Tang, Yuanyuan Tang, Yunni Gao, Yunni Gao, Yunni Gao, Jialin Jin, Jialin Jin, Jialin Jin, Xiaofei Gao, Xiaofei Gao, Xiaofei Gao, Jingxiao Zhang, Jingxiao Zhang, Jingxiao Zhang, Huatao Yuan, Huatao Yuan, Huatao Yuan, Jing Dong, Jing Dong, Jing Dong, Xuejun Li, Xuejun Li, Xuejun Li

“…Non-metric multidimensional scaling (NMDS) based on Bray–Curtis distances showed significant seasonal differences in phytoplankton community composition. Furthermore, β-diversity decomposition analysis revealed that turnover was the dominant component in both seasons, but the proportion of nestedness was significantly higher in spring compared to autumn (p < 0.05). …”
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Leveraging a foundation model zoo for cell similarity search in oncological microscopy across devices by Gabriel Kalweit, Gabriel Kalweit, Anusha Klett, Paula Silvestrini, Paula Silvestrini, Jens Rahnfeld, Jens Rahnfeld, Mehdi Naouar, Mehdi Naouar, Yannick Vogt, Yannick Vogt, Diana Infante, Diana Infante, Rebecca Berger, Jesús Duque-Afonso, Tanja Nicole Hartmann, Marie Follo, Marie Follo, Elitsa Bodurova-Spassova, Elitsa Bodurova-Spassova, Michael Lübbert, Michael Lübbert, Roland Mertelsmann, Roland Mertelsmann, Roland Mertelsmann, Joschka Boedecker, Joschka Boedecker, Joschka Boedecker, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Maria Kalweit, Maria Kalweit

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Characteristics of cardiopulmonary exercise capacity in adults with different degrees of obesity by Shukun Deng, Shengrui Mei, Qunyan Zhou, Wenjun Zhi, Wenjun Wu, Junyan Cai, Peng Yuan

“…Spearman correlation analysis was used to analyze the correlation between BMI and various indicators.ResultsThere was no statistical significance in gender composition, age, height, and exercise habit of the five groups of participants (P > 0.05). …”
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A chemical autonomous robotic platform for end-to-end synthesis of nanoparticles by Fan Gao, Hongqiang Li, Zhilong Chen, Yunai Yi, Shihao Nie, Zihao Cheng, Zeming Liu, Yuanfang Guo, Shumin Liu, Qizhen Qin, Zhengjian Li, Lisong Zhang, Han Hu, Cunjin Li, Liang Yang, Yunhong Wang, Guangxu Chen

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Sex-specific association of per- and polyfluoroalkyl substances (PFAS) exposure with vitamin D concentrations in older adults in the USA: an observational study by Hui Zhao, Yuxin Ren, Jianping Ni, Lanlan Fang, Tao Zhang, Mengmeng Wang, Guoqi Cai, Yubo Ma, Faming Pan

“…Methods This observational investigation utilized cross-sectional data obtained from the U.S. NHANES spanning the years 2003 to 2018. …”
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Dietary non-enzymatic antioxidant capacity and risk of breast cancer: the Swedish National March Cohort by Daniela Mariosa, Marta Ponzano, Alessandra Grotta, Ylva Trolle Lagerros, Essi Hantikainen, Hans-Olov Adami, Mauro Serafini, Rino Bellocco, Weimin Ye

“…However, sensitivity analysis on imputed covariates did not fully confirm our findings, indicating the need for future confirmatory research.…”
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Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Pop... by Shifali Singh, Lisa Kluen, Katelin Curtis, Raquel Norel, Carla Agurto, Elizabeth Grinspoon, Zoe Hawks, Shawn Christ, Susan Waisbren, Guillermo Cecchi, Laura Germine

“…As applicable, within-person reliability was also computed; we demonstrated strong reliability for processing speed (0.87). …”
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State of local immunity in patients with furunculosis by M.M. Popov, D.S. Samusenko, O.V. Ohnivenko

“…Results. Analysis of the cellular composition of the nasal mucosa shows that among the cells in the scrapings of patients of group 1 and group 3, destroyed epithelial cells predominate, the percentage of which is 61.4 ± 5.6% and 66.5 ± 6.3% of the total number of cells in the preparation, respectively.In patients of group 2, epitheliocytes are mainly represented by intact units, their percentage was 66.5 ± 0.6%, and destroyed cells – 20.7 ± 0.2%. …”
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Utility of 18F-FDG PET/CT and Cardiac MRI in early Cardiac Sarcoidosis by Muthiah Subramanian, Bharat Narasimhan, Radhika Korabathina, Suneetha Batchu, Vishnu Vardhan Ravilla, Mohan Roop, Sachin Yalagudri, Daljeet Kaur Saggu, Calambur Narasimhan

“…Methods: Data of 110 consecutive patients with biopsy-proven CS from the Granulomatous Myocarditis Registry were analyzed. …”
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Diagnosis and Treatment of the Sigmoid Colon Volvulus As a Form of Colonic Obstruction by A. G. Lebedev, P. A. Yartsev, D. A. Blagovestnov, B. T. Tsuleiskiri, I. E. Selina, G. A. Zaitsev, M. Drayer, N. V. Shavrina

“…High mortality does not allow us to call the results of treatment satisfactory, and a small number of observations does not allow us to obtain statistically significant results, which requires further case recruitment and data analysis.…”
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Effects of Therapeutic Hypothermia and Minimal Enteral Nutrition on Short-Term Outcomes in Neonates with Hypoxic–Ischemic Encephalopathy: A 10-Year Experience from Oman by Manoj Malviya, Sathiya Murthi, Dhanya Jayaraj, Vidya Ramdas, Fadia Nazir Malik, Valsala Nair, Nusrabegam Marikkar, Mukesh Talreja, Tariq Sial, Prakash Manikoth, Renjan Varghese, Khalsa Ali Al Ramadhani, Salima Al Aisry, Said Al Kindi, Ahmed Al Habsi, Ranjit Torgalkar, Munawwar Ahmed, Mohammed Al Yahmadi

“…Multivariate regression analysis revealed that the severity of HIE at admission (OR 3.4 (1.03–11.6); <i>p</i> < 0.04) and gestational age (OR: 0.624 (0.442–0.882); <i>p</i> < 0.008) were independent predictors of composite outcomes of death and brain injuries. …”
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In-vivo high-resolution χ-separation at 7T by Jiye Kim, Minjun Kim, Sooyeon Ji, Kyeongseon Min, Hwihun Jeong, Hyeong-Geol Shin, Chungseok Oh, Robert J. Fox, Ken E. Sakaie, Mark J. Lowe, Se-Hong Oh, Sina Straub, Seong-Gi Kim, Jongho Lee

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Effect of Pre-Freezing 18 °C Holding Time on Post-Thaw Motility and Morphometry of Cryopreserved Boar Epididymal Sperm by Mamonene Angelinah Thema, Ntuthuko Raphael Mkhize, Maleke Dimpho Sebopela, Mahlatsana Ramaesela Ledwaba, Masindi Lottus Mphaphathi

“…Thawing was accomplished by immersing the semen straws in warm (37 °C) water for 1 min and the samples were evaluated for sperm motility and morphometry traits using the computer-assisted sperm analyzer system. The data were analyzed using variance analysis. …”
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Poor sleep quality and associated factors among HIV-positive and negative postpartum women in Addis Ababa, Ethiopia: a comparative cross-sectional study by Milen Mihertabe, Alehegn Bishaw Geremew, Alehegn Bishaw Geremew, Elsa Awoke Fentie, Gidey Rtbey

“…Variables having a p-value of less than 0.05 in multivariable analysis were considered statistically significant and an adjusted odds ratio with a 95% confidence interval (CI) was computed.ResultsIn this study, the overall prevalence of poor sleep quality among postpartum women was 56.3% [95% CI (51.9, 60.6)]. …”
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Prevalence of virological failure and associated factors among adult individuals on highly active antiretroviral treatment (HAART) in public health facilities at Tulu Bolo Town, So... by Ashenafi Lamesa, Shibire Teshoma, Habtamu Oljira Desta, Belay Tafa Regassa, Tolossa Waqkene

“…The total sample sizes of 274 records of clients were selected using simple random sampling technique. Data were cleaned and entered into EPI info version 7.2.0.1 and exported to SPSS version 20.0 for further analysis. …”
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Exploring farmer perspectives on Bambara groundnut [Vigna subterranea (L.) Verdc]: production constraints, preferred varietal traits and implications for varietal development in no... by Josephine T. Pasipanodya, Lydia N. Horn, Cecil Togarepi, Julia Sibiya, Rudo Musango, Enoch G. Achigan-Dako

“…To compare motivators to increase Bambara groundnut production across the agroecologies, a Kruskal-Wallis test was conducted. The Friedman analysis of variance was computed to test for differences in production constraints, and the Wilcoxon Post hoc test was used for pairwise comparison of the constraints variables across the surveyed regions. …”
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CHARACTERISTICS OF CELLULAR IMMUNE STATUS IN THE PATIENTS WITH CHRONIC RHINOSINUSITIS WITH NASAL POLYPS by E. L. Savlevich, S. V. Khaidukov, O. М. Kurbacheva, G. P. Bondareva, K. N. Shachnev, A. S. Simbirtsev

“…Bilateral CRSwNP was clinically confirmed by endoscopic examination of nasal cavity and computed tomography scan of paranasal sinuses. In order to define the clinical phenotype of CRSwNP, allergy skin testing and a specific questioning were performed. …”
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