Delivery of care in high mortality hospital settings: a direct observational study examining 1848 h of neonatal nursing in KenyaResearch in context by Abdulazeez Imam, Michuki Maina, Jalemba Aluvaala, Vincent Kagonya, Onesmus Onyango, Fredrick Were, Sebastian Fuller, Kenneth Karumba, Mike English, David Gathara, Peter Mwangi, Lucy Kinyua, Lydia Thuranira, Virginia Njoroge, Ngina Mwangi, Loise Mwangi, Penina Musyoka, Zainab Kioni

“…We determined nursing hours per patient per 12-h shift to measure nursing workload (primary exposure variable) and used a composite measure, the nursing care index (NCI), to score the nursing care delivered to a baby (primary outcome variable). …”
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Genomic correlation, shared loci, and causal link between obesity and diabetic microvascular complications: A genome-wide pleiotropic analysis by Wei Zhang, Qinghua Zhang, Yan Luo, Leilei Ma, Xuejun Wang, Qiao Zheng, Xiaotian Zhang, Shentao Wu, Zhan Li, Yingfei Bi

“…To validate shared genetic regions, we conducted pleiotropic analysis under the composite null hypothesis (PLACO), functional mapping and annotation (FUMA), and colocalization analysis. …”
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Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study by Duncan Wagstaff, John Amuasi, Sumaiya Arfin, Diptesh Aryal, Mohd Basri Mat Nor, Joseph Bonney, Arjen Dondorp, David Dongelmans, Layoni Dullawe, Fathima Fazla, Aniruddha Ghose, Eva Hanciles, Rashan Haniffa, Madiha Hashmi, Adam Hewitt Smith, Bharath Kumar, Yen Lam Minh, Ramani Moonesinghe, Luigi Pisani, Cornelius Sendagire, Mohd Shahnaz Hasan, Maryam Shamal Ghalib, Moses Siaw Frimpong, Otavio Ranzani, Menbeu Sultan, David Thomson, Swagata Tripathy, Louise Thwaites, Rabiul Alam Md. Erfan Uddin, Mohd Zulfakar Mazlan, Wangari Waweru-Siika, Abigail Beane

“…The primary outcome is a composite measure of fidelity, reach and adoption. …”
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Constricting Gaps: Protocol development, implementation challenges and lessons learned for the reality map of unmet needs for Palliative Care Interventions in advanced cancer patie... by Natalie Kalbermatten, Razvan Curca, Alexandru Grigorescu, Daniela Mosoiu, Florina Pop, Vladimir Poroch, Ariana Rosiu, Patriciu Achimas-Cadariu, Florian Strasser

“…Later data become less, and data quality on QI variable, revealing gaps in research conduct competences, resources, and applicability of over-sophisticated quality assurance tools. …”
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Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain) by Ronald C Kessler, Jose Maria Huerta, Fernando Navarro-Mateu, Mari Paz Quesada, Teresa Escámez, Mª José Alcaráz, Catherine Seiquer de la Peña, Diego Salmerón, Gemma Vilagut, Maria Dolores Chirlaque, Carmen Navarro, Mathilde Husky, Jordi Alonso, Salvador Martínez

“…In all, 142 cases and 531 controls were interviewed and a subsample of 114 cases (80.3%) and 329 controls (62%) provided a biological sample.Exposure A history of 12 childhood adversities, lifetime mental disorders and sociodemographic variables was assessed with the Composite International Diagnostic Interview (CIDI)version 3.0). …”
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Atorvastatin and telmisartan do not reduce nasopharyngeal carriage of SARS-CoV-2 in mild or moderate COVID-19 in a phase IIb randomized controlled trial by Fabrice Bonnet, Adama Doumbia, Vanessa Machault, Frederic Nogbou Ello, Pantxika Bellecave, Corine Bernice Akpovo, Baba Toumany Sidibe, Laura Fernandez, Antoine Kouamé, Edgard Adjogoua, Mireille Dosso, Serge Niangoran, Valérie Journot, Serge Paul Eholié

“…The primary endpoint was viro-inflammatory success defined as a composite variable at day 11: Ct ≥ 40 and C-reactive protein < 27 mg/L. …”
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Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study by Shiming He, Yinghao Kuang, Xinfang Huang, Yafei Jian, Jinyan Zhang, Wanfen Huang, Yang Zou, Guotai Sheng, Wei Wang, Hongyi Yang

“…The present research examines the association between stroke risk and both the triglyceride glucose-weight adjusted waist index (TyG-WWI, a composite marker of insulin resistance and obesity) and its cumulative exposure (CumTyG-WWI). …”
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A large-sample modelling approach towards integrating streamflow and evaporation data for the Spanish catchments by P. Yeste, P. Yeste, P. Yeste, M. García-Valdecasas Ojeda, M. García-Valdecasas Ojeda, S. R. Gámiz-Fortis, S. R. Gámiz-Fortis, Y. Castro-Díez, Y. Castro-Díez, A. Bronstert, M. J. Esteban-Parra, M. J. Esteban-Parra

“…This work aims to investigate the capabilities of the Variable Infiltration Capacity (VIC) model in a large-sample application focused on the joint integration of streamflow and evaporation data for 189 headwater catchments located in Spain. …”
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Optimization of photocatalytic degradation of sulfamethoxazole from wastewater using developed N-doped TiO2/biochar by Hailu Ashebir, Saeideh Babaee, Palesa Diale, Abebe Worku, T.A.M. Msagati, Jemal Fito Nure

“…RSM employed Central Composite Design (CCD) comprising four variables and 30 experimental runs to model and analyze degradation process. …”
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Evaluation of antimicrobial photodynamic therapy and minimal intervention associated with deproteinisation in permanent teeth with molar incisor hypomineralisation: study protocol... by Ana Paula Taboada Sobral, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Raquel Agnelli Mesquita Ferrari, Amanda Rafaelly Honório Mandetta, Carolina Carvalho Bortoletto, Renato Araujo Prates, Alessandro Melo Deana, Rita de Cássia Loiola Cordeiro, Lourdes Aparecida Martins dos Santos Pinto

“…The teeth will subsequently be restored using a mixed technique with resin-modified glass ionomer cement and bulk-fill composite resin. The data will be submitted to descriptive statistical analysis. …”
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Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Ind... by Simone Solano, Mingming Yang, Paolo Tolomeo, Toru Kondo, Li Shen, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Jean L. Rouleau, Muthiah Vaduganathan, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Milton Packer, Scott D. Solomon, John J. V. McMurray

“…The primary outcome was the composite of HF hospitalization or cardiovascular death. …”
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Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study by Olivier D. Steen, Martje Bos, Sonja L. van Ockenburg, Yiling Zhou, Ilja M. Nolte, Harold Snieder, Kenneth Kendler, Judith G. M. Rosmalen, Hanna M. van Loo

“…We defined cases for three functional disorders (myalgic encephalomyelitis/chronic fatigue syndrome; ME/CFS, fibromyalgia, and irritable bowel syndrome; IBS), two internalizing disorders (major depressive disorder; MDD and generalized anxiety disorder; GAD), cardiometabolic diseases (obesity, metabolic associated steatotic liver disease, type 2 diabetes, hypertension and cardiovascular disease) and immune-related diseases (composite measures of auto-immune disease and atopy). …”
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Surface Defect Detection for Small Samples of Particleboard Based on Improved Proximal Policy Optimization by Haifei Xia, Haiyan Zhou, Mingao Zhang, Qingyi Zhang, Chenlong Fan, Yutu Yang, Shuang Xi, Ying Liu

“…The method integrates the variable action space and the composite reward function and achieves the balanced optimization of different types of defect detection performance by adjusting the scaling and translation amplitude of the detection region. …”
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Investigating the role of job satisfaction and work engagement dynamics in reducing turnover intentions among female bank employees by Nurdjanah Hamid, Wahda Rasyid, Andi Aswan, Insany Fitri Nurqamar, Romi Setiawan, Rianda Ridho Hafizh Thaha

“…The collected data were analyzed using Structural Equation Modeling (SEM) to ensure that each indicator appropriately defined its constructs of the variables. The study applied Composite Reliability (CR) and Average Variance Extracted (AVE) to verify that the loading weights and measurement models met the SEM requirements. …”
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Association of Systemic Inflammatory Response Syndrome With Cardiovascular Events After Mitral Transcatheter Edge‐to‐Edge Repair by Carlo Mannina, Akarsh Sharma, Andreina Carbone, Eduardo Bossone, Antonino Tuttolomondo, Edgar Argulian, Eric Neibart, Michael B. Hadley, Jonathan Halperin, George Dangas, Samin K. Sharma, Annapoorna Kini, Stamatios Lerakis

“…The primary end point of major cardiovascular events was the composite of nonfatal myocardial infarction, nonfatal stroke, and all‐cause death. …”
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Application of machine learning and neural network models based on experimental evaluation of dissimilar resistance spot-welded joints between grade 2 titanium alloy and AISI 304 s... by Marwan T. Mezher, Alejandro Pereira, Rusul Ahmed Shakir, Tomasz Trzepieciński

“…The use of a composite welded joint consisting of titanium and austenitic stainless steel metals is evidently a favourable selection for industrial applications employing the resistance spot welding (RSW) operation. …”
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Optimization of medium components for the production of exopolysaccharide by Lycoperdon pyriforme Schaeff.: Pers. using response surface methodology by MA Xiaokui, JIANG Hua, LI Junzhi, CHEN Yong, HE Xiaojing

“…A second-order polynomial models with EPS yield as response variable was then obtained and confirmed to adequately represent the actual relationship between the independent variables and responses through validation tests. …”
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Development and external validation of a risk prediction score (DASHI) for cardiovascular events following acute respiratory infections: derivation and validation retrospective coh... by Joseph J. Lee, Constantinos Koshiaris, Cynthia Wright-Drakesmith, Jennifer A. Davidson, Charlotte Warren-Gash, F.D. Richard Hobbs, James P. Sheppard

“…We derived two logistic regression models, one with the top ranked variables, and another including additional lower ranked variables. …”
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A Proposed Genetic Risk Score for Dilated Cardiomyopathy Susceptibility in the Chinese Han Population by Jianjun Lan, MD, Lin Wang, MD, Guoyuan Qiu, MD, Shihai Wang, MD, Chao Yang, MD, Mengnian Ran, MD, Hongyu Li, MD, Shiyang Li, MD

“…The predictive power of the genetic risk score and a composite variable for DCM risk were evaluated using receiver operating characteristic curve analysis. …”
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Estimating complications and mortality in patients with post-surgical chronic hypoparathyroidism in England: A retrospective matched cohort study by Narendra L. Reddy, Caoimhe T. Rice, Sara J. Carvalho, Jennifer A. Davidson, Elizabeth Glenister, Christopher T. Sibley, Alden R. Smith, Wahidullah Noori

“…Compared to patients without HypoPT, patients with post-surgical chronic HypoPT had higher adjusted risks of mortality (adjusted hazard ratio [HR] 2.89, 95% confidence interval [CI] 1.85–4.51, p<0.001) and composite renal complications (adjusted HR 4.10, 95% CI 2.25–7.46, p<0.001). …”
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